Conserved Protein Domain Family
Tis11B_N

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pfam04553: Tis11B_N 
Tis11B like protein, N-terminus
Members of this family always contain a tandem repeat of CCCH zinc fingers pfam00642. Tis11B, Tis11D and their homologs are thought to be regulatory proteins involved in the response to growth factors. The function of the N-terminus is unknown.
Statistics
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PSSM-Id: 398311
Aligned: 17 rows
Threshold Bit Score: 110.65
Threshold Setting Gi: 82186303
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
A4IIN5         1 MSTTLLSAFYDI-DLLYK-NEKVL-------------------------N-------------------NLALSTMLDKK 34  tropical clawed...
XP_005005192   1 MSTTLLSAFYDF-DFLYK-ADKSL-------------------------A-------------------NINLNTMLDKK 34  domestic guinea...
NP_001070621   1 MTTAVVSPFFDFsEMINN-KNKMLnynnnilssphpvsvpctgtslsisN-------------------PTGC--LLDRK 58  zebrafish
XP_006632729   1 MTTAVVSPFFDFsEVLNK-NNKMMnynnniltaphpssvpctgpsppisT-------------------PSGP--LLDRK 58  spotted gar
Q6P3H0         1 -mTAVVSSFFDY-EVTNK-NNKVMtfnsplssphlq--svpsmganssfT-------------------PTGT--LLDRK 54  zebrafish
XP_006638707   1 MSATILSAFYDI-EMLCKqTEKTLn-----------------------mN-------------------AIHLNSMLDKK 37  spotted gar
XP_005998341   2 sTTTLLSAFYEI-DFICKqTEKSL-------------------------N-------------------TLNLN-MLDKK 35  coelacanth
XP_028279700  14 MSATVLSAFYDM-DMLYK-QDKSMn-----------------------mN-------------------ALHINSMLDKK 49  Indian glassy fish
XP_023127552   1 MTTAVVSPFFDF-EVMNK-NNKLLsyn--------------------nnLgaphpmsvpctgtnvpissPAGA--LLDRK 56  clown anemonefish
XP_001382196   1 MSTTLLSAFYDI-DFFCK-TEKSL-------------------------T-------------------NLNLNSMLDKK 34  gray short-tail...
A4IIN5        35 AVGSPVSSTN----SnlfpgFLRRHSASNLQALSgNTNp----------aKFcpn-----------nnqLKEP------- 82  tropical clawed...
XP_005005192  35 AVGTPVATASg---StfapgFLRRHSASNLHALA-QPApspg----scspKFagaaagg----agpyapLKEPp------ 96  domestic guinea...
NP_001070621  59 AVGTPSTG-Gv---------YQRRHSVTSANTKL-NQN------------QF-----------------LNIAkadps-l 97  zebrafish
XP_006632729  59 AVGTPSSSVGv---------YQRRHSVTLPNSKF-NQN------------QF-----------------INNSlkvepss 99  spotted gar
Q6P3H0        55 VVGAPSV--Gl---------YQRRHSVSVTSSKS-TQN------------QF-----------------INNLkmdns-a 92  zebrafish
XP_006638707  38 AVGAPVINSStancSsytpgFYRRNSTSNLDSLA-NSN------------KYpvtp----------ysnLKDStss---- 90  spotted gar
XP_005998341  36 AVGTPVSSS-----SsfapgFLRRHSTSNLQALA-NNSp-----------KFsnns----------fgnLKES------- 81  coelacanth
XP_028279700  50 AVGAPVTTPGs--gGsftpgFFRRNSTSNMEAMN-NGN------------KYsvgs----------ygsLKENtp----- 99  Indian glassy fish
XP_023127552  57 AVGSPSVG-Gv---------YQRRHSVS--STKF-SQN------------QF-----------------LNSLkaadhss 94  clown anemonefish
XP_001382196  35 AVGTPVTTSPs---SsftpgFLRRHSTSNLQALT-HPNpspatvpgncspKFtgvnscsssggsssysnLKEPsgg---- 106 gray short-tail...
A4IIN5        83 ----AAGSTALLNRENKFRDRSFSENGERSQhlLHLQQQ 117 tropical clawed frog
XP_005005192  97 ---sGGSSTALLNKENKFRDRSFSENGERSQhlLHLQQQ 132 domestic guinea pig
NP_001070621  98 lgsgTGTTGSS-NKENRLRDRSFSETGDRLL--QKCSGP 133 zebrafish
XP_006632729 100 tggsS-------NKENRFRDRSYSETGDRLL--PKSagg 129 spotted gar
Q6P3H0        93 singSSN-----NKENRFRDRSFSENGERLRpssitcis 126 zebrafish
XP_006638707  91 --ssSTTTTAIMNKENKFRDRAYSENGERSQhiQVAQQK 127 spotted gar
XP_005998341  82 ----SQISTALMNKENKLRDRSFSENGERSQhlLQMQQQ 116 coelacanth
XP_028279700 100 --ssNSSATALMNKENKFRDRAYSESGERGV----LQQK 132 Indian glassy fish
XP_023127552  95 li--sgvgnasnNKENRLRDRSFSETGERLI--NKCLGP 129 clown anemonefish
XP_001382196 107 --ggSAGTTALLNKENKFRDRSFSENGDRSQhlMQLQQQ 143 gray short-tailed opossum
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