6R7Z


Conserved Protein Domain Family
Anoctamin

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pfam04547: Anoctamin (This model is not part of the current CDD release)
Calcium-activated chloride channel
The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.
Statistics
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PSSM-Id: 516306
Aligned: 285 rows
Threshold Bit Score: 157.405
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6R7Z_B        200 IRGYFGETIALYFGFLEYFTFALIPMAVIGL----------------PYYlf----------vwEdydkyVI-FAS-FNL 251  human
A0DTP9        676 LCQYFGESVGTYFYFLCFFSQMLLYQNCLGLl---------------YYLiqi---------------psKIiYLVfQLQ 725  Paramecium te...
A0DAH3        688 ICSYYGEKIGLYFFFMSYYTKMLTFISVCGFgcslaewilnnqdgeaSIIi-------------------TMiFTF-VLI 747  Paramecium te...
A0EAT8        668 ICGYYGEKIGLYFYFMSYFTEMTTPLAFSGLacsliqwiiwdnesdfYILv-------------------TIiFAF-VQI 727  Paramecium te...
A0E006        685 ICSYFGEKIGLYFEFSAYYIKYYGLLSLIGIiytiftylskfydedvFTGi-------------------VSsFSI-LLI 744  Paramecium te...
A0DHW5        686 ICSYFGEKIGLFLEFTTHHILCYSVLSILGFlftiamitskeldkqtYTAi-------------------ISiFSL-LVV 745  Paramecium te...
A0C5J6        679 ICIYFGEKIGLYFKFSSYYIQFSTIMAALGVifnmimystniqhndiSLVa-------------------QSiFSI-LII 738  Paramecium te...
A0CHM6        689 ICLYFGEKVGLYFEFTSYFIKFSTPMAAFGLlfsvllytsqdydnevYTAt-------------------MSvFSI-LLV 748  Paramecium te...
A0CY40        679 ICSYFGEKIGLYFEFTSYFIKFSTPMAALGLlfsvlmyisqnynnevYTAt-------------------VSvFSI-LIV 738  Paramecium te...
XP_001028021  847 ICEYFGERIALYFTFQSFYFKAQFSVALLSTp---------------IFIvyeyfgqtdkglgaQi----AGlIHIfIVV 907 
6R7Z_B        252 IWSTVILELWKRGCANMTYRW----GTllmKR----KFE-------------EPRPGFHGV-LgI--NsitgkeeplyPS 307  human
A0DTP9        726 I-TSLYTSKWEQQLKIFNQSF----GI---------NSQedidttsnkqigePKRSLIN-------------------DQ 772  Paramecium te...
A0DAH3        748 QWNSIVTDYWKQQQVRFNLKY----GQ---LNekekSTE---------------RSSFKGTfIrSleN----------DQ 795  Paramecium te...
A0EAT8        728 HWSNVFTDLWKQKQIYFNLKY----GQ---NDqdqqQVQ---------------RSKFKGKhIrSlvN----------DQ 775  Paramecium te...
A0E006        745 HWSSFVTDYWNQMQLTFNIKY----GQ---NKnakeSFT---------------RTAFKGKhIrSvgN----------DQ 792  Paramecium te...
A0DHW5        746 LWNSFVTDYWKTTQIKFNIRQ----GF---NKraqeKLI---------------LMSFKGQyIrSveN----------DE 793  Paramecium te...
A0C5J6        739 NLNCFLTDYWNQTQFAFNIQN----GQ---NNnykyNLI---------------RSSFKGEqIrSisT----------DQ 786  Paramecium te...
A0CHM6        749 HWSSFQTDCWYQQQLTFNLKF----GQ---NRdvkeSII---------------RSSFKGQnIrSieN----------DQ 796  Paramecium te...
A0CY40        739 HWNSFQTDCWHQQQLTFNLKF----GQ---NRnvkeSII---------------RSSFKGQnVrSieS----------DE 786  Paramecium te...
XP_001028021  908 IWSNVFYGQWTYREAEFSLKYnqsqSG---------EDEed------------iRPGFRGEyErS--I----------TS 954 
6R7Z_B        308 YKr-------QLRIYLVSLP--FV-----ClclYFSL--YVMMIyfdmevwALGLHeNSGse----wTs-VLLYVP---- 362  human
A0DTP9        773 MNvpsineldQIFRECVSM---LIfillqL---LYSVifIALY--------F--L------------C---AWFQSlfkq 821  Paramecium te...
A0DAH3        796 LNsaaqddsdLVLRLFLAS---ILlvlliS---AYSG--LVVGLftlttalrnsfgs----efsnvsvmslevTLS---- 859  Paramecium te...
A0EAT8        776 LNsievlyheYLKRTLVSS---MLlfffiL---FYIG--IIVSLfvftvqlhnkyqe----elkqfdiatievTSA---- 839  Paramecium te...
A0E006        793 LNsqeaihseIIKRIIISV---SVlifliG---SDIG--IIIGLyffnlflktild------qagnefqclevIIS---- 854  Paramecium te...
A0DHW5        794 LNslgssqaqIISKLIISI---FIlilliG---SDFG--VIIAkfnefnn----------------kfynleiIIS---- 845  Paramecium te...
A0C5J6        787 LNftgiihfqFFWRISISI---FVlilifG---SDVC--ITIGLyffnlylesifa------stsiqfrnfeiIVT---- 848  Paramecium te...
A0CHM6        797 LNsigvihskFIQRLIISI---FIlifliG---SDIG--IFVGLyyfnlylktkld------dlgndfqyfevIVT---- 858  Paramecium te...
A0CY40        787 LNsigvihskFIQRLVISI---FIlifliG---SDIG--RIIGLyffnlylksefi------dlgnyfqyfeiIVT---- 848  Paramecium te...
XP_001028021  955 NKlndysydrRLTEKSERNYwiLIffiliV---NIVIiyALIY--------LQSYFdDHNtidsgktFmgLNIFIP---- 1019
6R7Z_B        363 -SIIY---AIVIEIM-N---RLYRYAA----EFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFV-------- 422  human
A0DTP9        822 tTAINnseIIIIAILhlglnkLYTFHAqktiQQLVDFEQQRTIQAVKLSYNLKLYSFSIIQQLGPLLILRFFnhsfqlvc 901  Paramecium te...
A0DAH3        860 -ATIN---VFVQLFVdK----FYDYIS----TSVTDFENHKTMQKYETSFVVKKFILYFCSYVVPLLFIGYLngplnly- 926  Paramecium te...
A0EAT8        840 -AAMN---FIAQLIAdN----IFDKIA----CQLTEYENYKTVESYETSFVLKKFIFQFFSYIAPLLFLDYLnqplnly- 906  Paramecium te...
A0E006        855 -GSLN---YGIQYLIdS----YYEQIA----TILTDFENYQTSLQYETSYIMKKYTLYWFSQLFPLMIVCFLhsplsly- 921  Paramecium te...
A0DHW5        846 -SSLN---FGIQKLIeQ----YYEQIA----TFLTDFENLQISNQYETSYTIKKYTLYSLSGLFPLLVIQFLnspfyly- 912  Paramecium te...
A0C5J6        849 -AILN---YVIQIIVeY----YYESIA----IVLTDFENFQTVEHYENSYCLKKYALICFSQLFPLLILCFLngelnlk- 915  Paramecium te...
A0CHM6        859 -ASLN---YIIQLVIdQ----FYEQIA----TILTDFENFQTSYQYETSYIIKKYTLYCFSQLIPLLMISFLhsplgly- 925  Paramecium te...
A0CY40        849 -ASLN---YVIQLLIsS----FYEQIA----TILTDFENFQTSYQYETSYIIKKYTLHCSSQVVPLLMVSFLnsplqly- 915  Paramecium te...
XP_001028021 1020 -TI-----ILEFIFWvEe--FLFKKFA----LFTCREANFKTTKEFEQSYSTKLFTFIFFNHLVPPTLISFIidqnigcv 1087
6R7Z_B        423 -----LK----------DMKLLR-QSLATLL---IT-----SQIL-------------NQIM-ESF--------LPywLQ 456  human
A0DTP9        902 qsdscEQyigyyfltyiIIKSVE--KLCVFL----------FNFYslrrqplfiykfqQHDInEYI-------------- 955  Paramecium te...
A0DAH3        927 ------------csksncSRHVQ-YYFSTIIiwqFL-----FKIL------------------QLFkfisdlakYP--KI 968  Paramecium te...
A0EAT8        907 ------------cartncERHVK-YYFSAIViliLF-----KQIV------------------NFCiflfkltkIK--IK 948  Paramecium te...
A0E006        922 ------------cqeencKQQVQ-YLFGTTIcwiFC-----AQVI------------------KFVklf------fqeKK 959  Paramecium te...
A0DHW5        913 ------------cweescKNEIQ-YFFATTIfwiFT-----LQFI------------------KYFrly------fkvKE 950  Paramecium te...
A0C5J6        916 ------------csqnncIGQAQ-YFFGTTLlltIInvkrrIQQI------------------K--------------EK 950  Paramecium te...
A0CHM6        926 ------------ckdencQHNVE-YYFGTTMmwiFL-----MQVI------------------RFLktffhelvKS--PQ 967  Paramecium te...
A0CY40        916 ------------ckeencRHNVE-YYFGTTMmlmFL-----MQVI------------------KFLmtfqndmvKN--PQ 957  Paramecium te...
XP_001028021 1088 qddcsYH----------LSVYIRsYQYIIVF----------KSIV------------------EII--------YP--LL 1119
6R7Z_B        457 RK---HG--Vr-------------vKrkvqalkADIDATLYEQVIL--EK-EMGTYlgtfDDYLELFL--------QFGY 507  human
A0DTP9        956 ----------------------------------EVQSKKPSNIK---------------DQYFNCIEenlqqnmvELTI 986  Paramecium te...
A0DAH3        969 K----YE--I---------------Ndnd-ihqFIDETSRRQSYAIspER--YGTL----EDYMEILI--------LYSL 1012 Paramecium te...
A0EAT8        949 S----YD--Y---------------Neid-imeFVEDQSSRQPYSQdfER--YGTM----QDYMELFV--------LISF 992  Paramecium te...
A0E006        960 NY---ESn-Kq-------------qSlnlsliqFIQEQEQKTPFQNsqEK--YGII----NEYMEFFL--------LLAL 1008 Paramecium te...
A0DHW5        951 QF---HIn-Qq-------------iQntdsllqLIQDQNSKVPFWRssEK--DGIV----DEYMEFFL--------FSTL 999  Paramecium te...
A0C5J6        951 S----Y---S---------------Sknl--ltFIENQESKTPFQQtqEK--YGII----DEYMKFFL--------LSTL 992  Paramecium te...
A0CHM6        968 K----LY--P---------------YnhstlcdFIENQEKRIPFQKsiEK--YGNI----DDYMDFFL--------QLTL 1012 Paramecium te...
A0CY40        958 K----LY--P---------------NnqqslcdFIEIQEQRIPFQKsvEK--YGNI----DEHMDFFL--------QLTL 1002 Paramecium te...
XP_001028021 1120 RSslnNVtqLvkqlvnkdvdqkqqyLfdhvnieIENQSGLMDSVIDeiDQpT--------RDYIEMFTyycfnvtyGFGF 1191
6R7Z_B        508 VSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRVFKR--PFSEPS-ANIGVWQLAFETMSVISV------VTNCALIgmsp 578  human
A0DTP9        987 LTYFAYIYPITYFMQWLLFVVQIYADKAQYLYYYQRpwP---QIdCFVKVWNNILQYIILSSViitsygLSNSLVFq--- 1060 Paramecium te...
A0DAH3       1013 LIIFGYSFPLSYFLLWSFNILQLQVKKYSFMYCLQR--PWPQNE-SSLGIWNNILDLVNQIGI------LTNTGIItvly 1083 Paramecium te...
A0EAT8        993 LSIFGYTFPFSFFILWISNIMQIQVKKNTFLYCLQR--PWPKNE-SSLGIWNFFLEIISLICL------LTNTGVVtiqy 1063 Paramecium te...
A0E006       1009 INLFGCLFPFSIALFWIWIIIQFQIQKYRLLYQIQR--PWPKGD-GSLGIWQEINQLINFVTL------LCNSGLIciyy 1079 Paramecium te...
A0DHW5       1000 INLFGCVFPLSVTFFWIWMILQVQILKLRLCYQLQR--PWPKNE-GSLGVWDDLNQLINLVAI------LSNSGITsiyy 1070 Paramecium te...
A0C5J6        993 INMFGGLFPLSFTLFWIWMILQFQIVKFKLLYQIQR--PWPKGD-SSLGIWFEIHQFINFISL------LSNCSLIcvyy 1063 Paramecium te...
A0CHM6       1013 TNIFGCLFPFSITLFWIWNILQVQISKLKLLFLFQR--PWPKGD-GSLGIWDDFYQLINFVTL------LCNSGLIciyy 1083 Paramecium te...
A0CY40       1003 INIFGCLFPFSVTLFWIWTILQVQISKLRLLYISQR--PWPKGD-GSLGIWDDFFQLINYMTL------LSNTGLIcmyy 1073 Paramecium te...
XP_001028021 1192 PLVFAITFG----ITFIKMIVTRRLF----TRRIKR--PNPQNA-STIGIFRQFMNLGSSLSI------LTYTGIFcftr 1254
6R7Z_B        579 qvnavfpeskaDLILIVVA-VEHALLALKFILAFAIPDKPRHIQMKLARL 627  human
A0DTP9       1061 ----------dKSQIFVFVsFMLLSYTMNFVYQVWYSETPSYLQK----- 1095 Paramecium tetraurelia
A0DAH3       1084 n------kkygEQLVLVFLsLLISNSLFKFVIASVFGDTPFRLTQLTIRH 1127 Paramecium tetraurelia
A0EAT8       1064 n------kqfgYELIMVFLgVLIFNCFGKFFIGAIFGQIPDALGDLMKRH 1107 Paramecium tetraurelia
A0E006       1080 y------gklqDQVVLLFLpLLFYNFFVKYITMSLFGGTPTILEQIMRRC 1123 Paramecium tetraurelia
A0DHW5       1071 k------srllDDIILLFLsLLFYHFLIKCITLGIFGNTPRIMQQIIQRG 1114 Paramecium tetraurelia
A0C5J6       1064 y------kylqDDVIQLFVtLLFYNFFIKYITNTTFLSPPLILEYIVKRG 1107 Paramecium tetraurelia
A0CHM6       1084 y------dklhDQIIILFLgLLFYNFFIKYLTNSIFGNSPIILDQIVKRS 1127 Paramecium tetraurelia
A0CY40       1074 y------etmkDQVIILFLaLLFYNFFIKYLTNSIFGNSPIILDQIVKRS 1117 Paramecium tetraurelia
XP_001028021 1255 sq---kpdwgpFTQLNAFMfISFFFFVVKFFIDRYYSELDSKTMDILKRQ 1301
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