8GZG,8DY9,7ZF2,8X6G,3HUG,6IDO


Conserved Protein Domain Family
Sigma70_r4
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pfam04545: Sigma70_r4 (This model is not part of the current CDD release)
Sigma-70, region 4
Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif. Due to the way Pfam works, the threshold has been set artificially high to prevent overlaps with other helix-turn-helix families. Therefore there are many false negatives.
Links
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Statistics
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PSSM-Id: 516304
Aligned: 108 rows
Threshold Bit Score: 45.5108
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8GZG_F 364 VLDTLSPRERDVLRLRYGlddgRMKTLEEIGQIFNVTRERIRQIEAKALRKLRH 417 Synechocystis sp. PCC 6803
Q9RI52 141 ALSRLPQAQRDVLCMAFY----EDLTQAQIAERTGVPLGTVKSHARRGLHRLRT 190 Streptomyces coelicolor
Q9A7S1 130 ALKSLSRGERLCVSLCYG----ADWSHGEAAEALNIPIGTVKSHVKRGLDKLRA 179 Caulobacter vibrioides
Q9AAF3 146 AMQTLNPDQSQAIEMAFF----QEQTHSQISEALGVPLGTVKARIRFGMMKLRA 195 Caulobacter vibrioides
Q9RKI2 138 ALGALPDKHRQVVQLVDI----DGLTYAEAAHLLDVPEGTVMSRLHRARKRIRA 187 Streptomyces coelicolor
Q9A3F1 123 ALASLPQRQRMLVSDVKL----TGLSLAEAGARAGISEGAAKVALHRALKALAE 172 Caulobacter vibrioides
Q73WV3 186 ALDSLPPEFRAAVVLCDI----EGLSYEEIGATLGVKLGTVRSRIHRGRQALRD 235 Mycobacterium avium subsp. paratuberculosis
Q9K7Z1 126 ALKQIPTEQREAIIRSYF----RGETHSEIATTMDKPLGSIKSLIRYGLNNLRK 175 Bacillus halodurans
P94370 124 LFSKLDPKLRTPVLLRHY----YGYTYAEIGVMLQIKEGTVKSRVHKGLQQIRK 173 Bacillus subtilis subsp. subtilis str. 168
Q9AD34 172 ALARLTPDQWECLRLRYW----DNLPFCEVGQRMDRSTGAAKILKDRALRSLSA 221 Streptomyces coelicolor
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