Conserved Protein Domain Family
Choline_transpo

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pfam04515: Choline_transpo 
Plasma-membrane choline transporter
This family represents a high-affinity plasma-membrane choline transporter in C.elegans which is thought to be rate-limiting for ACh synthesis in cholinergic nerve terminals.
Statistics
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PSSM-Id: 398290
Aligned: 278 rows
Threshold Bit Score: 102.271
Threshold Setting Gi: 159474360
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002952038  366 IGASIVAGFVLLITLLCISRIRIAVACVKVASQAVGSMP-SIIFFPILPF--VLEVGLVI-YWIAVT--A-----LmysS 434  Volvox carter...
XP_001581677  184 AFLLSITISLIFIFIYFRKNISAISPMVSVSVDIFRRVPsLLHVAPILIFggLFAFAFVV-FGYFFSkgI---------G 253  Trichomonas v...
XP_001616656  397 FGLLAHGVVFLFVLYLYRNTYKYTHRLITVALDFVNSVS-NLLYAPCVVS--AASLAWFF-LWMCGYvyV---------M 463  malaria paras...
A0DXS7        271 iGTAGIGLLFLFNIMKLFNKINLGISLIKTSSQIVLVLK-QLRFFAIFVA--FIGFVQLGySCIVIFygM---------T 338  Paramecium te...
A0DPM3        324 IVFLALAAIYLIVTLILFKRIQRGISLLKTAQHIIQVLS-QIRSFPFIVA--FIGLVVCClAFILVCfaM---------T 391  Paramecium te...
XP_001581044  286 VVIWCIAFIIILIIIFLWSKLKSAVAIIKVAAMALGYNF-LVIFVPIITM--IFCFLFWA-ALLVSSvtLytsasF---K 358  Trichomonas v...
EAX96980      106 VIALVIAALIIWFLIRIWSKVNLALSHIEFACKVFYNNLaKFIFIRIIWL--FIFILIGS-IVLVSSaaLysiyeF---K 179  Trichomonas v...
XP_976576     357 ISVVVLAGLYVILLMILSKRIVKIVGFLKIASQVVQIMQ-QIKWIPFYVL--IIAIVVAAlSLINVPfgL---------S 424  Tetrahymena t...
XP_001010415  422 WVMLIVAGVYLLIVINLFNRINLAIGFVKASSRVIKVLN-QLTIVPFFSV--FFQVAAGAlTVISCIyaM---------T 489  Tetrahymena t...
ETW39963      361 IIIFIQSFFFLSIFFIYKSTYKYTSQIIGITLNFIYKMT-NIIYSPIIVS--SISFVWFF-VWLYIYimI---------M 427  Plasmodium fa...
XP_002952038  435 GDLTahcrtqsskesfsfskytnvsnlmdattfnpsselsssfnyssyslspnatmgncytnvttdqraflCGRDPNcyL 514  Volvox carter...
XP_001581677  254 DA-----------------------------------------------------------------------VVSDgrM 262  Trichomonas v...
XP_001616656  464 TAGTlheqrln-----------------------------------------------------leldsngNSEIVSlqK 490  malaria paras...
A0DXS7        339 IGERstv--------------------------------------------------------------qaLNINGDavK 356  Paramecium te...
A0DPM3        392 VGTTelt--------------------------------------------------------------raKYIDGHllY 409  Paramecium te...
XP_001581044  359 YEIDn-----------------------------------------------------------------dGNDKGIgqV 373  Trichomonas v...
EAX96980      180 YNIPd-----------------------------------------------------------------dGFFKGIgrI 194  Trichomonas v...
XP_976576     425 VADVvvvn------------------------------------------------------------snpGAISGGklK 444  Tetrahymena t...
XP_001010415  490 IGQVvqvp------------------------------------------------------------taaSAIQNNetK 509  Tetrahymena t...
ETW39963      428 TAGGvhekrlr-----------------------------------------------------meldsngFSEIMPlqK 454  Plasmodium fa...
XP_002952038  515 SYDWNNRLKYAFIYHFFGLLWTNQVIIGFACVTIAGAIAQYYWSrgdsanmSafPVLVALKNTIIYHMGSICFAAC---- 590  Volvox carter...
XP_001581677  263 KIESHGSLVWPIILFILAGQWFYEFLRTLLRISVSRIVCRLYFQke----pPslS--ESIKHILKYHTGTVFLGSFiiyl 336  Trichomonas v...
XP_001616656  491 VFHYFRSSYLFSILWICTYFFVCEILQSLNQFTISYLGAVWYFCdkdsan-yklsaqATMKTILNYHLGSLILSSF---- 565  malaria paras...
A0DXS7        357 IFTTTQIYQLSLPFQAFMILFFLLFVMSVNEMFNTYALSVWFFTkrk--dvVqiPLLVVLRELLLHHLGSCVYAVF---- 430  Paramecium te...
A0DPM3        410 KVIYNDYIQMGLIYVAFTVFFTLTLILTMNDMFTSYALSVWFFTkqk--dtVriPYCFSFKTLFRYHFGTCVFIAF---- 483  Paramecium te...
XP_001581044  374 KFDLNKVLQYMLIYNFVYLIFISVHMYFVNYYASSVSIVKWYFSgqggktccgcscfFGFWLAWTKALGTITISSL---- 449  Trichomonas v...
EAX96980      195 TFDW-NIVFFMLIYNIVFLVFIHYLLIHLCHYVTSAAIVKWYFTerkgnshfgrisfHGIWFAWKKGLGTVTISCL---- 269  Trichomonas v...
XP_976576     445 VMQFSGFAYFIGFYDFFIFIIWMLFLLGFRDLFVSYSITLWFFTkrk--dtVqiPKWVIFKNIFRYHFGTVVMFSL---- 518  Tetrahymena t...
XP_001010415  510 VIEYSSYSVYLILFLFYMFFNWQLFAHNVNNMITSFALCIWFFAkkk--dtVeiPLKITLKRIFRYHIGTVSLYVL---- 583  Tetrahymena t...
ETW39963      455 FFYYFKSSSFFSILWVYSYFFICEILQSLNQFTINYLGTVWYFSdksnfp-kqnnvwKVMKTIINYHLGSLVLSSF---- 529  Plasmodium fa...
XP_002952038  591 I-IAIIQLIRFLLEY------L----DRKTKEIq-----qQNKFAE-----------------WAMCCVKCCMWCLEQI- 636  Volvox carter...
XP_001581677  337 L-SDLVYLLKRLKKY-----------SEKVQNR---------F-VK-----------------FLINCLISLFIIITKI- 376  Trichomonas v...
XP_001616656  566 I-NLCTKHLRVLFFWanstlsLpffySESIYKLkerfalfLRP--------------------------------ISNL- 611  malaria paras...
A0DXS7        431 M-EIFFFIPKWIFYT----------------------------IYYflsslpqdsmivrfiqgCCLCCLAC----YQNC- 476  Paramecium te...
A0DPM3        484 N-LMFLTIPQSIMDY----------------------------SRSimrflpqtsscvrytqaSCMACIHA----FEVF- 529  Paramecium te...
XP_001581044  450 I-MTPLYLFIIFMEYldrkskme---------------------------------napifiqFLIKCLKCCLWCFTKI- 494  Trichomonas v...
EAX96980      270 IrTTLMILVRQLANY------------------------------------------------------------LNKLp 289  Trichomonas v...
XP_976576     519 I-STVITIPKIFIMA----------------------------LRRslrslpqylnsvryfqaTCNCCLFS----YEKF- 564  Tetrahymena t...
XP_001010415  584 M-KPIFIIPKMLLDL----------------------------VIAifrqlpqgsqfvryiegCFCFCINI----YRSF- 629  Tetrahymena t...
ETW39963      530 I-NLLFKPLRVIFFWtnstlsLpffyNHIIHKIkhnfyifLKP--------------------------------ISKI- 575  Plasmodium fa...
XP_002952038  637 ----------VKFINRN----------AYIMMAIKGKGYCCSAIQAVKLIVSNA-L-RIAVVNLVGDWLI----FLGKVS 690  Volvox carter...
XP_001581677  377 ----------AGDINRL----------SFVFTALKGVSFWDSCKWAVDAIMDPNfA--------ATEIIIyrvfWFIKIS 428  Trichomonas v...
XP_001616656  612 ----------IDTHTMA----------AYCEISMTSYPYLLACSTSSKKLINST-SpAASLHG-ITYIVNiifpCLTTLG 669  malaria paras...
A0DXS7        477 ----------LRYLSKH----------ALVQVAIWSEGYSLSSRKAYFLQDRHK-E-KIHDLDFLIEFIL----FLLKLS 530  Paramecium te...
A0DPM3        530 ----------LRYISKH----------SVVQVAIWSEPYYQSAKKAYFLIFRNQ-D-KIKDLDFLQTLIV----FQIRMA 583  Paramecium te...
XP_001581044  495 ----------VQYLNKV----------LFTIQQIFNTNFGPSAKLVVDVVISDA-LlTVMLNG-ISFFIL----FLSKVV 548  Trichomonas v...
EAX96980      290 ltgipfintfINMLFRLsnliafvlasTYTTQHIFNTPWIPSAKLEIGFIAIDK-LfTIIFM--VIVVIIdwvaLIGNFS 366  Trichomonas v...
XP_976576     565 ----------LRYFSKS----------SLVQVAITSMEFYPSSKIAYFLIFRNK-E-KISDMDGMQQFVV----SNIKFL 618  Tetrahymena t...
XP_001010415  630 ----------LRYISVN----------CFVQTCLFGDGYGTASKKAYFLINRHK-E-KLKDLDFLISFMI----YQIKLC 683  Tetrahymena t...
ETW39963      576 ----------IDSYTSA----------AYCEMSISSYNYLFACDTSCKKLINST-SpAAALHG-ITYILNiifpCFTTLI 633  Plasmodium fa...
XP_002952038  691 V-------AAAC-GVI-A-------YAMTEA--KYYNspeefpntYLYSPVLVIAISVITAYAVAEIFFAVFEMAIDTVI 752  Volvox carter...
XP_001581677  429 IsltfsaiAYFIsSYI-G--------LFYS--------------------TIFVSMTYIIIFYIVDSVETLLFASCESIL 479  Trichomonas v...
XP_001616656  670 V-------TFLSfNIFnNverygdlF-------SPSF---------VPNPFFAALTIGVLCGMITSHFVTTLSTLTDTIL 726  malaria paras...
A0DXS7        531 N-------SLVI-SLP-I-------YIYLSVsdTTLLgvk---vaDIESPLIPTLFVFLIGFFYVSVFQVSYDITTKSVI 591  Paramecium te...
A0DPM3        584 T-------AFMA-SIP-I-------YIYINFaeQTFMgkp---tsGIESPIIPTLYVFICGMFFSNIFQGSYDITCKTII 644  Paramecium te...
XP_001581044  549 V------------SVItTllfmiwaY-------YGKNs-------SIAGSLLAAFVVFFLSYIVSSFLLSAYDNIIDIVF 602  Trichomonas v...
EAX96980      367 M-------YVILfVLIdQimgegfnL------------------------FNPSLVLAAL---YGIIFLHVFRSIIDIIY 412  Trichomonas v...
XP_976576     619 I-------SFTS-FLF-V-------YVILSFinTTPLtny--stsEIENKFFPGLIVGMFSYFFSSIFLGSYDITCKSVI 680  Tetrahymena t...
XP_001010415  684 C-------ALII-AVL-L-------YIIIRTtsYTPIlqn--dlsEVETPILPAGVIFIICYQISDIFQGSFHMACKTII 745  Tetrahymena t...
ETW39963      634 I-------TFLSfNIFnNfqryndlY-------SSNF---------IPNPFFASLIIGTLCGIISSYFITLISSLSDCIL 690  Plasmodium fa...
XP_002952038  753 LAFCEDCD 760  Volvox carteri f. nagariensis
XP_001581677  480 VCVHEDVk 487  Trichomonas vaginalis G3
XP_001616656  727 YCFICEcy 734  malaria parasite P. vivax
A0DXS7        592 QLYLVDRE 599  Paramecium tetraurelia
A0DPM3        645 QLYCMDSE 652  Paramecium tetraurelia
XP_001581044  603 VCYQSEKS 610  Trichomonas vaginalis G3
EAX96980      413 VCQQSEKS 420  Trichomonas vaginalis G3
XP_976576     681 QCYLIDQE 688  Tetrahymena thermophila SB210
XP_001010415  746 QCYFIDKE 753  Tetrahymena thermophila SB210
ETW39963      691 YCFVCECy 698  Plasmodium falciparum NF135/5.C10
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