Conserved Protein Domain Family
Choline_transpo

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pfam04515: Choline_transpo 
Plasma-membrane choline transporter
This family represents a high-affinity plasma-membrane choline transporter in C.elegans which is thought to be rate-limiting for ACh synthesis in cholinergic nerve terminals.
Statistics
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PSSM-Id: 427989
Aligned: 273 rows
Threshold Bit Score: 90.7184
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002952038                  366 IGASIVAGFVLLITLLCISRI--RIAVACVKVASQAVGSMP-SIIFFPILPF--VLEVGLVI-YWIAVT--AL-MYSSGD 436 Volvox carteri f. nagariensis...
WGS:AAGF:cds.TTHERM_00294750A 298 SFCIIFGIVSLLYVLCKCKQI--RMGIALVDVSSDYTTDVC-TSQLIPFVMW--FIYVLCLV-FLLLAGvyAYgIGEESD 371 Tetrahymena thermophila SB210...
XP_001581677                  184 AFLLSITISLIFIFIYFRKNI--SAISPMVSVSVDIFRRVPsLLHVAPILIFggLFAFAFVV-FGYFFSkgI-----GDA 255 Trichomonas vaginalis G3...
19_pfamImport                   1 IIIFIQSFFFLSIFFIYKSTY--KYTSQIIGITLNFIYKMT-NIIYSPIIVS--SISFVWFF-VWLYIYimI-----MTA 69 
XP_012652782                  275 GLLAISGIFSLVMFFSFRKIIntQKDIQILLAPFRGIHSM--KI--VPFFTS--IIQLGAILiTYGLIVivM-----ASG 343 Tetrahymena thermophila SB210...
18_pfamImport                   1 WVMLIVAGVYLLIVINLFNRI--NLAIGFVKASSRVIKVLN-QLTIVPFFSV--FFQVAAGAlTVISCIyaM-----TIG 70 
16_pfamImport                   1 ISVVVLAGLYVILLMILSKRI--VKIVGFLKIASQVVQIMQ-QIKWIPFYVL--IIAIVVAAlSLINVPfgL-----SVA 70 
EGR33911                      231 YVIAVIGGIYLLTLIMIAKRL--RKITSFFITVSQVVDILT-QIKFIPYLLL--LAAISIGGlILIMVPhgF-----TVA 300 Ichthyophthirius multifiliis...
A0DXS7                        271 IGTAGIGLLFLFNIMKLFNKI--NLGISLIKTSSQIVLVLK-QLRFFAIFVA--FIGFVQLGySCIVIFygM-----TIG 340 Paramecium tetraurelia...
A0DPM3                        324 IVFLALAAIYLIVTLILFKRI--QRGISLLKTAQHIIQVLS-QIRSFPFIVA--FIGLVVCClAFILVCfaM-----TVG 393 Paramecium tetraurelia...
XP_002952038                  437 LTahcrtqsskesfsfskytnvsnlmdattfnpsselsssfnyssyslspnatmgncytnvttdqraflCGRDPNcyLSY 516 Volvox carteri f. nagariensis...
WGS:AAGF:cds.TTHERM_00294750A 372 QPqnp-------------------------------------------------------------fnkYIYNSN----- 385 Tetrahymena thermophila SB210...
XP_001581677                  256 -----------------------------------------------------------------------VVSDgrMKI 264 Trichomonas vaginalis G3...
19_pfamImport                  70 GGvhekrlr-----------------------------------------------------meldsngFSEIMPlqKFF 96 
XP_012652782                  344 KRqvl-------------------------------------------------------------tapTAFPNPlyVDL 362 Tetrahymena thermophila SB210...
18_pfamImport                  71 QVvqvp------------------------------------------------------------taaSAIQNNetKVI 90 
16_pfamImport                  71 DVvvvn------------------------------------------------------------snpGAISGGklKVM 90 
EGR33911                      301 DIviip------------------------------------------------------------ileGQIDGNkvKTM 320 Ichthyophthirius multifiliis...
A0DXS7                        341 ERstv--------------------------------------------------------------qaLNINGDavKIF 358 Paramecium tetraurelia...
A0DPM3                        394 TTelt--------------------------------------------------------------raKYIDGHllYKV 411 Paramecium tetraurelia...
XP_002952038                  517 DWNNRLKYAFIYHFFGLLWTNQVIIGFACVTIAGAIAQYYWS---RGDSanmSafPVLVALKNTIIYHMGSICFAAC--- 590 Volvox carteri f. nagariensis...
WGS:AAGF:cds.TTHERM_00294750A 386 ------RYLILFYIFGLIWISEFLSIYAYFLVSSSAQQWYFKrsyQSLLk--S---PVKQAVKLGFYHLGTLAYASL--- 451 Tetrahymena thermophila SB210...
XP_001581677                  265 ESHGSLVWPIILFILAGQWFYEFLRTLLRISVSRIVCRLYFQke-------pPslS--ESIKHILKYHTGTVFLGSFiiy 335 Trichomonas vaginalis G3...
19_pfamImport                  97 YYFKSSSFFSILWVYSYFFICEILQSLNQFTINYLGTVWYFSdksnfp----kqnnvwKVMKTIINYHLGSLVLSSF--- 169
XP_012652782                  363 VTKDYVFYLIPLLLVLLLIFLETFFLFQKFCYSFAVQVWYFSrqksil-----drpstRGIIFCFAKHLGTCVKGAC--- 434 Tetrahymena thermophila SB210...
18_pfamImport                  91 EYSSYSVYLILFLFYMFFNWQLFAHNVNNMITSFALCIWFFAkkk-----dtVeiPLKITLKRIFRYHIGTVSLYVL--- 162
16_pfamImport                  91 QFSGFAYFIGFYDFFIFIIWMLFLLGFRDLFVSYSITLWFFTkrk-----dtVqiPKWVIFKNIFRYHFGTVVMFSL--- 162
EGR33911                      321 EFSKFSYAMAIYDIFMFFIWMFFLLGFRDIYISYCLCIWFFTkrk-----dtVkiPRWVVFKQIFRYHLGSVVMYSL--- 392 Ichthyophthirius multifiliis...
A0DXS7                        359 TTTQIYQLSLPFQAFMILFFLLFVMSVNEMFNTYALSVWFFTkrk-----dvVqiPLLVVLRELLLHHLGSCVYAVF--- 430 Paramecium tetraurelia...
A0DPM3                        412 IYNDYIQMGLIYVAFTVFFTLTLILTMNDMFTSYALSVWFFTkqk-----dtVriPYCFSFKTLFRYHFGTCVFIAF--- 483 Paramecium tetraurelia...
XP_002952038                  591 -IIAIIQLIRFLLEY------L----DRKTKEIq------qQNKFAE-----------------WAMCCVKCCMWC---L 633 Volvox carteri f. nagariensis...
WGS:AAGF:cds.TTHERM_00294750A 452 -VLPLYTIANFIFEIfygcgkGiqskETERKRAqsqydaewENNSKD-----------------QIDKVSNCCVSCsnlY 513 Tetrahymena thermophila SB210...
XP_001581677                  336 lLSDLVYLLKRLKKY-----------SEKVQNR----------F-VK-----------------FLINCLISLFII---I 373 Trichomonas vaginalis G3...
19_pfamImport                 170 -INLLFKPLRVIFFWtnstlsLpffyNHIIHKIkhnf-yifLKP-----------------------------------I 212
XP_012652782                  435 -IIIITWPFRSLLRRlkaklkqvke-----------------------------dnrdskwlqcWLFTCTP--------F 476 Tetrahymena thermophila SB210...
18_pfamImport                 163 -MKPIFIIPKMLLDL-----------------------------VIAifrqlpqgsqfvryiegCFCFCINI-------Y 205
16_pfamImport                 163 -ISTVITIPKIFIMA-----------------------------LRRslrslpqylnsvryfqaTCNCCLFS-------Y 205
EGR33911                      393 -VSACVTFPKLIMKS-----------------------------FIKslsglpqysntvrylqtCCKCMIDF-------Y 435 Ichthyophthirius multifiliis...
A0DXS7                        431 -MEIFFFIPKWIFYT-----------------------------IYYflsslpqdsmivrfiqgCCLCCLAC-------Y 473 Paramecium tetraurelia...
A0DPM3                        484 -NLMFLTIPQSIMDY-----------------------------SRSimrflpqtsscvrytqaSCMACIHA-------F 526 Paramecium tetraurelia...
XP_002952038                  634 EQIVKFINRN----AYIMMAIKGKGYCCSAIQAVKLIVSNA-L-RIAVVNLVGDWLI----FLGKV--------SV---- 691 Volvox carteri f. nagariensis...
WGS:AAGF:cds.TTHERM_00294750A 514 EGRFRFVKKE----GIIQTALTGRDFKKACHESFYLMKRNE-K-YFKSLQGLGSLML----LLGKC--------FI---- 571 Tetrahymena thermophila SB210...
XP_001581677                  374 TKIAGDINRL----SFVFTALKGVSFWDSCKWAVDAIMDPNfA--------ATEIIIyrvfWFIKI--------SIsltf 433 Trichomonas vaginalis G3...
19_pfamImport                 213 SKIIDSYTSA----AYCEMSISSYNYLFACDTSCKKLINST-SpAAALHG-ITYILNiifpCFTTL--------II---- 274
XP_012652782                  477 FHFFEYYSKYqsstSIMHTALYGLGWSDSAEKTYYLFQRNL-SrTERFSE-LFGYHR----LIGSIcasccaffFI---- 546 Tetrahymena thermophila SB210...
18_pfamImport                 206 RSFLRYISVN----CFVQTCLFGDGYGTASKKAYFLINRHK-E-KLKDLDFLISFMI----YQIKL--------CC---- 263
16_pfamImport                 206 EKFLRYFSKS----SLVQVAITSMEFYPSSKIAYFLIFRNK-E-KISDMDGMQQFVV----SNIKF--------LI---- 263
EGR33911                      436 EIFLRYFSKH----SLIQVSLTSLDFYISSKRAYGLMFRNQ-D-KISDMDQMQEFVV----NNTKF--------CI---- 493 Ichthyophthirius multifiliis...
A0DXS7                        474 QNCLRYLSKH----ALVQVAIWSEGYSLSSRKAYFLQDRHK-E-KIHDLDFLIEFIL----FLLKL--------SN---- 531 Paramecium tetraurelia...
A0DPM3                        527 EVFLRYISKH----SVVQVAIWSEPYYQSAKKAYFLIFRNQ-D-KIKDLDFLQTLIV----FQIRM--------AT---- 584 Paramecium tetraurelia...
XP_002952038                  692 ---AAAC-GVI-A-------YAMTEa--KYYNspeefpntyLYSPVLVIAISVITAYAVAEIFFAVFEMAIDTVILAFCE 757 Volvox carteri f. nagariensis...
WGS:AAGF:cds.TTHERM_00294750A 572 ---CCSS-TFL-C-------YLILSdseTYKKe--------LYSPVLPTVLITYITFTIGNIFVTVYSSSSDSILQSFCV 631 Tetrahymena thermophila SB210...
XP_001581677                  434 saiAYFIsSYI-G--------LFYS--------------------TIFVSMTYIIIFYIVDSVETLLFASCESILVCVHE 484 Trichomonas vaginalis G3...
19_pfamImport                 275 ---TFLSfNIFnNfqryndlY-------SSNF---------IPNPFFASLIIGTLCGIISSYFITLISSLSDCILYCFVC 335
XP_012652782                  547 ---YLFSvDKTqNllgqsmdYLFLP--------------------YAVAGITVFFGFYLPQNFCMSFDVVIEAMIFSLTA 603 Tetrahymena thermophila SB210...
18_pfamImport                 264 ---ALII-AVL-L-------YIIIRttsYTPIlqnd--lseVETPILPAGVIFIICYQISDIFQGSFHMACKTIIQCYFI 329
16_pfamImport                 264 ---SFTS-FLF-V-------YVILSfinTTPLtnys--tseIENKFFPGLIVGMFSYFFSSIFLGSYDITCKSVIQCYLI 329
EGR33911                      494 ---AFVS-ALF-V-------YVYLSffeQTVFlknn--tkeIENKVIPSLVMFVIGYFFSAIFQGSYDITCKSLIQLYLI 559 Ichthyophthirius multifiliis...
A0DXS7                        532 ---SLVI-SLP-I-------YIYLSvsdTTLLgvk---vadIESPLIPTLFVFLIGFFYVSVFQVSYDITTKSVIQLYLV 596 Paramecium tetraurelia...
A0DPM3                        585 ---AFMA-SIP-I-------YIYINfaeQTFMgkp---tsgIESPIIPTLYVFICGMFFSNIFQGSYDITCKTIIQLYCM 649 Paramecium tetraurelia...
XP_002952038                  758 DCD 760 Volvox carteri f. nagariensis
WGS:AAGF:cds.TTHERM_00294750A 632 DEE 634 Tetrahymena thermophila SB210
XP_001581677                  485 DVK 487 Trichomonas vaginalis G3
19_pfamImport                 336 ECY 338
XP_012652782                  604 DEE 606 Tetrahymena thermophila SB210
18_pfamImport                 330 DKE 332
16_pfamImport                 330 DQE 332
EGR33911                      560 DQE 562 Ichthyophthirius multifiliis
A0DXS7                        597 DRE 599 Paramecium tetraurelia
A0DPM3                        650 DSE 652 Paramecium tetraurelia
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