7WWB


Conserved Protein Domain Family
Choline_transpo

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pfam04515: Choline_transpo (This model is not part of the current CDD release)
Plasma-membrane choline transporter
This family represents a high-affinity plasma-membrane choline transporter in C.elegans which is thought to be rate-limiting for ACh synthesis in cholinergic nerve terminals.
Statistics
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PSSM-Id: 516292
Aligned: 257 rows
Threshold Bit Score: 89.5593
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7WWB_A        294 ISATVFTVILFLIMLVMRKRVALTIALFHVAGKVFIHLP-LLVFQPFWTF--FALVLFWV-YWIMTL--LflgtTGSPVq 367  human
A0EIK5        271 ITFAVLCVYAIFTLCWNLRKMKFMISLVKLATTFLYQNK-TIIIVPIVFF--FLVMSTLL-VWIASAlaV----LSEQQm 342  Paramecium te...
XP_004039215  231 YVIAVIGGIYLLTLIMIAKRLRKITSFFITVSQVVDILT-QIKFIPYLLL--LAAISIGGlILIMVPhgF----TVADIv 303 
A0DXS7        271 IGTAGIGLLFLFNIMKLFNKINLGISLIKTSSQIVLVLK-QLRFFAIFVA--FIGFVQLGySCIVIFygM----TIGERs 343  Paramecium te...
A0DPM3        324 IVFLALAAIYLIVTLILFKRIQRGISLLKTAQHIIQVLS-QIRSFPFIVA--FIGLVVCClAFILVCfaM----TVGTTe 396  Paramecium te...
XP_001581677  184 AFLLSITISLIFIFIYFRKNISAISPMVSVSVDIFRRVPsLLHVAPILIFggLFAFAFVV-FGYFFSkgI----GDAvv- 257 
XP_001616656  397 FGLLAHGVVFLFVLYLYRNTYKYTHRLITVALDFVNSVS-NLLYAPCVVS--AASLAWFF-LWMCGYvyV----MTAGTl 468 
XP_001348472  361 IIIFIQSFFFLSIFFIYKSTYKYTSQIIGITLNFIYKMT-NIIYSPIIVS--SISFVWFF-VWLYIYimI----MTAGGv 432  Plasmodium fa...
XP_001010415  422 WVMLIVAGVYLLIVINLFNRINLAIGFVKASSRVIKVLN-QLTIVPFFSV--FFQVAAGAlTVISCIyaM----TIGQVv 494  Tetrahymena t...
XP_976576     357 ISVVVLAGLYVILLMILSKRIVKIVGFLKIASQVVQIMQ-QIKWIPFYVL--IIAIVVAAlSLINVPfgL----SVADVv 429  Tetrahymena t...
7WWB_A        368 n----------------eQGFVEFKISGPLQYMWWYHVVGLIWISEFILACQQMTVAGAVVTYYFTrdkrN---LPFTPI 428  human
A0EIK5        343 dysl----------dsqiYPFEKIQLKFDTLIKLMITVLALIWLMQYILSLARFLNASTATLWYFHassn------kgfL 406  Paramecium te...
XP_004039215  304 iipil-------egqidgNKVKTMEFSKFSYAMAIYDIFMFFIWMFFLLGFRDIYISYCLCIWFFT----KrkdTVKIPR 372 
A0DXS7        344 tvqa---------lningDAVKIFTTTQIYQLSLPFQAFMILFFLLFVMSVNEMFNTYALSVWFFT----KrkdVVQIPL 410  Paramecium te...
A0DPM3        397 ltra---------kyidgHLLYKVIYNDYIQMGLIYVAFTVFFTLTLILTMNDMFTSYALSVWFFT----KqkdTVRIPY 463  Paramecium te...
XP_001581677  258 -----------------sDGRMKIESHGSLVWPIILFILAGQWFYEFLRTLLRISVSRIVCRLYFQ----Ke--PPSLS- 313 
XP_001616656  469 heqrlnleldsngnseivSLQKVFHYFRSSYLFSILWICTYFFVCEILQSLNQFTISYLGAVWYFCdkdsan---yklsa 545 
XP_001348472  433 hekrlrmeldsngfseimPLQKFFYYFKSSSFFSILWVYSYFFICEILQSLNQFTINYLGTVWYFSdksnfp---kqnnv 509  Plasmodium fa...
XP_001010415  495 qvpta-------asaiqnNETKVIEYSSYSVYLILFLFYMFFNWQLFAHNVNNMITSFALCIWFFA----KkkdTVEIPL 563  Tetrahymena t...
XP_976576     430 vvnsn-------pgaisgGKLKVMQFSGFAYFIGFYDFFIFIIWMLFLLGFRDLFVSYSITLWFFT----KrkdTVQIPK 498  Tetrahymena t...
7WWB_A        429 LASVNRLIRYHLGTVAKGSF----IITLVKIPRMILMY------I----HSQLKGK-------ENAcarCVLKSCIC--- 484  human
A0EIK5        407 YDSFKLAVRYHNGSITAEAIysffFSGIAKAFNLIYDSlnrcr---------------------lkrhnFILNCFASisl 465  Paramecium te...
XP_004039215  373 WVVFKQIFRYHLGSVVMYSL----VSACVTFPKLIMKSfikslsglpq-----------ysntvrylqtCCKCMIDF--- 434 
A0DXS7        411 LVVLRELLLHHLGSCVYAVF----MEIFFFIPKWIFYTiyyflsslpq-----------dsmivrfiqgCCLCCLAC--- 472  Paramecium te...
A0DPM3        464 CFSFKTLFRYHFGTCVFIAF----NLMFLTIPQSIMDYsrsimrflpq-----------tsscvrytqaSCMACIHA--- 525  Paramecium te...
XP_001581677  314 -ESIKHILKYHTGTVFLGSFiiylLSDLVYLLKRLKKY-----------SEKVQNR---------Fv-kFLINCLIS--- 368 
XP_001616656  546 qATMKTILNYHLGSLILSSF----INLCTKHLRVLFFWanstlsLpffySESIYKLkerfalfLRP-------------- 607 
XP_001348472  510 wKVMKTIINYHLGSLVLSSF----INLLFKPLRVIFFWtnstlsLpffyNHIIHKIkhnfyifLKP-------------- 571  Plasmodium fa...
XP_001010415  564 KITLKRIFRYHIGTVSLYVL----MKPIFIIPKMLLDLviaifrqlpq-----------gsqfvryiegCFCFCINI--- 625  Tetrahymena t...
XP_976576     499 WVIFKNIFRYHFGTVVMFSL----ISTVITIPKIFIMAlrrslrslpq-----------ylnsvryfqaTCNCCLFS--- 560  Tetrahymena t...
7WWB_A        485 ---CLWCLEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENA-L-RVATINTVGDFML----FLGKVLI-------V 548  human
A0EIK5        466 clcCV--CENFIMYINNYAFVYIVMTSADYFESSKAVHFVIKRNH-SdFETLSG-LGEQFT----HFSKM---------F 528  Paramecium te...
XP_004039215  435 -------YEIFLRYFSKHSLIQVSLTSLDFYISSKRAYGLMFRNQ-D-KISDMDQMQEFVV----NNTKFCI-------A 494 
A0DXS7        473 -------YQNCLRYLSKHALVQVAIWSEGYSLSSRKAYFLQDRHK-E-KIHDLDFLIEFIL----FLLKLSN-------S 532  Paramecium te...
A0DPM3        526 -------FEVFLRYISKHSVVQVAIWSEPYYQSAKKAYFLIFRNQ-D-KIKDLDFLQTLIV----FQIRMAT-------A 585  Paramecium te...
XP_001581677  369 ---LFIIITKIAGDINRLSFVFTALKGVSFWDSCKWAVDAIMDPNfA--------ATEIIIyrvfWFIKISIsltfsaiA 437 
XP_001616656  608 -------ISNLIDTHTMAAYCEISMTSYPYLLACSTSSKKLINST-SpAASLHG-ITYIVNiifpCLTTLGV-------T 671 
XP_001348472  572 -------ISKIIDSYTSAAYCEMSISSYNYLFACDTSCKKLINST-SpAAALHG-ITYILNiifpCFTTLII-------T 635  Plasmodium fa...
XP_001010415  626 -------YRSFLRYISVNCFVQTCLFGDGYGTASKKAYFLINRHK-E-KLKDLDFLISFMI----YQIKLCC-------A 685  Tetrahymena t...
XP_976576     561 -------YEKFLRYFSKSSLVQVAITSMEFYPSSKIAYFLIFRNK-E-KISDMDGMQQFVV----SNIKFLI-------S 620  Tetrahymena t...
7WWB_A        549 CST-GLA-G-------IMLLNYq----Q------DYTVWVLPLIIVCLF----AFLVAHCFLSIYEMVVDVLFLCFAID 604  human
A0EIK5        529 IFLiTTIgT-------FIYVKEq--------------tDFVLQLYTFAIiafiTLSIATLFMDMFGQSADALLLAYFTD 586  Paramecium tet...
XP_004039215  495 FVS-ALF-V-------YVYLSFfeqtvFlknntkEIENKVIPSLVMFVI----GYFFSAIFQGSYDITCKSLIQLYLID 560 
A0DXS7        533 LVI-SLP-I-------YIYLSVsdttlLgvk-vaDIESPLIPTLFVFLI----GFFYVSVFQVSYDITTKSVIQLYLVD 597  Paramecium tet...
A0DPM3        586 FMA-SIP-I-------YIYINFaeqtfMgkp-tsGIESPIIPTLYVFIC----GMFFSNIFQGSYDITCKTIIQLYCMD 650  Paramecium tet...
XP_001581677  438 YFIsSYI-G--------LFYS------------------TIFVSMTYII----IFYIVDSVETLLFASCESILVCVHED 485 
XP_001616656  672 FLSfNIFnNverygdlFsp-------sF-------VPNPFFAALTIGVL----CGMITSHFVTTLSTLTDTILYCFICE 732 
XP_001348472  636 FLSfNIFnNfqryndlYss-------nF-------IPNPFFASLIIGTL----CGIISSYFITLISSLSDCILYCFVCE 696  Plasmodium fal...
XP_001010415  686 LII-AVL-L-------YIIIRTtsytpIlqndlsEVETPILPAGVIFII----CYQISDIFQGSFHMACKTIIQCYFID 751  Tetrahymena th...
XP_976576     621 FTS-FLF-V-------YVILSFinttpLtnystsEIENKFFPGLIVGMF----SYFFSSIFLGSYDITCKSVIQCYLID 686  Tetrahymena th...
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