5YZG,8I0W


Conserved Protein Domain Family
Saf4_Yju2

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pfam04502: Saf4_Yju2 (This model is not part of the current CDD release)
Saf4/Yju2 protein
This is a family of eukaryotic proteins that includes CCDC130 and CCDC94 from humans, Saf4 from fission yeasts and Yju2 from budding yeasts. Saf4 (also known as cwc16) is involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. Yju2 is a splicing factor that is associated with the Prp 19-associated complex and acts after Prp2 in promoting the first catalytic reaction of pre-mRNA splicing.
Statistics
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PSSM-Id: 516282
Aligned: 75 rows
Threshold Bit Score: 184.117
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5YZG_Y         9 KYYPPDFDpSKI---------P--KLKLP--KDRQYVVRLMAPFNMRCKTCGEYIYKGKKFNARKETVQNevYLGLPIFR 75  human
XP_012397553   9 KYYPPDFDpTKHgslnryhhsHplRERARklSQGILVIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGN--YYTTPIYR 86 
XP_005611899   9 KYYPPDFNpEKHgslnryhnsHplRERARklSQGILIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGN--YYTTPIYR 86 
4_pfamImport   1 RY-------HNS---------HplRERARklSQGILIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGN--YYTT---- 58 
XP_008985634   9 KYYPPDFNpEKHgslnryhnsHplRERARklSQGVLIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGN--YYTTPIYR 86 
KAF8363923     9 HYYPPDFDyKKHrnlnnyhgtHalRERAAkiKEGILIIRFEMPFNIWCLGCNNHVGMGVRYNAEKKKVGM--FYTTPLYE 86 
Q09651         9 FYYPPDFNyKTHkslngyhgtHalRERAKkiDQGILVIRFEMPFNIWCLGCHNHVGMGVRYNAEKKKIGM--YYTTPLHE 86  Caenorhabditis ...
XP_002629820   9 FYYPPDFNyKTHkslngyhgtHalRERAKkiDQGILVIRFEMPFNIWCLGCHNHVGMGVRYNAEKKKCGM--YYTTPLYE 86 
2_pfamImport   1 FYYPPDFNyKTHkslngyhgtHalRERAKkiDQGILVIRFEMPFNIWCLGCHNHVGMGVRYNAEKKKCGM--YYTTPLYE 78 
Q5EA37         9 KYYPPDFNpEKHgslnryhnsHplRERARklSQGILIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGN--YYTTPIYR 86  domestic cattle
5YZG_Y        76 FYIKCTRCLAEITFKTDPENTDYTMEHGATRnfQAEK----------LLEEEekrvQKERedeelNNPMKVLENRTKDSK 145 human
XP_012397553  87 FRMKCHLCVNYIEMQTDPANCDYVIVSGAQR--KEERwdmadneqilTTEQE----KKQKl---eTDAMFRLEHGTTDQS 157
XP_005611899  87 FRMKCHLCVNYIEMQTDPANCDYVIVSGAQR--KEERwd-------mAENEQvlttEHEKkqkleTDAMFRLEHGEADRG 157
4_pfamImport  59 FRMKCHLCVNYIEMQTDPANCDYVIVSGAQR--KEERwd-------mEDNEQvlttEHEKkqkleTDAMFRLEHGEADRS 129
XP_008985634  87 FRMKCHLCVNYIEMQTDPANCDYVIVSGAQR--KEERwdmadneqvlTTEHE----KKQKl---eTDAMFRLEHGEADRS 157
KAF8363923    87 FRMKCHLCDNYYVIRTDPKNFDYELVEGCRR--QEKRfdpstvdgsaPIDRG----EHLKl---aADSMYKAENAEDDRQ 157
Q09651        87 FRMKCHLCDNYYVIRTDPKNFDYELVEGCSR--QELRfdptdiaqigAVDRG----FTQKl---aADAMFKKEHEAEDKD 157 Caenorhabditis ...
XP_002629820  87 FRMKCHLCDNYYVIRTDPKNFDYELVEGCSR--QELRfdptdiaqvgAVDRG----FAQKl---aADAMFKKEHEASDKE 157
2_pfamImport  79 FRMKCHLCDNYYVIRTDPKNFDYELVEGCSR--QELRfdptdiqqvgAVDRG----FAQKl---aADAMFKKEHEAEDKE 149
Q5EA37        87 FRMKCHLCVNYIEMQTDPANCDYVIVSGAQR--KEERwdmedneqvlTTEHE----KKQKl---eMDAMFRLEHGEADRS 157 domestic cattle
5YZG_Y       146 LEMEVLENLQELKdLNQRQAHVDFEAMLRQHRLSeeERRRQQQEEDEqETAALLeEA---RKRRLLEDSDSede------ 216 human
XP_012397553 158 KLQKAIPSLSNIQ-EAQSAWKDDFALNSMLRRKF--REKKKAIKEEEeKTLALQtKAn-lSIPLVPETEEDrklaallky 233
XP_005611899 158 TLHKAVPTLSHLQ-EAQSAWKDDFALNSLLRRRF--REKKRALQEAEeRDQALQaKAs-lAIPLVPETEADrrlaallk- 232
4_pfamImport 130 TLKKALPTLSHIQ-EAQSAWKDDFALNSMLRKRF--REKKKAMQEEEeRDQALQaKAs-lAIPLVPETEDDrklaallk- 204
XP_008985634 158 TLKKALPTLSHIQ-EAQSAWKDDFALNSMLRRRF--REKKKAIQEEEeRDQALQtKAs-lTIPLVPETEDDrrlaallkf 233
KAF8363923   158 KGTKDDKKIDHLE-WLQERMRDDFAANSALRRSF--RTEKKSLNEQRaLDDDLRkRAs-lSIKLMPEHPEDkkvagmitr 233
Q09651       158 KAATEEGRVDKLE-WIQERMRDDFTANSFLRAQF--RNEKKSLNETRaRDANLRdKLsigTTQLLPETEEDrriasmmtr 234 Caenorhabditis ...
XP_002629820 158 KAAGEEGRVEKLE-WIQERMRDDFSANSYLRAQF--RNEKKYLNESRaSDANLReKLsigTTKLLPESEEDrrmasmmtr 234
2_pfamImport 150 KAAGEEGRVDKLE-WIQERMRDDFSANSYLRAQF--RNEKKSLNETRaRDANLReKLsigTTSLLPETEEDrrmasmltr 226
Q5EA37       158 TLKKALPTLSHIQ-EAQSAWKDDFALNSMLRKRF--REKKKAMQEEEeRDQALQaKAs-lAIPLVPETEDDrrlaallkf 233 domestic cattle
5YZG_Y       217 ----------------------aaPsPLQ-PALRpnp---taILDe-------A--PKPKrKVEVWEQSVGSLGsRPp-- 259 human
XP_012397553 234 hsldsye-dkqklkrteifgrswfPsTPV-HG-------------------------ASNsKVNSVLKKLAVSr-KPmps 285
XP_005611899 233 -----------------lhtldsyEdKQR-LKRTeisrrswfPPAaapgtgtsTstSTSSgTGSSVLKKLAQSRrPApag 294
4_pfamImport 205 -----------------fhtldsyEdKQK-LKRTeiisrpwfSST--------PgpRTGSsKAGSVLKKLAQNRrCApvg 258
XP_008985634 234 htldsye-dkqklkrteiisrswfPsTPG-S--------------------------GSSsKVSAVLKKLAQSr-RTala 284
KAF8363923   234 yknvksyedrqredresiecsrifKkGEE-MDDD-----------------------EPSsSKERLVKSLQVQKnRKlne 289
Q09651       235 yrdtkthddhlessrdriesrrifRrPEE--TDTpst--ssgSSg----------gAVPs-ASERLKATMKAERdKRina 299 Caenorhabditis ...
XP_002629820 235 yknskthgdhlhstrdkiesrrifDhPNT-LSDTpsp--sgsSs------------GVPMtSSERLKATMQAERdKRina 299
2_pfamImport 227 ykdakshddfletsrdrieskrifGrSEA--PDTpst--ssgSs------------GAPt-PSERLKATMKAERdKRina 289
Q5EA37       234 htldsye-dkqklkrteiisrswfPsTPGaSASS-----------------------SSSsKTNSVLKKLAQNr-RAtpt 288 domestic cattle
5YZG_Y       260 ------------------lSRLVVVKKAKA------------------------------------DPDcSNGQPqaapt 285 human
XP_012397553 286 as------------sitssDLGIVRRKSRDglegpqesgeape-----------psamkevdenipGGSsSETHYppdve 342
XP_005611899 295 tp-------------itvgTLGIVRRRPQHaggipglggprv------------pegttqdrpahpQDCsQETVEtpqts 349
4_pfamImport 259 sp-------------itveDLGIVRRRSREalenlrlaaetpkpgepwvpegntqdrpasppdgspETAeTPRSRgppgq 325
XP_008985634 285 ts------------pitvgDLGIVRRRPRDvpespqhaantpkcge-----prvpeetaqdkpvspGDCpQETAEtpkcs 347
KAF8363923   290 eferkrr--igeasgltasALGIVKKKQVK------------------------------------VEPdGDDEDavevk 331
Q09651       300 sfsta------gtssatqkLLGIKRKSASS------------------------------------Lgvqikkaape--- 334 Caenorhabditis ...
XP_002629820 300 tfssshrllhqistlssasNLGIKRKSTVP------------------------------------Slivrkkktpv--- 340
2_pfamImport 290 tfsa---------gssgvnFLGIKRKSTTS------------------------------------Lgiqkkkvvptt-- 322
Q5EA37       289 ss------------pvtmgHLGIVRRRSREvpespqhvaetfksge-----pqlpegtnqnrpvspQDCsLETAEtpkns 351 domestic cattle
5YZG_Y       286 pga------------------------pqnrkeanPTPLTPGASSLSQlGAYLDSDD 318 human
XP_012397553 343 tqgg---------------------------------psstsilssSLvADYSDSES 366
XP_005611899 350 gpggqegsgqhr-------tpsapgpsqdtaspapQDLRQPGGLSSSLvADYSDS-E 398
4_pfamImport 326 agkrqdrp--------------rsppgpsqeaaasQDTPHPGTLSSSLvADYSDSES 368
XP_008985634 348 glkgqegsrqdkslspagssqevadapdsrhpcslSS---------SLvADYSDSES 395
KAF8363923   332 edvsdvk-----------------eettslfddvkEIKPEMGSSLSALvQ-YSSSSD 370
Q09651       335 -------------------------nsslqdeepaVEKPNISNPISLIaQEYGNSSD 366 Caenorhabditis elegans
XP_002629820 341 -------------------------dsktleaetsV----PVNPISLVsADYGDSSD 368
2_pfamImport 323 ------------------------tdgadtknsvkPEAPPPSNPVSLVaQEYGDSSD 355
Q5EA37       352 salgqeescqdrpqpppdtspeapnpqdtpqpcslGS---------SLvADYSGSES 399 domestic cattle
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