Conserved Protein Domain Family
Pox_VP8_L4R
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pfam04498: Pox_VP8_L4R 
Poxvirus nucleic acid binding protein VP8/L4R
The 25 kDa product of Vaccinia virus gene L4R is also known as VP8. VP8 is found in the cores of Vaccinia virions and is essential for the formation of transcriptionally competent viral particles. It binds both single stranded and double stranded DNA and RNA with similar affinities. Binding is thought to involve cooperative interactions between protein subunits. The protein is proteolytically cleaved during viral assembly at an Ala-Gly-Ala site. Possible roles for VP8 include packaging and maintaining the DNA genome in a transcribable configuration; binding ssDNA during transcription initiation; and cooperation with I8R protein to unwind early promoter regions. VP8 may also function in either transcription elongation or release of mRNA molecules from viral particles.
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Statistics
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PSSM-Id: 282367
Aligned: 7 rows
Threshold Bit Score: 302.433
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P15913  32 ARSKFPKSLLSMYRVTPRVMTRYPLKLITNESITGVVITTVYNLKKNLNIPQnNKLTTQDIERYYLDKSVEVINLMVGNT 111 Fowlpox virus strain ...
Q6TVS0  32 ARVRFPRSLLSLFNVVPRTMTRYETELVGTEMVVGAVFTTAYNIRRNLGLGE-DPVTMRDIEKYFLDSDNEVLTLIVHNT 110 Orf virus
P03295  33 AKSKFPRSMLSIFNIVPRTMSKYELELIHNENITGAMFTTMYNIRNNLGLGD-DKLTIEAIENYFLDPNNEVMPLIINNT 111 Vaccinia virus WR
Q6TUV0  33 AKVRYPRSFLSIFNIIPRNMTKYELELVQTENITGAVFTTAFNIKKNLGMND-ENLTIEAIEGYYLDPNNDILTLMINNT 111 Yaba monkey tumor virus
Q9Q8N8  33 AKLKYPRSFLSIFNIVPRNMTRYELDLVQTENITGAVFTTVFNIKKNLGILE-EKLTIEAIENYYLDPNNDVLTLMIDNT 111 Myxoma virus
Q98241  31 AKVKFPRSLLSMYRVVPRTMSRYELALVQSETVTGVVFTTVYNVRRNLGLEErEALSLPALEKYYLDKANDVLTLMVNNT 110 Molluscum contagiosum...
Q070F8  31 AKLRYPKSFLSIYRVVPRNTSKYRLRKLATETLVGFAMTTMESVRKSLNV---TTATAQQVEEYFLD--NDVVTLAVGNT 105 Crocodilepox virus

P15913 112 SLGDLacGRPRRTKSSkKKDPVIFLGISAPLILVMNSKKSINTYIQDK-KSDPSSDYVNINPGIGVLENYGNTYLLDIHN 190 Fowlpox virus strain ...
Q6TVS0 111 DFSAMs-GVRRRGGRR-ITNPVIFRSGSTPLLIVMESRKKTNIYRERT-AEQANASYREVGSSLALVTRYAGLQLVDVHT 187 Orf virus
P03295 112 DMTAV---IPKKSGRRkNKNMVIFRQGSSPILCIFETRKKINIYKENM--ESASTEYTPIGDNKALISKYAGINILNVYS 186 Vaccinia virus WR
Q6TUV0 112 SLMEV---VPKRKSKR-NKNPVLFRQGSVPLFFIFESRKKVDIYKENIeNKKDSTSYSQIDENIALISKYSNMQLLDVHS 187 Yaba monkey tumor virus
Q9Q8N8 112 SLKEI---SPRKKSRR-TKNPVLFRQGSIPLFFIFESRKKVDIYKENV-NKAVDGSYIKIDDNVALMGKYANMSLLDVHS 186 Myxoma virus
Q98241 111 NLEHI--AAYRMRSRR-LLNPVVFRAGAVPLALVFTSRKKLSIYREDTsQAAEDSTYTKIAANVALAGKYAGLLLLDVHT 187 Molluscum contagiosum...
Q070F8 106 DVSKL--GSYKKRSRA--KNPVVYRKSSAPVLLVFRSKNKMDVMIEDR--EETTGTYARHEAG-AVVNTYLQTNFIDVYD 178 Crocodilepox virus

P15913 191 PSSVLTISTIYGL-DNNMELKKLSTASEIDAYQDVN-IGKSVDLKKFNEIFNTMKKHLSLSNF-S 252 Fowlpox virus strain NVSL
Q6TVS0 188 PSSVLTVSAVYGF-TEDKGLKKLGSDKELADYQSTP-LTDPIRLSDFSKLFDGVKKSIQLTNV-P 249 Orf virus
P03295 187 PSTSIRLNAIYGF-TNKNKLEKLSTNKELESYSSSP-LQEPIRLNDFLGLLECVKKNIPLTDI-P 248 Vaccinia virus WR
Q6TUV0 188 PSAFMKLNGVYGF-THKNELRKLSSNKEIEEYSNKP-LQEPVRLNDFINLFDCVKKNIPLTNV-I 249 Yaba monkey tumor virus
Q9Q8N8 187 PSAFMKLNAVYGF-THKNELRKLVSDKEIEEYSGQP-LQEPVRLNDFIGLFDGVKKSIPLTSI-P 248 Myxoma virus
Q98241 188 PGTALMLTAVYGL-DDRRELRKLADSTALENHQQSGaLSEAMKLSDFRAVFEGLKKSVPLTNLeM 251 Molluscum contagiosum virus subtype 1
Q070F8 179 PADQLTLDAVYGVpGSDLSLVKM-EGKALEKYQVTG-IQESITLSEFKELFSSAKKNIGVSNF-I 240 Crocodilepox virus
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