6HQA,6MZD,6MZL,2J4B


Conserved Protein Domain Family
TFIID_NTD2

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pfam04494: TFIID_NTD2 (This model is not part of the current CDD release)
WD40 associated region in TFIID subunit, NTD2 domain
This region is an all-alpha domain associated with the WD40 helical bundle of the TAF5 subunit of transcription factor TFIID. The domain has distant structural similarity to RNA polymerase II CTD interacting factors. It contains several conserved clefts that are likely to be critical for TFIID complex assembly. The TAF5 subunit is present twice in the TFIID complex and is critical for the function and assembly of the complex, and the NTD2 and N-terminal domain is crucial for homodimerization.
Statistics
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PSSM-Id: 516276
Aligned: 103 rows
Threshold Bit Score: 100.277
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6HQA_B        102 DDPATIKRGYSILKSWCESSLDFYRPELEKFLYPVFVHCYLDLIARGYPSHAREFYDKFSKDHSVLHEYEISklggiSLK 181 Komagataella p...
9_pfamImport    2 ADPSSYDDNYRILQQFIEMSMDGNKCELSLLLYPVFLHMYLELVYNNHQTKAKAFFAKFRGEMEHYHDADLHqlsniTTK 81 
XP_002424707   72 GDPKIYESVYVDLKNFIENSLDIYKHELGTILYPVFVHMYLELVYNNHEDEAIKFMNRFKCDQEDYYQDDLRklsyvTKK 151
XP_001845816   57 GDPDIYENSYMDLRRFVEESLDIYRHELGLILYPVVVHMYIELVYNGHEEQAKKFISKFGPEQEYYYQDELAklamiTKK 136
NP_001164203   57 GDPETYEDSYMELKRFVEGSLDIYKHELGMILYPVLVHMYLELVYNGHTEKAINLMKKFGPEQDSYYQEDLRklalvTKR 136
XP_011057802   59 GDPAQYEKAYSELKKFVEGALDIYKHELGTILYPVLVHMYLELVYNNHSQEAKQLMEKFSGNLQEYYQDDLKrlsnvTKR 138
11_pfamImport   2 GNPDQYEEAYMDLKKFVDGSLDVYKHELGMILYPVFVHMYLELVYNKHEKQAIRLMEKFGKDQEHYYQHDLRrlsqvTNR 81 
EFX87221      101 GDPNAYEKAYLSYRRFVESSLDVYKHELSLVLYPLFVHMYLEMIYNQHESEAAKFMERFSTDQEDYYQDDLKkvsfiTKK 180
XP_002413739  100 GDPDIYEDTYTVFKRFVESSLDSYRHELAMILYPAFVHMYLELVYNEHEEQAVKFMERFGPEQEEYYQEDVKrlsclTKK 179
XP_015792913   26 HEPRVYEEGYMNLYKFIDSSLDAYKYELYTLNYPVFVHMYLELVYNNHEDAAKKFMEKFGPHQEDFYQEDIKklaiiTKP 105
6HQA_B        182 EHLQENDVAKIF--RSHKFKVLIGRTTFNLLLYFLNE--NDAVgggVVLRLINQYI 233 Komagataella phaffii GS115
9_pfamImport   82 SHMEGNNFIYNL--KSNKFVVRISRESNHLIKKFLED--KNVP---IIRNILNVQV 130
XP_002424707  152 DQMKGNELTDTF--KSSEFIIRMSRDTLSLLKRHLLE--KKHS---VVLNIIQEHL 200
XP_001845816  137 DQMSGNDLTDTF--KSNSFTIRISRDTLSLLKRHLHE--KKAS---VILNIVNEHL 185
NP_001164203  137 DHMNGNELTDTF--KSNQFIIRMSRDTLSLLKRHLND--KKAS---VLLNIIQEHL 185
XP_011057802  139 EQMAGNELTDTF--KSNQFIIRMSRDTLSILKRHLQE--KKHS---VLLNIIQEHL 187
11_pfamImport  82 DQMIDNEIIDTF--KSNEFIIRMSRDTLATLKRHLQE--KNQS---IILNIIQEHL 130
EFX87221      181 EHMKGSDLMENF--KSSQFTVRMSRDTYSVLKRFLQD--KNQS---IVMNVIQEHL 229
XP_002413739  180 DHMKGNEFMDNF--RSGQFTVRMSRDTYNFLKRHLQD--KKNT---VLQNIIQEHL 228
XP_015792913  106 SQMKESEIIDNFnnGQSRFTIRLSKDTFYYLKRYLQDssKSTS---IIQNVIQEHL 158
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