4RC1


Conserved Protein Domain Family
4HFCP_synth

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pfam04476: 4HFCP_synth 
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4-HFC-P synthase
(5-formylfuran-3-yl)methyl phosphate synthase, also known as 4-HFC-P synthase, is involved in the production of methanofuran. This family has a classical TIM-barrel structure whose biological unit is a homohexamer.
Statistics
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PSSM-Id: 398265
Aligned: 55 rows
Threshold Bit Score: 200.862
Threshold Setting Gi: 170777262
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4RC1_B         10 LLVSPIDVEEAKEAIAGGADIIDVKNPKEGSLGANFPWMIK---AIRE------VTPK-------------D-LLVSATV 66  Methanocaldoco...
jgi:Plim_1240  19 LLVSVRNAEEARLVVNSGVAVLDVKDPARGALGRADESVWR---EILAvagkhrVAPGvsekssgrptrvhSgLVTSLAL 95  Planctopirus l...
WP_015245790    4 LLVSVRSVEEASDALAGGASIIDIKEPARGPLGRADTEVWQ---AIRE------TLPT-------------G-VCLSVAL 60  Singulisphaera...
jgi:Isop_2173  10 LLVSVASATEAVEALQGGADLIDLKRPDRGPLGRPDASDVL---DLAR------ILPD-------------P-HQRSLAL 66  Isosphaera pal...
WP_013626798    4 LLISVRNAAEAGIALAGGCDVLDVKDPSAGSLGQPALNTLAeilETLK------HLQS-------------S-IPTSCAL 63  Rubinisphaera ...
jgi:Psta_3306   4 LLVSVRDVREATLALEAGVDLLDVKEPSAGPLGFASLDTLLsiaQIAR------KLAP-------------E-VPLSAAI 63  Pirellula stal...
jgi:Msil_2396   4 MLASVINGAEAETALASAVDMIDLKDPARGALGALPAGLVA---SIVA------TVAG-------------R-KKTSAAA 60  Methylocella s...
WP_012116066   15 LLASVADLAEMEVALGAGADIVDLKNPAEGALGAWAEAPLK---AAVArwraagCVTG-----------------LSATV 74  Xanthobacter a...
Q0BU42          4 MLTSVTGPEEAEVALAGGADIIDLKDPSIGALGAVSPDVVRhtvDAVArwdaahNHSG---------------HKVSAVT 68  Granulibacter ...
WP_013947253   12 fLASVTTAGEAEIALAGGADIIDCKDPAAGALGALSAATVR---EIVA------GVGG-------------R-LPVSATI 68  unclassified H...
4RC1_B         67 GDVPYKPgtis----laaVGAAISGADYIKVG----LYG-VKNYYQAVELMKNVVRAVKDID----ENK-IVVAAGYADA 132 Methanocaldoco...
jgi:Plim_1240  96 GELLEVE-----------PCAIPEGVDVLKVGlaqcGRQqCAGQREDQEGWTRKWLQFREQTealsKRSfRWMAVAYFDS 164 Planctopirus l...
WP_015245790   61 GELPEWTdqp------dpARSAFTGISYRKLG----LAG-------VGPDWKAIWAKLRDRW----REGpAWVAVVYSDW 119 Singulisphaera...
jgi:Isop_2173  67 GELADGPpdlhwvahlgeAR-----PRFVKFG--------TSRCRASDDQTPSFSWRERARAwvesHDW-QVILGIYADF 132 Isosphaera pal...
WP_013626798   64 GELVDWSpdpvam-------ftlnrLSYLKIG----PAG-LGKFDDWADRFATLQQQFRQAG----VNQpRWIAAFYLDF 127 Rubinisphaera ...
jgi:Psta_3306  64 GELADPLalple---------qlhpYRYLKLG----LAG--MARSPWPSQWEHVRGQLADQS--------QLVPVIYADF 120 Pirellula stal...
jgi:Msil_2396  61 GDQFAAPadav----eaaRALVATGVDFVKIG----LQG-GAAGAAIVDALGAHKGDA------------ALIGVLFADQ 119 Methylocella s...
WP_012116066   75 GDQPLDAatil----aaaRRTASTGVPLVKIGfplpLDGaGAALAPVLDALRPLALET------------RLIAVLFADQ 138 Xanthobacter a...
Q0BU42         69 GDLPMDPaliv----qaaEAMVEAGVHYVKIG----FFE--GDPQKVLDALAPLSGRV------------RLVAVLFADR 126 Granulibacter ...
WP_013947253   69 GDLPPEPdvlt----naaSDMAATGVDIVKIG----FFG-SEDPRRAIAALGA-AHARST----------KLVAVLMADQ 128 unclassified H...
4RC1_B        133 y--rVGAVEPLI-VPKIARDA------GCDVAMLDTAIKD-GKT----LFDFQSKEILAEFVDEAHSYGLKCALAGSIKK 198 Methanocaldoco...
jgi:Plim_1240 165 ----AARAPDLEeVKTFAIQQ------QLAGVLIDSYEKT-GQT----MTDVYSWEQLSACRDELVAAGMLLAIAGQIRE 229 Planctopirus l...
WP_015245790  120 q--rANAPQPVDvLEEALAVG------ECTGILIDTWDKG-RPS----TVDHSWLP----WLAQARQGGLTIALAGGLND 182 Singulisphaera...
jgi:Isop_2173 133 dqpgVNGLEPTR-AVEEAHAL------GCAGLLVDTFDKAnPTR----WYRQPAPPITPDWVAHARASGLLVALAGSLDA 201 Isosphaera pal...
WP_013626798  128 e--aAASFDPLAvLTETKLRKqlcdrlGCAGILLDSFDKQ-GPSaaelILDRRRTQTLRDLLATARELGLMTAFAGRLSF 204 Rubinisphaera ...
jgi:Psta_3306 121 p---SAQAPPPNeVLELAIAQ------AASVLLIDTWDKD-RGN----LFAAISVAELSAIIEQARAAEIQVVVAGKLAL 186 Pirellula stal...
jgi:Msil_2396 120 n-------PDLD-LLNRMAER------GFKGAMLDTFEKG-AGR----LLDHMDVAALAPFVDRCRELGLICGLAGSLEA 180 Methylocella s...
WP_012116066  139 d-------PDLS-TIAQFAEA------GFHGVMLDTADKA-AGG----LLAHLPVPRLAGFVAEARAAGLLTGLAGSLKL 199 Xanthobacter a...
Q0BU42        127 k-------PDLA-ILPTLKGA------GFYGAMLDTADKG-AGG----LLSHMKAPALLDFTRACRRIGLEPGLAGSLEE 187 Granulibacter ...
WP_013947253  129 n-------PDFA-LVADLAAA------GFSGVMVDTADKS-AGR----LTTVLSAARLMEFVRLARDNRLFVGLAGSLRE 189 unclassified H...
4RC1_B        199 EHIPILKEI--GTDIVGVRGAACkGGDRNnGRIDRELVKELK 238 Methanocaldococcus jannaschii DSM 2661
jgi:Plim_1240 230 EMLPVLKKL--EPHLLAVRSAVCqLRDRN-RSVSPEALEKFS 268 Planctopirus limnophila DSM 3776
WP_015245790  183 SRIERLGPL--DPDWIAVRGAACrEGDRG-SGLDPVRVARLa 221 Singulisphaera acidiphila
jgi:Isop_2173 202 QAIPRLATW--QPDFIAVRSAAClHGDRR-GPIDPRRVEHLR 240 Isosphaera pallida ATCC 43644
WP_013626798  205 EDVRTLQAAriQPDLFAVRSAVClENQRQ-AGIEAARVRQLT 245 Rubinisphaera brasiliensis
jgi:Psta_3306 187 ADVPQLRAI--GARYWGVRTAVC-ESTRD-GTLAPEKIAAWK 224 Pirellula staleyi DSM 6068
jgi:Msil_2396 181 PDVPRLLPL--RPDYLGFRGSLCkGGERG-GALDLAAVAMIR 219 Methylocella silvestris BL2
WP_012116066  200 QDIAPLATL--KPHYLGFRGALCaTG-RT-SALDPAQLARVR 237 Xanthobacter autotrophicus
Q0BU42        188 PDVPRLLLL--APAFLGFRRALT-EGARA-GAVTLERVRTVR 225 Granulibacter bethesdensis CGDNIH1
WP_013947253  190 RDIDVLAGL--GPDLLGFRGALCaQG-RV-SAIELSRVVSVR 227 unclassified Hyphomicrobium
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