6Z93


Conserved Protein Domain Family
2-thiour_desulf
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pfam04463: 2-thiour_desulf (This model is not part of the current CDD release)
2-thiouracil desulfurase
This family of proteins, predominantly found in Bacteria, are involved in the desulfuration of 2-thiouracil into uracil in the 2-thiouridine degradation pathway. It has been demonstrated that these proteins contain a Fe-S cluster required for their activity.
Links
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Statistics
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PSSM-Id: 516261
Aligned: 297 rows
Threshold Bit Score: 61.7265
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6Z93_A            6 IVSACLLGQPVRYDGQSKgi--vSNwLDALgAegRALAFCPEVAGGLPTPRPPAERqGE------H-VVTESGLDVTAEF 76  uncultured b...
WP_012448561     26 LISRCLGFAPCRFDGSMFrenliDQ-LQGF-V--KFVPVCPEEELGLGTPRKTLRLyESre--ghGlYQQDTGSDLTQEM 99  Natranaerobi...
WP_014552709     10 ILSKCLEYCRCRYNGDKIpdkfvRK-LEKH-V--NYIKICPEVEMGLGVPRNSVRLiKDqd--qyKlVDSMTGKDHTDKM 83  Halanaerobiu...
sklmb:Mhar_1666  18 VVSRCIEVDHCRYNGQIIssdfvKS-LQPY-V--QFLPVCPEVEIGLGVPRDSVRLvSTnreketRlVQPATDRDVTAEM 93 
WP_013194432     10 LVSRCLEFENVRYDGHVIssqivKD-LEPY-V--DYIKVCPEVEIGLGVPRDPIRIvKIng--ryRlIQHRTNRDITEEM 83  Methanohalob...
WP_013898899     10 LVSRCLEFDSVRYDAKTIpsrivKD-LEPY-V--NYIKVCPEVEIGLGVPRDPIRIvKSag--eyRlIQPATGRDVTEEM 83  Methanosalsu...
WP_015324446     10 VVSRCLEFDKVRYDGQVIhsrivRD-LEPF-V--DFVKVCPEVEIGLGVPRETIRIvRKdg--syRlVQPATGEDLTDRM 83  Methanomethy...
WP_013037131     13 LVSRCLEFEKVRYDGQVIhcqavRD-LEPF-V--DFIKVCPEVDIGLGVPRDTLRIvKIkg--eyRlVQPKTGNDVTEKM 86  Methanohalop...
Q2FNS4           18 VISRCIEHDPVRYNGDMIsstevAA-MKPY-V--TFIPVCPEVEIGLGIPRSSIRIvRTka--gdRlIQPTTNEDLTDRM 91  Methanospiri...
WP_004076781     13 VVSRCLGFGHVRYDGSMIksdevEA-LKKY-V--NFIPVCPEVEIGLGIPRAVIRIvRInn--edRlIQPSTGRDITEQM 86  Methanoplanu...

6Z93_A           77 DRGAELALGLCLAQGIRFALLKEGSPSCGSGRI--Y------------NgrfegvsmagEGKTTALLRRHGIQVFSEDQ 141 uncultured ba...
WP_012448561    100 KDFAYDYLSTVD--NLQGAILKTRSPSCALKDAkiYaektsnitskrgA-----------GLFSECLLEQWPNLPVEDE 165 Natranaerobiu...
WP_014552709     84 NNYLEKIISELKEEEIEGFIAKTRSPSCGSNDAkvYpkagkvpalgekK----------AGYFTTELKKSFSSLVIENE 152 Halanaerobium...
sklmb:Mhar_1666  94 NTFAGSFLDAVG--DVDGFILKASSPSCGIRNTkvYptagrsaaltrsA----------SGLFGAAVLARHPHLAVEDE 160
WP_013194432     84 DKFTDDFLDKLQ--DVDGFIFKSGSPTIGYRNIkvYsgmesatviekgS-----------GFFAAKILEKYNGYPVEEN 149 Methanohalobi...
WP_013898899     84 DSFTDQFISRLP--EVDGFIFKSGSPTIGIRNIkvYsgvkdapvieksS-----------GFFARKILTRYSGYPIEED 149 Methanosalsum...
WP_015324446     84 NSFTEGFIKDLQ--EVDGFIFKSKSPTIGLRNIkiYagaenapvvergT-----------GFFAGKLLENYPGYPLEED 149 Methanomethyl...
WP_013037131     87 DEFTDSFLGELV--EVDGFIFKSKSPTIGIRDIkvYgglsnagviergS-----------GFFADKILKRYSGYPLEED 152 Methanohaloph...
Q2FNS4           92 NTFTEGFISSLP--SVDGFILKNKSPTSGISNVniYpsvgksaaiekgP-----------GFFGGRILETFTDYPIEDE 157 Methanospiril...
WP_004076781     87 NEFSESFLSKTD--KTDGFIMKNRSPSSGISNVnvYpgpdksnkidrrA-----------GFFGGAIIDRFPDYPVEDE 152 Methanoplanus...
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