5XOX


Conserved Protein Domain Family
Thg1

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pfam04446: Thg1 
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tRNAHis guanylyltransferase
The Thg1 protein from Saccharomyces cerevisiae is responsible for adding a GMP residue to the 5' end of tRNA His. The catalytic domain Thg1 contains a RRM (ferredoxin) fold palm domain, just like the viral RNA-dependent RNA polymerases, reverse transcriptases, family A and B DNA polymerases, adenylyl cyclases, diguanylate cyclases (GGDEF domain) and the predicted polymerase of the CRISPR system. Thg1 possesses an active site with three acidic residues that chelate Mg++ cations. Thg1 catalyzes polymerization similar to the 5'-3' polymerases.
Statistics
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PSSM-Id: 398244
Aligned: 171 rows
Threshold Bit Score: 98.7045
Threshold Setting Gi: 509084068
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5XOX_B              9 VRqFE--THDVILPQCYIVVRIDGKKFHEFSKFY-EFAKPNDENALKLMNACAKNLVLKYKnDIILAFGESDEYSFILKS 85  Saccharomy...
WP_013109777       10 MRvFEtaADLCVLPGMFMVARLDGRSFTRLTKDVcPFEAPFDERFRDLMVSTTESLMNCGF-RVLYAYTQSDEISLLFDL 88  Planctopir...
WP_044002115       10 LRvFEtaHDHCALPGLYLVARLDGRGFTRLTKEVhPFEAPFDVRMRDYMAETTRHLLECGF-RIVYGYTQSDEISLLLHP 88  Hymenobact...
jgi:Cal7507_3479   10 MRvFEtaHDYCVLPGLYIVARLDGRSFTRLTKEVhQFEAPYDIRFRDLMLATVEHLLNCGL-DITYGYTQSDEISLLFAQ 88  Calothrix ...
jgi:Clocl_2735     10 MRvYEtaHDYCVLPEVYMVARIDGRNFTRLTKEIhKFESPYDIRFRDYMVATTEHLMNCGF-RVIYGYTQSDEISLLFHI 88  Hungateicl...
MPITM:COCOR_06225  10 MRvFEtaHDLCVLPGVFMVARIDGRGFTRLTKEVhAFESPFDVRFRDLMVATTGHLMESGF-RVVYGYTQSDEISLLFHP 88  Corallococ...
WP_012793384       10 MRiYEtaHDKIVLPGMYMVARIDGRGFTKLTKEThPFEAPFDPRFRDYMVETVKHLMNCGF-NVVYGYTESDEISLLFHL 88  Chitinopha...
EIC28543           10 MRvFEtaHDHCVLPGIHIVARIDGRCFTTLTKDKhRLEAPFDLKFRDMMIETVKHLMQCGF-KINYGYTQSDEISLWLDL 88  Methylomic...
jgi:Cha6605_5557   10 MRvFEttNDLYVLPGIFMVARVDGRGFTRLTKETcKFEAPFDPMFRDAMVATLQHLMQCGF-KVVYGYTESDEISLLLHP 88  Chamaesiph...
tgen:AM1_3767      10 LRiYEtaYDLCVLPGLQMVARLDGRNFTRLTKETlDLDAPFDATFRDAMVATVQHLMTCGF-RVLYGYTQSDEISLLLHP 88  Acaryochlo...
5XOX_B             86 STTLFNRRKDKLATLFGSFFTSNYVALWAKFfpekplnikhlPYFDSRCVAYP 138 Saccharomyces cerevisiae S288C
WP_013109777       89 EEQLFGRKLRKYNSLLAGEASAQFSLKLRQP-----------ACFDCRISQLP 130 Planctopirus limnophila
WP_044002115       89 SEDSFGRKLRKYTSVLAGEASAKFSLLLGDI-----------GVFDCRISQLP 130 Hymenobacter swuensis
jgi:Cal7507_3479   89 QENTFNRKLRKLNSVLAGEASAKFSLLLGAI-----------GCFDCRISQLP 130 Calothrix sp. PCC 7507
jgi:Clocl_2735     89 DENAFGRKVRKFNSILAGEASAKFSVLLGDV-----------ACFDCRISELP 130 Hungateiclostridium clariflavum DSM 1...
MPITM:COCOR_06225  89 DEDTFGRKTRKLNSVLAGEASAKFSLLLGDL-----------GTFDCRICELP 130 Corallococcus coralloides DSM 2259
WP_012793384       89 AEGAFGRKHRKYNSILAGETSAKFSLQLGSL-----------AAFDCRICELP 130 Chitinophaga pinensis
EIC28543           89 NDGLFERKERKLNSILAGEASAKFSLLLGDV-----------AAFDCRICQLP 130 Methylomicrobium album BG8
jgi:Cha6605_5557   89 EDVTFDRKLRKLNSVLAGEASAKLSTVLGTV-----------AAFDCRISQLP 130 Chamaesiphon minutus PCC 6605
tgen:AM1_3767      89 DEQTFARKLRKLNSVLAAEASAKMSLILGCI-----------AVFDCRISQLP 130 Acaryochloris marina MBIC11017
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