6WC3,8EKI


Conserved Protein Domain Family
RINT1_TIP1

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pfam04437: RINT1_TIP1 (This model is not part of the current CDD release)
RINT-1/TIP-1 family
This family includes TIP-1 (also known as Tip20) protein from yeast which is part of the Dsl1 complex, a multisubunit tethering complex involved in retrograde trafficking of vesicles from Golgi to ER, its homologue from animals RINT-1, a Rad50 interacting protein which participates in radiation induced checkpoint control and in membrane trafficking from the endoplasmic reticulum (ER) to the Golgi complex; and MAIGO2 (Mag2) from plants which functions in the transport of storage protein precursors between the ER and Golgi complex. They are part of the CATCHR (complexes associated with tethering containing helical rods) family which includes proteins from the GARP/EARP, exocyst, conserved oligomeric Golgi (COG), and Dsl1 complexes and share a structural fold consisting of helical bundles.
Statistics
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PSSM-Id: 516244
Aligned: 58 rows
Threshold Bit Score: 286.884
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6WC3_A       122 WNFVCMANNFRIKFIYHFTSPSAESEQQSIENYFKFLDKYLSENLYKYMDIFED--ESKGITRTLIHKQFINHILEPVRE 199 Eremothecium go...
XP_015787512 225 LPLQLMVKPLRKRFTYHFMTNVRTNQLSKPEWYLTQIMNWIKDHENFLSEHVTVlfKDQETEFASLKIQFTCALLELAAD 304
5_pfamImport   1 LPFQLLLRPLKRRFRYHFTGTKQTNVIHKPEWYLTQILGWLSNHAGFLEHTIQPvlDENGHGHIDAVVMFTQGLLKLIED 80 
EDO38509     241 LPLDWLLKPLRKRFKFHFYGKKQTNNLEKPEWYFTQILNWIKSHGDFLQHTVQPvlDKAELSFIDAKLEFIRGLLAVTTE 320
ELK01327     290 LPIQIMLTPLQKRFRYHFRGNRQTNVISKPEWYLAQVLLWIGNHTEFLDEKIQPilDKVGSS-INARLEFSRGLMMLVLE 368
XP_069048725 284 LPIQIMLLPLSKRFRYHFTGNRQTNTPNKPEWYLTQVLMWMGNHSAFMEEKIQPilDRDGAR-INARVELCRGLLSLALE 362
XP_003972690 284 LPIQIMLLPFRKRFRYHFCGNRQTSSLSKPEWYLTQVLLWMSNNSTFMEEKIQPilEG-AETHLSARVELCRGLLALVQE 362
6_pfamImport   1 LPIQIMLLPLNKRFKYHFYGNRQTNSLSKPEWYLTQVLMWMGNNSTFMEETIQPilDRGGVT-LSAKVELCRGLLSLVQE 79 
XP_002172421 196 L-MKCICRPFNIQFKYHFMTEKKTNTPSKPEWFYEFALKVFRSSLSFI-QLFQQimPEGMIAV----HEFMKVMQELMKE 269
Q9C0W8       200 LFMQVYITPYVNQFRYHFMSQKQTNVLSKPEWFFEFLLKVFRSNRSFYMLMRDIkfFPGVPPF----FTFINLLNNVAKE 275 Schizosaccharom...
6WC3_A       200 KVNVTMTKIaasnsASDVKMLVLLISEIFITDNALKK-SHYYDg------VGLVS--LIDEaaLEVWQNFEVESAVSQFE 270 Eremothecium go...
XP_015787512 305 KLAKDLTKL-----SADDKLFSHAFDEVLLTQRELEDiNQDWLslfrencNLLSl--FAVEpyFTRLRNIERRRSMEYIE 377
5_pfamImport  81 KLTVDIEDL-----IYVDDLFSHVVDEVLLFDRELRV-AYDIPtpvlnrcSPVKv--LTQPhcMQKWLNIEKTCAAERLD 152
EDO38509     321 KMIHSLPEL-----LADEAVFSHFVDETLLFHKELHE-LYNYPltd---hsCLKv--LTRKqcLGKWVELERKYAIENME 389
ELK01327     369 KLAADIPCL-----LYDDNLFCHLVDEVLLFERELHS-VHGYPgtf---anCLHi--LSEEtcFQRWLTVERKFALQKMD 437
XP_069048725 363 KLAADAPRL-----LFDDALFCHLVDEVLQFERELRG-THAYPstl---pgALHi--LLDDavFQKWLSVEKKLAVEKVD 431
XP_003972690 363 KVASDALRL-----LYDDALFCHLVEEVLQFEKELRS-KLSYPpa----lPGLLHl-LLENtvLQKWLTVEKKMAVEKMD 431
6_pfamImport  80 KVASDASKL-----LYDDVLFCHLVEEVLQFEKELRS-NHSYPae----lPGVLHl-LLEDavLQKWLTMEKKMAVEKMD 148
XP_002172421 270 KINLIMDL-------DV--HLAHLIRETLYYSTKLKQ-LYNFPq-----kDSLSLylLKQPmvYSRWLDIEAADVKMQLN 334
Q9C0W8       276 KLTHIIKY-------DD--YLVHLVHETLQYSVRLEQ-HFHYTq------DPLIIflFEQNgtYDKWLGLETQLSLTKLE 339 Schizosaccharom...
6WC3_A       271 KLT-TPGAS----------------LM-SPKNGADFGKLLENMYRY-LEPFFSIDYrnlfsvKYQLVDEIFIQLPLKYRS 331 Eremothecium go...
XP_015787512 378 TIIsSETAWsplvtsiddededediLK-VPEIADNFILMLQSITDR-FSHLSKISH------QYAFIVL-ELEMLADFHL 448
5_pfamImport 153 TLMtSEEAWrsklsdv---sddideMM-TPQCAETFVTMLQTITDRyYKNLPSWEE------QLQFLDL-QITLLDDFRI 221
EDO38509     390 SLLaSENAWrpkyedv---ecgadeMR-APECAEGFITILTVMTDR-YRHLPGLDE------QSRFLAV-QLDLLKDFIT 457
ELK01327     438 STLsSEAAWisqykd----itdvdeMK-VPDCAETFMTLLLVITDR-YKNLPTASR------KLQFLEL-QKDLVDDFRI 504
XP_069048725 432 ALLaAEGAWssqyrd----iadldeLK-VPDCAETFMTLLLVITDR-YRSLPSPRA------RLSFLAL-QKELVDDFRI 498
XP_003972690 432 AMLsSEGAWscqyke----mcdmdeLR-APDCAETFMMLLQVITER-YRYLTCPSA------QLKFLGL-QKELLDDFRI 498
6_pfamImport 149 AMLsAERAWssqykd----isdmddLK-APDCAETFMTLLQVITER-YRTLPCPSA------QLKFLEL-QKELVDDFRI 215
XP_002172421 335 AIEsSKDAWelardd-----veelyTAvPIKSFVLYRNAMASLKSI-LEMIPCEEF------CRGFFHTLQLKPSIQFVD 402
Q9C0W8       340 DIKiASDAWelesdq-----sddfsSAvPTKMTVRFRDMIETTFSV-LQNLPSLDY------QFNFWRSVQLKPMMQYVN 407 Schizosaccharom...
6WC3_A       332 FLLSKNILQNELT-----------AEQQFE-------NTCVKLH-SLLLISNILVRFSHDFTFIEMTQQI---NKITDSd 389 Eremothecium go...
XP_015787512 449 RLSQIYr-----------------SLDSEGlnqwpftQRFFSIInTLNYVILLLNNWKNLPVFQDMSEFSlk-------- 503
5_pfamImport 222 RLIQVLr-----------------SSPREEi-----eF---AIInAARYVGTVLLEWGENLFFLQLKYHK-------DSc 269
EDO38509     458 LLSLTAe-----------------ESASNPv-----dACFISVLnATSYIGFLLEDWNDQTLFLQLHGYFssend----- 510
ELK01327     505 RLTQVMk-----------------EETRASl-----gFRYCAILnAVNYISTVLADWADNVFFLQLQQAA---------- 552
XP_069048725 499 RLTQVMk-----------------EESRCPl-----gPRYCAILnATNYVSAVLADWADNVFFLQLQQAA---------- 546
XP_003972690 499 RLTQVMk-----------------EDSRYPl-----sARYCAILnAVNYISTILRDWGDNVFFLQLQQAA---VSLNDEv 553
6_pfamImport 216 RLTQVMk-----------------EESRCPl-----gVRYCAILnAVNYISTILGDWGDDVFFLQLQQTA---VSLGEEa 270
XP_002172421 403 WLESYYQNHEGSTtlipg-gahvtSEQSFse-----vRRMCKLYgAFKLLLDWHLDLEDEEVYI-LSQETnleKPVDKQv 475
Q9C0W8       408 WLEAFYESHEssssihlpgslqtdKSKFDia----evERMCKLYsNFKLLMDWLDDIEDEDVYIRIGHKMgseNYA---- 479 Schizosaccharom...
6WC3_A       390 -yEY-----------------------IFDEVWESYDEAVIVLRDSIVHRWVKGLSSSLRNYFKYNEWDSI------Ata 439 Eremothecium go...
XP_015787512 504 -------------------------dsIFEDSLSLYNHMVNEMKKRIVDSLMKLIMEKIKAY-ASLRWHCFtl--ldD-- 553
5_pfamImport 270 kqSEntllppflif----panettdntVFDVIINLYDRICSEAIESQVQLILSEIHEKCKSY-MYEGWLALpt--aeEql 342
EDO38509     511 ----------------------sgdcgVFDEPLKSLCELQKYMSGLIVEDVVKGFRAKCKAY-RKERWHSLps--pkEla 565
ELK01327     553 --LEvfaenntlskl-elgqlasmessVFDNMINLLERLKHDMLTRQVDHVFREVKDAAKLY-GKERWLSLps--qsEqa 626
XP_069048725 547 --VDmgeevlgnlgvtetgrlaslegsVFEGLLGLLDRLRGDMLGRLLDAVLRDVKDKAQPY-CREKWLSLps--qaDqa 621
XP_003972690 554 llGGlglmelgq--------laalegsLFDSLLALLDRLKGDMMGRLLDWTMREFKEKAKPY-SQNRWLSFps--qqDqs 622
6_pfamImport 271 ipGGlgimemgr--------laslegsLFDGLLALLDRLKGDMLGRLLDFLMREIKEKAKPY-CQERWLSLps--qqDqs 339
XP_002172421 476 laEEs---------------------sVFLPLRKRLSKLCNQTFELLMHRVTQYLEATFDSFASINTWtlqekppsdksy 534
Q9C0W8       480 ---------------------------AFYQVKPRLSTLTNGSFRMILRAVSQTLRPLLDNYSDLDTWvikeqlpgaall 532 Schizosaccharom...
6WC3_A       440 PEQCSAELVGALAWMKKMTDIFDKYWyPQHIIAQIKVALLENIIKFMLNYVVKLNKFSENGLRQLTFDY-EALRATLGLP 518 Eremothecium go...
XP_015787512 554 --DMQYISYQLFYLISKSLELLKRKL-SHNILEELIETIADSIKTAIMKEVIYNNSFNGEGAQQLHRDVnINLFSVFRVY 630
5_pfamImport 343 VMVVSQSACPMLAVLQDRLHFLEMRL-CRELFSQLWRDVAENVDVFLFNEVIVKNHFNSGGAAQLNFDMnRNLFPMFGHY 421
EDO38509     566 VMVLSSGACDFLVYLKDRLNTLQKLL-AYKLFSALWVDLARALNMLIYQEVIQECRYNEGGAAQLQFDM-KNLFTLFGEY 643
ELK01327     627 VMSLSSSACPLLLTLRDRLLQLEQQL-CISLFKIFWQMLAEKLDIYIYQEIILANHFNEGGASQLQFDMtRNLFPLFSHY 705
XP_069048725 622 TMSLSSSACPMMLCLRDRLLQLQQLL-CVPLFQSCWQGLAERLDLFIYQEVILSSHFNEGGAAQLQFDMtRNLFPLFGHY 700
XP_003972690 623 SMSLSSSACPMMLCLRDRLLSLHQLL-GLSLFQLTWQGLAERLDHFLYQDVILANHFSDGGAAQLHFDMsRNLFPLFGQY 701
6_pfamImport 340 TMSLSSTACPMMLCVRDRLLNLHQVL-GFSLFHLAWQGLAERLDNFLYQDVILCNNFSDGGAAQLQFDMtRNLFPLFGHY 418
XP_002172421 535 EGSISPEAVGFDIALRRLINSIHEII-LGAPFFEIVCRIADIVEDWLLH-IMHTHQFSNRGAVQFARDSlQFLTA-FSDY 611
Q9C0W8       533 STSVSAEIVGFQSRLKEIIALLQKLL-IGSSQCEAIYQIGTLVESWMIK-IVMTHQFSVRGGVQFAMDAmQIVLE-FSDY 609 Schizosaccharom...
6WC3_A       519 LEHSSVAEElALFEYFNILSMKYTnnkITSKFLDAEYVS----S-------HHTRN-----FRELRESLQ---------- 572 Eremothecium go...
XP_015787512 631 TPNPESLII-ELVEACQLLNLAKG---NSLLLQDTLRKG----Nvs----------------ddILKDFN---------- 676
5_pfamImport 422 TSKPDNYFK-RVKEGCILLNLSTG---SALLLREVLEeslknptldsnikpVD--------PQNALNDIG---------- 479
EDO38509     644 TQKPENYYK-EVKECCILLNQMPG---SAILLIESLQAA----Hahde---------stnaPQATLNEMG---------- 696
ELK01327     706 CKRPENYFK-HVKEACIVLNLNIG---SALLLKDVLQsasg-----------------qppATAALNEVG---------- 754
XP_069048725 701 CKRPENFFK-HVKEACIVLSLSVG---SALLLRDVLQQG----Dsgsdvts----dpsqpsPVAALNEVG---------- 758
XP_003972690 702 CKRPENFFK-HVKEACIILRLSVG---SAILLRNVLEEA----EeetdagdHERPT-----LMSTLHELG---------- 758
6_pfamImport 419 CKKPENFFK-HVKEACIILCLNVG---SAILLRSLIKES----Dm-----tRDCAGtgdppPESALNELG---------- 475
XP_002172421 612 P---LVQMK-RLTSSLPLLTFE-------------------------------QTEkl--cIKDLLRQINngdye----- 649
Q9C0W8       610 P---LLKFE-RLMSTVELLSLESG-------------------------------Enk--lIKKLIIEINqknydfidef 652 Schizosaccharom...
6WC3_A       573 -----VS-H--LTSDEIADALYR 587 Eremothecium gossypii ATCC 10895
XP_015787512 677 -----VH-H--LSAKVAHKILSK 691
5_pfamImport 480 -----VN-L--ILPKQALDIIKR 494
EDO38509     697 -----VY-K--LSSHDALRILNL 711
ELK01327     755 -----IY-K--LAQHDVEILLNL 769
XP_069048725 759 -----IY-K--LSPGDVLILLNL 773
XP_003972690 759 -----VY-C--LAPCDVLYVLRL 773
6_pfamImport 476 -----VY-C--LAPCDVLILLSL 490
XP_002172421 650 -tlktINpEntLSPSESLDVLYR 671
Q9C0W8       653 fktkeIT----LSYEDALGVLYR 671 Schizosaccharomyces pombe 972h-
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