2K2E,2GM2,2AB1,2CYJ,1IHN


Conserved Protein Domain Family
DUF498

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pfam04430: DUF498 (This model is not part of the current CDD release)
Protein of unknown function (DUF498/DUF598)
This is a large family of uncharacterised proteins found in all domains of life. The structure shows a novel fold with three beta sheets. A dimeric form is found in the crystal structure. It was suggested that the cleft in between the two monomers might bing nucleic acid.
Statistics
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PSSM-Id: 516239
Aligned: 231 rows
Threshold Bit Score: 47.1517
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2K2E_A         14 VTAYGDGYIEVNq--VRF--SHAIAFApEGPVASw----pVQRPADITASLLqqaaglaevvrDPLafLDEPeagagarp 85  Bordetella per...
Q1AYX2          6 ITGLSWGRLETEr--GAF---KDAKLYpGGAREWdwnetgTRHDPGIQPADV-----------AEL--LERG-------- 59  Rubrobacter xy...
EDO32188       11 VDKLSWGHMTIg--cQSY---KDCKVWpGGSRAWdwnetgTKAR--VQPADI-----------EDI--LTSK-------- 62 
Q502H1          6 IASLSWGHMKVKgcsTSY---KDCKVWpGGSRAWdwretgTNHHPGVQPSDL-----------EEI--LRKG-------- 61  zebrafish
XP_003226014    6 IASISWGRMTVKgcsTTY---KDCKVWpGGSRTWdwretgTDHVPGVQPADV-----------EEV--VQKG-------- 61 
Q32PA8          6 IASLSWGQMKVQgstKIY---KDCKVWpGGSRDWdwretgTEHSPGVQPADV-----------EEV--VEKG-------- 61  domestic cattle
XP_005810605    6 IATLSWGLMKVKgcsSSY---KDCKVWpGGSRAWdwretgTDHYPGVQPADL-----------EEV--MKKG-------- 61 
14_pfamImport   1 ICSLSWGHMRVQgcsSSY---KDCKVWpGGSRAWdwretgTDHRPGVQPADL-----------EEV--LRTG-------- 56 
WP_013388747   12 ILNFSWGVMDIEg----YgqGKDFKLYpGGASPWnwsetgTEHSPGIQPADI-----------KEL--LDRG-------- 66  Ilyobacter pol...
2AB1_A          6 IASLSWGQXKVKgsnTTY---KDCKVWpGGSRTWdwretgTEHSPGVQPADV-----------KEV--VEKG-------- 61  human
2K2E_A         86 anaPEVLLVGTGRR-QHLLGPEQVRPLLAMGVGVEAMDTQAAARTYNILMAEGRRVvvALL 145 Bordetella pertussis Tohama I
Q1AYX2         60 ---AEVVVLGRGFYgRLGVCEETLRLLRERGVEVYAERTEEAVRRYNGLAPER-RAgaLIH 116 Rubrobacter xylanophilus DSM 9941
EDO32188       63 ---VQILVISRGMNgVLKVPPKTVQFAEARGVEVLVHLTEDAVKKYNQLAIQGARVggVFH 120
Q502H1         62 ---VQTLVIGRGMSeALQVPPSTLDYVKKQGVDVQVFQTEQAVREYNALAGKGEKVggVFH 119 zebrafish
XP_003226014   62 ---AKTLVIGRGMSeALQVPPSTVEYLKKHGIDVLVLQTEKAVREYNALASKGVKVggIFH 119
Q32PA8         62 ---VQILVIGRGMSeALKVPPSTVEYLKKKGIDVRVLQTEQAVKEYNALATQGIRVggVFH 119 domestic cattle
XP_005810605   62 ---IELLVIGRGMSeALQVPSSTVDFVKQQGIEVRVLQTQKAVAEYNKLAVQGAKVggVFH 119
14_pfamImport  57 ---VRALVIGRGMNeALQVPAATLAFVQQRGVEVTALQTEKAVAHYNQLAAQGARVggVFH 114
WP_013388747   67 ---CQVVVLSKGVEsSLKVMDSTIELLKKHNIEYHILDTKKAVELYNKLAGENFRIggLFH 124 Ilyobacter polytropus
2AB1_A         62 ---VQTLVIGRGXSeALKVPSSTVEYLKKHGIDVRVLQTEQAVKEYNALVAQGVRVggVFH 119 human
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