1L8D


Conserved Protein Domain Family
Rad50_zn_hook

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pfam04423: Rad50_zn_hook 
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Rad50 zinc hook motif
The Mre11 complex (Mre11 Rad50 Nbs1) is central to chromosomal maintenance and functions in homologous recombination, telomere maintenance and sister chromatid association. The Rad50 coiled-coil region contains a dimer interface at the apex of the coiled coils in which pairs of conserved Cys-X-X-Cys motifs form interlocking hooks that bind one Zn ion. This alignment includes the zinc hook motif and a short stretch of coiled-coil on either side.
Statistics
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PSSM-Id: 398227
Aligned: 53 rows
Threshold Bit Score: 38.6979
Threshold Setting Gi: 156567156
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1L8D_A         30 KNKIGDLKTAIEELKKAKgKCPVCGRELTDEH-REELLSKYHLDLNNSK 77   Pyrococcus furiosus
Q6FNZ8        661 HQTTLEFNRKALEVAINNdCCYLCSRSFENTEfRSKILKELKEKTDTKF 709  [Candida] glabrata
CCK70734      660 HQTTLEFNRKALDIAQNKdCCYLCSRKFENVEvKSRLLAELKKKTDANF 708  Kazachstania naganishii CBS 8797
XP_004177884  661 HQTTLAFNKKALEVAQNDdCCYLCSRKFEDATfRSKILDELILKTDAKF 709  Tetrapisispora blattae CBS 6284
XP_003684525  658 HQTTLAFNRKALEVAENSnCCYLCSREFDSTGlKSKLLNELKAKTNQQF 706  Tetrapisispora phaffii CBS 4417
XP_001646927  660 HQTTLAFNKKALEIAENNnCCYLCSRAFDDESfKSSLLNQLKERTNDEF 708  Vanderwaltozyma polyspora DSM 70294
XP_002497898  659 HQTTLEFNKKALEVAKTEsCCYLCTRKFDDEGfKSSILLRLQEKTDGKF 707  Zygosaccharomyces rouxii
XP_003680691  660 HQTTVEFNKKALEVAEREdSCYLCSRKFETEQfRSSLLAKLRVKVDSRF 708  Torulaspora delbrueckii
XP_003670961  660 HQTTLDFNRKALEIADRDnCCYLCARKFETDDfRGKILQQLRAKTDANF 708  Naumovozyma dairenensis CBS 421
CCF58024      658 HQTTLDFNRKALEVAEYDnSCYLCLRSFDTVEfKNEILQNLKAKTEAKF 706  Kazachstania africana CBS 2517
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