Conserved Protein Domain Family
Gar1

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pfam04410: Gar1 
Gar1/Naf1 RNA binding region
Gar1 is a small nucleolar RNP that is required for pre-mRNA processing and pseudouridylation. It is co-immunoprecipitated with the H/ACA families of snoRNAs. This family represents the conserved central region of Gar1. This region is necessary and sufficient for normal cell growth, and specifically binds two snoRNAs snR10 and snR30. This region is also necessary for nucleolar targeting, and it is thought that the protein is co-transported to the nucleolus as part of a nucleoprotein complex. In humans, Gar1 is also component of telomerase in vivo. Naf1 is an essential protein that plays a role in ribosome biogenesis, modification of spliceosomal small nuclear RNAs and telomere synthesis, and is homologous to Gar1.
Statistics
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PSSM-Id: 398216
Aligned: 209 rows
Threshold Bit Score: 87.3268
Threshold Setting Gi: 169802298
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5KH70       296 KkyaeagtEQVTSVTGGPTKKISKAEPTFTSagTVVVRAMqsRPgDFddgwLEEGSILCW-EDGRVLGTVYETFGPLTSP 374 Cryptococcus ne...
A0ECG9        49 PeskeqreFNFNYKNSDRIQLIGKIESLTKE--NIIIYSN------LlefvINLDQLIVN-GQQEILGKVDDVFGKVERP 119 Paramecium tetr...
Q22HG7       152 SdmerlvrFGVQFKGNEVLVELGQIMTIVDD--KIIIATNneMReAEkriiVDLDNIIFN-EQKNIIGNVDDVFGNIKNP 228 Tetrahymena the...
Q75JJ6       298 NdlpkeepIFVEIPKEVQICEFGILKSIVDD--VLVIKSi-----NVvsqaLDIDSIVCL-QDRTTIGRIYEVFGQVFQP 369 Dictyostelium d...
EFN83891      14 nglppvedLKISVSEV-TCDLFGEIIGIVEE--LVIIKPRae--kPA----LREETVLFIeQGQKTLGKIFDIFGPVKEP 84  Jerdon's jumpin...
EGI68144     321 EdlppiedLKISVPEV-LCNPLGKIEKIVEQ--LVIVKPNpg--eVT----LNLDTVLFVnKGTKALGKIFDVFGSVNEP 391 Panamanian leaf...
EFN69795      35 DdlppiedLKINVPEV-LCELLGEVDKIVEQ--LVIVKPKsn--kPA----LHIETVLFMeKGGRALGKILDVFGPVSEP 105 Florida carpent...
OWR54578     147 DdlppiedLAISLPAQ-ETIKIGKIASIVDR--LVIVRAFea--tPA----VDLDSVLFLdNGAKALGKVFDVFGPVTEP 217 Danaus plexippu...
XP_003138190 138 DtmpaieeLRIHVEEDIILKQFGKIMNIVDR--LVVIEADsnTA-------LDFETVIFD-AERNAVGRVFDIFGPVVKP 207 eye worm
EGT37828     149 DdlpplenLTIECNSN--LLEFGFVSKVIDC--QVIIVSTc---tEV----LDFDSYLFD-EKGNSIGQVYDIFGQVKTP 216 Caenorhabditis ...
Q5KH70       375 FYTVRLPpppfpypTPGSL----ATGTRLFYPFNPSYRSFvnmiavr-----------------dprykgTDASniy--d 431 Cryptococcus ne...
A0ECG9       120 HYSILLDgy----vNNLVQtnqlKIGDDVFINIDstsvlnp----------------------dainkkgCDASnqf--d 171 Paramecium tetr...
Q22HG7       229 FYCVIIDky----tEEMIAqkrlQVGQKVYMIEG--YNKLlmkaqle----------------fllrqkgCDASnrf--d 284 Tetrahymena the...
Q75JJ6       370 IYSVRIPs-----nLDITisnnnnnnn-----------------------------------nnnnnnnnNNNNnnnnnn 409 Dictyostelium d...
EFN83891      85 HYTIRFNn-----vEHIQErq-iTVGTPVYYCPDSCYTFFvflsel-------------------tkikgSDANcdggsd 139 Jerdon's jumpin...
EGI68144     392 YYCVRFNn-----aKHIQDnd-vKVGMQVYYCPNSEYTSLvflhel-------------------tklkaCDAIgd---- 442 Panamanian leaf...
EFN69795     106 NYCIRFNs-----sEHIQEnn-iKVGMPVYYCPNTQYTSLiflhel-------------------hklnsHDAMdd---- 156 Florida carpent...
OWR54578     218 HYCVRFNs-----lEHVRErg-vVTGADVYIAPRSAHTSYvflael-------------------mkvkgSDASwln--d 270 Danaus plexippu...
XP_003138190 208 MYAILFNd-----iKEASEw---KVGTAMYYAPA--ASQFthtvlte----------------klrhekaTDGCwdg--d 259 eye worm
EGT37828     217 QYVVRFNs-----sEEASMm---PINMKIYYAPT--DEKFsktpfkglnlaaanremirvlnrkldhkaaVERVaernqi 286 Caenorhabditis ...
Q5KH70       432 eeVPEE-EMEWSDDEAEAAAKRerKQK 457 Cryptococcus neoformans
A0ECG9       172 eeVLNDcDVEYSDDEIEAVSKKrgNKE 198 Paramecium tetraurelia
Q22HG7       285 eeVLNDnEIEYSDDEMESKAKTkrNNK 311 Tetrahymena thermophila SB210
Q75JJ6       410 nnNNNNnNNNNSNNNNNTLKKQgqLEE 436 Dictyostelium discoideum
EFN83891     140 gdHP-----DFSDDEEEKRYYEklNrq 161 Jerdon's jumping ant
EGI68144     443 dePP-----EFSDDEKEQAYYEnlKQK 464 Panamanian leafcutter ant
EFN69795     157 deLP-----EFSDDEEERAYYEmlKQK 178 Florida carpenter ant
OWR54578     271 iePPPS-HVDYSDDEEERRANRtrKEQ 296 Danaus plexippus plexippus
XP_003138190 260 geCPDD-MLAFSDDEAEQRYKAkhRsv 285 eye worm
EGT37828     287 aeIDSD--VEFSDDEAEKQYRKskQNA 311 Caenorhabditis brenneri
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