1D3Y,2ZBK


Conserved Protein Domain Family
TP6A_N
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pfam04406: TP6A_N (This model is not part of the current CDD release)
Type IIB DNA topoisomerase
Type II DNA topoisomerases are ubiquitous enzymes that catalyze the ATP-dependent transport of one DNA duplex through a second DNA segment via a transient double-strand break. Type II DNA topoisomerases are now subdivided into two sub-families, type IIA and IIB DNA topoisomerases. TP6A_N is present in type IIB topoisomerase and is thought to be involved in DNA binding owing to its sequence similarity to E. coli catabolite activator protein (CAP).
Links
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Statistics
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PSSM-Id: 516224
Aligned: 165 rows
Threshold Bit Score: 48.6196
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1D3Y_A          8 FAQTTKMLEFAKQLLETDDFSTLREAYYVSKNwgeaRFDDQQASNNVIEDLEAALGVLREHLG 70  Methanocaldococcus jannaschii
XP_015791709  171 RAQMLTLLCRVYLLLSSNRFATKRHLYYLDKG----AYGKQIVCDQLIEDLCCITNNTRKELH 229
EFA03167      314 FCRLVYMLGKVYNLLENNQKLTKREIYYQIKH----LVTNQEQVNRVVGDISQLVGVGPWDLN 372
XP_002429514   99 FATIMYLLSKIHKLLTTGQVSTRRELYYKNLK----NFKSQRDVDIAIKDISYILNAPPWELG 157
XP_001844767  254 FXLIIFLMSEIFKLLTLRTSCSKRELYYRDPQ----LTHSQRTVDKGLQDVCFLLEANLWELN 312
XP_002005902   66 FCLIVYLLAEIHQLHLTGGSCTIRGLYYRNTQ----VVRSQSYIDAAKMDVCRMLNTAPVNLG 124
14_pfamImport   3 FALIVHLLGKIYVLLSTNQICNKRELYYQDVE----FVGNQKRIDNAVDRISCLLNVPPWELG 61 
EFX89130       12 CLLLFHLLAKSHALLRTNTTSTKRDIYYEDVS----LWGSQPVLDSMVTQMTKLLNIPRCCLN 70 
XP_045093095   92 LDRDLHCLHQIYDLLENDKKSTKRELFYEHKL----IYEVQRNLDSSITSICELLNQSRAMLN 150
Q22236         92 LDRDLHCLHQVYDLLENDKRSTKRELYYEHKA----VYGNQKYLDSSIKSICELLNESRANLN 150 Caenorhabditis elegans
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