1D3Y


Conserved Protein Domain Family
TP6A_N

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pfam04406: TP6A_N 
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Type IIB DNA topoisomerase
Type II DNA topoisomerases are ubiquitous enzymes that catalyze the ATP-dependent transport of one DNA duplex through a second DNA segment via a transient double-strand break. Type II DNA topoisomerases are now subdivided into two sub-families, type IIA and IIB DNA topoisomerases. TP6A_N is present in type IIB topoisomerase and is thought to be involved in DNA binding owing to its sequence similarity to E. coli catabolite activator protein (CAP).
Statistics
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PSSM-Id: 398213
Aligned: 175 rows
Threshold Bit Score: 49.3882
Threshold Setting Gi: 75015344
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1D3Y_B                  6 KIFAQTTKMLEFAKQLLETDDFSTLREAYYVsk----------nwG--EARF-DDQQASNNVIEDLEAALGVLREHLGF 71   Methan...
Q0W5E7                 77 ASLAKLQFLINHVIETIVANSVSTKRDCYYMlknqfqk---------ypwmdlTGQGESDRLIDTLERIIRLNRENLNV 146  uncult...
WP_012310095           68 RTLSGVLYGMSRALDHLENGLTMTKRDFYYLhkve----------rlkGTLFpEDQRETDARIILMELILGMPREAFSI 136  Candid...
Q6MJB7                 73 QKLARVVFLLEMLLRNLETGTVNTKRELYYMckgeikgnprlkplD-----F-DDQPESDAIIDFIGDMLEVYREELNV 145  Bdello...
XP_015791709          169 KKRAQMLTLLCRVYLLLSSNRFATKRHLYYL--------------D--KGAY-GKQIVCDQLIEDLCCITNNTRKELHI 230  two-sp...
EMS67520              434 NVATRTAWAIPKLRESLHSGREMSQRTLLYL--------------N--KRLY-LDQAKSDGIINDLCCMTGCRRKSLNV 495  Tritic...
CBK41794               72 KKFMQTMLVADALAELQQADLTTSLREIYYRtkhti--------qdshENTF-DTQDESDPIIEDLEVSLIALREELHV 141  Nitros...
goetting:Ngar_c29790   72 PTFTQYLVMANAVRKLLDEEMESTIRGMYYAtlst-------vgdEknKQKFwTGQEDSDDAIKAIELLTGVPREEFSV 143  Candid...
CAP26347               90 KKLDRDLHCLHQIYDLLENDKKSTKRELFYE--------------H--KLIY-EVQRNLDSSITSICELLNQSRAMLNV 151  Caenor...
Q22236                 90 GKLDRDLHCLHQVYDLLENDKRSTKRELYYE--------------H--KAVY-GNQKYLDSSIKSICELLNESRANLNI 151  Caenor...
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