Conserved Protein Domain Family
PTPLA
?
pfam04387: PTPLA (This model is not part of the current CDD release)
Protein tyrosine phosphatase-like protein, PTPLA
This family includes the mammalian protein tyrosine phosphatase-like protein, PTPLA. A significant variation of PTPLA from other protein tyrosine phosphatases is the presence of proline instead of catalytic arginine at the active site. It is thought that PTPLA proteins have a role in the development, differentiation, and maintenance of a number of tissue types.
Links
?
Statistics
?
PSSM-Id: 516212
Aligned: 206 rows
Threshold Bit Score: 121.484
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
CCA76030      220 QSLALLEVVHSALGLVKSPVQTTAMQVASRLAVVWWFVEGQPTARITPFYTTMLIAWSLSEMIRTTYYTASLFNvvpprp 299
XP_015791406   55 QTLQFIEVLHVLIGLTGGSPLISFVQIGGRNLILHILINDIAAVQSKWFVPWLILAWSSIECFRYPFYISSLLN------ 128
KAF8359782     49 TLLQIIDVVHCLIGLTKGNIPASLVQIWGRLTMLW-IIHNCPDTRDTTPAALILIVYALVEPCRYPYYGFNALG------ 121
XP_020303246  218 TGLQLIDVAHALVGLTKGNYRVGLLQVCGRLAFIY-VIDGYPDIQSSWTTYVLIIAYFSIEIFRYPYYAASSLK------ 290
12_pfamImport   1 VILSYMEAIHPILGLVKSSPMQPFVQVTGRCIALYAAWLTTGEAEG-CAVNNLFIAWSLAEVIRYPTYICQLVG------ 73 
CBJ26346       72 QLVSTLELVHAFVGLVKSNPMNVFMQVFGRDLALFSVVTAFPPVRDSPWVLLMFTAWATSEVIRYPFYALNIAG------ 145
Q54Y54         31 QVLAFLEILHVLLGFTKSSLIPTMSQVFGRNHVLLLALAFTPEVQRHWGVWTMFFIWGLSELIRFPYYLYG-SN------ 103 Dictyostelium ...
XP_003291303   29 QILAFLEIFNVLLGITKSSVGPTLAQVLGRNHVLLVALIFVPEVYTHWGVALMFFIWGLSELIRYPLYLYTINN------ 102
XP_020428318   41 QVFAFLEIAHVYFGIVKSSLLPTVVQVLFRNQVLLGCLLYVPEAQVHWGVTLLFFFWGVSELIRFPFYIAQAYG------ 114
XP_002121888  202 VILSYVEAVHPLLGLVKSSWIQPFIQVSGRCFALLCLWLAEPTAKDGCSVSNLFIAWSLAEVIRYPTYTAQILG------ 275 vase tunicate

CCA76030      300 ttNPYvakavDILTNIRYSAFYVLYPLGSGSEYMCMLKGFPSFPskaaaltskegwkaiisrnppawrvlfervklwiyn 379
XP_015791406  129 --YKI-----KLITFLRYTAWYPIYPAGIILEALTIKSSLESLEasgkysvsl--------------------pnsanfs 181
KAF8359782    122 --VEI-----YPLMWLRYSAFLPLYPAGLSLEAINMTLAIPYYYrtyqtt-------------------------lfgip 169
XP_020303246  291 --IEI-----SLLTWLRYNMWILLYPVGLLLEGLTLYRSIPYYHrtekysikl--------------------pnvanig 343
12_pfamImport  74 --VEF-----KLLTWLRYHSWILLYPFGGYCEYVVITSAARYLDdtnshqlsl--------------------pnhfnwa 126
CBJ26346      146 --MCP-----PVLQWLRYSAFVLLYPLGFAGELGTWIVGLPHIKavglpgvp------------------------glpe 194
Q54Y54        104 ---SP-----KFLTWLRYNAFIILYPLGFLSENILWYNMLPIILerrihfidm--------------------pnkfnfg 155 Dictyostelium ...
XP_003291303  103 --STPp----QFLQFLRYNAFIILYPIGFAAENVLWYNMLPYIKereihsvrl--------------------pnsinfg 156
XP_020428318  115 --DCP-----PILTWLRYNAFIILYPIGFAAENILYYVMMPYILvrrvhfwdm--------------------pnylnfs 167
XP_002121888  276 --IEF-----KALSWLRYHAWIILYPFGGYSEFEVISAAANYLDekniykltl--------------------pnmfnfs 328 vase tunicate

CCA76030      380 wDAAAWTRVpFVFIWPAGLYILMSYMHVQRRKALGR 415
XP_015791406  182 fHLPTLLQLyLKLLIWPTSFLLLSHMYKQSKNAL-K 216
KAF8359782    170 vNAGVVMGGfLILVFPFIARFLLFHMLKQRKSKLGC 205
XP_020303246  344 fNFSFVLGIfFLFVFPFVAVHLLRHMWLQRRKKYED 379
12_pfamImport 127 fKLSTVLRCyVLVLVS-GVLVLMRHMWKMRQRKFGN 161
CBJ26346      195 gssiYVLYAyIVFAFAIGAPKLYMHMLRQRKKQLQG 230
Q54Y54        156 fNYYYFLLV-WITLTLMVFPQQYMHMFKLRAKKM-N 189 Dictyostelium discoideum AX4
XP_003291303  157 fDYYYFVIF-WICTTLLVFPFQYMFMFKLRSLKNKK 191
XP_020428318  168 fNYYYFLLI-WIGISLLGFPKQYLYMFTLRKKKMLE 202
XP_002121888  329 fKLSSFMRLyTAVLVI-GVLVLMRHMWKMRQRKFGK 363 vase tunicate
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap