pfam04377: ATE_C (This model is not part of the current CDD release)
Arginine-tRNA-protein transferase, C terminus
This family represents the C terminal region of the enzyme arginine-tRNA-protein transferase (EC 2.3.2.8), which catalyzes the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway of protein degradation by conjugating a destabilising amino acid to the amino terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis. N terminal cysteine is sometimes modified.
Jiyao W et al.(2023). "The conserved domain database in 2023.",