Conserved Protein Domain Family
ATE_N

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pfam04376: ATE_N 
Arginine-tRNA-protein transferase, N-terminus
This family represents the N terminal region of the enzyme arginine-tRNA-protein transferase (EC 2.3.2.8), which catalyzes the post-translational conjugation of arginine to the N-terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway of protein degradation by conjugating a de-stabilizing amino acid to the amino terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis. N terminal cysteine is sometimes modified. In S cerevisiae, Cys20, 23, 94 and/or 95 are thought to be important for activity. Of these, only Cys 94 appears to be completely conserved in this family.
Statistics
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PSSM-Id: 398189
Aligned: 275 rows
Threshold Bit Score: 69.499
Threshold Setting Gi: 557035375
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFO90701      15 SSCGYC-KDVRGQDaasssekgsfsvqnskfhvltvgeeaegdessgeeqpegriqssvtggvwahrmLVDDYAGLLDKG 93  Caenorhabditis ...
A0EF10        40 SSCLYE-CGKYQYIyylkp---------------------------------------------innfSIETMELLLERG 73  Paramecium tetr...
XP_001032957  95 TACKYC-GLYDSKYhcgfe---------------------------------------------anllLPDIYMELSNKG 128 Tetrahymena the...
XP_006688056  16 EECGYC-NGQKQDYyaneymkmlggps-----------------------------qsvgihmavgsmNSSQYMRLIDQG 65  Yamadazyma tenu...
EMG50029      12 SHCGYCdDSEKDDFyalesqlhshpfe-----------------------------kksviigsvaqfTCQEYDELMNIG 62  Candida maltosa...
XP_002546783  50 RHCGYCgDSKQEDHyaldsqvnshshk-----------------------------esvimgtsilqmSCQEYDELINMG 100 Candida tropica...
CCE43712      12 RHCGYC-NDTKQDYyalesqakaastgtqqr---------------------grdkqsimvgstitsmTCQNYDELINQG 69  Candida parapsi...
EDK43009      12 RHCGYC-SDSKRDYfalesqaraalserdhed-------------------tvetkqamtigcttiemTCQEYDELINKG 71  Lodderomyces el...
Q01EZ2        19 STCGYC-ASTTNTSvadga--------------------------------------------iahrlTTAVYNDLIEDG 53  Ostreococcus tauri
EEH60404      33 STCGYC-SSVAKTSrshgv--------------------------------------------sahvlSVGDYQSLIDHG 67  Micromonas pusi...
EFO90701      94 WRRSGKYLYKPNNkVTCCPQYTIRLDVTRFKMSRSQKR 131 Caenorhabditis remanei
A0EF10        74 FVRNAKYYRKYNHnQSCCVGYNTRVNIQENQPKKKQKa 111 Paramecium tetraurelia
XP_001032957 129 FFRSGKYFWKQNPyLSCCKEYAIRMNVLQFQISHHQKK 166 Tetrahymena thermophila SB210
XP_006688056  66 WRRSGTLVYKQDNlRNCCRYYTIRQGKDGFKITKKFRK 103 Yamadazyma tenuis ATCC 10573
EMG50029      63 YRRSGDFIYKSDLlKTCCRLYTIRTCLSMCKLTKEHRK 100 Candida maltosa Xu316
XP_002546783 101 FRRSGSFTYKPDLlKTCCRQYTIRTNLSMCKLTKEHRK 138 Candida tropicalis MYA-3404
CCE43712      70 FRRSGTFLYKSDLlRTCCRLYTIRTNMSYFKPTKKQRK 107 Candida parapsilosis
EDK43009      72 FRRSGTFLYKNDLlRSCCRLYTIRTNSSMFKINKKQRK 109 Lodderomyces elongisporus NRRL YB-4239
Q01EZ2        54 WRRSGRYVYKPVIgTTCCATHVIRLRCVEFTLSKSQRK 91  Ostreococcus tauri
EEH60404      68 WRRSGGWLYRPELkETCCRAYTIRLETEKFAPTRGQKR 105 Micromonas pusilla CCMP1545
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