2CMU,6B10,2EWO,1XKN,1ZBR


Conserved Protein Domain Family
PAD_porph

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pfam04371: PAD_porph 
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Porphyromonas-type peptidyl-arginine deiminase
Peptidyl-arginine deiminase (PAD) enzymes catalyze the deimination of the guanidino group from carboxy-terminal arginine residues of various peptides to produce ammonia. PAD from Porphyromonas gingivalis (PPAD) appears to be evolutionarily unrelated to mammalian PAD (pfam03068), which is a metalloenzyme. PPAD is thought to belong to the same superfamily as aminotransferase and arginine deiminase, and to form an alpha/beta propeller structure. This family has previously been named PPADH (Porphyromonas peptidyl-arginine deiminase homologs). The predicted catalytic residues in PPAD are Asp130, Asp187, His236, Asp238 and Cys351. These are absolutely conserved with the exception of Asp187 which is absent in two family members. PPAD is also able to catalyze the deimination of free L-arginine, but has primarily peptidyl-arginine specificity. It may have a FMN cofactor.
Statistics
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PSSM-Id: 398187
Aligned: 399 rows
Threshold Bit Score: 162.982
Threshold Setting Gi: 156212771
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2CMU_A                     6 XLAEFEKIQAILXAFPH-Efsd-waYC-IKEARESFLNIIQTIAKH----------AKVLVCVhtNDTi------gYEXL 66  Hel...
Q5QX70                     7 WLPDFMENQRLLLAWPYrSdv---wRKhADPARDALIKLIKQLPDN----------TPVSLVVpaSI---------SDSV 64  Idi...
bowmanTIA:P700755_002975   1 MPAEWEPQDAVWLGWESdS---------RYGFYPVVIEMIKTLTPN----------VTVKMAFdsDSL--------MHTA 53  Psy...
goetting:Curi_c05030      64 FPAEFEKQQAIWMQWPPeVydq----deAHPVSPIIINIMKAFESY----------IKVNVMVrdNDD--------INKI 121 Got...
jgi:Dtox_2812             47 FPGEFEKQQAIWMQWPSeIyn-----tgNRPVYPVIINMVKALDPY----------IRVKLISqsEEE--------IEQI 103 Des...
WP_013842075              37 FPAEFNKQQAVWLQWPSeIyn------tdRPVYPVILNIIKSLDPY----------IRINLMVrsQEE--------TNQI 92  Des...
Q31KC8                    67 MPAEFEPITSIWMAYPTyE------NQaGYPSQTVQKAMVKAIAPT----------VKIDFLLnePEE--------KVII 122 Syn...
WP_014435539               9 MPGEFEPQRRVWVSRPDnPdtwpgpAA-LERAQAQHAAWVDAMREV----------VEVAVV------------------ 59  Phy...
EDO33816                   1 ---manaKQTIVISLPGkKdn-------------yyVDDIKDIADFvfemdkqtygHDNLIVI--HDKsgrnllkqHEFV 62  sta...
jgi:Hoch_6757             26 lPGEFEPVERLLVAW-------------DDNLAPFLLDLIAVAVDE----------VPITVLVapGQP--------DDEI 74  Hal...
2CMU_A                    67 KNlp--------gVEIA-KVDTNDTWARDFGAISIEn--HGVLeCLDFGFNGWG-----------LKYps---------- 114 Hel...
Q5QX70                    65 PEal-------ksVQRI-ELDYDDIWLRDTTPLWQLnsdGQLA-ALSFDFDGWGgvqn---------------------- 113 Idi...
bowmanTIA:P700755_002975  54 KRylirqkidttnIKFY-VMPGDRYWIRDHGAAFLVngkGDLG-VADFDWNLFG-------------Ypvflkekfnnnq 118 Psy...
goetting:Curi_c05030     122 ESmlknsgysgtnIHFH-EISHSSIWTRDVGPIFIKdseNKLN-VVDFGFNNYSrggsedyirieSQI------------ 187 Got...
jgi:Dtox_2812            104 RAifnkhgylgtnVDYY-IINHRSIWTRDVGPIFVKdrySGMS-VVNFNFNNYSrggnhhyinveGQV------------ 169 Des...
WP_013842075              93 KDllknsgytvnnVHYY-VVNHMSIWTRDVGPIFVKspqNKLQ-VVDFGFNNYSrsgnpdyiaaeSQV------------ 158 Des...
Q31KC8                   123 NGwlktagipasqVRYH-LVPHEDLWIRDMGPIFAVn-aDQTQ-VVDFGFNAWSylaa---tdpaAMT------------ 184 Syn...
WP_014435539              60 -------------QDLVaEARPEDAWIRDWGPVFVVddrGGLG-AHDFRFNSWG-----------GKYppw--------- 105 Phy...
EDO33816                  63 NAq---------mIEID--EPGLDLWMRDFPPCMPK------Q-QVKFSYKPQY-----------IKAsra--------- 104 sta...
jgi:Hoch_6757             75 SFglrslgidpraVQRV-HAPVGSVWVRDFGPLVVRtreGGAE-IVDFAYHL-------------DDY------------ 127 Hal...
2CMU_A                   115 ------------------nlDNQVNFKLkslgflk--hplktxpYVLEGGSIESDGAGSILTN--------TQCLLEknR 166 Hel...
Q5QX70                   114 ----------------viaaDKAFSQSLcsrlmc----pvtnslLIAEGGAFTHNGQGDWLIG--------LACIk--qR 163 Idi...
bowmanTIA:P700755_002975 119 dsvnkymqerlpsiirtskvDSLMAKVEgaki--------fktnVVHEGGNIEVNGKGTLIVC--------ESAVRH--R 180 Psy...
goetting:Curi_c05030     188 --------------------DKSVAELYklpv--------vdtkLISEGGAIESNGQGTLMTT--------ESVVLK--R 229 Got...
jgi:Dtox_2812            170 --------------------DKLTAQALklpl--------intnLISEGGAIESNGKGTLMIT--------ESVALT--R 211 Des...
WP_013842075             159 --------------------DRLAAKLLnlpv--------iktdLISEGGAIESNGRGTMMVT--------ESVALS--R 200 Des...
Q31KC8                   185 --------------------DEQVDRKVagdldl----pilrssLISEGGNREFNGKGTLMLT--------EAVELQ--R 230 Syn...
WP_014435539             106 -----------------armDAGAARVLdfvekqhpglrrwrhgLFLEGGAFSVNGRGSVLTT--------AACLLDaeR 160 Phy...
EDO33816                 105 ------------------thDASRFDKFavmvglp---qweksdLVLEGGNIVENGEDIAIVT--------ERIFd---D 152 sta...
jgi:Hoch_6757            128 --------------------EDTLPGVLgrklwpq--wqlrrssLFLEGGNVLSDGQGRCVSTagfsdeplAELLIDd-- 183 Hal...
2CMU_A                   167 NPHLN---QNGIETXLKKELGAKQVLWYSYGyLKGDD----------------TDS---------------HTDTLARFL 212 Hel...
Q5QX70                   164 NPAMT---EPQIKSLLGQLLPGQRLHFF-DGgLVADE----------------TGG---------------HIDNMALFV 208 Idi...
bowmanTIA:P700755_002975 181 NPNLT---NDYIESEFKRVLGVSKVIWLKRG-LADDP-----------------NGffrritgdyvgggvqHSDEFVRFS 239 Psy...
goetting:Curi_c05030     230 NPEMT---KQQIEDEYKRVLGVKKIIWLKKG-LAEDDh--------------iTSG---------------HINEIARFT 276 Got...
jgi:Dtox_2812            212 NPKLS---KKQIENEYKRVLGVKKIIWLKKG-LAEDDq--------------iTNG---------------HIDEIARFS 258 Des...
WP_013842075             201 NPKMS---KAEIEKEYKRVLGVKKVIWLKKG-LAEDDp--------------iTTG---------------HIDEIARFA 247 Des...
Q31KC8                   231 NPGLT---KEKIETELKRVFNLKKVIWLQEG-VIDDElsyrgklpdgsltvlaTGG---------------HIDEYARFV 291 Syn...
WP_014435539             161 NPGET---RASVERLFAECFGAPGVVWLGEG-IRGDD----------------TDG---------------HVDDCAQFV 205 Phy...
EDO33816                 153 NKKFS---EKEVIRRVEQTI-KRKVVVV----PDPED----------------TTG---------------HADGIVSFL 193 sta...
jgi:Hoch_6757            184 ePPFSegdEVWVRDELRELLGCEHLVVV-PP-LVGEP-----------------TG---------------HVDMFTVVT 229 Hal...
2CMU_A                   213 DKDTIVYSA-------CED-K--NDEHYTALKKXQEELKTFKKLDKTPY--KLIPLEIP--------------------- 259 Hel...
Q5QX70                   209 DANTVLYAA-------TDN-T--AHPDYKTCQALKKQLDKL------PAyiQTIPLPLP--------------------- 251 Idi...
bowmanTIA:P700755_002975 240 NANTILLAWvdesekdLNP-I--NKMNYERLNESFEILKNATDQDGKPF--TIIKVPLPdlkprkiiatkeyskepsldi 314 Psy...
goetting:Curi_c05030     277 DQNTILLAQilpedryVNE-A--SSESYLRLEENYNILKNATDQDGKSF--NIIRVPMPstiyqr--------------- 336 Got...
jgi:Dtox_2812            259 SPNTILLAQvlpedryINS-I--SQKSYLRLEDNYRILLNSTDQDGMKF--RIVRIPMPttlyge--------------- 318 Des...
WP_013842075             248 NPNAILLAQvlpgdryTNA-I--TQESYRRMEENYEILRNATDQDGKPF--HIIRIPMPptiygk--------------- 307 Des...
Q31KC8                   292 DSNTILLAEvtaeeraSDP-L--AAINYQRLEENLKILQAATDQDGKPF--RIVRIPAAkpiyvnmtkedavfqalqelt 366 Syn...
WP_014435539             206 SEDAVLALE-----------ApaGHRDHDALSENLETLRAHG-----GF--DVHTLPSV--------------------- 246 Phy...
EDO33816                 194 DKNTLLITM-------LDDkG--GKDFYE------DIKKEVTDSYPH-L--KIIPLPSyskktk---------------- 239 sta...
jgi:Hoch_6757            230 GPAQAIVGR-------YASaI--DPVNARRLDLTAARLRDA------GF--RVRRIPMPdnrd----------------- 275 Hal...
2CMU_A                   260 --KAIfde-----------------nqqRLPATYVNFL-LC-NDALIVPTYNd--------PKDAL-ILETLKQHTPL-E 308 Hel...
Q5QX70                   252 --PPQlpareeragveltssslkrtvelPLLCSYVNVLqTS-K-LVVVPQFGl--------TTDAQ-AVRTVREALPErK 318 Idi...
bowmanTIA:P700755_002975 315 paNRFyiseapk---------vgdtllrVPASSYLNYL-VT-NGVVLISSYVdeg---sskEKENR-VRNIFEKQFPNrK 379 Psy...
goetting:Curi_c05030     337 ----------------------pnsegkIPIRSYLNYA-VT-NGSVVMQTYWkpglsselkQTEDR-VKEILRDVFPGrD 391 Got...
jgi:Dtox_2812            319 ----------------------adnqgkIPVRSYLNYV-VT-NGAILMQTYWipgrsnklkNLEKE-VRTIFKKEFPGrT 373 Des...
WP_013842075             308 ----------------------vdetgkIPVLSYLNYA-VT-NGAVLMQTYWqsgrsemlkTTENQ-VKDTLQKVFPGrR 362 Des...
Q31KC8                   367 feDGTviqdd-------------dqiktILAASYLNFV-IA-NDVVIVPRYWqpdrnleyqQKDQA-ALAAFQSVFPNkK 430 Syn...
WP_014435539             247 --DPGffydaatgr-----lgqdpaageLVPASHANFL-IS-NGSLFLPVFGc--------ASDDA-ALAAADRAAPElR 308 Phy...
EDO33816                 240 -----------------------khgfnTAEGSYANSL-VTyN-AVYVPCYGn-------hKKDEM-ALGVIQSCTSKa- 285 sta...
jgi:Hoch_6757            276 ----------------------------glfrSYTNAL-AL-NGSVLVPVYPe-------aADDERaALKVFEQAYPGrR 318 Hal...
2CMU_A                   309 VIGVD-CNTLIKQHGSLHCVTXQL 331 Helicobacter pylori 26695
Q5QX70                   319 VIAID-AREFVLGGGGLHCISHNL 341 Idiomarina loihiensis
bowmanTIA:P700755_002975 380 IVFIN-AMPQNWDGGGIHCSTQQQ 402 Psychroflexus torquis ATCC 700755
goetting:Curi_c05030     392 IIGID-SDDLNLWGGGIHCITQHM 414 Gottschalkia acidurici 9a
jgi:Dtox_2812            374 VIGIN-AENVNLWGGGMHCITQHM 396 Desulfofarcimen acetoxidans DSM 771
WP_013842075             363 IIGIN-VENVNRWGGGIHCITQHM 385 Desulfotomaculum ruminis
Q31KC8                   431 IVAIN-PENINAGGGGMHCIVQQQ 453 Synechococcus elongatus PCC 7942
WP_014435539             309 IVPVR-AEWLVVGLGALHCLSQQE 331 Phycisphaera mikurensis
EDO33816                 286 VIPIRvRGRVPELGGSVRCMTWQI 309 starlet sea anemone
jgi:Hoch_6757            319 VVPVV-SSAIIELYGAVHCATMTI 341 Haliangium ochraceum DSM 14365
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