6NIB,1XKN,2EWO,1ZBR,3HVM,6B10


Conserved Protein Domain Family
PAD_porph

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pfam04371: PAD_porph (This model is not part of the current CDD release)
Porphyromonas-type peptidyl-arginine deiminase
Peptidyl-arginine deiminase (PAD) enzymes catalyze the deimination of the guanidino group from carboxy-terminal arginine residues of various peptides to produce ammonia. PAD from Porphyromonas gingivalis (PPAD) appears to be evolutionarily unrelated to mammalian PAD (pfam03068), which is a metalloenzyme. PPAD is thought to belong to the same superfamily as aminotransferase and arginine deiminase, and to form an alpha/beta propeller structure. This family has previously been named PPADH (Porphyromonas peptidyl-arginine deiminase homologues). The predicted catalytic residues in PPAD are Asp130, Asp187, His236, Asp238 and Cys351. These are absolutely conserved with the exception of Asp187 which is absent in two family members. PPAD is also able to catalyze the deimination of free L-arginine, but has primarily peptidyl-arginine specificity. It may have a FMN cofactor.
Statistics
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PSSM-Id: 516202
Aligned: 318 rows
Threshold Bit Score: 174.189
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6NIB_A                8 MPAEWEPHSQCWIGWPErA----DNWR--DG-AVHAQLVFTRVAAAISRFEKVTVCA--SSaqWENARNQLpd------h 72  barrel m...
BAM02319              9 MPGEFEPQRRVWVSRPDnP----DTWPgpAA-LERAQAQHAAWVDAMREVVEVAVV------------------------ 59 
Q5QX70                7 WLPDFMENQRLLLAWPYrS----DVW---RKhADPARDALIKLIKQLPDNTPVSLVVpaSI--SDSVPEALk-------s 70  Idiomari...
jgi:HIMB59_00000130   3 LIPEWYNHDRCLIAWPCnL-------ElyKSqIHSARKEIANLANQIAEEEPVYIYCnsQD--LKDCRLTVsn-----qe 68 
Q5NHL8                4 WPAEWEEHSATWMIWPArId---M-WP--N--ITKAYEIYAKVANTIAKYEPVNMVV--NQhqLDIAKKYLgk------n 67  Francise...
WP_014966715         64 FPAEFEKQQAIWMQWPPeVydqdE--------AHPVSPIIINIMKAFESYIKVNVMVrdNDd-INKIESMLknsgysgtn 134 Gottscha...
WP_015758270         47 FPGEFEKQQAIWMQWPSeIyn---------tgNRPVYPVIINMVKALDPYIRVKLISqsEEe-IEQIRAIFnkhgylgtn 116 Desulfof...
WP_013842075         37 FPAEFNKQQAVWLQWPSeIyn----------tdRPVYPVILNIIKSLDPYIRINLMVrsQEe-TNQIKDLLknsgytvnn 105 Desulfor...
jgi:Hoch_6757        26 lPGEFEPVERLLVAW-----------------DDNLAPFLLDLIAVAVDEVPITVLVapGQp-DDEISFGLrslgidpra 87 
WP_014982522         93 LPAEWEPVERVLVAWPYlFp---GLW-----------PFHRNLVRAIAATTPVTVIVptPLf-AAAVALQLpg-----qp 152 Nocardia...
6NIB_A               73 VRVV-EISSNDSWFRDIGPTFVVrretsksddaehRIAGIDWT-------FNSWG-----------GLedgcYcDWSL-D 132 barrel m...
BAM02319             60 QDLVaEARPEDAWIRDWGPVFVVdd--------rgGLGAHDFR-------FNSWG-----------GK----YpPWARmD 109
Q5QX70               71 VQRI-ELDYDDIWLRDTTPLWQLns--------dgQLAALSFD-------FDGWGgvqn----------------viaaD 118 Idiomari...
jgi:HIMB59_00000130  69 ISII-EVDLDDSWMRDIAPIFYKed---------kELRSMNFN-------FNGYG------------K----YpNFKN-D 114
Q5NHL8               68 MTLI-SEAVDDSWARDIMPIFSFkad---------klIANNFD-------FNCWG-----------NK----FsPFDN-D 114 Francise...
WP_014966715        135 IHFH-EISHSSIWTRDVGPIFIKds--------enKLNVVDFG-------FNNYSrggsedyirieSQ----I------D 188 Gottscha...
WP_015758270        117 VDYY-IINHRSIWTRDVGPIFVKdr--------ysGMSVVNFN-------FNNYSrggnhhyinveGQ----V------D 170 Desulfof...
WP_013842075        106 VHYY-VVNHMSIWTRDVGPIFVKsp--------qnKLQVVDFG-------FNNYSrsgnpdyiaaeSQ----V------D 159 Desulfor...
jgi:Hoch_6757        88 VQRV-HAPVGSVWVRDFGPLVVRtr--------egGAEIVDFA-------YHL-------------DD----Y------E 128
WP_014982522        153 VDYA-VARLDDIWIRDYGPLVGVdd--------agRRVAVDTRyrpppaiFTGY-------------------------D 198 Nocardia...
6NIB_A              133 SLVKKKILDveRIprf----shsMVLEGGSIHVDGEGTCITT--------EECLLNKN---RNPHLS---KSQIEDELKA 194 barrel m...
BAM02319            110 AGAARVLdfvekqhpglrrwrhgLFLEGGAFSVNGRGSVLTT--------AACLLDAE---RNPGET---RASVERLFAE 175
Q5QX70              119 KAFSQSLcsrlmc----pvtnslLIAEGGAFTHNGQGDWLIG--------LACI--KQ---RNPAMT---EPQIKSLLGQ 178 Idiomari...
jgi:HIMB59_00000130 115 NLVSDFIcdqfki----pftkssITLEGGGITYDDQGNLFTT--------ESVLLNSN---RN-NLS---KQLLEKELKK 175
Q5NHL8              115 RRLKNDIAKqqKWqvn----sskMILEGGAVHSNGQGVLLTT--------KECLLNLN---RNPNMQ---KEQIESELIS 176 Francise...
WP_014966715        189 KSVAELYklpv--------vdtkLISEGGAIESNGQGTLMTT--------ESVVLK-----RNPEMT---KQQIEDEYKR 244 Gottscha...
WP_015758270        171 KLTAQALklpl--------intnLISEGGAIESNGKGTLMIT--------ESVALT-----RNPKLS---KKQIENEYKR 226 Desulfof...
WP_013842075        160 RLAAKLLnlpv--------iktdLISEGGAIESNGRGTMMVT--------ESVALS-----RNPKMS---KAEIEKEYKR 215 Desulfor...
jgi:Hoch_6757       129 DTLPGVLgrklwpq--wqlrrssLFLEGGNVLSDGQGRCVSTagfsdeplAELLIDDE-----PPFSegdEVWVRDELRE 201
WP_014982522        199 DSFPGRWagankl----gwrhlpLRLDGGNLWSDGRGTILTT----------SLLFRRnrfRG-------RARVHELLSE 257 Nocardia...
6NIB_A              195 YLGVRKVIWLpRG-LYGdDD--TNGHVDNMCCFVRPGAVLLSWtd-------dK--TDPQYERSEEAY-SLFSSVTDANG 261 barrel m...
BAM02319            176 CFGAPGVVWLgEG-IRG-DD--TDGHVDDCAQFVSEDAVLALE----------ApaGHRDHDALSENL-ETLRAHG---- 236
Q5QX70              179 LLPGQRLHFF-DGgLVA-DE--TGGHIDNMALFVDANTVLYAAtd-------nT--AHPDYKTCQALK-KQLDKL----- 239 Idiomari...
jgi:HIMB59_00000130 176 HFSLKNIIWFkEG-LFG-DD--TDGHIDNIFCPIGNDRYLIASte-------dK--TSKNYFILRQAK-ELVEEHFSSIN 241
Q5NHL8              177 ILGVKKILWLpYG-VAG-DFd-TDGRVDNVACFANKNTIIIQScy-------dE--NDENFARHQANM-TYLDKYAS--- 240 Francise...
WP_014966715        245 VLGVKKIIWLkKG-LAE-DDhiTSGHINEIARFTDQNTILLAQilpedryvneA--SSESYLRLEENY-NILKNATDQDG 319 Gottscha...
WP_015758270        227 VLGVKKIIWLkKG-LAE-DDqiTNGHIDEIARFSSPNTILLAQvlpedryinsI--SQKSYLRLEDNY-RILLNSTDQDG 301 Desulfof...
WP_013842075        216 VLGVKKVIWLkKG-LAE-DDpiTTGHIDEIARFANPNAILLAQvlpgdrytnaI--TQESYRRMEENY-EILRNATDQDG 290 Desulfor...
jgi:Hoch_6757       202 LLGCEHLVVV-PP-LVG-EP---TGHVDMFTVVTGPAQAIVGRya------saI--DPVNARRLDLTA-ARLRDA----- 261
WP_014982522        258 SFAVRNIIEL-PP-LAG-EF---TGHVDLIAKPADGETVLATE----------P--GRGVNRARRQRIiEILRRA----- 314 Nocardia...
6NIB_A              262 RKF--EVIKLHVPGPlymtekeaagvfqddgakPRlp------------------gtRLAA----------SYVNFY-IA 310 barrel m...
BAM02319            237 -GF--DVHTLPSVDP------------------GFfydaatgrl-----gqdpaageLVPA----------SHANFL-IS 279
Q5QX70              240 -PAyiQTIPLPLPPP------------------QLpareeragveltssslkrtvelPLLC----------SYVNVLqTS 290 Idiomari...
jgi:HIMB59_00000130 242 PNI--EIIEIPLPsetq------------------------------------idnkPLVA----------SYINFY-FC 272
Q5NHL8              241 -EF--NIVEIPQPRA------------------QYfa------------------geRLAL----------SYLNFY-IV 270 Francise...
WP_014966715        320 KSF--NIIRVPMPstiyqr--------------------------------pnsegkIPIR----------SYLNYA-VT 354 Gottscha...
WP_015758270        302 MKF--RIVRIPMPttlyge--------------------------------adnqgkIPVR----------SYLNYV-VT 336 Desulfof...
WP_013842075        291 KPF--HIIRIPMPptiygk--------------------------------vdetgkIPVL----------SYLNYA-VT 325 Desulfor...
jgi:Hoch_6757       262 -GF--RVRRIPMPdnrd--------------------------------------------------glfrSYTNAL-AL 287
WP_014982522        315 -GY--RVVELP----------------------------------------------YLPAylnwqvpvwrSYTNAL-TS 344 Nocardia...
6NIB_A              311 -NGAIIAPQFGDk-------KWDDE-AIRVLSKTFPHHEVVGIEgSREIVLSGGNIHCITQQQ 364 barrel medic
BAM02319            280 -NGSLFLPVFGC--------ASDDA-ALAAADRAAPELRIVPVR-AEWLVVGLGALHCLSQQE 331
Q5QX70              291 -K-LVVVPQFGL--------TTDAQ-AVRTVREALPERKVIAID-AREFVLGGGGLHCISHNL 341 Idiomarina loihiensis
jgi:HIMB59_00000130 273 kN-SLLIPKFNV--------EEDLQ-VYDIFQSLFPSKKIKMIE-TSNINYGGGNIHCVTMNM 324
Q5NHL8              271 -NNAIIMPAFGDp--------NDVI-AFEILQKCFKDRSIEQLN-IIDLVIGGGGIHCITMQQ 322 Francisella tularensis su...
WP_014966715        355 -NGSVVMQTYWKpglsselkQTEDR-VKEILRDVFPGRDIIGID-SDDLNLWGGGIHCITQHM 414 Gottschalkia acidurici
WP_015758270        337 -NGAILMQTYWIpgrsnklkNLEKE-VRTIFKKEFPGRTVIGIN-AENVNLWGGGMHCITQHM 396 Desulfofarcimen acetoxidans
WP_013842075        326 -NGAVLMQTYWQsgrsemlkTTENQ-VKDTLQKVFPGRRIIGIN-VENVNRWGGGIHCITQHM 385 Desulforamulus ruminis
jgi:Hoch_6757       288 -NGSVLVPVYPEa-------ADDERaALKVFEQAYPGRRVVPVV-SSAIIELYGAVHCATMTI 341
WP_014982522        345 -NGTVFLPLFDVa-------EADRA-AVRAYQRAMPDHDIVGVP-ARVPAGSGGTIHCLTLQI 397 Nocardia brasiliensis
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