Conserved Protein Domain Family
Ysc84

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pfam04366: Ysc84 
Las17-binding protein actin regulator
Ysc84 is a family of Las17-binding proteins found in metazoa. Together, Las17 and Ysc84 are essential for proper polymerization of actin; Ysc84 is able to bind to and stabilize the actin dimer presented by Las17 and thereby promote polymerization. An active actin cytoskeleton is necessary for adequate endocytosis. (pfam00018), or a FYVE zinc finger (pfam01363).
Statistics
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PSSM-Id: 398184
Aligned: 270 rows
Threshold Bit Score: 53.2834
Threshold Setting Gi: 503279441
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003663743   238 TSIGAGFVAGVDIYDCVLVINTREALDM-FI-K--IRVSLGSDLAVTAGP-FG-------AGGALDWGlpaggdrqrgke 305 Thermothelomy...
WP_012462496   112 SGWDLGLEVGIKAVDLLLLFNAQETIDL-LVkGkrCNIGV----GQSAQPgLVeltedqvSSPTAS-------------- 172 Methylacidiph...
MA:Minf_0478   123 SGMGFGLQVGGETTHYVLILNTKQAVDN-FArG--GKLKLKGEMEGVAGP-TTeterk---------------------- 176 Methylacidiph...
WP_015257208   103 GAVSLGLQFGGEVAEVVMVAKTQRAVDSlFAsA----FRLGGDASVAAGP-VG-------AGRRVTVTa----------- 159 Thioalkalivib...
jgi:TK90_2385  106 GSISFGMQFGGDAAEVVMVARTQDAVDSmFGsA----IRLGADASVAAGP-VG-------AGRGSTPTa----------- 162 Thioalkalivib...
WP_015404770   104 GAVSFGLQIGGEASEIVLMVMTDKGMDS-MLsT---SFKLGADVTVAAGP-LG-------QGAKAA-Ta----------- 159 Desulfocapsa ...
Q60B44          99 GAVTAGLQIGGELTDVIMMVMTESGMNA-LLsS---KFQLGADASIAAGP-VG-------TGSQVA-Tv----------- 154 Methylococcus...
Q6AJD5         107 GGVSLGLQAGAEASQVVMLVMSKKGMDS-LLtT---SFKLGADISVAAGP-VG-------AGAKAS-Ta----------- 162 Desulfotalea ...
jgi:Despr_1080 106 GSVSLGFQVGADASEIILLIMTDRGLNA-MLsT---DYKIGADVAVAAGP-MG-------ASAKAQ-Ta----------- 161 Desulfobulbus...
WP_013250858   113 GAASFGFQFGAQMSEVVLLILTQRGVDS-LLlG---NFKLGADGSVAVGP-VG-------AGISGA-Ttpnl-------- 171 Nitrospira de...
XP_003663743   306 akgsanpssgaatlapsplsadntqfqtppvtedldeddyddggkgkhparrpspfrdalkkpVYSYIKSRGFYAGVQID 385 Thermothelomy...
WP_012462496   173 ---------------------------------------------------------------VYVYLISKNKIKGIKIG 189 Methylacidiph...
MA:Minf_0478   177 -----------------------------------------------------------pkshIYVYKRSKGFFGGLALT 197 Methylacidiph...
WP_015257208   160 --------------------------------------------------------------dFISYARSQGAFMGMSLE 177 Thioalkalivib...
jgi:TK90_2385  163 --------------------------------------------------------------dFLTYSRSRGAYLGMSLS 180 Thioalkalivib...
WP_015404770   160 --------------------------------------------------------------dILAFARSKGAFLGVSIE 177 Desulfocapsa ...
Q60B44         155 --------------------------------------------------------------dILQFSRAKGIYGGLTLE 172 Methylococcus...
Q6AJD5         163 --------------------------------------------------------------dIIAYSKSKGVFGGLSLD 180 Desulfotalea ...
jgi:Despr_1080 162 --------------------------------------------------------------dILAFGRSQGIYGGVSLE 179 Desulfobulbus...
WP_013250858   172 ------------------------------------------------------------sadLLSFVRAKGLFAGVSLE 191 Nitrospira de...
XP_003663743   386 GTIIAPRDRANAEVYGKGv-sVGRILRGEVParslanlaqqqhggalstWPGGAKVLYDVLRGA 448 Thermothelomyces thermophilus...
WP_012462496   190 NFDLIADPATNWQYYKNKy-iPYQILSGRVP------------------VPESAQRLIQALAEP 234 Methylacidiphilum infernorum
MA:Minf_0478   198 GLDIAESKDTNKRYYH-KevsSKEILSGKVA------------------VPKGAQKLIHALNAP 242 Methylacidiphilum infernorum V4
WP_015257208   178 GSMLRIRDDFNESYYGERl-rPVQIIEGRKV------------------DAPGTQALRQDLLGF 222 Thioalkalivibrio nitratireducens
jgi:TK90_2385  181 GSRLTVRDDFNEAYYGEAq-rPVHIIESRRV------------------DHAGTRELRDLLASF 225 Thioalkalivibrio sp. K90mix
WP_015404770   178 GAIVNPRDKWNAAYYK-QkvsPADIIiGNTT------------------HNPQADALRTTMAEQ 222 Desulfocapsa sulfexigens
Q60B44         173 GAVITPREDLNAAFYG-RivdPVDILiRHTV------------------TNPLADRLRAAVAKA 217 Methylococcus capsulatus
Q6AJD5         181 GSVIAVRDALDKAYYK-KavsPSDILiAKSV------------------NNPASISYRETVQKL 225 Desulfotalea psychrophila
jgi:Despr_1080 180 GAAISPLDDWNRQYYG-KpvqLFDVLiNQRW------------------TNAQADPLRQLLPKP 224 Desulfobulbus propionicus DSM...
WP_013250858   192 GAVLISRDEWSRAYYG-KpvtPTDIViRREV------------------KNPHSETLRGEIRKA 236 Nitrospira defluvii
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