Conserved Protein Domain Family
DNA_pol3_chi

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pfam04364: DNA_pol3_chi 
DNA polymerase III chi subunit, HolC
The DNA polymerase III holoenzyme (EC:2.7.7.7) is the polymerase responsible for the replication of the Escherichia coli chromosome. The holoenzyme is composed of the DNA polymerase III core, the sliding clamp, and the DnaX clamp loading complex. The DnaX complex contains either either the tau or gamma product of gene dnax, complexed to delta.delta' and to chi psi. Chi forms a 1:1 heterodimer with psi. The chi psi complex functions by increasing the affinity of tau and gamma for delta.delta' allowing a functional clamp-loading complex to form at physiological subunit concentrations. Psi is responsible for the interaction with DnaX (gamma/tau), but psi is insoluble unless it is in a complex with chi.
Statistics
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PSSM-Id: 398182
Aligned: 219 rows
Threshold Bit Score: 75.6807
Threshold Setting Gi: 81627050
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4FVP2                   2 KISFYVLsesKAQDFLGFICQLTQTALNkSTQSLLILIEDDAAlLSALNEALWTQEATSFIPHqyllDADTDINHktlaP 81  Psych...
WP_015827760            17 EWWFYHL---ERTSLEEALGPLLEKCLQ-KDWRVLIVG-DGDR-LPKLDLGLWTWKADSFLPHarlgGRDE--IDpmaqP 88  Hirsc...
WP_013480486             3 QVWFYHL---ERTPLRAALPDLLEKTLQ-KGWKAYVLGEAGDM-LVGLDQHLWAYRDEAFLPH----GLESEPEAar-qP 72  Astic...
Q5NMX8                   4 RVDFYHL---LSAKLENILPRIAEKTLS-SDKKLLVVVPDDQQ-ARYWDDYLWRYEDTSFLPH----GRVGGGDEae-hP 73  Zymom...
Q1GS99                   3 RVDFYRL---TRDPVERVLPALAARVLG-NGDRLLVVAAAAMQ-RQDIDAALWTANPASFLPH----GHAGTPDEai-eP 72  Sphin...
BAK66168                 2 QVDFYQL---SRDPVETVMPAIARRILE-SGGRLLVVSDERDQ-LDRISRGLWNAGPETYLAN----DHADAPAShv-qP 71  Sphin...
WP_013040745             2 QVDFYQL---SRDPVEQVLPAIAGRVLD-MGARLLVVAREPER-LERISAGLWAGPPESFLAH----GRAGDDAEsv-qP 71  Sphin...
CCA92923                 2 RVDFYQL---SRDPAEVALPLIAGKVVG-SGERLLVVSADGEQ-RKRIRQALWSAGPDTFLAN----GEVGDGQEer-qP 71  Novos...
PRJNA213647:NX02_12330   2 QVDFYHL---TVRPVEAVLPRIADRVLE-SGARLLVVSADEAQ-RERIDGALWTQDKESFLPH----GLAGGAHDad-qP 71  Sphin...
WP_015457315             2 QVDFYHL---ASSPIERVLPRIAERLLV-DGARLLVVCADDGQ-AARLDQQLWTYAADSFLPH----GRAGDGGEal-qP 71  Sphin...
Q4FVP2                  82 ILLSSYMPa-----nFKGMVL-----NTT----IypvntfMAATnnaqpTRVLELIKPDAT-SVQEGRHKYKSYQQLGYE 146 Psych...
WP_015827760            89 ILLSNTPEpa----nKADIIVlldgkRLPnepdD------ATQY-----IRCMVVFDGDDFnARDTARSQFKGAKDAGQT 153 Hirsc...
WP_013480486            73 VLLGDSGGna----nAADVLFsvsamNLP----E------LSPY-----QRCLILFEGQDEtHLNWARAQWKALKARNLD 133 Astic...
Q5NMX8                  74 VLISTAMEav----nQASYIAltdglWRA----E------ALNF-----ERVFYFFD---EiAVQQARQAWRSLKNIDGE 131 Zymom...
Q1GS99                  73 ILLSGTLDtsp--pnGASRLAladgeWRE----D------ALAF-----DRTFFLFD---NsRIDDARATWRALAARddv 132 Sphin...
BAK66168                72 VLLSPGCEpl----nGARHAAladgrWRE----E------VLGF-----DRAFYFFD---EaTIAGARAAWRALSRTdgv 129 Sphin...
WP_013040745            72 VLLAQHCPaadlvanGARHVAladglWRE----E------ALGF-----ERAFYFFD---AeTIDGARASWRELAKRegv 133 Sphin...
CCA92923                72 ILLSDAPQpa----nGAKFMAiadgqWRE----G------SEPF-----ARTFYLFD---EsTVQQARGVWRELRSRegv 129 Novos...
PRJNA213647:NX02_12330  72 VLIGADVAaa----nGARHVAlvdgeWRD----A------ALDF-----DRAFHFFD---EaSIAAARTAWRALSGREGV 129 Sphin...
WP_015457315            72 VLIAATADaa----nGARNIAladgiWRD----E------ALAF-----DRAFHLFD---DgSIDAARAAWKALAGredv 129 Sphin...
Q4FVP2                 147 LT 148 Psychrobacter arcticus
WP_015827760           154 VS 155 Hirschia baltica
WP_013480486           134 LA 135 Asticcacaulis excentricus
Q5NMX8                 132 ch 133 Zymomonas mobilis
Q1GS99                 133 dn 134 Sphingopyxis alaskensis
BAK66168               130 vp 131 Sphingobium sp. SYK-6
WP_013040745           134 ip 135 Sphingobium japonicum
CCA92923               130 eh 131 Novosphingobium sp. PP1Y
PRJNA213647:NX02_12330 130 EP 131 Sphingomonas sanxanigenens DSM 19645 = NX02
WP_015457315           130 vr 131 Sphingomonas sp. MM-1
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