Conserved Protein Domain Family
SLFN_AlbA_2
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pfam04326: SLFN_AlbA_2 (This model is not part of the current CDD release)
Schlafen, AlbA_2
This is the AlbA_2 domain from the Schlafen (SLFN) family of proteins which are important in cell differentiation and defense against viruses. This domain is present at the N-terminal of all SLFN proteins and includes the SLFN box, a sequence unique to these proteins that may form a dimer interface. The AlbA_2 domain is RNA-binding and RNase region as it contains the highly conserved catalytic glutamic acid residues.
Links
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Statistics
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PSSM-Id: 516174
Aligned: 63 rows
Threshold Bit Score: 46.916
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q07XI6       223 EGQHVEFKACYQSSNTKrqydkk----nlsqqRITSVVAFLN--S-NdGNLFIGVDD--DMT---IHGIedelmqyhsds 290 Shewanella frig...
Q89W22        36 EGPVWDFKREWPFSYSDdff----------cgIARLVCAFAN--SdG-GIIVFGVHD--TER---TAGH----------- 86  Bradyrhizobium ...
WP_012085322  32 ESLHVDLKEEAGRRKGPtilpgatendraarvLAGEAACMAN--TpGgGVLVVGVAD--DGT---LIGT----------- 93  Kineococcus rad...
Q6NKB4        31 ESETLEFKEDPSCAGRGkqhgnpq--aaliekLIDEAVCLANgdA-GtGHIVVGIKDk-IGGpeaFTGT----------- 95  Corynebacterium...
WP_013164350  23 EDQDLDFKQWDGKSMDKav-----------qlLIRMAVCMAN--GgG-GTVVFGVADtvKGRsqaVLGV----------- 77  Desulfurivibrio...
Q9HJY5        32 EDTWIEVKSTYGVEVDPd-------------eIRKDFSCMAN--S-GgGYFLIGVGDqpNFK---VTGC----------- 81  Thermoplasma ac...
Q6N1X8        25 ESLTLEYKASPSLCRESkqi----------deLCKDVSAFAN--S-AgGQIVYGVAE--NKVthkPERV----------- 78  Rhodopseudomona...
Q7UYP5        20 EDDRWEFKSAMFLERSNkgef--------qkeLSKQVSALAN--S-GgGNLVFGLSD--SRV---LEPC----------- 72  Pirellula sp.
WP_011967239  19 ESTELEYK-RSFAKSNKdwk----------keLAKDVSAMAN--SnG-GIIVYGLK---EKE---ISKGhsv-------- 70  Bacteroidales
Q5E547        19 EDHFFDRKAFGLKGEK----------------VQKIAVAFAN--AdG-GEILVGIAD--DKDeviPEKRw---------- 67  Aliivibrio fisc...

Q07XI6       291 edkfvmqltslFRDSIYTRTTDNLELKALAKPKELITISLVSINGH--------TVAWVQ------VKQSREHLf----- 351 Shewanella frig...
Q89W22        87 -----------NKVAPNMDRLQQA-LNQLLSEKPSLKLRRYETGTAea-----vDVLLVS------PHDASAMPlr---- 139 Bradyrhizobium ...
WP_012085322  94 --------------ELDAQWLRRK-IYDLTDRRLTADVTPVLCRGV--------RLLLVR------SPEAVHPV------ 138 Kineococcus rad...
Q6NKB4        96 --------------TFDTEKIAKK-IFDGTRPNLRPEVHEVRYQNN--------RLIVIY------IPEALSLY------ 140 Corynebacterium...
WP_013164350  78 -------------PLEVDVNRLKKAVYDQTDPKIMPVFEELRVPEGt------gRLLIMQ------IHPGMPPY------ 126 Desulfurivibrio...
Q9HJY5        82 -------------DEIDFNRIRKI----LGDPNKMTAFPDFENKEVyse--dgkRVIIVY------IKPVNGSSviclkd 136 Thermoplasma ac...
Q6N1X8        79 ------------DEGVLDPKVTREWIEQVLLSRVNPRMQGIKVDRL--------DLGNLTygycltIPPTSVGPh----- 133 Rhodopseudomona...
Q7UYP5        73 ------------EQRVGRQPMKDY-LATLVEQSVEYPLRQFKVHRIpftgddsnSVFVVE------VDDSLAAPd----- 128 Pirellula sp.
WP_011967239  71 --------pedISPIPTSEMTKDQ-LSQLLSSNIQPIIDGIEISYIpyn--eenGFYIVS------VPQSNTAHq----- 128 Bacteroidales
Q5E547        68 -----------QGQESTEAYNSVIQALSELVPSVDFRFDFLTRVNEsr-----nYVLRVK------INKGLSVH------ 119 Aliivibrio fisc...

Q07XI6       352 ---FYREsksnYQFFIRTGRNKEK-IK 374 Shewanella frigidimarina NCIMB 400
Q89W22       140 -flKTVGdykaGVIWVRQGHEVVA-AE 164 Bradyrhizobium japonicum
WP_012085322 139 ----MYD----HKYHHRVADSCVE-VD 156 Kineococcus radiotolerans
Q6NKB4       141 ---SRSK----GQTSKRVGSHCEP-LS 159 Corynebacterium diphtheriae
WP_013164350 127 ---TDTS----GRGTVRIGKECRP-Lt 145 Desulfurivibrio alkaliphilus
Q9HJY5       137 knkQHTIyvyyTRSYLRTDCQKLP-CE 162 Thermoplasma acidophilum
Q6N1X8       134 ---QAPD----KRYYKRYDLQSIP-ME 152 Rhodopseudomonas palustris
Q7UYP5       129 --qAKSD----RVYYYRIDGHTKP-AP 148 Pirellula sp.
WP_011967239 129 ---NKLS----HMYHKRRNATVDA-ME 147 Bacteroidales
Q5E547       120 ---ETAK----KKIFLRQGAQSLPvTA 139 Aliivibrio fischeri ES114
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