Conserved Protein Domain Family
Fer2_BFD
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pfam04324: Fer2_BFD (This model is not part of the current CDD release)
BFD-like [2Fe-2S] binding domain
The two Fe ions are each coordinated by two conserved cysteine residues. This domain occurs alone in small proteins such as Bacterioferritin-associated ferredoxin (BFD). The function of BFD is not known, but it may may be a general redox and/or regulatory component involved in the iron storage or mobilisation functions of bacterioferritin in bacteria. This domain is also found in nitrate reductase proteins in association with Nitrite and sulphite reductase 4Fe-4S domain (pfam01077), Nitrite/Sulfite reductase ferredoxin-like half domain (pfam03460) and Pyridine nucleotide-disulphide oxidoreductase (pfam00070). It is also found in NifU nitrogen fixation proteins, in association with NifU-like N terminal domain (pfam01592) and NifU-like domain (pfam01106).
Links
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Statistics
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PSSM-Id: 516173
Aligned: 172 rows
Threshold Bit Score: 33.2787
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_012997475  403 IICKCNKVSEGDILEAIeRmkkigvK--VPSIDSIKFRTKATTGtCQGgfCRVKIAAILAR 461 Candidatus Aciduliprofundum boonei
WP_012414608  137 VVCKCFNVTEETIIKAV-R------NnnLHSVEDVTHFTKAGGA-CGK--CKGDIQKIIDk 187 Elusimicrobium minutum
WP_011735890  146 LVCKCFGITDAYLKKVI-E------TnkLTTVEQVTNFTKAGGA-CGG--CISSIKELIAQ 196 Pelobacter propionicus
P20628        143 LVCTCFGVSENKVRRIV-I------EndLTDAEQVTNYIKAGGG-CGS--CLAKIDDIIKd 193 Nostoc sp. PCC 7120 = FACHB-418
12_pfamImport   1 LICSCFGITDAKIKKAV-A------QnnLFSAEQVTNYVKAGGG-CGS--CLTKIDDIIRE 51 
WP_015196130  143 LICTCFGISDTKIKRVI-V------EnnLKTAEEVTNYVKAGGG-CGS--CLATIDDIIQs 193 Calothrix sp. PCC 6303
WP_015122248  143 IICTCFGITEPKIQRIV-K------EnkLTTAEEVTNFIKAGGG-CGT--CLATIDDIIIE 193 Rivularia sp. PCC 7116
WP_015225828  141 LICQCFGITDTKIKRVI-R------DnnLITAEQVTNYVKAGGG-CSS--CLAEIDDLLAE 191 Halothece sp. PCC 7418
WP_015145431  143 LVCKCFAVSQGQIKRVI-R------EnhLTTAEEVTNYIKAGGG-CGS--CLADIDDLLAE 193 Pleurocapsa sp. PCC 7327
Q2JP79        142 LVCSCFGVSEQKIRRLI-R------EnrLTSAEEVTAYSKAGGG-CGS--CLAQIEDLIAA 192 Synechococcus sp. JA-2-3B'a(2-13)
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