4BEC


Conserved Protein Domain Family
HSDR_N

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pfam04313: HSDR_N 
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Type I restriction enzyme R protein N-terminus (HSDR_N)
This family consists of a number of N terminal regions found in type I restriction enzyme R (HSDR) proteins. Restriction and modification (R/M) systems are found in a wide variety of prokaryotes and are thought to protect the host bacterium from the uptake of foreign DNA. Type I restriction and modification systems are encoded by three genes: hsdR, hsdM, and hsdS. The three polypeptides, HsdR, HsdM, and HsdS, often assemble to give an enzyme (R2M2S1) that modifies hemimethylated DNA and restricts unmethylated DNA.
Statistics
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PSSM-Id: 398143
Aligned: 75 rows
Threshold Bit Score: 39.1955
Threshold Setting Gi: 81768934
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4BEC_B   30 YQSESDLER-ELIQDL-RNQGYEF-----------------ISVKSQSAMLAnvreqlqnlngvvfndsew------rrf 84   Escherichia coli
O27023    2 KLNEEALED------------YFMkelrgmgwndipaaelgRDDPENPLIESelidsirrinqyiedddiq-----qviq 64   Methanothermobacter...
O28565    1 MKKEKEQSEdYLSEIL-KSFGWEE-----------------RKLSPDILDLTefkaalkrlndvddedike------vln 56   Archaeoglobus fulgidus
Q58611    9 IYVHNDIEEn-----L-NKLGWKEleg------------yeGEAFSNYIIKPileeqlkiindhigeykde------fie 64   Methanocaldococcus ...
Q57588   13 KKSEK--------------------------------------------------------------------------- 17   Methanocaldococcus ...
O25211    2 PYNEITRVQiPALMHL-AKLGYDFiptns-------kenkpNLDTATNILTNsftksferlnptknaqet--------la 65   Helicobacter pylori
Q9F6Z9    6 EFSELTRVQiPAAFHL-MRLGYTYlphngkei--------mgrdpetNILISifreqflkfnnyatdldve-----reln 71   Streptococcus therm...
Q48426    5 GQRER-MTQkRVIQFFtDHLGYHYlg-------------nwHKREDNRNIEPglvsawltkrgvsevliaralrqldraa 70   Klebsiella pneumoniae
Q8PUP0    4 GKPER-ATQdRIISLFhDELGYSYlg-------------nwIDREGNSNIEEellaayltkngytriqigval-hllkna 68   Methanosarcina mazei
Q8YTN1    5 GQRER-QTQnRIVQLFqQQLKYRYlg-------------dwHDRPNNSNIETeilstflrdkqgysnslitkalyelnkv 70   Nostoc sp. PCC 7120
4BEC_B   85 teqyldnpsdgildkTRKIHIDy-iCdfi-fddERlENiylidkknlMRNKVQIIQQFEQA-GSHANRYDVTILVNGLPL 161  Escherichia coli
O27023   65 elrgkaasiegcksiLEYLKNGvyiKsa---ttGEpRKvkildhdtpSHNSFTASRQVVFRrGDQTIRTDIMLFINGIPL 141  Methanothermobacter...
O28565   57 yletrsfdvegsmqiLDAIKKGvtiKds----eGIlKTiklidyanpEANSLVFSRQVSF----ADIIPDITLFVNGIPL 128  Archaeoglobus fulgidus
Q58611   65 kainklinepkpeeiLDYIKNGiliTldkgrkgQVsNRvklidykniEKNIFNYAHELKFK-GNDNIIPDFTLFINGIPI 143  Methanocaldococcus ...
Q57588   18 ------------------------------------RKfklidykniDKNTFFYLCEAEFKgNPKNSRPDITLFINGIPV 61   Methanocaldococcus ...
O25211   66 emkkrlncddlgksfYEYLLKSenqii---------------dfdnpNNNLYEMMTELPY----KSFRPDTTLFINGLPL 126  Helicobacter pylori
Q9F6Z9   72 nikieldqndlgrafYNRIVSDsgpTyvdw--------------enpENNTFHLALEVTCQnGGDEFRPDIVIFINGLPL 137  Streptococcus therm...
Q48426   71 slgegrilydankevYRLLRYGlkdKeg---agEQnQTvwlvdwknpEANDFAIAEEVTYN-GENKKRPDLVLYVNGIAL 146  Klebsiella pneumoniae
Q8PUP0   69 anrhnqslysnnqavYSLLRYGvpvKte---agKVtDSvqlinwqepEKNDFAIAEEVTLR-GKRERRPDIVLYVNGIAV 144  Methanosarcina mazei
Q8YTN1   71 agdqskslydinkqvYSLLRYGvnvKee---vgENtQTvwlinwekpLENDFAIAEEVTVK-GENTKRPDIVLYVNGIAI 146  Nostoc sp. PCC 7120
4BEC_B  162 VQIELKKR-----GvAireAFN--Q-IHRYSKEsfnsENSLFKYL------------------------QLFVISNGTDT 209  Escherichia coli
O27023  142 VNIELKNPvg-msE-TwadAYR--Q-IKDYEKT----VPELYKYV------------------------QMGVAAEDFAR 188  Methanothermobacter...
O28565  129 AIIECKKMa----K-SwkeGYA--Q-IKRYE-Qs---APELFKYV------------------------QIGFSFADRLV 172  Archaeoglobus fulgidus
Q58611  144 IIIEAKREfs-ekE-TyeeAIN--Q-INRYERE----APKLFNYV------------------------QFAIVYGDEKL 190  Methanocaldococcus ...
Q57588   62 VIIEAKATlk--iD-ShleGIS--Q-IRRYEKFs----PDLFRFV------------------------QFAISYGEEQL 107  Methanocaldococcus ...
O25211  127 VNIEVKQPya--kK-GikeERD--RhIKRYENPe---NKVFYNLA------------------------QIWLFSDNL-- 172  Helicobacter pylori
Q9F6Z9  138 SYIEVKQPnairdGkT---AIQseQ-SRTAVRFe---NRRFRRFNnitqlisfsdnlpyisgqgqqkqgSFYCSNAFSKT 210  Streptococcus therm...
Q48426  147 GVIELKRSt----V-SiseGIR--QnLDNQQKAf---IRNFFTTI------------------------QLVMAGNDLEG 192  Klebsiella pneumoniae
Q8PUP0  145 GVLELKNSr----V-TiedGIR--QnLSNQQPEf---NEWFFSTV------------------------QFIFAGNDSEG 190  Methanosarcina mazei
Q8YTN1  147 GVLELKRSt----V-SvseGIR--QnLDNQKSRh----------V----------------------------------- 174  Nostoc sp. PCC 7120
4BEC_B  210 RYFANTTKRD 219  Escherichia coli
O27023  189 YFPIVPWLDE 198  Methanothermobacter thermautotrophicus str. Delta H
O28565  173 YFPIVRWEES 182  Archaeoglobus fulgidus
Q58611  191 YIPTYPNEEK 200  Methanocaldococcus jannaschii DSM 2661
Q57588  108 YTPTMPNWYK 117  Methanocaldococcus jannaschii DSM 2661
O25211  173 -----PYDEN 177  Helicobacter pylori
Q9F6Z9  211 KFNAFKEERE 220  Streptococcus thermophilus
Q48426  193 LRYGVIETPE 202  Klebsiella pneumoniae
Q8PUP0  191 LRYGAIGTQE 200  Methanosarcina mazei
Q8YTN1  175 -------RLN 177  Nostoc sp. PCC 7120
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