3CH4


Conserved Protein Domain Family
P-mevalo_kinase

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pfam04275: P-mevalo_kinase 
Phosphomevalonate kinase
Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation of 5-phosphomevalonate into 5-diphosphomevalonate, an essential step in isoprenoid biosynthesis via the mevalonate pathway. This family represents the animal type of the enzyme. The other is the ERG8 type, found in plants and fungi, and some bacteria (see pfam00288).
Statistics
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PSSM-Id: 398111
Aligned: 41 rows
Threshold Bit Score: 125.374
Threshold Setting Gi: 505100507
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3CH4_B               16 FSGKRKSGKDFVTEALQSRL---GAdVCAVLRLSGPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKR--QADP 90 
XP_015782095         11 LSGKRKSGKDFVAELIEKRY----RnGLAVIHISKPIKQKYAELHGAAFDELMKASEYKEQFRLDMVKWSEKEKldRNDQ 86  two-spot...
WP_015287609          9 INGKRRSGKGLLTEKLKEKCakmFGdNIHVLSFAQPIKDITKPI----LNKLKWDGQDKEIVRPLWISMGEVGR--NIDA 82  Mycoplas...
WGS:AANI:GJ18008-PA   7 ISGKRKCGKDFISERLQKRL----AdRALIVRISEPIKREWARKLQLDINAMLSDGPYKEQYRRDMIIWSDEVR--RRDY 80  Drosophi...
EDW37223              7 ISGKRKCGKDYISERLQKRL----TnRAIIVRISEPIKSEWARKLQLDLSALLSDGPYKEQYRRDMIVWSDEVR--NKDY 80  Drosophi...
Q16I28               13 FSGKRKCGKDFLTERLLQRL---TTdKAQIIRISEPIKRSWAEKLGLDLGELLGDGPYKERYRKEMIEWSDQKR--AEDF 87  yellow f...
EDS42634             10 FSGKRKCGKDYLTERLLQRL---TPaRAQIVRISEPIKRCWADKLGLDLGELLGDGPYKERYRREMIEWSDGRR--AEDY 84  southern...
Q7PS33                6 LSGKRKCGKDFLADALLQRL---GTdRAQIVRISEPIKRHWAEAMGLDLAALLGDGAYKERYRRQMIEWSDGRR--QEDY 80  Anophele...
ETN65625             17 VSGKRKCGKDYLSDALLKRL---GHnRAQILRISEPIKRYWATQKGLNLDELLSDGAYKENYRKEMIVWSDEQR--HEDY 91  Anophele...
2_pfamImport          1 FSGKRKCGKDYITERLFQRM---NKeNVVVLKISAPIKLHFTNTKGLDYQTLLGSENYKEQYRKEMILWGEQER--KKDY 75 
3CH4_B               91 GFFCRKIVEg----------iSQ-PIWLVSDTRRVSDIQWFRE-AYG 125
XP_015782095         87 AYFLKLAIEle--------kaQErKVWLVADARRPADIGYFDSpQFD 125 two-spotted spider mite
WP_015287609         83 NIWCAKVLEkivkiidesiknNKsSLFLIDDLRFPNELDYFIKnikt 129 Mycoplasma cynos
WGS:AANI:GJ18008-PA  81 GFFCRAAMQqa--------avQNvDYVIVSDIRRKNDIRWFRE-TYG 118 Drosophila virilis
EDW37223             81 GYFCRAAMEea--------plDQiAYVIVSDVRRKNDIKWFRE-TYG 118 Drosophila persimilis
Q16I28               88 GFFCRQACLa-----------LAkEICVVSDIRRKTDVRFFRE-QYG 122 yellow fever mosquito
EDS42634             85 GFFCRAACSeg--------vvAArEVCIVSDVRRKTDVRFFRE-TFG 122 southern house mosquito
Q7PS33               81 GVFCRAACAt-----------IDrPICIVSDVRRQTDVRYFRE-AYG 115 Anopheles gambiae str. PEST
ETN65625             92 GVFCREACRt-----------MNrEICIVSDVRRRTDVRFFRE-TFK 126 Anopheles darlingi
2_pfamImport         76 GIFCRTAIEmfn-------glFLkPIWIVSDIRRKTDIRWFKE-NFG 114
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