3CH4


Conserved Protein Domain Family
P-mevalo_kinase
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pfam04275: P-mevalo_kinase (This model is not part of the current CDD release)
Phosphomevalonate kinase
Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation of 5-phosphomevalonate into 5-diphosphomevalonate, an essential step in isoprenoid biosynthesis via the mevalonate pathway. This family represents the animal type of the enzyme. The other is the ERG8 type, found in plants and fungi, and some bacteria (see pfam00288).
Links
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Statistics
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PSSM-Id: 516144
Aligned: 37 rows
Threshold Bit Score: 123.468
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3CH4_B         16 FSGKRKSGKDFVTEALQSRL---GADVCAVLRLSGPLKEQYAQEhglnFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGF 92   human
NP_001256276    7 ISGKRKSGKDYCTNLIREVLv-qKRFDVSVAGISHSLKMEFAKKhglkYEELLTDGPYKELYRKDMIQWGEEARCKDSGL 85  
EFP08897        8 ISGKRKSGKDYCAKLIKESIa-sKGVSVSAVGISHSLKEEYAKIhdlnFAELLTDGPYKEKYRKDMILWGEEARNKDFAV 86  
XP_045098889    8 ISGKRKSGKDYCTNNSIKAFe-kIQLSVSAVGISHSLKEEYAKIhnlnFAELLTDGPYKEQFRKDMIRWGEDVRNKIPSV 86  
XP_003046903  732 VTGESGSGKDYCADIWASVFt-mSAIRARTVSISDETKQGYAAAtgsdLRRLLSDRDYKEEHRPALTEFFQEQLKKRSEL 810 
Q16I28         13 FSGKRKCGKDFLTERLLQRL---TTDKAQIIRISEPIKRSWAEKlgldLGELLGDGPYKERYRKEMIEWSDQKRAEDFGF 89   yellow fever ...
XP_001866014   10 FSGKRKCGKDYLTERLLQRL---TPARAQIVRISEPIKRCWADKlgldLGELLGDGPYKERYRREMIEWSDGRRAEDYGF 86  
Q7PS33          6 LSGKRKCGKDFLADALLQRL---GTDRAQIVRISEPIKRHWAEAmgldLAALLGDGAYKERYRRQMIEWSDGRRQEDYGV 82   Anopheles gam...
XP_049549179   17 VSGKRKCGKDHLSDALLKRL---GHNRAQILRISEPIKRYWATQkglnLDELLSDGAYKENYRKEMIVWSDEQRHEDYGV 93  
WP_015287609    9 INGKRRSGKGLLTEKLKEKCakmFGDNIHVLSFAQPIKDITKPI----LNKLKWDGQDKEIVRPLWISMGEVGRNIDANI 84   Mycoplasmopsi...

3CH4_B         93 ----FCRKIVEGI-----SQ------PIWLVSDTRRVSDIQWFRE-AYG 125  human
NP_001256276   86 ----FCRAAISSTmd----------sDIVIISDCRRRTDYEYFSA-NYR 119 
EFP08897       87 ----FCRAAIKSVid----------sDVVIVSDCRRLTDYAYFNS-NFN 120 
XP_045098889   87 ----FCRAALLSVdd----------sDIVIVSDCRRITDLEFFVRtIKL 121 
XP_003046903  811 lkehFLKAMKNLad-----------vDVLMITGMRDEAPLVTFSP-LFP 847 
Q16I28         90 ----FCRQACLAla-----------kEICVVSDIRRKTDVRFFRE-QYG 122  yellow fever mosquito
XP_001866014   87 ----FCRAACSEG-----VVaa---rEVCIVSDVRRKTDVRFFRE-TFG 122 
Q7PS33         83 ----FCRAACATid-----------rPICIVSDVRRQTDVRYFRE-AYG 115  Anopheles gambiae str. PEST
XP_049549179   94 ----FCREACRTmn-----------rEICIVSDVRRRTDVRFFRE-TFK 126 
WP_015287609   85 ----WCAKVLEKIvkiidESiknnksSLFLIDDLRFPNELDYFIKnIKT 129  Mycoplasmopsis cynos
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