Conserved Protein Domain Family
Strep_his_triad
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pfam04270: Strep_his_triad 
Streptococcal histidine triad protein
All members of this family are proteins from Streptococcal species. The proteins are characterised by having a HxxHxH motif that usually occurs multiple times throughout the protein. The histidine triad is predicted to bind metal cations, in particular Zn2+. The zinc is transferred, on the surface of the streptococcus from the Strep_his_triad protein, a zinc scavenger, to apo-ADCAII, a cell-surface lipoprotein transporter that leads to Zn2+ uptake into the bacterium.
Links
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Statistics
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PSSM-Id: 486995
Aligned: 11 rows
Threshold Bit Score: 56.5947
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_012658387  345 EEDGLIFDPNQVTKLTSRGYVIPH----GNHWHVVPEDQLSPLEIYLARMH 391  Streptococcus uberis
2_pfamImport    3 GSEGYVFSKDNIIGVDDHGVTTEHredgHAHTHYIEFGELKGYELAKVEEW 53  
WP_013669059  329 ESDGLVFDPVKVTKRNNFGYVLPH----GDHFHIIPFDQLSDLEIAATEAY 375  Aerococcus sp. Group 1
Q8DPQ2        558 TSDGYIFDEHDIISDEGDAYVTPH----MGHSHWIGKDSLSDKEKVAAQAY 604  Streptococcus pneumoniae R6
Q8CWR4        561 TEDGYIFDPRDITSDEGDAYVTPH----MTHSHWIKKDSLSEAERAAAQAY 607  Streptococcus pneumoniae R6
Q8DQ07        438 EEDGYGFDANRIIAEDESGFIMSH----GNHNHYFFKKDLTEEQIKAAQKH 484  Streptococcus pneumoniae R6
1_pfamImport    3 TDDGYRFSPESIIEYDSNGLITQH----GDHSHYVPFADLDDEEIRQAQDY 49  
Q8DQ07        182 TNDGYVFNPADIIEDTGNAYIVPH----GGHYHYIPKSDLSASELAAAKAH 228  Streptococcus pneumoniae R6
Q8CWR4        196 TDDGYIFNASDIIEDTGDAYIVPH----GDHYHYIPKNELSASELAAAKAF 242  Streptococcus pneumoniae R6
3_pfamImport    3 TDDGYIFTPESIVSDQGDGYICQH----GDHFHYVPKDDLSANERAQAKAY 49  
4_pfamImport    3 TDDGYVFTVGSIVQDTGDAYICAH----GDHFHYVPKADLSPAERAAAAAY 49
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