1IG3


Conserved Protein Domain Family
TPK_catalytic

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pfam04263: TPK_catalytic 
Thiamin pyrophosphokinase, catalytic domain
Family of thiamin pyrophosphokinase (EC:2.7.6.2). Thiamin pyrophosphokinase (TPK) catalyzes the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis.
Statistics
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PSSM-Id: 398102
Aligned: 121 rows
Threshold Bit Score: 86.7861
Threshold Setting Gi: 144575727
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1IG3_A           52 FRHLWKKALL--RACADGGANHLYDLtegereSFLPEFVSGDFDSIRPEVKEYYTKK-GCDLISTP-DQDHTDFTKCLQV 127
CCP25822         17 VKKYLSCCSI--VICADSGARHAFNM------GVVPDLLVGDMDSISPADMEKVQKW-GVKKQNFPsEKDFTDTELAVCE 87  Tepidanaerob...
jgi:Toce_0828    17 LKKYVKQEDL--IICADSGIHHALKM------GVIPHLVVGDMDSVTEEDRGKICEY-NIKLYTFPkEKDFTDTELALEA 87  Thermosedimi...
O83531           18 VQYYLPAYDL--LIAADSGLDTALQF------GLVPDFVIGDMDSVKDNLFIQACD--KTRTHLFPrDKDFTDTELAVTL 87  Treponema pa...
CDD40358         19 AEQFLKHRSYgcVIAVDGGLEAAAAL------GVCPDEIVGDLDTVNPALFDSYRRKpGIELEIHRpEKDETDTELALLT 92  Clostridium ...
jgi:Desaci_3675  19 GKQALDKVDY--LICADGGANHALNS------GFMPEQLIGDLDSVTGENLSQCRNA-GCFIEQFPrEKDETDLELALLR 89  Desulfosporo...
CDC26278         17 CEKYLQNADC--IICCDGGMHHAKAL------GITPDYIVGDFDSVRPEVLEEYRNM-GISIRQFPtHKNETDMQLGMLL 87  Firmicutes b...
WP_118581711     17 CESYMDGADA--VICCDAGMRHAKAL------GIDPDYIVGDFDSTASEVLEYYKAK-NIPIRQFPtRKNETDMELGIIL 87  Anaerotignum...
WP_014255697     17 YEKYFKWAKA--VICVDGGAKYLRKF------GIVPDVLIGDLDSISDEDLDYLVSM-NVKIMKYPiQKDMTDTEIAVDY 87  Hungateiclos...
CDC21537         17 FKEYAKDCK---LIACDGGIDHCRKD------NIVPDIMVGDFDSATNENYMYFKNM-GVEEIKFPtHKDMTDMEIGMDL 86  Eubacterium ...
1IG3_A          128 LqrkieeKELQ----VDVIVTLGGLGGRFDQIMASVNTLFQATHiTPVPIII 175
CCP25822         88 A------LKLG----ADEALLLGGLGNRPDHSLANIFLMVSFKQ-QGLELKL 128 Tepidanaerobacter acetatoxydans Re1
jgi:Toce_0828    88 A------LKKG----VREAVLLGGLGDRPDHSLANIFLMVNFKK-KGIDLML 128 Thermosediminibacter oceani DSM 16646
O83531           88 A------HQLG----SDDLSIVGGGGGRADHFLYFMRLFA--AP-LSPRLWL 126 Treponema pallidum
CDD40358         93 A------ERKG----FHAVHLLGALGGRMDHALGNVQLLNQCLQ-NDVHAEI 133 Clostridium sp. CAG:299
jgi:Desaci_3675  90 A------KEKAfsagEQEIWLYGATGKRMDHFLGNLALMLAYAR-QGYRIHL 134 Desulfosporosinus acidiphilus SJ4
CDC26278         88 A------LELG----ATELVLIGGIGDRFDHTLANAHLLLYLLK-KGVRGIL 128 Firmicutes bacterium CAG:466
WP_118581711     88 A------LELG----ATDLVLFGGIGDRFDHTLANAHYLLSLLK-KGVRARL 128 Anaerotignum faecicola
WP_014255697     88 A------VDNG----FKEIVIIGGIGTRLDHTLANILLVKKLLD-KGVKCTL 128 Hungateiclostridium clariflavum
CDC21537         87 A------LKYG----ADEIYIFGGIGSRLDHSMGNVHLMCKSLE-KGVKTFL 127 Eubacterium sp. CAG:274
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