3S4Y


Conserved Protein Domain Family
TPK_catalytic
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pfam04263: TPK_catalytic (This model is not part of the current CDD release)
Thiamin pyrophosphokinase, catalytic domain
Family of thiamin pyrophosphokinase (EC:2.7.6.2). Thiamin pyrophosphokinase (TPK) catalyzes the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis.
Links
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Statistics
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PSSM-Id: 516137
Aligned: 106 rows
Threshold Bit Score: 86.782
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3S4Y_A        36 FRHLWNKALL--RACADGGANRLYditegeRESFLPEFINGDFDSIRPEVREYYATKGCELISTP-DQDHTDFTKCLKML 112 human
WP_015757359  17 HKKYLKDSDY--IICVDGGARHAE------ALKIIPQMLIGDFDSIAESTLEKFLSAGSQVKRYPpEKDQVDTELAIIEA 88  Desulfofarcimen...
WP_012447106  23 YCEELEKSDY--IIAVDGGANFLY------KVDETPDLLLGDMDSITAEAYQYYSRLDIPIKHHPaEKDESDLELALVTG 94  Natranaerobius ...
WP_015391388  17 LKSYLGKVDF--IIAADKGSECLY------NYNIVPDVLLGDFDSINRGVLNNVKAQVKEILQFPpEKDYTDTEIAINEA 88  Clostridium
WP_022744660  17 LENYIDKVDF--IIAADKGSECLY------SYNIIPDLLLGDFDSTNKESLNSIKLKAREVLEFPpEKDYTDTEIAIIEA 88  Clostridium sac...
WP_015615624  17 LRNYLDNETY--IISADSGANTLY------KYSIVPNIILGDFDSIHSNVLNYFQKVGCKTISYPaEKNFTDTEAAIEEA 88  Clostridium pas...
Q895P3        17 LLEELKDSDI--IIAADKGAEALY------KCNIKPNFIVGDFDSIDENILNYYRKNNINLNAFPvEKDFTDSEAAVIKA 88  Clostridium tetani
WP_011986838  17 LKQEMKDSSY--IICADSGANCLY------KYDIIPDFILGDMDSIDKETFSYFKEKGVCMDKYPkDKDFTDGLVALNKA 88  Clostridium bot...
WP_010077159  20 LEAEIISSQY--VIAADKGGEVLY------KYKRCPDLLVGDFDSIDNKTIDYFKQRNTPIEKYPmEKDFTDGEMAVEKA 91  Clostridium cel...
CCY60120      17 LETVLSDYDFqkIIACDKGLEICQ------ECDILPDLVIGDFDSAKTDIVASYRE-KTEFLDLDtHKDFTDTHVAISYI 89 

3S4Y_A       113 QKKieekdlK--VDVIVTLGGLAGRFDQIMASVNTLFQ 148 human
WP_015757359  89 IKL------K--PEQILLMGVLGDRLDHTLANIQLLVI 118 Desulfofarcimen acetoxidans
WP_012447106  95 INL------K--PKEIFVYGAFGNRVDHLFANIMVMLN 124 Natranaerobius thermophilus
WP_015391388  89 IKR------G--AREIYLFGALGSRMDHALGNIGLLLT 118 Clostridium
WP_022744660  89 LKR------G--AEKIYLFGATGSRMDHTLGNVGLLLT 118 Clostridium saccharobutylicum
WP_015615624  89 IKL------N--PQEVLLFGCTGSRLDHTLANLGLLHK 118 Clostridium pasteurianum
Q895P3        89 INM------G--THKIALLGCTGSRLDHVLSNINLLYY 118 Clostridium tetani
WP_011986838  89 IEL------K--ADTIVLLGCIGNRIDHILGNLGLLEI 118 Clostridium botulinum
WP_010077159  92 IAM------N--PQEIVLLGCNGARLDHVFSSIGLLYK 121 Clostridium cellulovorans
CCY60120      90 LEQ------EirPDEVILVGATGTRMDHTLANIGLLKQ 121
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