Conserved Protein Domain Family
RseC_MucC

?
pfam04246: RseC_MucC 
Positive regulator of sigma(E), RseC/MucC
This bacterial family of integral membrane proteins represents a positive regulator of the sigma(E) transcription factor, namely RseC/MucC. The sigma(E) transcription factor is up-regulated by cell envelope protein misfolding, and regulates the expression of genes that are collectively termed ECF (devoted to Extra-Cellular Functions). In Pseudomonas aeruginosa, de-repression of sigma(E) is associated with the alginate-overproducing phenotype characteristic of chronic respiratory tract colonisation in cystic fibrosis patients. The mechanism by which RseC/MucC positively regulates the sigma(E) transcription factor is unknown. RseC is also thought to have a role in thiamine biosynthesis in Salmonella typhimurium. In addition, this family also includes an N-terminal part of RnfF, a Rhodobacter capsulatus protein, of unknown function, that is essential for nitrogen fixation. This protein also contains an ApbE domain pfam02424, which is itself involved in thiamine biosynthesis.
Statistics
?
PSSM-Id: 398089
Aligned: 178 rows
Threshold Bit Score: 37.5413
Threshold Setting Gi: 359355641
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
WP_052199358           8 VVAIEGDIALLHTEGQSACGSCQansTCgtgllaklfptRARQPLRLPI------DhLarrplpGQRVVLGIDEDYLQRN 81  endosym...
CCX42452              17 VVALDGDRAVVRFARGSMCKHCG---ACl---------aIGEKEMELHVkntenaA-V------GDAVIVELAPKSIVSA 77  Clostri...
jgi:Nther_1269        14 VIERKDNYVTVEIERHSACKNCG---ACdf-------gmSGNKTSELELentvnaE-V------GDEVVVDMEGKDIVLA 76  Natrana...
jgi:Clole_1258         6 VKEVGKRYAIVQMERQEMCGECH---ACdy--------iTGKKDCILRCekeiecQ-V------GDMVELKLAQPTFLKA 67  Cellulo...
CDC18912               7 VIGTEKNKLVVRMTRKEACAKCR---ACsa--------gLKEQDMLLKAvnlcnaK-V------GDRVEVMLETADFMKA 68  Eubacte...
WP_016407731           5 VHEVKGDLAMVKIQRKEACGECR---ACfs--------gMMKTEMDIEAknlcdaE-E------GDWVELELQENAFFNA 66  Anaerot...
goetting:EAL2_c09830   9 VVEKSADKAIVSIVRHSACAGCG---ACgm--------aSESSKVKIEAintvdaN-V------GELVSIDMKNPDVLKA 70  Peptocl...
WP_012063491           7 VVSLEGKMAKVLMQRQASCGDCT---ACkm--------gQEEMKLEVKAlnnanaQ-V------GQRVEIDMEHQNVLAA 68  Alkalip...
WP_012159558           7 IISIDGERAKVSLQKQSACGDCK---GCrw--------gEDNMKMEVEAinrikaK-V------GDRVEIDMEHQNVLAA 68  Alkalip...
WP_013361512           7 VVNVEANNAYVQIDRKTACESCK---ACgl-------gtSDEKSIIVQAinnikaQ-K------GDIVELDLESPDVLLA 69  Acetoan...
WP_052199358          82 TLLLYAVPLLGLLGGAILGDLSsagdtaggGSELAAIFGGLFGLTAAIFWVRWRSHCa--tARLAHSVRIL 150 endosymbiont of ...
CCX42452              78 SMLAYVFPLLALLLGIWCGLSVf--------GELGGILLGLVCCLLAYGVLRCLDRRf--aKKQTFAPRMS 138 Clostridium sp. ...
jgi:Nther_1269        77 SFLIYLFPLFSLVLGLFLGNMVaae--ingDENLIGLAFGILFMGFSYTGLKMYDNKvktsQPQKFKPKIL 145 Natranaerobius t...
jgi:Clole_1258        68 TYVMYGFPLIGLIIGLVIGLGAsklf-rlgSEDLWVLIGGLLGIVLPLIGIKWAENQg---KFKKYLPHII 134 Cellulosilyticum...
CDC18912              69 TCIMYGIPCAMFIIGILAGYYGfeal-gksGGEFAGFGLGIVLVVLTYLIIRTQEKRf---KNGNYVPKAI 135 Eubacterium sp. ...
WP_016407731          67 VIVMYGLPFIGFIVGIVLGYFGvpklipniSPVLPSLVLGVLGIVLAMLWIHSQNHRw---ESGKYRPLAt 134 Anaerotignum fae...
goetting:EAL2_c09830  71 AFIAYGIPLLVLIAGVLSASAAlstlgykgDSEVAAGMVSLLLTGAAYLIIRKNEDKi--gKLIGYNPAIT 139 Peptoclostridium...
WP_012063491          69 AFIVYMIPLFALMMGIFAGNAMlsalgvenYRDLLTAFAGFIFMATSFMVIKIRENKf--kTNKDFTPIIS 137 Alkaliphilus met...
WP_012159558          69 AFIAYVIPLITLILGVILGSMIldkidivqNKEVGAGIFGLVLTAISYGIIRLKENSf--kQNQQFIPIIT 137 Alkaliphilus ore...
WP_013361512          70 AFIIYGIPLLALILGIFVSYVVmka--inyNSEILMLLTGVVFMIISFIVIRLYEPKl--kESKKFSSTVV 136 Acetoanaerobium ...
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap