5NMP


Conserved Protein Domain Family
Cyclase

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pfam04199: Cyclase 
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Putative cyclase
Proteins in this family are thought to be cyclase enzymes. They are found in proteins involved in antibiotic synthesis. However they are also found in organisms that do not make antibiotics pointing to a wider role for these proteins. The proteins contain a conserved motif HXGTHXDXPXH that is likely to form part of the active site.
Statistics
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PSSM-Id: 398050
Aligned: 394 rows
Threshold Bit Score: 58.7821
Threshold Setting Gi: 123654788
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5NMP_E          26 VDLTQTLSP-SFptlqlpsqfgqvqpfki--erishydasgpawywnnFscgeH-TGTHFDAPAHwitgrdypgnsvdti 101 Ralstonia sol...
WP_014083617    17 IDISIPLSNtDDnpiawylskpsiqpvqm--dnwtgsvaagsstnfnnIsfnpHaHGTHTECIGHltnef-----ysvnk 89  Flavobacteriu...
jgi:Celly_1814  20 lDISMPLKGdKSnvnawyvgapviephtd--gdfvglvsegssvnfnnIsfnpHaHGTHTECVGHitekf-----vsvnq 92  Cellulophaga ...
CDF80857        20 IDISIPLRAsSTnvsafyveppviepikdd-egflarvsdgaafnfntVsftpHgHGTHTECVGYvsref-----nsvne 93  Formosa agari...
WP_013305399    20 LDISIPMKGgESdvnawyidhskiephte--gefvgavskgavvnfndIwfnpHsHGTHTECVGHiteef-----hsvnk 92  Maribacter sp...
CAZ96431        20 LDISIAIKGgSEnvtawyvdppeikahee--dgfvgkvsegasinfndIafnpHaHGTHTECVGHitdef-----hsvnk 92  Zobellia gala...
jgi:Murru_1739  20 LDISIPLKGgDNnvnawyldppkitpheq--dgfvgkvsegastnfndIwfnpHsHVTHTECLGHiseef-----nsink 92  Muricauda rue...
WP_015482133    20 IDISIAIDVsKQnvnawylddpkifpeev--dgenisvengavvnfnsIhfnpHsHITHTECVGHitekv-----hsvnq 92  Polaribacter ...
WP_014166083    16 YDISIPLSNtETnpiawyiekpviepvrf--gdwvgkvsegsainfntIsfnpHgHGTHTECLGHitkqt-----ysinq 88  Flavobacteriu...
jgi:Halhy_3071  33 IDISMPLRAgTQnancfyaphpefwpveapefgfigdttkggavnffnIkinpHgNGTHTECVGHiarek-----ytinq 107 Haliscomenoba...
5NMP_E         102 ApENFVAPAVVIDAsaqvreneDw-LlTVDFLQA------WEQRHgRipAGAWVLFRTdwslrVgdaaaflniredgaht 174 Ralstonia sol...
WP_014083617    90 TlDCFFFLAKLITVmpek-indDyqI-GLSQIEpll-------hdnA--VCKALIIRTlp--nEpakksrk---ysntnp 153 Flavobacteriu...
jgi:Celly_1814  93 KlKQFFFLAEVITIapek-igdDfvI-SKKQLQyal--------gkK--KREAVVIRTip--nLedkigaq---ysntnp 155 Cellulophaga ...
CDF80857        94 NlKQFFFLAEVITVavek-lgeDlvI-SKKQLQfal--------gnK--KRKAVVIRTip--nTvdkltmq---yshtnp 156 Formosa agari...
WP_013305399    93 NlKNYFFLAEVITIapek-fhdDfvI-SKKQLQyaf--------gnK--KRDAVIIRTlp--nLrdktskq---ysntnp 155 Maribacter sp...
CAZ96431        93 NlKQYFFLAEVITIapem-ldgDfvI-SKKQLKyal--------gnK--KREAVVIRTlp--nLsqkksrq---yshsnp 155 Zobellia gala...
jgi:Murru_1739  93 KlKKFFFLAELITVapeq-mgdDfvI-SEKQIKyal--------gnK--KRQAVVIRTip--nLgykrskk---ysdtnp 155 Muricauda rue...
WP_015482133    93 NlKHYFHLAELITIapie-vdgDlvI-ATKQLKmal--------rnK--KRDAVVIRTlp--nLtdkksmk---ysntnp 155 Polaribacter ...
WP_014166083    89 ClKEFFFVTEVITVqpeq-iegDlvI-TKKILEnkratttEWEKSyN--SIQALVIRTlp--nTidkkskn---yshtnp 159 Flavobacteriu...
jgi:Halhy_3071 108 ClRHFHFFAKLISIwpqrmengDrvI-LRQQLEPcfvv----------hklEALVLRTlp--nDdwklntn---ysganp 171 Haliscomenoba...
5NMP_E         175 PGPTQEAVEWLIGERnVHGFGVETINTDA 203 Ralstonia solanacearum GMI1000
WP_014083617   154 PYITKEAALFIKKQG-VKHLLVDLPSLDK 181 Flavobacterium branchiophilum
jgi:Celly_1814 156 PYLLEEGAVFLREKG-VEHLLIDLPSVDK 183 Cellulophaga lytica DSM 7489
CDF80857       157 PYLLEDAAIYLREKG-VEHLLVDLPSLDK 184 Formosa agariphila KMM 3901
WP_013305399   156 PYLLEEAAQFLVNKG-VEHLLVDLPSVDR 183 Maribacter sp. HTCC2170
CAZ96431       156 PYLTQEAAEFLVEKE-VGHLLVDLPSVDK 183 Zobellia galactanivorans
jgi:Murru_1739 156 TYLTEEAAKCLVKKG-VEHLLIDLPSVDK 183 Muricauda ruestringensis DSM 13258
WP_015482133   156 TYLLEETAVFLKEKG-IKHLLVDLPSVDK 183 Polaribacter sp. MED152
WP_014166083   160 PYLTEEAAIYLRELG-IKHLLVDLPSIDR 187 Flavobacterium columnare
jgi:Halhy_3071 172 PYIHHEALDFLVECG-VKHLLVDLPSVDR 199 Haliscomenobacter hydrossis DSM 1100
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