5NNB


Conserved Protein Domain Family
Cyclase

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pfam04199: Cyclase (This model is not part of the current CDD release)
Putative cyclase
Proteins in this family are thought to be cyclase enzymes. They are found in proteins involved in antibiotic synthesis. However they are also found in organisms that do not make antibiotics pointing to a wider role for these proteins. The proteins contain a conserved motif HXGTHXDXPXH that is likely to form part of the active site.
Statistics
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PSSM-Id: 516100
Aligned: 324 rows
Threshold Bit Score: 57.2789
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5NNB_A         19 VDLTHTLDP-DFpvivlppefgqcarfrm-eeisaydhrgpawkwhnISMSEH-TGTHFDAPSHwisgkd-vpngsVdei 94  Roseibium aggr...
WP_014202299   20 iDLSSVLGLpGKelkawwaddvdispvvn-gdwigsvekgapvnffnIKFNPHgNGSHTETYGHiskek------esvhn 92  Owenweeksia ho...
WP_014799748   20 LDISISLQAgNQnpncyygenptfetirfgdnfvgsvaeggacnyqkVTITPHgNGTHTECYGHlnnqekn---nitinq 96  Bernardetia li...
26_pfamImport   1 VELGYPIYE-GMpvypglpevkvtlr--------edleagadwngsvLSIYLH-AGTHVDAPWHymgg----sapgIdci 66 
WP_004078362    3 IRLSYALNR-HTplypgtdamklepa--------ksiekgdssnttlITFNGH-SGTHLDAPNHfcek-----kmtVsel 67  Methanoplanus ...
BAJ46674        3 IYLSHILTR-NSpcyddgprpeftpd--------kqiargdssntyfIKLLNH-IGTHVDAPYHfdpn-----grkIssy 67 
XP_003061438   47 VDITAPV---DAslvtwekadglgashr---vqsssradgddanvseLAFGAH-TGTHVDAPRHfard----sdagIetl 115
XP_002500783   14 VDITATI---RAslptwlsetglgeghr---tetwsmlngddanaseLTFSAH-TGTHVDAPRHfvpwk---nqqgMetv 83 
XP_052167299   52 VDISHYYRE-EMpewesadgtgggflrl----vrsmrngsdianfseLRLTAH-SGTHVDAPGHvfdhyy-hagfdVdtl 124
EFJ19762       22 TDITHSLRQ-DLpvwdskeglgkvvsl------vasiangslvnvseLQLIVH-TGTHVDSPSHflqkdflngvdtTnsl 93 
5NNB_A         95 PaEAFVG-PVVVIDC--SKGaa----------------enDDFElTPEII-AG-----------WESEHGr-IPEDAWVL 142 Roseibium aggr...
WP_014202299   93 YlKKYHF-VSWVVSLapEKAkn-----------------gDSII-TLEALkKSltk----------------whGIEALI 137 Owenweeksia ho...
WP_014799748   97 SlKTFWF-VARLISLepTKItemhleneefnqlkeiaeigDEVI-FKKNI-Ekklk-----kieSIDNNk---iPYEALI 165 Bernardetia li...
26_pfamImport  67 PiDRFFYeKPLLLDV--PAkk------------------kND-LiTVEQL-LAygdelykadllIFNTHSyeKRSVDFMD 124
WP_004078362   68 LkPENIIeGAVCIDI--RKNgd--------------------sPvIPEDI----------------RPFRdeIRDTEALF 109 Methanoplanus ...
BAJ46674       68 RaDELVFeKPLLIDV--Skd-------------------aGE-LiTVSDL-EKhsqt---------------lhnVDLLL 109
XP_003061438  116 YlS-WMNgPAMVIDAfdVPAl------------------------TAEAL-AS-----------LDIPRG--VEr---VV 153
XP_002500783   84 DiG-AMNgPALLIEAydVPVl------------------------NREAL-EA-----------LGIPNA--VSr---LI 121
XP_052167299  125 DlA-ILNgPALLVDVprDSNi------------------------TANVM-ES-----------LHIPKG--VRr---VL 162
EFJ19762       94 KlD-ILTgLVLVVETpkDQNi------------------------TAEVV-KN-----------V-VPPG--VEr---VL 130
5NNB_A        143 MRTDWSKRRGADylnmrADGph-sPGPTPEAIRFLIEERn-iRGFGTETVGTDA 194 Roseibium aggregatum
WP_014202299  138 IKTgdykdgh-------dfsgsnaTYFEPELLAFIRDRGv--EHVLVDLPSVDR 182 Owenweeksia hongkongensis
WP_014799748  166 IRTlpnsdtkkn----klysgqnpPYLEPNIGTFLAQKNi--NHLLLDLPSVDR 213 Bernardetia litoralis
26_pfamImport 125 YATGFSA-------------------VGPEAAEFIREKLpnvKGVAIDTLSIEN 159
WP_004078362  110 IRTGsgdirdad----pdtyatvhPWIHPDVPDYLREICpelRFFGLDAISVAV 159 Methanoplanus limicola
BAJ46674      110 IRTSFQRYrekdpe----afmrrgPCLSAEAASFLRQ-FgtlRALGVDTISISS 158
XP_003061438  154 FRTDNTRRRLMRl----RAFqrdyvaFTEDGARWMVDFRpdvKTIGVDYVSVAA 203
XP_002500783  122 IRTDNTRRKLMHt----TAFtpdyvaFDTEGAKWLVEHRpdiRAIGIDYLSVAA 171
XP_052167299  163 FRTLNTDRKLMWk----KEFdtsyvgFMKDGAQWLIDNTd-iRLVGVDYLSVGa 211
EFJ19762      131 FRTLNTERRLMWk----REFtsdftaLTKDGAEWIAQNTs-lKLIGLDYLSVGV 179
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