Conserved Protein Domain Family
TAP42

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pfam04177: TAP42 
TAP42-like family
The TOR signalling pathway activates a cell-growth program in response to nutrients. TIP41 (pfam04176) interacts with TAP42 and negatively regulates the TOR signaling pathway.
Statistics
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PSSM-Id: 398032
Aligned: 151 rows
Threshold Bit Score: 155.057
Threshold Setting Gi: 122021950
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPE05987      10 LKATHRAAERKRDaietgavrysPADPDAYGDAVRGAIAAYEKCDRLVAQLALFSTNESAEDIATGHLPYLLVPFYIAEL 89  Ophiostoma pice...
EDQ72779      10 lpqlltQAQQIHSl---------ANSSQIGNDEVKKGCQLLRKCQEIADRIGLFSTNEEKEDISTGDLKYLLVPYYLGEL 80  Physcomitrella ...
EFJ30093      10 lpllFQRAQALHTr---------STSSQLDPDELNKGIRLLLQCQEMVDKLAIFSSNEKKEDVSTSDLKYLLVEYYLGEL 80  Selaginella moe...
XP_005849467  12 LPALFQRGRALLKqle-----glPASDAGTQQLVQRGGAVWRQAAAAADALALFSSNEELEDLATADIKYLLIPFYAAEA 86  Chlorella varia...
XP_002504031  38 LDVYTR-----------------LQSTSVDDDEISQAAAALRQAALQADRAGVLSANEVLDDIATSDLKYVLCEFYLAEV 100 Micromonas commoda
XP_003054916  17 LAAYTK-----------------LQSGALDEETLASAAAALRHAVNRIDVEGVFSKNETKDDIATADLRYLLAPFYLAEV 79  Micromonas pusi...
CBJ30104       9 legllLEGQRLYTkvs----nadFDGDEDRDYTTARAKAALESLQMGVAREGVFSANEEVGEIATPVLPLLATDFYLGSL 84  Ectocarpus sili...
Q57XV0        15 VRSLFNGLAQRYKdtv-----lkSETSIEQDENSRSLIPHLEKLWYMMGAMGVVSPNEQLDDISTNALELLWTPYIIADL 89  Trypanosoma brucei
Q4DEG1        10 vkgrFNELLRQYEegi-----lgGMHSGEQSTIARSLIPHFELLWRQMAVMGVVSSNEQLDDLSTSSLELLWIPYIIADL 84  Trypanosoma cruzi
EGD75770      10 lPALFAKAMSCWQd---------VRAGKDPQKRLDEGLASVKRAAHFLLHLNVFSDNEEHTEHSTLSLRYLAIPFIHAEL 80  Salpingoeca ros...
EPE05987      90 ALKIPAysstst------------pasrpAERRAVLKRAREAYERYLHHLDGYSLLTANYVRLL------QAYtedpkef 151 Ophiostoma pice...
EDQ72779      81 TEKLET-----------------------EDRVQLVRVAKGQLLSFIRTCERLELLSESDAQVLsregraTPE------- 130 Physcomitrella ...
EFJ30093      81 TERTPA-----------------------TERIDVVRAAINHLKTFVRSCELLDLVPEGELVALtrdtpvDPA------- 130 Selaginella moe...
XP_005849467  87 LTHTHAad--------------------pRARIAALTSAAEQYRAFLHRCRQYGLLSPPATAMAdaalqqgdgggdh--- 143 Chlorella varia...
XP_002504031 101 VSRTRApn--------------------pAARAPFAAEAADALEAFLRRCEVHDLLTPEAKRQReglkrgPGAqna---- 156 Micromonas commoda
XP_003054916  80 VGSTRTra--------------------pAARLPVATEASSAHATFLSWCERHEFIPRGDGDGAsassaaADPa------ 133 Micromonas pusi...
CBJ30104      85 MIKLPFtn--------------------pQIRLKVLEQAEALLFKYLDTCERLQLFDAADLQAWqamlkeAERstsg--- 141 Ectocarpus sili...
Q57XV0        90 YQRLQGpmptpapvtpg--etnevagaagMTREEALSRSHHWYDVFFRWAQDCELVDERTLDTYrtf------------- 154 Trypanosoma brucei
Q4DEG1        85 YQRIQGpiptleatsllsssapetrntsdMTREEALTLSKGWYDIFFQWMLDYELVDERTLEKYrnm------------- 151 Trypanosoma cruzi
EGD75770      81 LSRKFPaerdp--------------evrdKERITYVVRARELYQQFIRNLRDMefpfaapkvvd---------------- 130 Salpingoeca ros...
EPE05987     152 stvgsvsgsstgvgagrapkaglagladptARRNAKIANFQAEKELRGKLDVLKQRQQQrreikrrrkirireaeeetad 231 Ophiostoma pice...
EDQ72779     131 ------------------------------TRRAEKVARFRKQRAAESKLQEIKERKERrrrsmqat------------- 167 Physcomitrella ...
EFJ30093     131 ------------------------------TRRAEKITRFKRQRAAESKLQEINERKERrrrsmqaa------------- 167 Selaginella moe...
XP_005849467 144 ------------------gskqqgrtldaaTLRQNKIEKFKREKYVKGRLAELEQRQRQqagageg-------------- 191 Chlorella varia...
XP_002504031 157 ---------------------------dpgTARADKVARFRRERAIRARLEELDVTRRRraeeallnadw---------- 199 Micromonas commoda
XP_003054916 134 ------------------------------TARDRKVARFKRERAIRARLEDLDAKRRArrqdallnaew---------- 173 Micromonas pusi...
CBJ30104     142 --------------------------drqaITREQKIERFRRQQRTQQKMKEIEELLRTe-------------------- 175 Ectocarpus sili...
Q57XV0       155 ----------------------------raDNRTQRVELSRKRRELEVVLLQYEDKVEYlqakrkrmkel---------- 196 Trypanosoma brucei
Q4DEG1       152 ----------------------------hpDQRTQRVELSRKRRELEEEKRRYEQQVQYllakrkrmqal---------- 193 Trypanosoma cruzi
EGD75770     131 --------------------yyleakpgnrRERDTKIAHLKAMKAAESTLQEIEEVVKSk-------------------- 170 Salpingoeca ros...
EPE05987     232 nagstedahndgaddddddddddDDED-----EEEARKLYMAQVFYSVHMAFQGLDGINVEDDMLASAPVPQ-----NNg 301 Ophiostoma pice...
EDQ72779     168 ---------------akstsveqGEENlpdedDEEEREAWFLQISLALCKSLDLVEMLQREEEMLAAVQAANee-grEAf 231 Physcomitrella ...
EFJ30093     168 ----------------gkqvvdyGEEDipdgdDEEEREAWFVQLSLAVSKAVDLLEMLQREETMLLAVRKENen--ggEf 229 Selaginella moe...
XP_005849467 192 ----------------ehaggqrGGDA-----EEADRELWMLQADLAALQAAERMGTLQQEVQILAHAAAMPe------- 243 Chlorella varia...
XP_002504031 200 ----------------ddedpdaspeD-----EVEERERWTLLIEDAVAKSLDNLDHLARELEMIAARDELAaarpaGRp 258 Micromonas commoda
XP_003054916 174 ------------ddedpecgqddGGED-----DAEARERWTLAIEDATIKASDAKPRLELELTMLRDREALEasaasRRn 236 Micromonas pusi...
CBJ30104     176 ----------------------gKDCEdegegDGMKRERSLLLLAGLASEALDGVSGMSKETEMLKHLVKAReqegaGPd 233 Ectocarpus sili...
Q57XV0       197 ------------maedgdeisesNGDE-----EEALRGRALARLRWSVYEACHHLQLSARELEMLTALSPERrqeiaN-- 257 Trypanosoma brucei
Q4DEG1       194 ------------aeedgdeledtNGDE-----EDALRNRALSRLRWSIYESCQQLQLSFRELEMLQALSLEQrqaiaI-- 254 Trypanosoma cruzi
EGD75770     171 ----------------------dLDED-----DEMHREHMMALLHSYLLKACDQVENVGVELSMLEHVVRMRaagehPPs 223 Salpingoeca ros...
EPE05987     302 svrggssstagGLgdnrqrsgrgiddelseridqldmqngaslqrlqgalgagaptwAGTRGGPLLTKEGRP-------- 373 Ophiostoma pice...
EDQ72779     232 skemlderhsrAD--------------------------------------------DWHRQGAAKAQTSRP-------- 259 Physcomitrella ...
EFJ30093     230 aqavlderhakAE--------------------------------------------AWHRESATKSKVLRP-------- 257 Selaginella moe...
XP_005849467 244 --------------------------------------------------------qQRQREREQRQQAGPP-------- 259 Chlorella varia...
XP_002504031 259 raggvnaragrGVytlmpdg-------------------------------avvpgfhDASNGSASSIGGQPtgqq---- 303 Micromonas commoda
XP_003054916 237 addgggeeeeeEEggevgerrirg----------------------rgggggggglkTYTIRGKDGDGRGQS-------- 286 Micromonas pusi...
CBJ30104     234 gqhararrdedDSi------------------------------------------rSNGLEVTHISRVGGN-------- 263 Ectocarpus sili...
Q57XV0       258 ---------------------------------------------------------NHQRTLDAVRRGELSlgrhtyti 280 Trypanosoma brucei
Q4DEG1       255 ---------------------------------------------------------DHQKTIEAVQRGEKSlgrhtyti 277 Trypanosoma cruzi
EGD75770     224 sqq-----------------------------------------------------------lrdeAKQRKP-------- 236 Salpingoeca ros...
EPE05987     374 -----KQP----------FTITagsnmgigN--------------------------------------NRAQMAKNVFR 400 Ophiostoma pice...
EDQ72779     260 -----AIP----------ITCA--------TyaqdviegrvaiqpnhqhthgapmlfgpasvvsgslstDRERQIAQVFQ 316 Physcomitrella ...
EFJ30093     258 -----AQP----------ITCA--------Tfaqdviegranisdghqh--shqplfgpaslvgssittERERLAAQVFQ 312 Selaginella moe...
XP_005849467 260 -------Pdllrqlhaa-------------------------------------------agglagagaRREQLAAGVFR 289 Chlorella varia...
XP_002504031 304 --tasVPPelmeslrrmy-----------------------------------------gtgvaggsarSAERIRSEVFR 340 Micromonas commoda
XP_003054916 287 -----VPPevlaamrarlg---------------------------------------lgpgaggindrDRDRIARDVFR 322 Micromonas pusi...
CBJ30104     264 -----LQI-------------------------------------------------------------RKEDVRANVFK 277 Ectocarpus sili...
Q57XV0       281 lpgglVAPggpfpvdrinSTVM--------Sai-----------------------------------aSQESFRQKVVE 317 Trypanosoma brucei
Q4DEG1       278 lpgglITPggpipttqvgSVAM--------Sai-----------------------------------aNQQAFRQKVVK 314 Trypanosoma cruzi
EGD75770     237 -----EPP----------LVLT--------Sdavksma-------------------------asgktiNRANFKLLTRG 268 Salpingoeca ros...
EPE05987     401 PGH-NL------PTMSIDEYLDEEFRrgnVIEGGGAQSGLVPEP--------------DEDNyek------gdAETMKAR 453 Ophiostoma pice...
EDQ72779     317 PSH-SL------PSMSIEQAGLAEMK---IMRTWNETNQKIFDEarqsswvgeekkddDDSDd---------eAATNKAR 377 Physcomitrella ...
EFJ30093     313 PSH-SL------PSMSIEQAGLKEME---MMRKWQEGNQQLQQEskstwl---eeeskDGSDd---------eAEESKQR 370 Selaginella moe...
XP_005849467 290 PGH-VQ------PTMSVEQFGELE-----MVEQQRREAAAKERHe---------------rQqaarraedveeEQVQQQR 342 Chlorella varia...
XP_002504031 341 PSH-VL------PTMTVEQAGEIEHRe--MMERQRAQAENAARRa---------------rEesemtqeereeRDLAKAR 396 Micromonas commoda
XP_003054916 323 PSH-IL------PTMTVEEAGEMEYRe--LMERTARQAANAKAAa---------------eEeakltedereaRELARTR 378 Micromonas pusi...
CBJ30104     278 PTV-AL------PTMTVEEFGEIELEr--ATERTQQEAAAQKDSsstrrry-dqlemdGDEDded-----lveQAAYHDR 342 Ectocarpus sili...
Q57XV0       318 ----ELminrnnPTMTLAEFADAEMA---DVQRRMEANADAQRLqq-----------eEDELlgpe---gveeRQRKRDS 376 Trypanosoma brucei
Q4DEG1       315 ----DLmvernpPTMTLQEFAEAEMA---DVQRRMDASAAAKRQqe-----------eEDERlgpd---gveeRQRQRDT 373 Trypanosoma cruzi
EGD75770     269 YGPiGA------PTMTMEEVAQIEMQq--AMEAQRRQQQEEAQAq------------eVDPDsee-----asvAETYKLR 323 Salpingoeca ros...
EPE05987     454 AWDEFTESN 462 Ophiostoma piceae UAMH 11346
EDQ72779     378 AWDDWKDDN 386 Physcomitrella patens
EFJ30093     371 AWDDWKDEN 379 Selaginella moellendorffii
XP_005849467 343 AWDDFKDDN 351 Chlorella variabilis
XP_002504031 397 SWDEFKDDN 405 Micromonas commoda
XP_003054916 379 AFDEFKDDN 387 Micromonas pusilla CCMP1545
CBJ30104     343 AWDDWKAEN 351 Ectocarpus siliculosus
Q57XV0       377 ALADWKDDH 385 Trypanosoma brucei
Q4DEG1       374 RLADWKEDH 382 Trypanosoma cruzi
EGD75770     324 AQDEWNDDH 332 Salpingoeca rosetta
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