pfam04168: Alpha-E (This model is not part of the current CDD release)
A predicted alpha-helical domain with a conserved ER motif.
An uncharacterized alpha helical domain containing a highly conserved ER motif and typically found as a tandem duplication. Contextual analysis suggests that it functions in a distinct peptide synthesis/modification system comprising of a transglutaminase, a peptidase of the NTN-hydrolase superfamily, an active and inactive circularly permuted ATP-grasp domains and a transglutaminase fused N-terminal to a circularly permuted COOH-NH2 ligase domain.
Jiyao W et al.(2023). "The conserved domain database in 2023.",