Conserved Protein Domain Family
Alpha-E

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pfam04168: Alpha-E 
A predicted alpha-helical domain with a conserved ER motif.
An uncharacterized alpha helical domain containing a highly conserved ER motif and typically found as a tandem duplication. Contextual analysis suggests that it functions in a distinct peptide synthesis/modification system comprising of a transglutaminase, a peptidase of the NTN-hydrolase superfamily, an active and inactive circularly permuted ATP-grasp domains and a transglutaminase fused N-terminal to a circularly permuted COOH-NH2 ligase domain.
Statistics
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PSSM-Id: 398026
Aligned: 364 rows
Threshold Bit Score: 103.844
Threshold Setting Gi: 189185405
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_014437878         555 LPSRVADNLFWLGRYTERAEGNVRLLRAIGHRHADpae-phPREMAAMLRALAVVTGVaeaatadraaaaqepasdggrd 633  Phycis...
jgi:Namu_4572          1 MLSRIAESLYWLGRHVERADCTARILDTYLHLLPAgswqadHQVIRSLLDSMGLSDDEtvg------------------- 61   Nakamu...
WP_016338202           1 MLARNAESLYWIGRYVERADDTSRILNVSVHQLLEdasvdpDHASRQLLAVLGISPEg---------------------- 58   Amycol...
WP_012395342           1 MLARNAEALYWIGRYVERADDTARILDVAIHQLLEdssidpDHASRLLLRVLGIDPPDhel------------------- 61   Mycoba...
Q0SH79                 1 MLARNAESLYWIGRYVERADDMARILDVAVHQLLDdasvdpDRTSRLLLRVLGIEAPDtql------------------- 61   Rhodoc...
WP_013805950           1 MLARNAESLYWIGRYVERADDLARILDVAVHHLLEdstvdpDRASRVLLRVLGTNPPDgpl------------------- 61   Hoyose...
goetting:GPOL_c29590   2 MLARNAESLYWIGRYVERADDMARLLDVAIHQLLEdatadvDSSVRLVIQVLGLDAPAs--------------------- 60   Gordon...
jgi:Srot_0475          1 MLARNAESLFWIGRYVERADDTARILDVGVHQLLEdatvdsDQQARGLLRILGITPPe---------------------- 58   Segnil...
jgi:Tpau_2798          1 MLARNAEALYWIGRYSERADDTARMLDVTAHQFLEdatvdeDRVSRQLVRVLGIPEPPa--------------------- 59   Tsukam...
BAK33288               1 MLSRIAESLFWIGRYVERADHTARMVQTQLRVIAEdtsrheAESCRSLLALMSVGISPd--------------------- 59   Microl...
WP_014437878         634 agraeA------GDVLSAILDPRGP-H--GLTSTLAACRAAGSRVRDRLSVDAWRILErlgrgderelrggvagdpedal 704  Phycis...
jgi:Namu_4572         62 ---agSqad-sgQLVRALVFDSERA-S--SVAGALTAARDNARGVRDAIPLDVWECLNvt-------------------w 115  Nakamu...
WP_016338202          59 -----MdtldvwKLTELVAYAKDNP-A--SIVGSINSARENTRGAREVVSTELWECLNat-------------------w 111  Amycol...
WP_012395342          62 ---------dvwSLTDLVAFSTNAS-GgcSIVEAISAARENAKSAREVTSIETWECLNtt-------------------y 112  Mycoba...
Q0SH79                62 ---------dvrSVTELVAFSRNQV-G--SIIDSLASARENARGAREVTSSEMWECLNtt-------------------y 110  Rhodoc...
WP_013805950          62 ---------dvwSLTERVAYSREDS-G--SIVDSLTSARDNARGAREVTSAEMWECLNtt-------------------v 110  Hoyose...
goetting:GPOL_c29590  61 -----EtdldvwSLTERVAYAKEST-G--SIVDLIRSARENARGAREVTSSEMWECLNtt-------------------y 113  Gordon...
jgi:Srot_0475         59 -----GeelhvwSMTDLVAFDRENG-N--SIADSLYRARENARGAREVTSTEMWESLNtt-------------------f 111  Segnil...
jgi:Tpau_2798         60 -----DqpldlrSVTEVVAYNRDPGsG--SIAATIYAARENARGAREVTSSEMWECLNst-------------------y 113  Tsukam...
BAK33288              60 -----QpeptvaELLRRLCWDAREP-T--SIFHSWAAARDNARRAREVIPLEVWESINtt-------------------w 112  Microl...
WP_014437878         705 aDAM------------ELFDGLLLTLAAFAGHSHESFTHEEGWRFLDLGRRIERAVTTAELMRSMLVRpvwlgggeatga 772  Phycis...
jgi:Namu_4572        116 hGLrtreag--gagphVFLRWVGERCAIANGLVSEVMTHDEGWQFLVLGRSLERADMTIRLLAAAESEtgs--------- 184  Nakamu...
WP_016338202         112 nAVPdrqryarragphAFLSFVEERAAMFAGLADSTMSRDDGWLFMVLGRSVERADMVVRLLLSRVQDsas--------- 182  Amycol...
WP_012395342         113 hALPereraakrlgphEFLSFVEGRAAMFAGLADSTLSRDDGYRFMLLGRAIERVDMTVRLLLSRVGDsas--------- 183  Mycoba...
Q0SH79               111 nGLAereraskrlgphEFFRYVEERAAMFAGLADSTMSRDDGYRFLLLGRSIERVDMLARMLLSRAGDrps--------- 181  Rhodoc...
WP_013805950         111 nGLAsreraarllgphEFFRYVEERAAMFAGLVDTTLSRDDGYRFLILGRSVERIDMLVRLLLSRAGDras--------- 181  Hoyose...
goetting:GPOL_c29590 114 nGLAdaerrsrrlgphEFLSYVKNRAAMFAGLADATLSHDDGYRYLLLGRSVERVDMTIRMLLARAGDrag--------- 184  Gordon...
jgi:Srot_0475        112 nGIAdseklarklgphEFFSYVENRAALFSGLVDSTLSRDDGYLFLLLGKHLERIDMGIRLLLVGSGDrs---------- 181  Segnil...
jgi:Tpau_2798        114 nGLAereraarrlgphEFLNYIKNRAAMFSGLTDSTLSRDEGYRFLLLGRSIERMDMAIRLLLSRAGDras--------- 184  Tsukam...
BAK33288             113 qKLPtrqfn--ivraySFLDWARDRSALVNGLARSTMVRDDGWQFFLLGRCLEQIDMTSRMVasasp------------- 177  Microl...
WP_014437878         773 gpgpagrasaseglLLGALLEVGVSAMTYRSRHRALPRIVPVLELLLLDPKNPRSVVWQLHAIEQHLADL-Pdapggphp 851  Phycis...
jgi:Namu_4572        185 ------------vpPWRALVSACGGWEPYVRSYGGSIGQRTAYEFVLLDRMFPRSVIRTLNTAESCLGELeAigstrym- 251  Nakamu...
WP_016338202         183 ------------spGWITVLRSAGAQDTYLRTYRGALDAARVVQFLLRDTLFPRSVFHALRQAEECLERLdPgvnsr--- 247  Amycol...
WP_012395342         184 ------------spAWVTLLRSVGAHDTYLRTYRGVLDAARVVEFMMLDRLFPRSVYYSLRMAEHNLDELlHnpqsr--- 248  Mycoba...
Q0SH79               182 ------------spAWVTVLRSAGAHDTYLRTYRGALDANRVVEFILLDRLFPRSVFHAIRQAELCLAELdHqpdsr--- 246  Rhodoc...
WP_013805950         182 ------------spSWVTVLRSAGAHDTYLRTYRGALDAGRVVEFLLLDRLFPRSVFHTIRTAEVALEELdHrprsr--- 246  Hoyose...
goetting:GPOL_c29590 185 ------------spAWVNVLVSAGAHDTFLRTYRGVINAENIVEFMLLDRLFPRSVFHALSVAEHNLADLeKgpsr---- 248  Gordon...
jgi:Srot_0475        182 ------------daSWVSVLRAAGAHDTYLRTYRGLLNSTSVVEFLVLDRLFPRSVFYSLHRVEECLAELdRgdlys--- 246  Segnil...
jgi:Tpau_2798        185 ------------spTWVTVLRATGAHDTYLRTYRGVLDASRVVEFILVDRLFPRSVIHALTTAEDCLSAIeGgregr--- 249  Tsukam...
BAK33288             178 ---------ttgsaNWPSVLRGMGGYDAFLRTYKGLYTDAEAAEFLLVDSRFPRSVMHGLVAAQECLAKVtVanpsg--- 245  Microl...
WP_014437878         852 agatpgRSRHHAAAEAAGRLL-AEVSGSVpaglaaveggrrealatlLERVVTGLPGLSDEVSRAY 916  Phycisphaera mikurensis
jgi:Namu_4572        252 dprrdpSSARRIVGRTRTGLDyRTGAELAadr------------eqmLATLQRTVYSAHTAVTKSF 305  Nakamurella multipar...
WP_016338202         248 --anekSEALRQLGRARSELEfLRPSDLLedl------------pkrLGALQTSIKDIGDAVSVQY 299  Amycolatopsis
WP_012395342         249 --igatTEAQRLLGQARSKLEfVQPGVLLesl------------dsrLSGLQRTCRDVGEALTLQY 300  Mycobacterium
Q0SH79               247 --vgprAEAQRLLGRARSELEfLPPGVLLedl------------qdrLAGLQETCRELGEAIALQY 298  Rhodococcus jostii RHA1
WP_013805950         247 --igarAEALRLLGRARSELEfLRPGMLLedl------------qtrLLSLLELCTEVNEAVSLQY 298  Hoyosella subflava
goetting:GPOL_c29590 249 --tgaqAEALLLLGRARSSLEfLEPGDLLdgl------------qerLLDLQDTCRAVNEAVTAQY 300  Gordonia polyisopren...
jgi:Srot_0475        247 -rvgsrNEARRIIGSARSALEyTRASDLVddl------------yarLSSVQSACLETGEAVADRY 299  Segniliparus rotundu...
jgi:Tpau_2798        250 --lgtrTEAQRLLGRARGELEfLAPGELLddl------------qrrLVALQELGHEAGEAITARY 301  Tsukamurella paurome...
BAK33288             246 --aeksAEAARLLGRLRARLEyTPIQEILsgl------------ddeMTAVQGVSTAVAGVIDKTF 297  Microlunatus phospho...
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