Conserved Protein Domain Family
Arv1

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pfam04161: Arv1 
Arv1-like family
Arv1 is a transmembrane protein with potential zinc-binding motifs. ARV1 is a novel mediator of eukaryotic sterol homeostasis.
Statistics
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PSSM-Id: 398023
Aligned: 80 rows
Threshold Bit Score: 101.55
Threshold Setting Gi: 339898498
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003834258   3 ICISCRYPVKTLYTTYSKAddralgkGVRLTQCPRCKRFADKYVEHDFVVLFIDLILIKPELYRHLLFNRLGrdddkfdv 82  Leptosphaeria m...
Q4Q9J8         3 VCIECGHGVPRII---KPD-------TETVERCGMCGRICDICYEFGDVQIWIDVVLLRHRAWAHVLFNQTD-------- 64  Leishmania major
XP_003392601   3 VCIECGHGVPRII---KPD-------TETVERCGECGHICDICYEFGDVQIWIDVVLLRHRAWAHVLFNQTD-------- 64  Leishmania infa...
XP_005993413   6 RCIECDEEAKELYRDYNHG-------VLKITICKSCQKPVDKYIEYDPVIILINAILCKTQAYRHIIFNT---------- 68  coelacanth
XP_003215870   8 RCIECNQKAAELYKDYQRG-------VVRISICKSCQKPVDKYIEYDPVIILINAILCKAQAYRHILFNT---------- 70  green anole
Q9D0U9        28 RCIECNREAQELYRDYSHG-------VLKITICKSCQKPVDKYIEYDPVIILINAILCKTQAYRHILFNT---------- 90  house mouse
XP_002591897   5 TCIECGRGAEELYRDFGGG-------NLKISHCDHCEQVVDKYVEFDPVLVLLDALLHKPQAYRHILLNS---------- 67  Florida lancelet
XP_787555     12 RCIECGFSARELYHDYGNG-------IIKISHCEKCKQVVDKYVEFDPVIVLLDALLFKPQAYRHVLFNK---------- 74  purple sea urchin
PNI55152      19 RCIECNQEAKELYRDYNHG-------VLKITICKSCQKPVDKYIEYDPVIILINAILCKAQAYRHILFNT---------- 81  chimpanzee
NP_001107083   7 KCVECNEDANELHRDYSNG-------ILKITICSSCRKPVDKYIEYDPVIILIDATLCKIQAFRHILFNT---------- 69  zebrafish
XP_003834258  83 csphalshrsqmlmrtthhPQRSILRLSILLLLFDVYLTWARIEklplppsspyyttaapslpntpftsahppppTNALV 162 Leptosphaeria m...
Q4Q9J8        65 ----------------------YYTKLVIFVLCCVVE------------------------------------------- 79  Leishmania major
XP_003392601  65 ----------------------YYTKLVIFVLCCVVE------------------------------------------- 79  Leishmania infa...
XP_005993413  69 -------------------NINIHWKLCVFCLLCEAYLRWSQL--------------------------------QGSEQ 97  coelacanth
XP_003215870  71 -------------------EISIHGKLCIFCLLCEAYLRWLQL--------------------------------QGSSQ 99  green anole
Q9D0U9        91 -------------------KINIHGKLCMFCLLCEAYLRWWQL--------------------------------QDSSQ 119 house mouse
XP_002591897  68 -------------------DIQFHWRLSVICLLCDAYIKWAQLK-------------------------------SADTT 97  Florida lancelet
XP_787555     75 -------------------VITFHWRVCIVCLLCDAYMKWAHK--------------------------------SAAPT 103 purple sea urchin
PNI55152      82 -------------------QINIHGKLCIFCLLCEAYLRWWQL--------------------------------QDSNQ 110 chimpanzee
NP_001107083  70 -------------------EINIHWKLCVFCLLCEAYLRWSLL--------------------------------QGSQS 98  zebrafish
XP_003834258 163 LQAQPLLI-------QYLFF--------------LVLVTL---------------------------------STLAFHL 188 Leptosphaeria m...
Q4Q9J8        80 ----AVVVhsltvlkAIPFFtddlensslytperQVRSLQ---------------------------------LVRIIQS 122 Leishmania major
XP_003392601  80 ----AVVVhsltvlkAIPFFtddlensslytperQVRSLQ---------------------------------LVRIIQS 122 Leishmania infa...
XP_005993413  98 DSDPTDLIryakeweFYRMY---------------GIASL---------------------------------ELTAFLI 129 coelacanth
XP_003215870 100 SPDPDDLIryakewdFYRMF---------------AIASV---------------------------------EQAAFLT 131 green anole
Q9D0U9       120 SPAPDDVIryakewdFYRMF---------------VIASF---------------------------------EQAAFLT 151 house mouse
XP_002591897  98 DSQQHQLGfyalewdFYLMF---------------LLATV---------------------------------ELALFLG 129 Florida lancelet
XP_787555    104 EGESKPFLtyalqwdFYAMF---------------MIAGL---------------------------------ELLAFIA 135 purple sea urchin
PNI55152     111 NTAPDDLIryakewdFYRMF---------------AIAALgwsavaqsqltaalnswaqaillprppqvagttEQTAYFI 175 chimpanzee
NP_001107083  99 SSDPADIIrytkeweFYCMF---------------ALAAL---------------------------------ELTVFFI 130 zebrafish
XP_003834258 189 PIRLLCCLspstptppssssptslyhklipyfP--HPTPLSTAL-------------------LI----SSCTKLFPILL 243 Leptosphaeria m...
Q4Q9J8       123 SFLPLMNYpsaif---------------hifvFtfTENALVASIatwlgrffyrsyghrerlwFVeaalASYAKLSYALF 187 Leishmania major
XP_003392601 123 SFLPLMNYpsaip---------------hlfiFifTENALVASIatwlgrffyrsyghrehlwFVeaalASYAKLSYVLF 187 Leishmania infa...
XP_005993413 130 GVFAVLWLqrp-------------------rfMkeKTTLLLKSL-------------------LL----SCYGKLLLIPA 167 coelacanth
XP_003215870 132 GIFSTLWLaksv-----------------alrTkeDLTFLLKAL-------------------LL----SSYGKLLLIPA 171 green anole
Q9D0U9       152 GIFAFLWVqqpm-----------------takRapDFVLLLKAL-------------------LL----SSYGKLLLIPA 191 house mouse
XP_002591897 130 CCMLLLRVsre------------------vlfPdvSFSSVVRAL-------------------LL----SSFGKLLVIPA 168 Florida lancelet
XP_787555    136 GVVGICFLhsals--------------nsrehWkaRSSRLVKAL-------------------LL----SSAGKLLVIPV 178 purple sea urchin
PNI55152     176 GIFTFLWVerpm-----------------takKkpNFILLLKAL-------------------LL----SSYGKLLLIPA 215 chimpanzee
NP_001107083 131 GVLVILWTaqc------------------fsgAslQFAPLLKAL-------------------LL----SSYGKVLLIPA 169 zebrafish
XP_003834258 244 IIWDYDLPSSAT-AVSWAVIVNNVAAL 269 Leptosphaeria maculans JN3
Q4Q9J8       188 LIWAIPPSMLP--MVDVLYVLW--LGC 210 Leishmania major
XP_003392601 188 LIWAIPPSMLP--MVDFVYVLW--LGc 210 Leishmania infantum JPCM5
XP_005993413 168 VIWGHDYSFLCLwLIKMFVLTSNSQAI 194 coelacanth
XP_003215870 172 VIWEHDYTHLSLkLIKVFVLTSNSQAI 198 green anole
Q9D0U9       192 VIWEHDYTPLCLrLIKVFVLTSNFQAv 218 house mouse
XP_002591897 169 VIWGETNSTVYLgLTRLFVFTCNSLAm 195 Florida lancelet
XP_787555    179 VIWGETHIYTTLlLTRLFMAVASTQai 205 purple sea urchin
PNI55152     216 VIWEHDYTSVCLkLIKVFVLTSNFQAI 242 chimpanzee
NP_001107083 170 VIWEHDFSPLCFsLIRLFVLTSNSQAI 196 zebrafish
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