2ZME,2ZME,1U5T


Conserved Protein Domain Family
EAP30
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pfam04157: EAP30 (This model is not part of the current CDD release)
EAP30/Vps36 family
This family includes EAP30 as well as the Vps36 protein. Vps36 is involved in Golgi to endosome trafficking. EAP30 is a subunit of the ELL complex. The ELL is an 80-kDa RNA polymerase II transcription factor. ELL interacts with three other proteins to form the complex known as ELL complex. The ELL complex is capable of increasing that catalytic rate of transcription elongation, but is unable to repress initiation of transcription by RNA polymerase II as is the case of ELL. EAP30 is thought to lead to the derepression of ELL's transcriptional inhibitory activity.
Links
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Statistics
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PSSM-Id: 516071
Aligned: 203 rows
Threshold Bit Score: 71.1017
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2ZME_A          7 GAGAIaKKKLAEAKYKERgtvLAEDQLA--QMSKQLDMFKTnLEEFASKHKQEIRKNPEFRVQFQD-------------- 70  human
CCA66502      341 GIHGLvELRRNEVESTAT---SMQSALQ--DLEALMKQAKE-MVALAESFNRSLKEHEAQReqlpeda------------ 402
XP_001878573  285 GISGIlKTVETSAQGRAT---HMQESLQ--DLEAFMIKAKD-MVQLAAELNEKLTAASSSTSNASTlshaspmsssatlv 358
XP_007334236  306 GITGIlRNVETSAQGRDT---DLKNALQ--DLEALMIKARD-MVKLAGELNEKLTSATSTTAVDSNsnsgtttptsstt- 378
10_pfamImport   2 GIDGIlRTVETSAQNSES---DLSNALQ--DLEALMVKAKD-LVHLAAELNEKLTASSTITTQPPRaptaspfsssysst 75 
XP_007399159  320 STDGIlQEVQTAAAATQT---NMEDALQ--DLETLKIQARE-MVRYAEELNERLTAVSALPSSFSSspapagaapgsa-- 391
EMD35198      330 GITGIlQTVDDTQRTTAT---NMQDALQ--DLEALMIKWKD-MVRLAQDLNERLTAASTSTPAYPYgvsetgpamttq-- 401
EPS99274      314 GINGIlRTVETTAATSQT---DMEDALH--DFEALTVKWRD-MVKLAQDLNERLTASSLPDAGSAKvmttqavep----- 382
Q4UIF6        127 GISRVlEIQREKIEEC-E---DLCTATT--ELSALKNKCK-----LVKEVLVKVTKYDQEGFNATid------------- 182 Theileria annu...
XP_001009663  144 GIKDMqKKEEQKQQEQQK---IVQSSFQkgDISSLFQNARE-LKEISQYLKGNLSKVDKQHEQSDld------------- 206 Tetrahymena th...

2ZME_A         71 ------------------------------MCATIGV----DP---------LaSGKGFwsemLG--VGDFYYELGVQII 105 human
CCA66502      403 ------------------------qfiigsSMARLGLvs-tVP---------S-SFEdkgk-----seaeWLDDLARELT 442
XP_001878573  359 -----------------astepeeatfirsSLSQLGLqmtnTP-----------VTLdmmk-----derrWFEELAREFA 405
XP_007334236  379 ------------------helpeeatfirsSLAQLGLqmtdVP-----------VTNdmik-----dedkWVNELAKELA 424
10_pfamImport  76 stpapsnaplfstttlvpstepeeaafirsSLSQLGLqmsnAP-----------VTMdmir-----dersWIEELARELA 139
XP_007399159  392 ------------------avepeeatfirsSLAQLGLqmsnAP-----------VTLdmiq-----derkWHEELARELA 437
EMD35198      402 ------------------avepeeatfirsSLAQLGLhmnnTP-----------VTLdmvr-----deqrWVEELAKELA 447
EPS99274      383 ----------------------eeatfirsSLAQLGLqmanAP-----------VTLdmvr-----derrWVDELARELA 424
Q4UIF6        183 -----------------------------rVFKSLGVevfsqsdnqdnsnipsnsctNS----DSdsDQEVLNQLKKILS 229 Theileria annu...
XP_001009663  207 -----------------------------kILSDLGYf---NV---------I-TKEeag--------nsYLDQLSHQIY 236 Tetrahymena th...

2ZME_A        106 EVCLAL---KHRNG-----------GLITLEELHQQVLKGRgKfAQDVSQDDLIRAIKKLkaLGTGfgi---ipvGGTYL 168 human
CCA66502      443 TVLLGVngdGGLMKh---------rGMIALDEVWGAWNRAR-G-VALIPPATFMQVLPILatQTQRrvlt-rafhSNLKV 510
XP_001878573  406 RVLQGStppKEGSGgmm-----rnrGMIALDEVWGGWNRAR-G-VALIPPSTFLQVIPLLpsCTNPpirl-rtfpSGLNV 477
XP_007334236  425 GVLKgmm---------------kdrGIIALDEVWGGWNRAR-G-VALLPPTTLLLVLPHLpnYTSPqihkrtfvkSGLSV 487
10_pfamImport 140 GVLQGSadgLAGNKtgkfigimkerGIVALDEVWGGWNRAR-G-VALIPPSTFLQTLPHLpaYTSPpirs-rvfkSGLSV 216
XP_007399159  438 GVLQGTpgrGKAAAagmm----rrrGIVALDEVWGGWNRAR-G-VALIPPATFLLALPYLpqCTDPpiht-rtfsSSLSV 510
EMD35198      448 GILQGQgktQgmm---------rkrGIIGLDEVWGGWNRAR-G-VALIPPATFLQVLLHLpgCTSPtiqmrtfgsSSLSV 516
EPS99274      425 GILQGSgggTGREglm------rrrGVVGLDEVWGGWNRAR-G-VALIPPSTLIQVVPQLpqYTDPpirmrtfaaSGLSV 496
Q4UIF6        230 LLLSKN-------------------ESILLHEFYVAANRlm--ltDLLSPSQLVKYVNRLekDYLckln--kvgnVYLIT 286 Theileria annu...
XP_001009663  237 SICNelfp--------------klgGIITLLDVFYFVNKKR-Q-TCLLNPQEVLDACSKFqaLGLNaiv---teyGNVKV 297 Tetrahymena th...

2ZME_A        169 IQSvpaELNMDHTVVlqlae-------kngyVTVSEIkasLKWETERARQVLEHLLKEGLAWLD 225 human
CCA66502      511 VHT---PWYSQKSFTsrllty----ldatgpRKTGEIarqENLSVGLVQEMIFSAEQDGAVVRD 567
XP_001878573  478 LHT---PPYTREAFAarlsrf----lvmmgpKTTIQValqENLTVSLVAEMIDIGESEGDVCRD 534
XP_007334236  488 LHA---PRYTPQAFSdrlvsy----lmsegpKTTMEVailEEITVALTKEMIDDAEMRGDVVRD 544
10_pfamImport 217 LHT---PPYTHAAFAsrlvgt----lvmagpQTGAQIaqeENITMGLAGDMIVAVEADGEICRD 273
XP_007399159  511 LHT---PPFTRAAFSarlvgl----ltlvgpRTTVDVayeESLPIGLVQEMVLEVEGVGEICRD 567
EMD35198      517 LHT---PPYTKAAFAsrmvsl----ltlagpKTTVDVaheEELPIALIQEMITEVEEAGEICRD 573
EPS99274      497 LHA---PPYTRAAFAarlvgm----lslagpQTVVQVareEALPIGLTQEMVNEVEEDGEICRD 553
Q4UIF6        287 KNH---EKISEEEFCsdligi-----lnsgpTDLIKYskeANISTTLAQVKLNLAEQIGLVVRD 342 Theileria annulata
XP_001009663  298 V------EQTTFDTEkdfqenigkyithsvgITAEQLgrkLNISPVICRIKLNKALKTGKLVID 355 Tetrahymena thermophila SB210
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