4C0D,4BY6


Conserved Protein Domain Family
NOT2_3_5_C

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pfam04153: NOT2_3_5_C (This model is not part of the current CDD release)
NOT2/NOT3/NOT5 C-terminal
NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes. This entry represents the C-terminal SH3-like domain of NOT2, NOT3 and NOT5, which mediate heterodimerization and NOT-module assembly.
Statistics
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PSSM-Id: 516069
Aligned: 158 rows
Threshold Bit Score: 84.1929
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4C0D_B        60 FASPWASSPCRP----QDIdfHVPSEY----LTNIhIRDKlAAIKLGRYGEDLLFYLYYMNGGDVLQLLAAVELFNRDWR 131 human
XP_004345483 379 FMAPWPESHRKE------PefELPPCYr---STPP---VSfPPQKIPLLSDEALFYIFYSSPRDLVQEAASMELQKREWR 446
EMR67253     336 VYSLFNDVPPRP----AVPefRLPECYsv-nNVQP---LEn---KISSFNEETLMWIFYSCPGDFQQHKAATELNNRNWR 404
EKD04185     280 FVTPWVDPTSMQhppqIEDmfVIPSCYh--------VVPPpVESKLPNFAEETLFYIFYSAPQDIVQLMAAEELYNRGWR 351
Q5KKD7       264 FVTPWAEPNSLPpp-qIEEsfHIPQCYy--------VHAPpVESKLQNFAEDTLFLAFYMSPQDVLQLRVAEELYARGWR 334 Cryptococcus ne...
CCA70388     369 FATPWADYMSVEp--tTEPnyHLPSCYnv-aPPPP---NPk---KAAQFSDETLFFTFYSMPRDLFQDIAAQELYNRKWR 439
EPT00281     453 FITPWADSSAAHt---VEPdfHLPACYnv-qPPPP---GPa---KAQAFSDETLFFMFYSSPRDALQEIAAQELFNRNWR 522
XP_003034287 426 FITPWADQSAAHs---VEPefHLPSCYav-nAPPP---GPq---KAQAFSEETLFYMFYAHPKDALQEVAAQELYSRNWR 495
XP_007329903 471 FITPWADQSAAHs---VEPdfNLPACYlsvqAAAP---GLl---KASAFSDETLFFMFYSSPRDALQEVAAQELFNRNWR 541
ESK83477     415 FITPWADQSAAHt---VEPdyHIPTCYnv-pSSVP---GPs---KAQAFSDETLFFMFYSSPRDALQEVAAQELWNRNWR 484
4C0D_B       132 YHKEERVWITRAp-------gMEP--------TMKTNTY-ERGTYYFFDcLNWRKVA-K-EFHLEYD 180 human
XP_004345483 447 FLKDAKIWFQRVpg-------hES--------TKLPQG--EKCFCTVFDpNTWEKVSk--MLVIDYE 494
EMR67253     405 WHKKLKMWLTKDeh-------mHP--------RPLSREH-EEGYYIIWNtAEWRKERr--SLTLYYS 453
EKD04185     352 FSTDLRVWITSG-----------PlsqidlhgDQSSQPSvIRGPFSVFNpATWSRQDtGgDFTVELS 407
Q5KKD7       335 YHTELQTWLTSPtlasidlskADR--------SSGQPNW-IRGPFAYLDtRTWVRQRtAeDFTIDAN 392 Cryptococcus neoformans
CCA70388     440 YHKTQRLWIHMDg--------vNP--------ESLRPGA-EPALFTIWDvEAWERQPr--MLRFDVR 487
EPT00281     523 YHKEMRVWLTKEtg-------tAP--------SQKVNGG-EHGTYSYWDpDNWEKARk--EMTVHYQ 571
XP_003034287 496 YHKELRVWITKEss-------tTI--------VQKSAHG-EQGTYTIWDpESWSKEAk--ELSVMYA 544
XP_007329903 542 YHKELRLWITKEtg-------tTP--------SQKVQGG-EQGQYTFWDpENWCKERk--EMTVLYv 590
ESK83477     485 FHKELRLWITKDsg-------aPP--------SQKIPMG-ETGQYTYWDpENWMKERk--DMTVLYS 533
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