4YKE,8BAH


Conserved Protein Domain Family
Mre11_DNA_bind

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pfam04152: Mre11_DNA_bind (This model is not part of the current CDD release)
Mre11 DNA-binding presumed domain
The Mre11 complex is a multi-subunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2, and is involved in checkpoint signalling and DNA replication. Mre11 has an intrinsic DNA-binding activity that is stimulated by Rad50 on its own or in combination with Nbs1.
Statistics
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PSSM-Id: 516068
Aligned: 135 rows
Threshold Bit Score: 115.386
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4YKE_A        290 FEVEKIPLRTVRPFVIREITL-------ATDKRfk----------gLekKQDNRQEVTKRLMQI-VEE-MIAEANEMWrs 350 Thermochaetoid...
EGT55264      356 FASKPIPLQTVRPMVCDELVL----------DKippgcrpvtrterP--KNRDGRYIDEIAIEAkLNE-MIARATSGR-- 420
EFP00620      354 FASKPIPLQTVRPMICDELLL----------DKippgcrpatkldrP--RNRDGRYIDEMAIEAkLNE-MISRAKAKR-- 418
EFX72660      297 FCIEKLPLRTTRPFVFDTLSLdefcdigYQFANd---------------------eVVEKIRSK-IND-MLDFSKTLL-- 351
XP_001961753  301 FKLKELPLQTVRPFVHESVVL-------SDLSDel---------elT--QGNASANVHKYAKKR-VEA-MIEQAKSQL-- 358
XP_001846301  292 FRLDPIKLQTVRPFVFETVNL-------AEFADel---------qlD--EGDVQQKVQNFAAEK-VEE-MIERAKGKL-- 349
14_pfamImport   1 FKLEPILLKTIRPFVFDTVKL-------SDWNMk-----------lY--GNNPSDIIQEYVDKY-IRSkLLEKAKDLK-- 57 
EFN86093      295 FKMKSIKLNSIRPFVFDNMIL-------RDHHDi-----------kV--GISLAESISQYVDQY-IENnIMCKVAEQL-- 351
EFN61231      295 FKMKPLKLKSVRPYIFENLIL-------SDHDIki----------hD--CISLADSVSQYVDRY-IENeLMPKVAKQL-- 352
EGI60927      294 FKIKPLKLQSVRPFIFDNLVL-------HDHDIkm----------rN--CVSLANAISQYVDQY-IENnIMPKVAEQI-- 351
4YKE_A        351 lhedsqdDEDEE-QPLPLIRLKVEYSspegTKFEVENP--QRFSNRFAGKVANQNDVVHFYRKKTGTTRKPKE-GKRELP 426 Thermochaetoid...
EGT55264      421 ---------GPRqPELPLIRLKVIYDgd-wINVLPANA--KRIGLRYENTVANAVDMVTIKKVSSNQAKEKKM-KDDETQ 487
EFP00620      419 ---------GPRqPELPLIRLKVIYDge-wLNITPANA--KRIGLRYENTVANAVDMVTIKKNISSEARARRQrGQQNNE 486
EFX72660      352 -------SGHPDqPTLPLLRLRIEHE----SDQQFLNTrdLHVELGLEKLVANPEDVVKLLRKRSAQDKIKVD-VDEEAW 419
XP_001961753  359 -------TGHPQqPTLPLIRLRLLYT----DEACMFNT--IRFSQMFSTQVANAQDVVLFSKIAKRKTEKEGP-QSLDKE 424
XP_001846301  350 -------TGNQKqPKLPLIRLRIEVT----EVEQQFNA--IRFGQGYSGRVANPQDMVTFKRKITRVKDELKP-LDKDAL 415
14_pfamImport  58 -------TDDPNqPTLPLIRLRIEYE----EEYECFNV--VRFGQTFTGQVANPANMVIMKRKAAARTSRKGN-RAADAP 123
EFN86093      352 -------TGYPDqPLQPLIRLRIFHE----DDNQIFDT--LSLARKYCDEVANPMEMIIFRKIKNVEKIRRAI-RDGLED 417
EFN61231      353 -------TGYPNqPSQPLIRLRIFYN----DDNEQFDT--LSLAQKYCDEVANPMEMIIFRKMKSGEKSKRF--NDEIDD 417
EGI60927      352 -------TGYPGqPLQPLIRLRIFYD----HDSEQFDT--LSLAQRYCDEVANPMDMILFRKRKTGDKGKRTI-EDEIDD 417
4YKE_A        427 egi---aeALEDSDS--ISVDALVQEFFAQQ----SLKILPQAPFGDAVNQF 469 Thermochaetoides thermophila DSM 1495
EGT55264      488 fk-----dELGHVSA--ANLQTIINDYFINQpiaeQLTVLKPFGIGKALDQY 532
EFP00620      487 la-----dELGHVSA--ANLQTMINDYFTHQplddQMTVLKPFGIGKALDQY 531
EFX72660      420 da----vfNMESINMveGHLENLLVDYYKESk--kPLLVMHERTLAEAVRYY 465
XP_001961753  425 a------iRKAMEAEnaTHVEELVARYFDGAnaknPLKLFHSKALSEMTFRL 470
XP_001846301  416 ne-----aYQNQREAtaKRAEEVVHRYFKEAdpdkQLEVLSAKSMTELTRRM 462
14_pfamImport 124 ---------EPSIPDinISMTELIEQYFEGLpekaHMKVLSRTWLAEGMSRF 166
EFN86093      418 veeitelfQGNLEQDwnRTVPGGIKKYFDMEenkdKLTVLTVTALNEALNRY 469
EFN61231      418 ldditelfQADIGQDwiSTVPGGIKKYFDMEenkdKLTVLTVTALNEALNRY 469
EGI60927      418 pddiaelfEGDKGENwtSTVQGGIKKYFDMEenkdKLTILTVTAMNEALNRY 469
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