Conserved Protein Domain Family
SCAMP
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pfam04144: SCAMP (This model is not part of the current CDD release)
SCAMP family
In vertebrates, secretory carrier membrane proteins (SCAMPs) 1-3 constitute a family of putative membrane-trafficking proteins composed of cytoplasmic N-terminal sequences with NPF repeats, four central transmembrane regions (TMRs), and a cytoplasmic tail. SCAMPs probably function in endocytosis by recruiting EH-domain proteins to the N-terminal NPF repeats but may have additional functions mediated by their other sequences.
Links
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Statistics
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PSSM-Id: 516061
Aligned: 117 rows
Threshold Bit Score: 84.1521
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_004345615 119 KPNFPF----FYPIVYISIAHDMPEQtMRNQIRLALTLWFFMMAAFIWGFls-vMIPFFDGDALnksagwdnDTaAF-FL 192
XP_004357281 360 EANYPS----FFPVTRFAVEEDIPYA-NRRLVRLSAVTFAACAVALIWNFgv-sIGALTIGAH------------GNfFV 421
Q02465        82 QANFPS----SYPMIRLNLEEDIAIReYRQIVKFGIFVFLWEAAALVYNWvv-sIGTIVYSAV------------DNfFL 144 Dictyostelium d...
XP_001329671  79 EPNWPK----FYPLVHFDIN-EVDAS-YRSYVNETFFSWVCMLVTYFLNFia-sLTLLSAGDAVn------sPG-TKiSL 144
XP_001330362  77 PPNWPA----FYPLVHFDIE-EVPPG-LRSFVNEAMFGWCLMCIAFALNWls-cVCLLNAGDSVg------sPG-TKiIL 142
XP_001568573  37 DPNFPPecccVKPIIYHNIREQVPVP-QQRFMYILAGLYITLMVLIVYNIva-aLVAFILG-----------GNvTHfGL 103
Q387I0       202 EANFPPkflcIKPLVNHTIG-MVPEP-RRKYVKFNYVIWMVNCVLLVANAsv-aITVAFSPYENefegpkasNKaQAtAL 278 Trypanosoma brucei
XP_001565560  45 LPNFPRkflcIHPLVYHSIS-VVPEH-RQLFVKMAFWDWVAVCILLVANCvv-aIGVTSAPIRSnvavnhdiNKvLNgVL 121
Q4QA24       163 TPNFPPkflcIHPLVHHSIS-TVPEH-RQLFVKMAFWDWVAVCILLLANCgi-aIGVSSAPVRSnivvhddiNKaQNgVL 239 Leishmania major
XP_001326362 101 KRNFPM----ILKIYKYYPEEELPNDaVKMVQLLKWTMYT-FTFIMFLNAlisfLSLTPCASEEi------kSPaASiVF 169

XP_004345615 193 ALIWMLAGVPLSFY-FWFFRLYTLHR----DlgaDKTpgVsyfFWFFHGLVNFLWCCIYAIGPPqIPGMAGFVVAVNIFn 267
XP_004357281 422 ALFYMLAGIPICYF-V-HRRLYRAARtgepH--------Aq-yNFLAAYMGLLAFNFIFWLGFK-KSGMHGLIWMINLF- 488
Q02465       145 ALFYMIVGVPTLYF-L-TRKLYRAASvperA--------RksyAYLMALLGVVLFNIIFFVGFK-RSGMNGLIWVISLF- 212 Dictyostelium d...
XP_001329671 145 SALYFFFICPIALD-LDALSVYRALKt---A---PST--LaftKIFICLALTLIFEFVLAVGAQ-SSGSVGLITTIDLF- 213
XP_001330362 143 STLYLFVVVPLSLD-LTGLAVYRVMKi---E---PST--FaflKVLICLSAATLFEFILAIGLD-SSGSVGLITMLNLF- 211
XP_001568573 104 SFLF-LLGIPGAWI-VWYYNVYCAIV----Y---SSR--PrqkLALLGLFLGVAFDVWMAVGVT-GFGGCGWLYAFSL-- 169
Q387I0       279 SIAY-LLGVPLSFF-VWHWPIYKACI----T---GLA--TrhlVSLCGLLVALAFAIFMLVGLP-DTGACGAILAMEVY- 345 Trypanosoma brucei
XP_001565560 122 AILY-LIGIPLSFL-LWYWRIYRGCS----T---GRP--PqhiLALCGLFIALAQAIFALVGSE-SYGVCGIILAKWIQ- 188
Q4QA24       240 AILH-LTGIPLSFL-IWYWRIYQGCS----T---GRP--PqhiLALSGLLVALAHAIFALVGPK-NYGLSGIALAKWIQ- 306 Leishmania major
XP_001326362 170 ACVY-FAFGPLVFTeICLMLLYDSLK----N---KKG--AryfFSIITIFLYLAFCIYVIVGLS-DYGSFGYIISINLLr 238

XP_004345615 268 asEDSNKLYATFIVISGVIWTVCAGFSL-LFLLWIVRWYRSS 308
XP_004357281 489 --HNDHNAVGALNVISLFFFTVTLILVAgIFFKVLRTTYTKR 528
Q02465       213 --HNDHNAVGAMATVSLFFWFVGVF----LTIALFIMYLRLN 248 Dictyostelium discoideum
XP_001329671 214 --ASKCVGTGIFGIIVTICFAVTIFFTT-KLLIRLWKFFRGT 252
XP_001330362 212 --FNGHWFIGILGILTTAALGLTCANHG-RLVLGIWKYYRGT 250
XP_001568573 170 ---MRTVTSFVMILISAILWSLHGFALC-VVMLRYWRVSGTL 207
Q387I0       346 --EGKSNYLLIPLGVVISLWCFETAYFF-YCMVVQWKFYRLD 384 Trypanosoma brucei
XP_001565560 189 --ETRATGVVVPVAVIAVLWAVQAVFTC-YMITKMFIFYRRD 227
Q4QA24       307 --ATRESGVAAPVAIMAVLWAAQAVFTG-FMIFKVFVFYRRD 345 Leishmania major
XP_001326362 239 --APKNKWVGIVALIFSILGTLHCVFLG-WVWWMIVVYFKRN 277
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