1RQ1


Conserved Protein Domain Family
ERO1

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pfam04137: ERO1 (This model is not part of the current CDD release)
Endoplasmic Reticulum Oxidoreductin 1 (ERO1)
Members of this family are required for the formation of disulphide bonds in the ER.
Statistics
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PSSM-Id: 516058
Aligned: 143 rows
Threshold Bit Score: 231.296
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1RQ1_A         27 NIRDDLSALLKSDFFKYFRLDLYKQCSF--Wd--------ANDGLC-------------LN------------------- 64   brewer's yeast
XP_001470947   63 QTHLLLSHIQQQKFYRTIKVPKDQQCLYfkQq--------EEHAVC-------------KN------------------- 102 
Q24DE0         73 KIYQKLDELSHTKFFRTFKVNIDTECKFf-----------SVEGIC-------------KS------------------- 109  Tetrahymena t...
A0CXB3         84 QIFPLLDELTYKKYFKIFRVNLENDCPFs-----------IGEYIC-------------TS------------------- 120  Paramecium te...
Q4MZU9         82 TIHLKLSNILSDYYFRIFLVNLDSNCKSk-----------PRINSCpsqthylsldknkTKngatpfsllnt------pt 144  Theileria parva
Q57UW3         73 GITGLLNNITSHPYFRYFKVNLDRECRY--Wv-------aEASCTC-------------DS------------------- 111  Trypanosoma b...
XP_002503130   43 QLHEILAELTNTTYFRLFPVDLSRKCKF--WnkqketdedKHEPSC-------------SApaeedpsnpfggg--ssna 105 
XP_003061145   55 ELHELLGELADTTYMRLFPVDLNRPCKF--WgkdagagaeEETPSCaagdasdadeepaSAafshsssssfagdravsla 132 
XP_009515583   79 HFHPLLHELSRLTFFRYFKVDLGKECPYlpWq--------DD-GMC-------------AS------------------- 117  Phytophthora ...
XP_001464642   71 SLLDILNRITVSPYFRYFKVNSAKPCPY--Wa-------vSLLCTS-------------AE------------------- 109  Leishmania in...
1RQ1_A         65 --------RACSVDVvEDWDTLPEYWQPE---------------------------ILGSFNNDTMkeaddsddeckfld 109  brewer's yeast
XP_001470947  103 --------KSCSICK-CEQEDIPLEWRKEdq------------------------------------------------n 125 
Q24DE0        110 --------QGCSVCR-CDENNIPLPWKKT-----------------------------DFIQQSKY-------------- 137  Tetrahymena t...
A0CXB3        121 --------KKCVICT-CNTSEIPSNWLSP---------------------------ASSPIKQPK--------------- 149  Paramecium te...
Q4MZU9        145 pnsnktevAKCHVDR-CNSREVPLSIMGNrk------------------------------------------------- 174  Theileria parva
Q57UW3        112 --------NGCQICT-CDDSGIPETLKYPyd-----------------------msDVSTVERRAA-------------- 145  Trypanosoma b...
XP_002503130  106 fapaeqapTACSLDL-ASKD--PGSMKWAp--------------------------ATTPVDRRITeq-----------e 145 
XP_003061145  133 pslepsaaPSCSLTP-PSPIDNPRLGERQs--------------------------ATTPVDRTISpr-----------e 174 
XP_009515583  118 --------IDCAVCE-CPSHEIPAPWSQLdqqetqsrnvektgeagkpcdeqtgesTLSKVERKNA-------------- 174  Phytophthora ...
XP_001464642  110 --------NTCDVCK-CDENSIPEALRADed-----------------------msELNTPDGSVA-------------- 143  Leishmania in...
1RQ1_A        110 qLCQTSKKPVDIEDTI---------N----------------YCDVN--DFNGKN---AVLIDLTANPERFTGYGGKQag 159  brewer's yeast
XP_001470947  126 eCYIKNNDYEDETTQK---------Eky------------dwYWSLN--QENDFKd--GEYVDLVENIEGYTANKEPN-- 178 
Q24DE0        138 -------------------------DyadwaqepevkitdewQWRVE--EFNESE---GSYVDLKDNVEAFTGYQGQN-- 185  Tetrahymena t...
A0CXB3        150 -------------------------DnfafwdserylspsewIWHVE--DIENDK---GVYVDLKLNPEAFTGYQGQH-- 197  Paramecium te...
Q4MZU9        175 eNYVLRFSEGLVGSTDgfg---fnrD----------------FLVRS--NLVPDN---CVFVDLLRNPPSYTGYNGQD-- 228  Theileria parva
Q57UW3        146 ------PDKHAAKGFE---------D----------------EIKPI--DPDRD----ATYVDLLQNPEANTGYSGPKaa 188  Trypanosoma b...
XP_002503130  146 hVAIAANDDGANDCADadlp-efwmD----------------MCGYDapPPGSEDhgaLEYVNLQLNPERWTGYNGSH-- 206 
XP_003061145  175 dAALASASAPEEDCEEdessptfwlD----------------MCRAQ--DAQETHa--TEHVNLKRNPERWTGYNGSH-- 232 
XP_009515583  175 -VAGESFNEWEEVSNA---------N----------------VWATQ--GEAEET---MTYINLLENPERYTGYSGVQae 223  Phytophthora ...
XP_001464642  144 ------KTVLQPVNLD---------D----------------WGDWL--KADDG----AEYVDLASNPEGNTGYSGPLaa 186  Leishmania in...
1RQ1_A        160 qIWSTIY-----QDNCFTI---------------GET------------GESLAKDAFYRLVSGFHASIGTHLSKEYLN- 206  brewer's yeast
XP_001470947  179 -IWKIIY-----TEDCFqg-----------------------------qQLSSEKMVLNSIISGFHASISSHICEFYQDl 223 
Q24DE0        186 -IWKLIY-----EENCF------------------Qge-----------dLCLEQRALNRILSGLHASVSTQLSELYIDf 230  Tetrahymena t...
A0CXB3        198 -IWDVIY-----RENCY------------------Qgs---------lnEMCKEKRALNKLVQGLHTSISTQLSEFYVD- 243  Paramecium te...
Q4MZU9        229 -DWRLMYdeidkYDNMS----------------------------------CKESLHFYKLISGMRGAISAFSALNYECt 273  Theileria parva
Q57UW3        189 rVWQAVY------NNCNI-----------------Dglpsn---dtagvEN-REKALLRQLLSGLHTSITMHVAAFFYNd 241  Trypanosoma b...
XP_002503130  207 -VWSAIY-----EENCL------------------Kqsg-------svdDMCYEERVLYRLLSGMHASVNIHIALKAKTp 255 
XP_003061145  233 -VWRAIY-----DENCLRNgrrdgrrevmggggdAIVggasesestgidGLCYEERVLYRLLSGMHASVNVHVALRAKPp 306 
XP_009515583  224 rIWKSIY-----EENCFt----------------pPees-------kldGMCLEERVYYRLISGLQASINTHIALTYKF- 274  Phytophthora ...
XP_001464642  187 qVWRAIY-----AENCL------------------Ssd---------kdGTCQELSILRTLLSGLHMSINIHVCTSFYKd 234  Leishmania in...
1RQ1_A        207 --------------------TKTGKWEPNLDLFMARIGNFPDRVTNMYFNYAVVAKALWKIQPYLPE------FS----- 255  brewer's yeast
XP_001470947  224 -------------------sKEEAKLNPSWEFYFEKVGNYEDRIKNLLFYYEFLLRAVQKSSEVFVN------FP----- 273 
Q24DE0        231 -------------------nKNRTKMYPNWKLYFEKVGNYPERIHNLYFYYSVLLRAINRAESVIRN------YN----- 280  Tetrahymena t...
A0CXB3        244 --------------------LSTNKTYPNYPMYFERVGNHPERIRNLFFLYSVLLRAVQLATPGIQK------HEinsms 297  Paramecium te...
Q4MZU9        274 naye-----------ayedqTELPSYQSNYHYYNNKLSKHKDRLENIYYTYKYILSAVVRLKGYLDN------------- 329  Theileria parva
Q57UW3        242 tkgdsplrslgvlnnpnisfY------PNCGMF-RRIVKNDEFIRNLFVVYQFVLRALAKTKRAFLAnsslynSG----- 309  Trypanosoma b...
XP_002503130  256 kk----------------gvVGREDWSADPARFAAHYGQHPERLRNLHFSFVVLLRALRKAAPTLGV------MD----- 308 
XP_003061145  307 k-----------------raAGIAEWSEDPERYARHYGEHPERLRNLHFSFVVLLRALRKAAPALLD------VD----- 358 
XP_009515583  275 ---------------------GN-SWGMNPSLFVNRVGKHRERLQNLYFAYLFVMRAISKYRHELLA------YD----- 321  Phytophthora ...
XP_001464642  235 pelsspqrnagiynnpnisfF------PNCQMYNKRIAPFPDFVGNLYILYQFTLRALAKSRSFFTNdvsifnTG----- 303  Leishmania in...
1RQ1_A        256 FC----DLVNKEIKNKmd--nvI-SQLD----------------TKIFNEDLVFA--------------NDLSLTLKDEF 298  brewer's yeast
XP_001470947  274 YKtg-dLESDKEVVQLikgfisQiTSQNrv---------------lQFDVN-LFK--------------DQDSVEIKRNY 322 
Q24DE0        281 FTtg-dFQEDAKTYQLvgdildYtTSQCd----------------qPFHEEILFN--------------TDQGRKYKKHY 329  Tetrahymena t...
A0CXB3        298 FD------EDTRSQYLlnnilnLgNSQCs----------------kAFDEQQFFN---------------QITFEQKKDY 340  Paramecium te...
Q4MZU9        330 FNs---------NLQLvnndlyL-----------------------HLKDFLTFInksnittdsngsnhNNLQTECGKEM 377  Theileria parva
Q57UW3        310 FNga-aTDGDVr----------LySNIGelfss-------klfrVATFDEQKFFE--------------SPGAHLLVRQM 357  Trypanosoma b...
XP_002503130  309 LSlgqdKAEDARTGALmr--rlLdTHILssc----------sgvFGAFDESMLFRggagv-----ngeaSSPVAELKSQF 371 
XP_003061145  359 VKlgedAVEDARTEALmr--rlLdTHILssc----------agvFDAFDESELFRasis-------stsDASAASLKTQF 419 
XP_009515583  322 YNtg-nAADDLRVREIlrqlllEgSDDArasgvscpayaecssvLSGFDESALFRvqadglsidqlvqaKQEKEQLEVQF 400  Phytophthora ...
XP_001464642  304 ARge-aTLTDLq----------LhDNIKelfns-------rlicSPTFDEGAFLE--------------SEKGRSLIPQF 351  Leishmania in...
1RQ1_A        299 RSRFKNVTKIMDCVQCDRCRLWGKIQTTGYATALKILFEINDADeftkqhiVGKLTKYELIALLQTFGRLSESIESV 375  brewer's yeast
XP_001470947  323 QKYVKNIAQLMDCVSCEKCKLFAKIQVQGISLAMNIIFADNSDEr------VKYMKRNELIALINTLHKSSESIQII 393 
Q24DE0        330 QQYIHNITKIMDCVECEKCKVFGKMQVYGIGVALKILFSDDSSTq------IQKLQRNELITLINAFVKCASSLDVV 400  Tetrahymena ther...
A0CXB3        341 QRYIHNISRIMDCVECQKCRVFGKMQTYGLGTALKILFSESPSEf------SGKLKRNELVALINTFGKVSSSVKSI 411  Paramecium tetra...
Q4MZU9        378 VEKFDRLIELVNCVECEKCKLHGKLKLSAIQTSIKILMTDVDKLg------ELDLNRNDLVALFHGLDYFAQSILII 448  Theileria parva
Q57UW3        358 KRVVHNVTTLMDCVTCEKCRAWGKLETAALATALKIVFGSAEN--------VVELNRGERVALINFARQLAISVKNV 426  Trypanosoma brucei
XP_002503130  372 KGVFHNISEVMDCISCQKCKLHGKLQLLGLGTALKVLLLPEHLH-------ATALSRSEVVALVNTVAKFSHAILAA 441 
XP_003061145  420 KGVWHNISDVMDCISCQKCKLHGKLQLLGLGTALKVLLLPEHLH-------RGALSRSEVVALVNTAAKFSHAILKA 489 
XP_009515583  401 REKFQNVSRIMNCVTCEKCRLWGKLQTMGLGTAIKILLAEDVST-------IPKLHRNELIALINVANNLSRSVDGV 470  Phytophthora sojae
XP_001464642  352 KAMMLNVTRLMDCVTCEKCRIWGKLETKGIAVAMKVIMNPENE--------RITLDRSEMVTLVNLARQLAFSVRNA 420  Leishmania infan...
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