Conserved Protein Domain Family
COG3_N
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pfam04136: COG3_N (This model is not part of the current CDD release)
Conserved oligomeric Golgi complex subunit 3, N-terminal
This entry includes the Conserved oligomeric Golgi complex subunit 3 (COG3, also known as Sec34) which is a component of the peripheral membrane COG complex, involved in intra-Golgi protein trafficking. COG is a member of the complexes associated with tethering containing helical rods (CATCHR) family which also includes the exocyst, GARP and DSL1 complexes, which are evolutionarily related and share structural features consisting of alpha-helical bundles towards the C-terminal and an N-terminal coiled-coil region.
Links
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Statistics
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PSSM-Id: 516057
Aligned: 88 rows
Threshold Bit Score: 119.164
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_013934077 108 EFQNYLRYNYEENKQFLKETNAIIQDLNKLLVIGDQVTLQTVDFQKKSTQLIVEIEQLNRLHENISSNLTLFESLDPIVQ 187 
XP_001324484  52 IKRDKTEKMIESAEYLIDKIKECKEQLQLAEDKRKVISANAELIHGECDSQLAAEQRLDIFVRSIDSILHYFDDLEKITV 131 
CCJ28477      92 LLKKEYLKKLSISENLMTQVSNILEKLELINNDVKNACKNSYNFRIDYEKLIKEEQNMIILDNQITENLEVYDSLDMAFK 171 
XP_007875229 101 LFKKEYLEKISICEDLITHVSKMFEKLRVINIDLKKSYENSHVFRNNYEKLEKEKQNAILLKDQIRQNLEAYCSLDVIYK 180 
XP_003678696  78 NYLGQLESHVQRYEMVLQQSYKVHDQIEHAIQTFNSISSNSNDFVNKTKNLYEENHQLSALHEKIPAIMQYFTALDPIMR 157 
XP_004181423  91 TYLEQLDSNIYNYNLVLNQTILVENQLTSIIDKFNDVKTDTTNFIEIINNVNNEYSKLNKINQDIPAILNHFEILEPIMR 170 
XP_002172710 101 kLLEQLNVTAAYTDCLITKSDTLHESLSLLRNRFSRSEKEMLEFSMRCDELTSGERTLLHTADKIQESWNYFQPLKELSK 180 
Q9Y7Z4       103 kKINELQTFTNIIDQILGQTNNIESTLLSMKEKFESSEKKLSEFSEMCENLSTDEMRFSEIADGIRKGLTIFAPLKELTR 182  Schizosaccharo...
XP_013022400  99 iCMRELQAYSAFADRLSQQTSEIKQTLSSIKNTFLTSEQKLNEFSQTCDTLGTEEEAFARLAVDIDHGLSYFAPLKELTR 178 
XP_015790918 102 irfkCLQDNLNLCQTLSKQIECLLDNLYYLKKMFDSKASKITSVHSMCENILQQERSLIMAVEAINEKLNYFKELEVMTK 181 

XP_013934077 188 TL-NTSssGSIVAKDSFrHDILEELDRCLIFVHdpKHSTFKEIGIYKHRFKQCMIRALTLVKNYITTAIRD 257 
XP_001324484 132 DF-KSP--IFSVLSPDF-QNNLKIIENGIRFFE--VNPKFKDSRNYYLKYQSNQQKVTDLIKDFMSTTFNR 196 
CCJ28477     172 LL-NTSg-IEFIKKPEF-FNILKKLDKGLLMMK--KHPEYKDSKMYSIKFKQCLTKAMTLICIFFVQIMKE 237 
XP_007875229 181 LL-NTSg-VELITKPEF-FDMLKKLDKGSQMMK--EHPEFKNSWIYREKFEQCLTKAMTLICVFFVQVIKE 246 
XP_003678696 158 RL-NHAssSNVVRKNSF-GNMLISIDQSLFFFE--EHPNLEEAELYRIKFKRCLIRACELVSNYLSGILRQ 224 
XP_004181423 171 RLkNSSssLKIVQRDSF-KTMLKNIESSLVFLE--LNKNFKDYEIYRIKFKQCLIRCIELITNYSVTLLKN 238 
XP_002172710 181 LL-HKPa-PDLVTKYVF-KDALSQLYRCIAFLQ--LHNNFLDSPEYLEQYERLLSNALGIIRTYFIRSIKS 246 
Q9Y7Z4       183 VF-RHPp-PDFAGKVSF-KEHITQLNTCIMFLE--ENLDFQESPHYLGQYKKLLSQAMDIFKPYFIRIIKQ 248  Schizosaccharomyces pom...
XP_013022400 179 VF-RHPp-SDLVSRSSF-RDHVLQINKCIQFLE--ENMDFQESDVYLTQYKRLLTQAFTMFKNHFFRLIKV 244 
XP_015790918 182 KL-GSS--SVLILNESL-MPTLTRLDECINFLA--CKSNYKESEHFIDQYKILQDTALETIKKYVINSIQN 246
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