8Q62,6V69,6V6S


Conserved Protein Domain Family
GCP_C_terminal

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pfam04130: GCP_C_terminal (This model is not part of the current CDD release)
Gamma tubulin complex component C-terminal
This is the C-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast. Furthermore, family members such as human GCP4 (Gamma-tubulin complex component 4) have been structurally elucidated. Structure-based sequence analysis revealed the existence of an exposed surface area conserved in all human GCPs and in GCP4 orthologs. This area is located in the C-terminal domain of GCP4, which was confirmed in vitro to bind directly to gamma-tubulin. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains.
Statistics
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PSSM-Id: 516054
Aligned: 222 rows
Threshold Bit Score: 136.995
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8Q62_C        509 LVAHLRSIKRYFLMDQGDFFVHFMDLAEEEL-----RKPVEDITPPR---LEALLELALRMSTa-nTdpfkdd------- 572  human
NP_001345669  689 LMDELFVLRAIYLLGSGDMLQQFLITIFDKLdrgnsWDD---DFE-----LNNLLQESIRNSadkmlltapds-lvvsla 759 
ERN16739      673 LMDELGLLRAIYLFGSGDLLQQLLTVLFDKLdrgeyWDD---DFE-----LNTLLQESIRNSadgmllsipds-lvvtis 743 
CDY37582      901 LMHELAVLRAIYLLGSGDLLQHFLTVIFNKLg---kGELTNDDFE-----LNIILQESIR-NSad--------------- 956 
EYU25384      603 LMDELGVLRAIYLLGSGDMLQHFLSVIYNKLd---kGESLDDDFE-----LNTLLQESIR-NSad--------------- 658 
XP_004238185  629 LLEELEVLRAIYLLGSGDLLQHFLTVVFNKLd---kGESLDDDFE-----LNTTLQESIR-YSad--------------- 684 
KZN00030      619 LMDELGLLRTIYLLGSGDLLQHFLTVIFNKLdkgesWDD---DFELNmesIRNSADGMLL-Sapdalv-----------v 683 
XP_039171616  652 LMDELAVLRAIFLLGSGDLLQHFLTVIFNKLd---rGENCDDDFE-----LNTLLQESIR-NSad--------------- 707 
XP_007225377  655 LMDELAVLRAIYLLGSGDLLQHFLTVIFNKLdkgetWDD---DFE-----LNTILQESIR-NSadgVllsvpdslivslt 725 
KOM51534      660 LMDELAVLRAIYLLGSGDLLQHFLTVMFNKLdkgeaWDD---DFE-----LNTILQESIR-NSsdcMllsapdslv-vti 729 
8Q62_C        573 lkidlMPHDliTQLLr----VLaietkqekamahadpTELAl-----------------------------SGLEAFSFD 619  human
NP_001345669  760 kydthNGEEgiSTSKk---gRA---------------LGFGi-----------------------------DALDMLNFT 792 
ERN16739      744 khparDGEHalSPVStpkssRN---------------HSFGi-----------------------------GALDPLQFT 779 
CDY37582      957 ----aMLLNspDSL------VV---------------SISRegcldkdkddkgdvvplsstrksrinnfgiDCLESLKFT 1011
EYU25384      659 ----nVLLSapDSL------VV---------------SVSRspgfgedeqnspsi---stprkgrnqssgmDVLDSLKFT 710 
XP_004238185  685 ----aALLStpDSL------VV---------------SVTRnnatieddqrgmpll-tsiprksrgqnfgiDGLDSLMFT 738 
KZN00030      684 sitkdNGANveEKLSas-alVS---------------TPRKtkgn-----------------------fdiDGLNSLKFT 724 
XP_039171616  708 ----gNLLTspDSL------IV---------------SISRsqgsnndeqntttaf-tstprkgsvqslgiDGLDSLKFS 761 
XP_007225377  726 knhdlNGNEqpPNM------AS---------------QPSTprksra-------------------hsfgmDGLDQLKFT 765 
KOM51534      730 tknsvDNDEqaSTS------GT---------------ALNAprqshv-------------------nsfgiNGLDMLKFT 769 
8Q62_C        620 YIVKWPLSLIINRKALTRYQMLFRHMFYCKHVERQLC-----S-V-WisnkTAKQHSLHS-AQWFAGAFTLRQRMLNFVQ 691  human
NP_001345669  793 YKVSWPLDLIINTEALKKYNQVMGFLLKVKRAKFVLDetrkwM---W----KARGRTAHN----FKQHLIVAQKLLHFVD 861 
ERN16739      780 YKVSWPLELIANQEAIKKYNQVMNFLMKVKRAKFVLDkarrwT---W----KDRGATNIN----QKRHLLLEQKLLHFVD 848 
CDY37582     1012 YKVPWPLELIANSEAIKKYNQVMGFLLKVKRAKYVLD-----KaRrW-----MWKGKGSA-TKIRKHHWLLEQKLLNFVD 1080
EYU25384      711 YKVSWPLEVIANAEAMRKYNQVMSCLLKIKRAKFVLDkarrwM---W----KDKGTATIK----RKRYWLLEQKLLHFVD 779 
XP_004238185  739 YKVPWPLELIANTEAIKKYNQVMRFLLKVRRAKFVLD-----KaRrWm--wKDRSSASIN----RKHHWLLEQKLLHFVD 807 
KZN00030      725 YKVPWPLELIANTEALKKYNQVMSFLLKVKRAKFVLD-----KaRrWm--wKDRSSTTLT----RKRHWLVEQKLLHFVD 793 
XP_039171616  762 YKVSWPLELIANAEAIKKYNQVMGFLLKVKRAKFVLD-----KaRrWm--wKGKGIATYS----RKHHWLVEQKLLHFVD 830 
XP_007225377  766 YKVSWPLELIANVEAIKKYNQVMGFLLKVKRAKFVLDktrrwM---W----KGRGTAANNhKRH----WLVEQKLLHFVD 834 
KOM51534      770 YKVPWPLELIANTEAIKKYNQVMRFLLKVKRAKFVLD-----KvRrW-----MWKGRGSA-TNYRKHHWLVEQKLLHFVD 838 
8Q62_C        692 NIQYYMMFEVMEPTWHILEKNL-KSA-SnIDDVLGHHTGFLDTCLKDCMLTNP--E--L--L----KVFSKLMSVCVMF- 758  human
NP_001345669  862 AFHQYVMDRVYHSAWTELCDGMtAa--TtLDEVMEVHEAYLSSIQRQCFVASD--KlwAliA----SRVKTILGLALDF- 932 
ERN16739      849 AFHQYVMDRVLHSAWLELCEGMaSa--GsLDEVIEVHESYILSVQRQCFVAPDklw--amiA----SRIRSILGLALDF- 919 
CDY37582     1081 AFHQYVMDRVYHTAWRELCEAM--VKaGsLDEVIYVHETYLLSIQRQCFV-VQekLwaI--Ia---SRINMILGLALEF- 1151
EYU25384      780 AFHNYVMDRVYHNAWRELCEGVaAa--GtLDEAIEVHEAYLLSIQRQCFV-VPdkLwgLi-----aSRINSILGLALDFy 851 
XP_004238185  808 AFHHYVMDRVYHSAWGELCEGL-AAArS-LDEVIEIHEAYLMSIQRHCFAVPEk----L--WaliaSRINSILGLALDFy 879 
KZN00030      794 AFHQYVMDRVYHSAWRQLCEGV-SAAgS-LDEVIEVHEAYLLSIQRQCFV-VPdkLwaLi-----aSRINTILGLALDFy 865 
XP_039171616  831 AFHQYVMDRVYHSAWRELCEGM-ATArS-LDEVMEVHEAYLLSIQRQCFV-VPdkLwaLi-----aSRINSILNLALDFy 902 
XP_007225377  835 AFHQYVMDRVYHNAWRELCEGMtAa--RsLDEVIEVHELYLLTIQRQCFV-VPd---kL--WaliaSRINNILGLALDFy 906 
KOM51534      839 AFHQYVMDRVYHSAWLELCEGM-GAAkS-LDEVIEVHETYMLSIQRQCFV-VPd---kL--GaliaSRINSILGLALDFy 910 
8Q62_C        759 --TN--CmQKFTQSMkldgelggqtlehstvlglpagaeerarkelarkHLAE-HAD-TVQLVSG---FE--ATINKFDK 827  human
NP_001345669  933 --HN--VeQTLSTGG----------------------------------TASA-VRTr----------CE--MEIDRIEK 961 
ERN16739      920 --HS--IqHTLC-SG----------------------------------GAAP-AIK-Ar--------CE--LEVDRVER 948 
CDY37582     1152 ------------YSI----------------------------------QQTLsSGGaVSAAIKAr--CE--MEIDRIEK 1181
EYU25384      852 ------SiQQt-LS-----------------------------------SG-----GaIS-TVKA----RceKEVERIEK 879 
XP_004238185  880 ------SvQQt-LS-----------------------------------SG-----GaVS-AIKA----RceMEINRIEK 907 
KZN00030      866 ------SiQQt-LS-----------------------------------SG-----GtIS-TIKA----RceMEVDRIEK 893 
XP_039171616  903 ------SvQQt-LS-----------------------------------SG-----GaIP-TIKA----RceMEVERIEK 930 
XP_007225377  907 ------SiQL----T----------------------------------LS-----GgTVSAIKAkceME----VDRIEK 933 
KOM51534      911 niQQtlSgGG----------------------------------------------------AASaikARceMEVDRIEK 938 
8Q62_C        828 NFSAHLLDLLARLs-I-Ys--tSDCeHGMASVISRLDFNGFY 865  human
NP_001345669  962 QFDECVIFLLRILs-FkLn--vGHf-PHLADLVTRINYNHYF 999 
ERN16739      949 QFDECIAFLLRVLs-FkLn--vGHf-PHLVDLVTRINYNYFY 986 
CDY37582     1182 QFEDCIAFLLRVLs-SkLn--vGHF-PHLADLVTRINYNYHY 1219
EYU25384      880 QFDDCMAFLLRILsvK-LnvgqFP---HLAALVTRINYNCFY 917 
XP_004238185  908 QFDDCIAFLMRILsfK-LnvgqFP---HLADLVTRINYNHFY 945 
KZN00030      894 QFDDCIAFLLRVLsfK-LnvgqFP---HLADLVTRINYNYFY 931 
XP_039171616  931 QFDDCIAFLLRVLsfK-LnvgnFP---HLADLVTRINYNYFY 968 
XP_007225377  934 QFDDCIAFLLRVLsfK-LnvghFP---HLADLVTRINYNYFY 971 
KOM51534      939 QFDDCIAFLLRVLsfK-Lnvg---hfpHLADLVTRINYNYFY 976 
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