Conserved Protein Domain Family
CW_binding_2

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pfam04122: CW_binding_2 (This model is not part of the current CDD release)
Cell wall binding domain 2 (CWB2)
This domain is found in 1 to 3 tandem copies in a wide variety of bacterial cell surface proteins. It has been show the three tandem repeats of the CWB2 domain are essential for correct anchoring to the cell wall. It was shown that in SlpA and Cwp2 that these domains were essential for the binding of PSII an anionic teichoic acid-like component of the cell wall. The structure of the Cwp8 and Cwp6 proteins shows that this domain forms a trimeric arrangement with each domain adopting a structure with some similarity to the Toprim fold. A groove containing many conserved residues was predicted to be the site of the PSII molecule.
Statistics
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PSSM-Id: 516051
Aligned: 734 rows
Threshold Bit Score: 30.6089
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_021934834   277 RFSGSNRYKTAIEIAK-Ay-----KdvlnrdidtviL--VSAdsF----PDALSATPLACKKNAAILLTnKd----rLNK 340 Peptostreptoc...
359_pfamImport   1 RIGGQDRYETAALVAErLg-----Gng--------qAilAnG--Dt--fPDALAIGPYAGATETPILLTqasqlpqsTQT 63 
WP_015263576   136 RIGGADRYETAALVADhLg-----Gng--------qVvlTsG--En--fPDALAIGPYAGITETPILLTkaqelptiTRH 198 Desulfitobact...
Q24S73         116 RIGGADRYETAALVAErLg-----Gng--------qVilTsG--En--fPDALAIGPYAGITETPLLLTkakelpevTRQ 178 Desulfitobact...
199_pfamImport   1 RYGGANRYATAAAIAEaMg-----Qtg--------kAvlVnG--EtahyPDALAISPYAAYHGIPILFTeasrlpaeTAR 65 
188_pfamImport   1 RYGGADRYATAAALASaLg-----Ttg--------rAviAnG--EdghyPDALAISSYASYLGVPILFTatnalpavTEQ 65 
343_pfamImport   1 RLGGANRYATAQQIANeL------Gmt-------geAvvVnG--Dn--fPDAISMSSIAAQYGVPILLTavndlpqeTDQ 63 
257_pfamImport   1 RIAGDNRYETSANIAKyLqenqklRtn--------kAviAyA--Qn--fPDALAVSSWAAQNGVPILLTetntlpdaTAD 68 
230_pfamImport   1 RISGHSRTDTAALIASeVsp---kGse--------kIviAnG--Yd--fPDALSIASYAANEGIPILLTeskklpagTKA 65 
205_pfamImport   1 RIAGSDRFGTAAAIAE-Kl-----Gntg-----qavI--VSGsnY----PDAVAAAAHAAISGRPILLTgSf----sLNS 59 
WP_021934834   341 YTAay---lKEANn--iKNVIIVGGQGAVSAE 367 Peptostreptococcus anaerobius
359_pfamImport  64 ELkkla----------ateTLVVGGEGAVSSN 85 
WP_015263576   199 RLegfgayqLNEeaeavtrTIVVGGEGVIAPT 230 Desulfitobacterium dichloroeliminans
Q24S73         179 KLvelgayqLNQeseavtkTTVVGGEKAISPE 210 Desulfitobacterium hafniense Y51
199_pfamImport  66 ALttqn----------vgaAIIVGGEGAISAE 87 
188_pfamImport  66 TLteqk----------vsaSIVVGGEGAVPAG 87 
343_pfamImport  64 LLrqla----------vtgTVVVGGKGVISTH 85 
257_pfamImport  69 VLtdlq----------isdTIITGGTSVISAQ 90 
230_pfamImport  66 SInklk----------akeTIVVGGPLAVNES 87 
205_pfamImport  60 TTRqt---lRKLSv---TETEVIGGEGAVSSR 85 
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