Conserved Protein Domain Family
Ureidogly_lyase

?
pfam04115: Ureidogly_lyase 
Ureidoglycolate lyase
Ureidoglycolate lyase (EC:4.3.2.3) is one of the enzymes that acts upon ureidoglycolate, an intermediate of purine catabolism, releasing urea. The enzyme has in the past been wrongly assigned to EC:3.5.3.19, enzymes which release ammonia from ureidoglycolate.
Statistics
?
PSSM-Id: 397990
Aligned: 45 rows
Threshold Bit Score: 160.833
Threshold Setting Gi: 74691738
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q0U7M7         9 SIRIPIELLTPTAFAQFGVIVENpTtslsa---klpiPQRipp--peSVNANQGSATKYLDVSHMSNLYslap-skkPAR 82  Parastagonospor...
Q5KIN4       382 PMIIPALPLTPEAFKPYGQVVQGfS------------LPTsapkgihVNIANQGTAFKFHRLAKPAESYapg--llqKGG 447 Cryptococcus ne...
O13843         3 AKKIYAQALTDEAFAPFGSVVQQkD------------DVK-------MVSANGGTAKKYLKVSESIQNYekss-sasTRK 62  Schizosaccharom...
Q5BDA0        11 SLSITPEPLTRDAFAPFGTAVIPpLprsvttapnplsSHPkhplvtfPVAANQLSALKYSPISPLINNYpsqcpsnqPSE 90  Aspergillus nid...
Q7RW83        13 dmVVDAVPLELEAFKPFGDAVANpQpnlhpamaakanD-Tagm-pfdAIVANQGTAIKYQHVSRIENLYdqap-sgrTGV 89  Neurospora crassa
Q6C2M0        10 TRSVFVKPLTIDNFAPFGGVMSL--------------EHQqr---peDVGANYGTATKIKDVSPVTNNFayap-skqPAR 71  Yarrowia lipoly...
Q6BHQ1        11 IGTVIAEPLTPEAFAPYGGVISA-D------------HQIks---vtSTAANYGTAVKIHKVAPIVNNFkdcp-sgkEAT 73  Debaryomyces ha...
XP_001383536  11 IPAITAEPLTPEAFAPFGGVISA--------------DHQien--aaSSSANYGTATKIHKVAPIVNNYdkcp-sgvVAT 73  Scheffersomyces...
Q74ZI4        14 PPMIVPVPITAAAFEPYGSLMSH--------------SDQlag--caARNANQGTAVKVHAGTTRCLLGs------aVRE 71  Eremothecium go...
Q6CLX4         1 MQCIPVVPLSITAFEEFGSIVSPdE------------EVRrld--ssQKNANQGTAIKLLQVSHIENQFpqs---lkVKN 63  Kluyveromyces l...
Q0U7M7        83 AVMNMFVC-APRELRphepsesmpsswgdleldddddlggnfrrqlLDVGILERHPFTTQTFVPMGLsPAekh---tqYL 158 Parastagonospor...
Q5KIN4       448 IHVGAVKAsSKMDIKng---------------------------krIKVELLERHRHTSQAFVPMGA-EPgkegkqgaFV 499 Cryptococcus ne...
O13843        63 GVWNFFST-HPSVHPande------------------------haaFQISVLERHPFTTQTFIPMCRsSDeq-----aYL 112 Schizosaccharom...
Q5BDA0        91 ARMSMFSC-FPRTLRavtstgegk--------------vggaqkvvFDVGILERHPYTSQTFSPLGLsSDdks---ayYL 152 Aspergillus nid...
Q7RW83        90 AVSNMFTC-ASRALPrrleag--------------------verevFPVTVLERHPFTSQTFVPLRA-DPqs-----rYL 142 Neurospora crassa
Q6C2M0        72 SIWYGFRC-SPPNHLtstkn----------------------sqstYTCKVLERHPFSTQTFVPMGRnKDdq-----aYL 123 Yarrowia lipoly...
Q6BHQ1        74 ANWNIFRCsFPKNSIvteak----------------------nelvYKAKVLERHPFSTQTFIPMGL-ELsr----nsYL 126 Debaryomyces ha...
XP_001383536  74 ANWNIFRCtAPKHLIsdyg-----------------------tykrYTSKVLERHPFSTQTFLPMGQdLHkv-----sYL 125 Scheffersomyces...
Q74ZI4        72 PAWHLFRSfVPPQLRcalatsp------------------tphvlrHPVPVLEQHPFTSQTFVPIGQgSGp------vYI 127 Eremothecium go...
Q6CLX4        64 PSCNLFRC-FPKGALqkrfalvds--------------dgslkkyqHEIKVLEKHPFSTQTFIPMGRdIKsg----yaYL 124 Kluyveromyces l...
Q0U7M7       159 VIVAP--TLpasasrrntgrpppyptphverkkslkdifararpspystestpppssfsrlpasarpkgpGLPDLKNLRA 236 Parastagonospor...
Q5KIN4       500 VVAAL--NGp-----------------------------------------------------------dDKPDLSTVRA 518 Cryptococcus ne...
O13843       113 IAVAPnaPD-------------------------------------------------------------GMPDWNQTQA 131 Schizosaccharom...
Q5BDA0       153 VIVAP--TLlgqtatart-------------------------------------------eagesvsirDPPNLSKLRA 187 Aspergillus nid...
Q7RW83       143 VVVAP--NLspsaqdqqlpvpss---------------------------------rppgtianrelpgrGLPDLKGLRA 187 Neurospora crassa
Q6C2M0       124 VIVAKtgTD-------------------------------------------------------------GLPDVNTLEA 142 Yarrowia lipoly...
Q6BHQ1       127 VIVAK--SDkdt-------------------------------------------------------lptSLPEPSSVRA 149 Debaryomyces ha...
XP_001383536 126 VIVAAndPHsg---------------------------------------------------------aqVLPDPSTVRA 148 Scheffersomyces...
Q74ZI4       128 VVVARpsAR-------------------------------------------------------------GEPDLLTLRA 146 Eremothecium go...
Q6CLX4       125 VVTALpdKN-------------------------------------------------------------GEPDLLTLQA 143 Kluyveromyces l...
Q0U7M7       237 FVANGAQAVTYGAGTWHAPMIVIGd--RPIDFVVVqf---aNDVgLE-----DCQEILLKPnHSAAE 293 Parastagonospora nodorum SN15
Q5KIN4       519 FLATAAQGVNYDEGIWHHSLLTVG---GDLNYAIV------EAQmSVpneirDCEKVVPPS-ELHVE 575 Cryptococcus neoformans
O13843       132 FVAKGAQGVTYSAGVWHAPMVTIG---KETMLAAFny---eNGVaED-----DCQVQSTES-PIEVF 186 Schizosaccharomyces pombe 972h-
Q5BDA0       188 FVASGEHAVTYGPGTWHAPMVVVGe--CKVDFVVTqf---vNGVaAE-----DCQEVCFGE-GIVVD 243 Aspergillus nidulans
Q7RW83       188 FIATTDQAVTYGAGTWHSPMVALGpadKAIDFFVFqf---aNEVsVE-----DCQEVLFGPsTitvr 246 Neurospora crassa
Q6C2M0       143 FEARGDQAVTYGVATWHAPMVVLH---KPIDFGVFih---eNSVpEE-----NCQEVYFEP-GVNVE 197 Yarrowia lipolytica
Q6BHQ1       150 FICKGNQSITYGQGIWHAPMVVIDedpPHIDFAVLi----hENG-VDn---eDVEECYFEP-GFNIK 207 Debaryomyces hansenii
XP_001383536 149 FVCKGNQSVTYGAGTWHAPMVVIDeetAHIDFAVFih---eNGVaDE-----DCQECYFKP-GFSIN 206 Scheffersomyces stipitis CBS...
Q74ZI4       147 FVCAGTHAVTYAPGVWHAPMIAAAp-qDYVDFLSLthvlddPQQpEA-----DCVEHSYTPdPLQLA 207 Eremothecium gossypii
Q6CLX4       144 FLCKSNQAVTYGAGVWHAPMIVVGe-eEYLDFTVIinelhdHNQlQY-----DLEERFYDS-QLSLN 203 Kluyveromyces lactis
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap