Conserved Protein Domain Family
Gpi16

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pfam04113: Gpi16 
Gpi16 subunit, GPI transamidase component
GPI (glycosyl phosphatidyl inositol) transamidase is a multi-protein complex. Gpi16, Gpi8 and Gaa1 for a sub-complex of the GPI transamidase. GPI transamidase that adds glycosylphosphatidylinositols (GPIs) to newly synthesised proteins. Gpi16 is an essential N-glycosylated transmembrane glycoprotein. Gpi16 is largely found on the lumenal side of the ER. It has a single C-terminal transmembrane domain and a small C-terminal, cytosolic extension with an ER retrieval motif.
Statistics
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PSSM-Id: 486877
Aligned: 44 rows
Threshold Bit Score: 376.196
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005850415   7 PVIVLLLRWGVGSAA----AYTEELALQQLSDGSVLAHFEFS---AAAPLh--AE----------------HAGSFPAAL 61 
CCE73121       8 LWISCLQAVLGQPSE----AYNEVLKFRPLPRNSLLASFEFN---IVSSP---VQlkyhgedsrqtwegheHYELFPRVL 77 
O94380         9 LFAYSLLSFSLTAATid-eTYDESLFIKSFSSRYSYVSFAFE---IGAST---DSthssv-------fsesSFSLFPLSI 74  Schizosaccharom...
XP_013021264   7 vlVCLCSFFALGYASln-eQYNEALYLENLSNRHTYASFTFE---IDKKT---NKengya-------fsepNYQFFPLSL 72 
XP_006681170  12 aLVASSSIRSLLASTlafePYSERLELSQMADGKVLAQFAFT---TLTDLs--NSasq-----------dnHYGLLPRSI 75 
3_pfamImport   1 -IILFTAYFSLTASSpikdEYHEELFMKPL-GGYVYSYFQFS---TLWEIpflTKhna-----------fdHCHIFPRPM 64 
Q949U5        15 QSFLVAIAFGSKEVE----EFSEALLLKPLPDRKVLAHFHFE---NRAPPs--NShg-------------rHHHLFPKAI 72  thale cress
XP_004247080  15 KSFGSIIAEEEDQIE----QFSEALLLRPLPDRKVLAHFHFE---SKVPPt--RThg-------------sHHHLFPKSI 72 
XP_002502505   4 aFLLVVLAASVGAAResreTFQEEALVRPLPDGRIAFVAHFR---QETSLv--AR----------------HHETFPKAI 62 
Q5KE79         9 LLFAPVFVAAVPSSN----SFHESLTLHPLPDGKLSVLFEFTtyfTQTKPt--SSip------------qyHHSITPPSL 70  Cryptococcus ne...
XP_005850415  62 LALARRHGVRQLELSLTQGRWTWEQQRQvAAGAGGSAAasrPAG-LELKVSfdgs-trdtQAAYSALTQALGGMLCAGIA 139
CCE73121      78 GPIVEASNTRELHLRFSQGWYDTESSGR-LPFNGSKSG---GTG-VELWAVieapdldaaKADWVKLTNALSGLFCASFN 152
O94380        75 ARVMDECQVSELHIRATRGRWDYENWKE-SPDNGFYSG---GLG-FEVWAFmand---psmkYWLKLTNQLSGLLCASLN 146 Schizosaccharom...
XP_013021264  73 ARIMKDQKVMDLHVRATKGRWDYGFWKQ-PPDNGLQSG---GLG-FEVWASfidd---qdleAWYKLTSQLSGLFCFSSN 144
XP_006681170  76 GEVVQTFDIDELHLTFTQGRWSYDRWGH-----SDFTA---PIG-VELWAWfnst---spdtKWKGLTNALAGLFCSSLN 143
3_pfamImport  65 GELIQRYNVQELHVSLTKGLWRYEDWGY-----PVQTA---PPG-AELWAWfkhd-tidiDSKWRELTSALSGLLCASLN 134
Q949U5        73 SQLVQKFRVKEMELSFTQGRWNHEHWGGfDPLSSMNAK---PVG-VELWAVfdvp-qsqvDTSWKNLTHALSGLFCASIN 147 thale cress
XP_004247080  73 YQLVHKFRVQEMELSFTQGRWNYARWGGyDPISSRNAK---PPG-VELWATfdvp-qhqvDASWRNLTHALSGLFCASIN 147
XP_002502505  63 AQIARATGVADAELSFTQGRWMYRRWGR----PPVGAK---PIG-AELWAAfaaesdevaDEGWANLTAMFGGQFCASLS 134
Q5KE79        71 LLPLQTNDISELSISFVAGRWDQRRSSQsGPLHYLSGG---GGGeVRGWVRngneg-gseeeRWGTVTHALGGLFCAGLG 146 Cryptococcus ne...
XP_005850415 140 TAPRLAVMAaPAVGwfaqQQPAAVggGAASsgkqrrqgQRAQQIYAWLPQEGLCSENLAAWRRLLPCRHHAGLGALL-QP 218
CCE73121     153 FINDPITTS-PRLQ----FEGKKT--GYLAnl-----gNSLFLLRAALPNEPICTENLTPMLRLLPTRGKRGISSLL-DG 219
O94380       147 YIDSSNTYQ-PQLS-----YPGSF--SF----------SNNTQYFASLPQEDVCTENLSPLFKLLPCKRKAGIASLL-DS 207 Schizosaccharom...
XP_013021264 145 NIDELNTYQ-PLLS----FVPSSF--T-----------SSHSRYFASLPQESVCTENLSSLLKFLPCKGEAGIASLI-DS 205
XP_006681170 144 FLDQAVTSQ-PLLS----FLPSGS--HSKR--------EGLQIRYGSLPREAVCTENLTPWIKLLPCQAKSGLASLL-NA 207
3_pfamImport 135 FIDSHNTLS-PELS----LKPTGI--EDASrp-----lNHTHLRYATLPREIVCTENLTPWKKLLPCNLKRGLSALL-NS 201
Q949U5       148 FLESSTSYAaPTWG----FGPNSD-----------------KLRYGSLPREAVCTENLTPWLKLLPCRDKDGISALM-NR 205 thale cress
XP_004247080 148 FLESSTAYSsPQWS----FKSFAT-----------------NIRYGTLPREAVCTENLTPWLKLLPCRDKAGLSALM-DR 205
XP_002502505 135 ALRDEQVVVePALV----FRPWDG--SARVdrd--gisSDNRRRHGSLPAEAVCTENLTPWLKLLPCRDRAGIAALLgSR 206
Q5KE79       147 PREAGENVK--TFGr--iYPPHRG--NP----------DGLTHFLLSHPHHNLCTENLTPFLFLLPSKGLSGLSALLsQP 210 Cryptococcus ne...
XP_005850415 219 VQLAAAPYHSLGLQLwvpqgaplanasaSASSasARSQGGQqewLELRQVLTAVlpaad--------------------- 277
CCE73121     220 HKIFDSLWHSMSIDL-------------VTQCd-DSFSNCA---LRMDQTIISAidvirslrrieeggipkptpgeklrc 282
O94380       208 HLFFDTDWHSFSIDV-------------YPS---ENQSLAS---VKMGIIIQAVvdverngrrkgkttfqpps------e 262 Schizosaccharom...
XP_013021264 206 HLLFDTDWYSLSIDI-------------APN---HPDDLSS---MKLIVKIQTVidvertnrrklgtkfpppp-----ef 261
XP_006681170 208 YKIFDGNFQSIGVHI-------------QPKCmtPDCVTMG---VEYRQTFAVVldpi---------------------- 249
3_pfamImport 202 DNIYNTVYHSLGIHF-------------RPVCmdPSCTRTG---VELVQSVSLVydlv---------------------- 243
Q949U5       206 PSVYRGFYHSQRLHL-------------STVEsgQEGLGSG---IVLEQTLTVVlqpett-------------------- 249 thale cress
XP_004247080 206 PSIYRGFYHSQRLHL-------------ISNEfdLAAASSG---MVLEQTLTVVlqpvtlgsg----------------- 252
XP_002502505 207 SSVFGAEYVSFTARV-----------------------RVRgdaLELTQSATLVvdan---------------------- 241
Q5KE79       211 GIIFSWGFQSEGIEV-------------IMPNddHPEGKWT---GWWEGVVDLMppg----------------------- 251 Cryptococcus ne...
XP_005850415 278 ------------qqeqqQEQQGRglLEALFGSSPPA------ACPA--------------ADSSTLYLpggrsaAAAHYM 325
CCE73121     283 desryhdiwecfplgdpEDLSYD--IESIFGRAIHG------AAFEdssvste-vsfeadPSVWQIEAis--nrSGQEKR 351
O94380       263 ychdedmdslhclmsgySTEHHT--VDDLFHKVPKE------RCLLs-------------STFSDVFV------------ 309 Schizosaccharom...
XP_013021264 262 cnddiandplrcltatyTSSSHT--LEDLFHKLPET------QCPLs-------------PSKDDILV------------ 308
XP_006681170 250 --------------rtnSQKDWS--LESLFDRTFPK------ACPFslsttvhldilniqPDTVVILPdphidqSTSTA- 306
3_pfamImport 244 -------------iigrDETHWS--IQRQFGQGLGL------TCPL--------------ATTSSVIVditsnaTGNTFK 288
Q949U5       250 ------------svesnMQPSWS--LSSLFGRQVVG------RCVL--------------AKSSNVYLqlegllGYESKN 295 thale cress
XP_004247080 253 ---------mtssvgsiQQPSWS--LSTLFGRKVSG------RCVL--------------SNASNVYVqlepdlVSELKT 301
XP_002502505 242 --------------kiaREPEGGhrLTSLLGVDRGGgangirACAA--------------ATSTAVHVqtkggtAFAFGG 293
Q5KE79       252 --------------agvKNVKREtgLEKLFKKRLPP------SCPEtessv----irlilPENEKVNVepqgrvVGEWR- 306 Cryptococcus ne...
XP_005850415 326 akavaasrgACRQh--------------------------DTPAgplLACDIaqqvqQAQQpEQQQAQISGqqqQQHlhp 379
CCE73121     352 ---------TDLT---------------------------NAGQlnhISYKI-----ADQK-DYNFNFTTA---NST--- 383
O94380       310 ----------------------------------------SNGDk-iDTFSL-----DEAA---NIQIPIQ---STSd-- 335 Schizosaccharom...
XP_013021264 309 ----------------------------------------KNSPslvVSYPL-----EMAR---DISVPVL---PEKr-- 335
XP_006681170 307 -----------------------------------------------VSYTY-----HLSTdPFQLNVRWN---DATv-- 329
3_pfamImport 289 lypstydrkVSNR---------------------------GGQRtvlAIYNLf---kQRTDaRYNIEVVYD--------- 329
Q949U5       296 vdteieahqlwkn--------------aefelslkperviRESCsflFIFDId---kSSDSePFDLGLTWKrpsKWSc-- 356 thale cress
XP_004247080 302 tsetqqqsdVGNLiseawsdmsfemsesavrvikeangflKESSl-lYEFSLe---nYSDSrPFDLEFRWKrpvTWSs-- 375
XP_002502505 294 rkvhtavadEGRRvdta-------------------vaadEASRpawLSWDV------SAAeDFDVAVRPGggdEGT--- 345
Q5KE79       307 ----------------------------------------DGKWrqvMEWNAk----DREMvGKDLKVWWD--------- 333 Cryptococcus ne...
XP_005850415 380 pasllqagqgggAEGGPpqagalHLLPLQVVQHTIQRGPLSGTLVVGIRVPAAAAaraaa--eaagpQLLLHVMQLLPWQ 457
CCE73121     384 ------------ITSPL------PPPPLHAYRSLTGYSQDKGGIRVSFTNLN-SN------------NVKFIYFESLPWF 432
O94380       336 -----------------------NHT-VTVDRSLSNDGNHWGSLSSTIYNPS-SS------------PRTIVYFEKFPWF 378 Schizosaccharom...
XP_013021264 336 -----------------------PESPVFIERSLTNSGNHWVGIISIFTNPS-DE------------AYSIVYFERLPWY 379
XP_006681170 330 ------------NYRNP------KLAPIQTHRYLSGVGQEHGGVVIVFINDL-DV------------PMAATYMDSIPWI 378
3_pfamImport 330 ---------------KIrqnvanVPPVIYANRYITGYGQEFGGIKTKIFNRY-RQ------------PLKVLFLENIPWF 381
Q949U5       357 ------------QQAP-----------LHSSRFLMGSGNERGAIAILLKATESQEklsgrdltngqcTIKANIFQIFPWY 413 thale cress
XP_004247080 376 ------------QLAP-----------LQARRFLMGSGNERGAIAISLKSVGRSEyakssvneegrcLLRVDVFQVVPWY 432
XP_002502505 346 -----------------------VAPELYAERVVTGSGYHRGGISIELRRPEGSKsa---------sGTRARLFQTLPWY 393
Q5KE79       334 -------------EERFeyprtiDPPAISVMKTVIDSQASDGTFQIKISNHENI-------------TREAIYSEIWPWW 387 Cryptococcus ne...
XP_005850415 458 LRVDATSLQVLLDGQp-------lHPRSPQLVWQSLDVRP---DRT--ATLELLLRLPSTaAApagsdalqagrwheVRV 525
CCE73121     433 MRVYLSTFKIELQNTtgt-----ysvKDENEFIKKSYFKPa-iDRKrpSQLELFLTVPPE-SS--------------LII 491
O94380       379 VRVYLHTLTITLNGT----------RINTKDFIEKLYYQPl-rDRKagTMMEIQFSIPPH-TN--------------LIV 432 Schizosaccharom...
XP_013021264 380 ARVYLHTMKITVNDK----------PISPLEFFQDQVYQPl-kDRKagTMIESRFEIPAH-SS--------------VVI 433
XP_006681170 379 IKLFMHTFKVELENP----------SSNISDIIRQTYYQPa-iDRIrpNVLELDLVLGPK-SK--------------TTL 432
3_pfamImport 382 VPIYFHTLKVFSGDK------------ELQPLVKR--YFPg-kERVrpYYLELLIELPPR-SV--------------TSV 431
Q949U5       414 IKVYYHTLQIFVDQQ----------QKTDSEVLKKINVSPs-tDKVssGMMEMMLELPCEvKS--------------VAI 468 thale cress
XP_004247080 433 VKVYYHTLKVFLDER----------LHSLADVVERTNVSPs-eDKVspGLMEIALRLPCDvHS--------------VIL 487
XP_002502505 394 VRVFIHTLAVEMDGVpvpvptsgaDVGANGGAVEALRWVPg-vDRRrpSTMELQVLMPASaSV--------------ARV 458
Q5KE79       388 VKGWMSEMAVCIEDE-----------GPRADLLKSISYNPsnpPDIppTTIHLSIQLPPR-ST--------------LVL 441 Cryptococcus ne...
XP_005850415 526 QVGYRAAFVSVFDHAPDASRGVDIPPALATLapdha----------------ctspsSPSSSSGDgssgpaappllrrlq 589
CCE73121     492 NYDFDKSLLLYAEYPPDANHGFDVEPAAISV--------------------------IGDDNEIF--------------- 530
O94380       433 HFNVEKTPLRLDEYPPDANRGYNLPPAIISV--------------------------FDENNTKL--------------- 471 Schizosaccharom...
XP_013021264 434 SYDIEKTTLRLQEYPPDANRGYDLPPSIVSV--------------------------FGKDDVEI--------------- 472
XP_006681170 433 TFDFDYTFLKYTEHHPDANHGFELGFGVLTL--------------------------FPDSGLTFdkhhs---------- 476
3_pfamImport 432 SVEFDYAFLKWQEYPPDANHGFYMGAASVTA--------------------------LLPLARNYtapprdrslli-dsi 484
Q949U5       469 SIEYDKGFLHIDEYPPDANQGFDIPSALISFpdhhasldfqe-----elsnspllssLKEKSL----------------- 526 thale cress
XP_004247080 488 TLEFDKGFLHIDEYPPDANQGFDIPSALIRFpgiktkmdlfed---ksackspilskLQEESP----------------- 547
XP_002502505 459 SFKFEKAFLRISEFPPDANRGFDLPAALLSLppvsprdghefgesrlldlvegvaseVGDTHS----------------- 521
Q5KE79       442 TIPFTKLTLKYTDHRPDAERGQEIPAGVLTLldlv------------------gergVPEAESEAspsswtspq------ 497 Cryptococcus ne...
XP_005850415 590 agcaprqqYSGSGGGGLAPLPLPDLSMPFNVICFTSTLLAILLGGVANVVLRSPaeLAGQAASEGGAPAWRRK-L 663
CCE73121     531 --------YEMHTTSLLLTLPTPDFSMPYNVIILTCTVMSLAFGSIFNLLTKKV--ITEEELEKLSAEGKLAK-I 594
O94380       472 --------CSLRTAALLMFIPTPDFSMPYNVIIFTSTVIALTFGGIFNLLTRRF--VPQQSKFQNRQPSMLQR-L 535 Schizosaccharomyces ...
XP_013021264 473 --------CQLRTSALLMFIPTPDFSMPYNVIILTSTVMALTFGGSFNFLTRRI--VPISELPKSQKPSLLQR-L 536
XP_006681170 477 ----qsdqRRIYTESLLVRLPTPDFSMPYNVITLTCTLFALFFGSVFNALTREFrpVEVTGGKVSPLQRIKTM-L 546
3_pfamImport 485 nasrngypVRITTEVLIISLPTPDFSMPYNVICLACTVVALAFGPLHNITTKKFvlTSAEK------KSFIKK-T 552
Q949U5       527 --------VRSYTEVLLVPLTTPDFSMPYNVITITCTIFALYFGSLLNVLRRR---IGEEERFLKSQAGKKTGgL 590 thale cress
XP_004247080 548 --------VLWYTEVLLVPLTTPDFSMPYNVITITCTVFALYFGSLLNALRRR---VDEEERLLKNKAAKPSGpI 611
XP_002502505 522 --------EGVYMQGALLTLPTPDFSMPFNVTTMVCTLMSLLAGALLTTLTRRPgwEGFGKLKAEQRKRLKslek 588
Q5KE79       498 inalrsnrARVYTQRILLDIPTPDFSMPYNVIIMSSTVMAVFFGLMHGGLTRRWgwVEVPEDPEEPKEGVRMGek 572 Cryptococcus neoformans
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