6WR4,7D0I,8POE


Conserved Protein Domain Family
ATG9

?
pfam04109: ATG9 (This model is not part of the current CDD release)
Autophagy protein ATG9
In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg9 plays a direct role in the formation of the cytoplasm to vacuole targeting and autophagic vesicles, and it is the sole transmembrane protein in the autophagosome-forming machinery. It colocalises with Atg2 at the expanding edge of the isolation membrane where Atg2 receives phospholipids from the endoplasmic reticulum (ER). Atg9 is a lipid scramblase that translocates phospholipids between outer and inner leaflets of liposomes. Phospholipids delivered by Atg2 are translocated from the cytoplasmic to the luminal leaflet by Atg9, driving autophagosomal membrane expansion.
Statistics
?
PSSM-Id: 516041
Aligned: 103 rows
Threshold Bit Score: 297.867
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
6WR4_A        37 WHHIENLDLFFSRVYNLHQKNGFTCMLIGEIFELMQFLFVVAFTTFLVSCVDYDILfankmvn------hslhptePV-- 108  human
XP_002681988  89 HLGVTNLDAFFQQVYVYFYEKGFWCMLVDRCLRLCTVFFMMIFSTFLFVFLNWYDMwhcqdvac-----ktvpvfrKNvw 163 
Q387F1        16 SGRIGDVHVFMKNLYRFWVYKGLWFSCLASLVDFLNSVVVFCLVVFLTTVFDWPVAa------------------aCD-- 75   Trypanosoma br...
XP_003116677 104 WDHVLNLDEFFTHIYEYHQNGGYLCIVLQKAFSLLQFVFVMSFTTFFTQCVNYEFLfantnvt-------shgtvnQG-- 174 
XP_020305167  77 WDGVENLDQFFTRVYEYHQNGGYLCIVIKHILTLLQFIFVVWFVAFLQARVDYDVLfknknis-------aegkpvGG-- 147 
Q6EBV9       185 WHHIQNLDSFFTKIYSYHQRNGFACILLEDVFQLGQFIFIVTFTTFLLRCVDYNVLfnnqpkn------htrrgplHS-- 256  house mouse
XP_032526689  58 WNHIKDLDSFFTRMYSYYVRGGFYPMIMSDFFYLLQFIFIVWFSTFLVHCVDYPRLfrndp-----------eanrSE-- 124 
XP_009028971  57 WNHLSDLDEFFTRIYAYVQRHGFLAMALQDIFQIIILWYVVIFPTFICVGVNYDVLfqdh-------------fniTY-- 121 
8POE_A       222 WHHIQNLDSFFTKIYSYHQRNGFACILLEDVFQLGQFIFIVTFTTFLLRCVDYNVLfanqpsn------htrpgpfHS-- 293  human
XP_007504680 176 WHHIQNLDSFFTKLYNYHQRNGFACMFLEDAFQLGQFVFVVTFTTFLLRCVDYDILfanrpvnhtrpgshqnpgilQS-- 253  gray short-tai...
6WR4_A       109 KVTLPDAF--------LPaqVCSA--RIqeNGSLITI--LVIAGVFWIHRLIKF-------------------------- 150  human
XP_002681988 164 TMNAFHIV---------------------------VLlfEFVVCFYWMYLLVKY-------------------------- 190 
Q387F1        76 EVSCGTVTlthhmrlpTE--RGASh-VL--LCLIL----LVSSAASATYEFLKFletcslqmetermvrvivdtgytspf 146  Trypanosoma br...
XP_003116677 175 KRHFGDAV--------VD--NCAG--HL--SIWMIFA--ILAAVVYWVTRVVKH-------------------------- 212 
XP_020305167 148 KIRLGDVI--------YP--D-WS--HV--DVFTLCL--LVFAALFWFFRVTRV-------------------------- 184 
Q6EBV9       257 KVTLSDAIl------pSA--QCAE--KI--HDSPLLVflLVLAAGFWLFQLLRS-------------------------- 298  house mouse
XP_032526689 125 KLTLNDVIf------sTS--VCVS--HI--SWTWWCL--ITLCCIIWIMKFFIS-------------------------- 164 
XP_009028971 122 KVIINDAIr------pWK--EVKE--RF--NPFLILF--LITSSFYLVFKTFKG-------------------------- 161 
8POE_A       294 KVTLSDAI--------LPsaQCAE--RIrsSPLLVLL--LVLAAGFWLVQLLRS-------------------------- 335  human
XP_007504680 254 KVTLSDAIl------pAA--QCAQrvRS--SSILIFL--LFLASGFWLFRLLRS-------------------------- 295  gray short-tai...
6WR4_A       151 --IYNICCYWEIHSFYLHALRIPMSA-LPYCTWQEVQARIV-QTQKEHQIC--IHKRELTELDIYHRILRFQNYMVALVN 224  human
XP_002681988 191 --LRDLLGMLSIKHFFNTELNITEKD-IQTIQWVEVVEKII-EFQNKKKIN--IIK-NVDEFDILNRIMRKENYLISFIN 263 
Q387F1       147 hrLAHIWRRMRVQSDGHEELPDHGLPfIGNMAWGDFLDEVCaRIQRDRSFGviEHK-EFDSLRAVQALMVYENYFITFHQ 225  Trypanosoma br...
XP_003116677 213 --AQYIMKMTEIQQFYVQELKIQDDQ-LPNLTWHAIVKRIC-EAQKKLRLS--IHQDNITSIYIYHRILRYKNYMTGMIN 286 
XP_020305167 185 --FYQIYQFNEIRTFYHSALGIEDAL-LSDLKWQDVVQLIC-EKQPSIHLI--LNKDGITALDLYQRILRHKNYFVALVN 258 
Q6EBV9       299 --VCNLFSYWDIQVFYREALHIPPEE-LSSVPWAEVQSRLL-ELQRSGGLC--VQPRPLTELDVHHRILRYTNYQVALAN 372  house mouse
XP_032526689 165 --MYHLYYAYDTKLFYNNALKIKESE-LTWVTWSTIQDRVR-EAQPEHQMC--VHKQEINELDIYHRILRFNNYMVAMVN 238 
XP_009028971 162 --LYNISKYWEIRRFFTYALEIQPSE-LANKKWHEVQTLLM-LVQQKLHMC--VHKNELTELDIYHRILRFKNYMVALVN 235 
8POE_A       336 --VCNLFSYWDIQVFYREALHIPPEE-LSSVPWAEVQSRLL-ALQRSGGLC--VQPRPLTELDIHHRILRYTNYQVALAN 409  human
XP_007504680 296 --LCNLLNYWDIRTFYKEALHIPPED-LSKVPWGEVQSRLL-ALQRGGGLC--VLPRPLTELDVHHRILRYPNYLVALAN 369  gray short-tai...
6WR4_A       225 KSLLPLRFrlPGLGEAVFFTRGLKYNFELILFWGpgsLFLN------EWSLKAEYKRGgqrlelAQRLSNRILWIGIANF 298  human
XP_002681988 264 KDVMNLTL--PFSQKT-YLSEIIVYNLRI-VVDN---MFDS------EFKINEAFVKN------PNALRAFFVKLGLINL 324 
Q387F1       226 HGILERGA-----------LKYADENVIRMLIRS---LFD-------------EFSTLvrgkdhVTLLRWKVVKYLVVYA 278  Trypanosoma br...
XP_003116677 287 KRILHPVFevPFLGPIAYLPNNLKHEIERILFTS------StsawtnGPNLRDEYKHHehlemaAKKMKEDCKFYGFLSL 360 
XP_020305167 259 KEILPPVInvPFIGSMPYLPNGLKMNLEWLLFYG------VwspwkgPYELKEEYKHPqnifrlADELDSAILKMAIGNF 332 
Q6EBV9       373 KGLLPARCplPWGSSAAFLSRGLALNVDLLLFRG------PfslfrgGWELPEAYKRSdlrgvlANRWRRTVLLLAAVNL 446  house mouse
XP_032526689 239 KNLLPLQIhvPFIGDFHYLSRGLKWNLEFLLFYGpw---------esRWQLRSAYKDHtkrmllARQLERQIILLALVNL 309 
XP_009028971 236 KSVLPMKFnlPFWGEIVYFTSGLKYNYEMILFWG------PgapfanSWHLRKEYKSYnkrkelATILSRRIFIAGIINL 309 
8POE_A       410 KGLLPARCplPWGGSAAFLSRGLALNVDLLLFRGpfsLFRG------GWELPHAYKRSdqrgalAARWGRTVLLLAALNL 483  human
XP_007504680 370 KGLLPARFplPWGGSATFLSQGLALNLDLLLFRGpisLFRG------GWALPSTYKRScqrrtlAIRLRWTLLFLALVNL 443  gray short-tai...
6WR4_A       299 LLCPLILIWQILYAFFSYAEVLKREPGALGARCWSLYGRCYLRHFNELEHELQSRLNRGYKPASKYMNCF--LSPLLTLL 376  human
XP_002681988 325 LLAPFLLIYIILYTSFKYLAELKNDPKKALGRRWSLYSTFKFREYHELAHEYERRLKEGYGPSIDYLNQF--PNVLLSIV 402 
Q387F1       279 LFYPFVVAHFLLRVLVKNAAMVRTDWGGYMTKDWNKRALWTFSLYNEVPHVLSARIASGRQIVMEMICRLkpHSS----G 354  Trypanosoma br...
XP_003116677 361 ILMPLLLPFQMMESFFSLTELIKRRPDGLGMRRYSNYGRYLVRHFNELDHELSARLNRSHIYAAAYMDQF--FSPVLEIV 438 
XP_020305167 333 IFFPLVFIYQVLYFFFTYGELLRRDPGSFAMRRYSNYGRNKLRHFNELDHELRMRLSKSHRAATQYMEQF--LSPLGQVI 410 
Q6EBV9       447 ALSPLVLAWQVLHAFYSHVELLRREPGAFGARRWSRLARLQLRHFNELPHELRARLGRAYRPAAAFLRAAepPAPLRALL 526  house mouse
XP_032526689 310 ILAPLIQAWQILYFFFNYAELIKRSPGSLGLRTWSLYARVTLRHFNELEHELRDRLNRAHKPATKYLASF--SSPITTVL 387 
XP_009028971 310 LLAPVIFVWTLLYLVISHFALFRTDPGQVSLRSWSLYGRQYLRHFNELDHDFNARLNRGYRAAVKYMGLF--WSPVMAAI 387 
8POE_A       484 ALSPLVLAWQVLHVFYSHVELLRREPGALGARGWSRLARLQLRHFNELPHELRARLARAYRPAAAFLRTAapPAPLRTLL 563  human
XP_007504680 444 ALCPLVLAWQGLHAFFSHAELLRREPGALGMRRWSRLARLQLRHFNELPHELRARLARAYRPAAHYLRAAapPAPLPALL 523  gray short-tai...
6WR4_A       377 AKNGAFFAGSILAVLIALTIYDEDVL-----AVEHVLTTVTLLGVTVTVCRSFIP-DQHMV-FCP------EQLLRVILA 443  human
XP_002681988 403 ANRAMFFISAIAGVIIVLSYLNNSLTlyltvFNQNLLTWLTTLLLGWAFAKGFVI-DEHAV-FNP------KQKLDDVCE 474 
Q387F1       355 KRFVCRVASGIILVLLSLSLVNTSLLvsgnlCGIPLLWWLTGSIAAFSVCNETPPvERE---YNY------LPDLERLVK 425  Trypanosoma br...
XP_003116677 439 AKNVTFAAAAIVGILTILSAWDEDVL-----QVEHVITVITVCGIIVLICRGMIP-DENLV-WQP------EILMTHVTS 505 
XP_020305167 411 ARKVQFVAGAICIVFLLLGLWDEDVL-----SVEHVLTIISTCGLIAVACQSFIG-DENMI-YWP------ETLLDMVIA 477 
Q6EBV9       527 ARQLVFFSGALFAALLVLTIYDEDVL-----AVEHVLTTMTALGVTATVARSFIP-EEQCQgRSS------QLLLQAALA 594  house mouse
XP_032526689 388 AKNAVFLSASVLGVLVVLSVYDEDVL-----TVEHVLTIITILGCVLAGARALIG-EEERL-GGScgpargEELLVQVLG 460 
XP_009028971 388 AQFIVVISSGFLIFFVICAVTDEDTL-----AVQGVIKIMTLLGLVVSVVRHLIP-DENMV-RNP------ETLMTLIQS 454 
8POE_A       564 ARQLVFFAGALFAALLVLTVYDEDVL-----AVEHVLTAMTALGVTATVARSFIP-EEQCQgRAP------QLLLQTALA 631  human
XP_007504680 524 ARHAGFFAGALLAALLVLTVYDEDVL-----AVEHVLTAMTGLGVALTVARCFIP-EEELLgRSP------KPLLQAALA 591  gray short-tai...
6WR4_A       444 HIHYMPDHW----QGNAHRSQTRDEFAQLFQYKAVFILEELLSPIVTPLILIFCLR-PRALEIIDFFRNFTVEVVGVGDT 518  human
XP_002681988 475 ILHHHDLKW----KGKGHHHDVRDDFVAHFIPSYSYFLNEIVSVFVTPIILIISLP-RSAERISSFVDQITVDYHGLGHI 549 
Q387F1       426 QLHYSQEEWn--hSGESFYSAVTWDF---LESRFSVIISDIARTLFMPCILLGLLFdGSLPALMECVQSESVRVDGLGSV 500  Trypanosoma br...
XP_003116677 506 ELHYLPSTW----KGKAHTAGVRHEFDQLFQMKWMFFVLELTSPIFTPFVLLFWMR-PRCTQLANFFHDYTERVDGLGDV 580 
XP_020305167 478 QIHYAPDLW----KGKAHTDMVRKEFGHLFELKAKFLLEELLSPILTPFILLFWIR-PKAKELVDFFHNFTISVEGLGDV 552 
Q6EBV9       595 HMHYLPEEP----GATGARASSYWQMAQLLQYRAVSLLEELLSPLLTPLFLLFWFR-PRALEIIDFFHHFTVDVAGVGDI 669  house mouse
XP_032526689 461 HVHYLPAAW----RGRAHTRHVAAHLQHMFQFRAVYILFELLSPLLCPLVL-FQLR-TRAVDIVDFYRNFTVSVLGIGDV 534 
XP_009028971 455 QTHYMNDSW----KGQAHTRKVMDEFSQLFQYKLVYLINEMVSAIVCPFILIFSLR-PNSLQIVDFLRNFTVTLEGIGDV 529 
8POE_A       632 HMHYLPEEPgpggRDRA-----YRQMAQLLQYRAVSLLEELLSPLLTPLFLLFWFR-PRALEIIDFFHHFTVDVAGVGDI 705  human
XP_007504680 592 HMHYLPEEP-----GSVREANTHHQMSQLLQYKAISLLEELLSPVLTPLALLLWFR-PRALEIIDFFRHFTVDVSGVGDV 665  gray short-tai...
6WR4_A       519 CSFAQMD 525  human
XP_002681988 550 CGHAAFK 556 
Q387F1       501 AREAAFD 507  Trypanosoma brucei
XP_003116677 581 CSFAVMD 587 
XP_020305167 553 CSFAQMD 559 
Q6EBV9       670 CSFALMD 676  house mouse
XP_032526689 535 CSFAQLD 541 
XP_009028971 530 CSFAQMD 536 
8POE_A       706 CSFALMD 712  human
XP_007504680 666 CSFALMD 672  gray short-tailed opossum
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap