5HB3,8TJ5


Conserved Protein Domain Family
Nic96

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pfam04097: Nic96 (This model is not part of the current CDD release)
Nup93/Nic96
Nup93/Nic96 is a component of the nuclear pore complex. It is required for the correct assembly of the nuclear pore complex. In Saccharomyces cerevisiae, Nic96 has been shown to be involved in the distribution and cellular concentration of the GTPase Gsp1. The structure of Nic96 has revealed a mostly alpha helical structure.
Statistics
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PSSM-Id: 516032
Aligned: 97 rows
Threshold Bit Score: 212.825
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5HB3_A        49 PHIVEAYRAVMEMVGEHpdageaprerqfakmyldpntqsanalamrkQILKGATTFLEKQFWNEVNSLIAKYPQDanlg 128 Thermochaetoide...
XP_004984390 259 VTMQKMWHLIQALVGEGsthrn---------------------vsrkmSLVIGARHHLEWGHEKYILETINSHPALaalg 317
O22224       247 VNMQKIWQLVQAITGEDsavrqg--------------------vskrmALAIGARHHLQHGHEKFIMDTIQTHPTQaalg 306 thale cress
XP_003543674 248 VTMRKIWHLVQMLMGEDsavqc---------------------vskrmSLIIGARRHLEWGHEKYIMDTIQSHPAQaalg 306
EEC18450     220 RGAADLWDMVCALLDAPrrgver-------------------deafnaGFVRQARRYLERSYCRYMRMIVQGNLEQasmg 280
XP_005814359 219 KNVSDLWLMVKQMADVLlvpardalk-------------srtavemqmAFVRQALGFLENRYKSFTMGTVFGNLHQaqlg 285
XP_001633614 214 KSVRDFWPFIKDLGEIGhsresphki--------------rfspefqvQFLERARHFLEERYLRYVQETVYDNLQSaqlg 279
XP_002108984 221 ANIVDIWDLIYEIADIEitevidpla-------------lryeaesqmLFINKARNCLERRYLDYVKKTIYGNLHQaklg 287
XP_019849727 220 KSIKDSWLLLKMLLDVHtlppdahnh--------------rsssnllkQFIQKSRTFLEKQYLEYVKDLVYSNLSQsqlg 285 Amphimedon quee...
XP_002131359 226 VNVTALWKMVKCVTDVQasigsslis-------------rrtskpmlhNLVNQALTYLEKAYLDYMQTCVYARPHIaqlg 292 vase tunicate
5HB3_A       129 GLPDVVSKIKAYIRLR-----IARKT-LVPDNVELQQING---EYVWAIVFYLLRAGFVTEAAQYVNSNQAHFrAidrTF 199 Thermochaetoide...
XP_004984390 318 GSVGNLQKIRAFMRVR-------LRDqGVLDFDATDLRRQppvDTTWQQIYFCLRTGYYDEARQVAQSSRAAH-----NF 385
O22224       307 GSVGNLQRIRAFLRIR-------LRDyGVLDFDSTDARRQppvDTTWQQIYFCLRTGYYEEAREIARSTRSSQ-----QF 374 thale cress
XP_003543674 307 GGVGNLQRIRAFLRIR-------LRDyGVLDFDAGDARRQppvDTTWQQIYFCLRSGYYDEARNVAQSSRTSH-----QF 374
EEC18450     281 GVPGTLNLVTSFLNVKapvvaSASEG-CTVL--------G---QPVWALVYLCLRCGDLDAAAEVCRRAGAMA-G---EL 344
XP_005814359 286 GVPGTYQLVRSFLNIKlpgplPGMQD-GEVE--------G---QPVWAVIYYCLRCGDMNAAMTVVSRAQHQL-G---DF 349
XP_001633614 280 GVPGTFPLVKSFLKIKlphgaQGLED-GDLD--------G---TPIWPLIYYCMRCGDPDSALQAVGYIPQHL-S---DF 343
XP_002108984 288 GVPSTYHTVKSFLNITmpnsvLNLED-GLVD--------D---KPVWAMIYYCIRCGDLKAMLNAADL--QYL-G---EI 349
XP_019849727 286 GVPGTAKLIQSYLKLKhasamPGLED-ELVD--------G---QPLWAIVFYCMRCGDLEAARSVLGSHY--------DV 345 Amphimedon quee...
XP_002131359 293 GAPGTINLVKSFLRVQpantvQGYED-GDVD--------G---APLWAVIFYCMRSGDLDAAVEVVKHNENII-P---EF 356 vase tunicate
5HB3_A       200 SGYINSYASSEERRLKRQMQDRCMSEYNQRIRNape---gsIDPFRM-ACYKIIGR----CDLSNRSLDGLQTDVNDWIW 271 Thermochaetoide...
XP_004984390 386 APLLADWISTNGAV-SQDTALAASEECDKMLRMgdrpgrpgYDRKKL-LLYAIICGcrrqIDRLLKDLPTLFNTIEDFLW 463
O22224       375 APLLTEWITTDGMV-AAESAAIASEECEKMLRMgdrlgrtaYDKKKL-LLYTIISGsrrqIERILRDLSTLFNTIEDFLW 452 thale cress
XP_003543674 375 APLLTEWINKGGMV-PEEIATAASEECERMLRTgdrvgrtaYDKKKL-LLYAIISGsrrhIDRLLRDQPSLFSTIEDFLW 452
EEC18450     345 APLLEECAASEDRRLGPSSENKVRLQYTRSGGSa------sGDPFKQ-AVFCVLGR----CDVAQDHAQ-VATTVEDYLW 412
XP_005814359 350 KSWFQEYMSSPDKRLSPASENKLRLHYRRALRNs-------ADPYKR-AVYCLIGK----CDVNDSHGE-VADKTDDYLW 416
XP_001633614 344 KDFFREYINSDRRRINPSTESKVRLQYRRSVRTs-------QDPFKR-AVYCLVGH----CDLADNHQE-LATKTEDYLW 410
XP_002108984 350 TNYLEEFANSPNHSISAPSATKVQLMYKRSEGHs-------SDPFKRfELFTVL-------------WE-VVTRLIVTLK 408
XP_019849727 346 AQYLEEYQNTPDYRLSPTSENTLKQLYNKTVRNs-------TDPYKK-AVFCVLGR----CELNNTHYQ-VLVKTEDYMW 412 Amphimedon quee...
XP_002131359 357 SVWMQEYVREG-KKLSSSSENKMKIQYKRSVRTs-------PDPYKT-AVYCIVGR----CDINDVHGE-VAQKAEDYLW 422 vase tunicate
5HB3_A       272 LQFNL-----------AREt--DRsLELAGES---YGLAELQASIRE-IGLKHFpktaaedtngsFGMFFYLQILAGMFE 334 Thermochaetoide...
XP_004984390 464 FKLSA-----------LREhnnASsSSVLNEGlvpYTLDDLQSYLNK-FEPSYYtks-----gkdPLIYPYVLFLSIQLL 526
O22224       453 FKLSC-----------IRDvtgGSsSVVLNDGlapYSLDDLQAYLNK-FEPSYYtkn-----gkdPLVYPYVLLLSVQLL 515 thale cress
XP_003543674 453 FKLSA-----------VRDcpsGPsSIVLSDGlipYSLDDLQSYLNK-FEPSYYtkn-----gkdPLVYPYILLLSIQLL 515
EEC18450     413 LHLCQ-----------VHTeelq--vqePQDW---LTLSRLQRILLEdHGESHFdaq------nqPFLYFQVLFLTAQFE 470
XP_005814359 417 LKLNQ-----------VCFddds--sssPQDR---LTLPQLQKQLLEdYGESHFsas------qqPFLYFQVLFLTAQFE 474
XP_001633614 411 LKLSL-----------VSVdq-----sdAQDE---MTLDQLQILLLEqFGETHFgay------qqPFLYFMVLFLTGQFE 465
XP_002108984 409 LQLKQkiifglrhgitISNtpne-dnsqSQEV---FTLPQLQTLLIDhYGESHFnay------qqPLLYFRVLLLTMQFE 478
XP_019849727 413 LKLCQ-----------VNVdg-----gySSDQ---LNFSSLQHLLLKdYGESHFdaq------rnPHLYFQVLLLTVQFE 467 Amphimedon quee...
XP_002131359 423 LKLSQ-----------Vvvde----ssaHPDV---LTLSRFQKLLVEdYGESHFnam------snPLLYFQILFLTCQFE 478 vase tunicate
5HB3_A       335 QAIAYLYP-FSy----VDAVHFAIALTYYGLLRPvdaASAGNeLLS------HntrsmPQINFGRMLGYYT-RDFRAANP 402 Thermochaetoide...
XP_004984390 527 PAILYLSKeIGedgyhVDAVHISIALADHGVLPDgvgSGQ------------KigvmdACAEAASIIRQYGsIYLRSGNI 594
O22224       516 PAIMHLSKeAGdggynIDAVHIAISLVDHSVLSEgsgTGH------------KlsvmdSNAEASSMIRQYGsMFLHHGDL 583 thale cress
XP_003543674 516 PAVLYLSKeAGdegynIDAAHLSIVLADHGVLSEgagSGQ------------KlgvmdAYAEVSTIIRQYGsMYLRLGDL 583
EEC18450     471 AAIEFLSRyEPl---rCHAVHVALVLYEAGLVTPph-sVQAG-LVSkapdggPp-----RLNLARLVTSYT-RKFEATDP 539
XP_005814359 475 AAVAFLFRvERl---rSHAVHVALVLYELRLLLKss-gQSAQ-LLSqepgdpPm---vRRLNFIRLLMLYT-RKFESTDP 545
XP_001633614 466 AAVEFLSRvEFf---rSHAVHIAISLYEMGLLAVse-sLQTQ-LLTtdpstpQp---fRQLNFARLIMSYT-RKFEMTDP 536
XP_002108984 479 AAIEFLFRiARy---rTHSIHFAISLYEAHILSLsk-sSQSQ-LLeps--dpQp---sRRLNFCRLIMSYI-RKFEGTNT 547
XP_019849727 468 AAIEFLSRiDSl---rCHAVHFALALHDQNLLHPce-sFNSP-LLKdep------ngiARLNLGKLVIGYT-RKFALTDP 535 Amphimedon quee...
XP_002131359 479 KAIEFLSRfENl---rSHATHVALALHSHELLLTad-sLHAK-MITteaadeSpltvvERLNLSRLVMLYT-RKFEITDP 552 vase tunicate
5HB3_A       403 AAAVDYLVLICLNAD--------------EaaggqqAQA-ALCHEALRELVLESREFSRLIGDIRPDGRRIRGVIEERGP 467 Thermochaetoide...
XP_004984390 595 DLALEYYAQAAAAMGggevswigqgnadqQ------RQRsLMLKQLLTEILLRDGGIQLLLGP---SGMGEEGELKKYMM 665
O22224       584 QMTVEYYAQAAATVGggqlawsgrsnvdqQ------RQRnLMLKQLLTEILLRERGIYFLLGA---RGSGEEGQLGRFFP 654 thale cress
XP_003543674 584 QMALEYFAQAAAAVGggelswtgrgnvdqQ------RQRnLMVKQLLTELLLRDGGIYLLLGA---RGTGEEGELGRFVT 654
EEC18450     540 REALNYFYFLRKLKG--------------V------HGE-NLFVACVSELVLETREFDALLGKMERDGCRRPGAVDR--- 595
XP_005814359 546 REALQYFYFLRNEKD--------------S------QGE-NMFMRCVSELVIESREFDMLLGKLEKDGSRKPGIIDK--- 601
XP_001633614 537 REALQYFYLLRNIKR--------------P------HGG-DLFMECVSELVLETREFEMLLGKLEPNGTRKPGCIDK--- 592
XP_002108984 548 REALQYLYLLKGIKN--------------P------QGE-DVFESSLSELALETREFDMLLGSLNSDGSKKLGCIDK--- 603
XP_019849727 536 REALEYFYRLKDLKD--------------S------LDR-NLFFSCVSELALESREFEMILGRIEPDGSKRHGCINK--- 591 Amphimedon quee...
XP_002131359 553 REALNYFHFLRNIQ---------------T------DGQ-SLFIHCTSELVRETGEFEMLLGRLNADGSRKPGAVDK--- 607 vase tunicate
5HB3_A       468 LIALGQEDDFIRTITLQAASFADDNGRTTDAVLLYHLAEDYDTVVSIVSRALSEAISLeigedpmrliPVKPRvtnaegq 547 Thermochaetoide...
XP_004984390 666 DWRS------RQQFLLEAAHRCQEAGLYDKAVEIHKRVGDFAMALQIINKCLSDAVCamarnm----------------- 722
O22224       655 DSRL------RQQFLVEAAHQCQEAGLYDKSIELQKRVGAFSAALETINKCLSEAICslargr----------------- 711 thale cress
XP_003543674 655 DPKA------RQQFLIEAACQCQEAGMYDKSIEIQKRVGSFSTALDTINKCLSEAICalfrgr----------------- 711
EEC18450     596 -FQ---AD--THRIVEAVAGDCEKRGLYEDAVRLLDLCGKHDEAVRLLNRLLGQQVPL----------PSGP-------- 651
XP_005814359 602 -FA---GD--TRTIISKVALEAENKGLFEEAVRLYELAKNPDKVLELMNRLLSPVIAQ----------VSAPQ------- 658
XP_001633614 593 -FQRDRQD--TQAIIERVAKDTEEKGLFEEAIRLYDLAKNHDKTIELMNKLISQVVST----------CGAPQ------- 652
XP_002108984 604 -FYISG----AKAVIEKVAVESEKKGLFEEAIKLYDLAKNHEKVLEILNRLLSQVVPK----------SNDSD------- 661
XP_019849727 592 -FSPKVGEKVEAEITSFIAEEAEGQGRFEDSVRLYDLAQEREKVLELLSHLLSGVVSS----------PSPPQ------- 653 Amphimedon quee...
XP_002131359 608 -YCA--GD--TKLLIAKVASDTEAKGLNEDAVYLYDLCGKHDQTLALLNRLLSPVISS----------SDNSH------- 665 vase tunicate
5HB3_A       548 veeaapgsslSLAAIDDPVELAKAMMG--MYERDHMFWQ-KIREPNRVACSVLLQMADIKSLVEQGRWAECLDKIRALDI 624 Thermochaetoide...
XP_004984390 723 --------ldgesRATALIHSGNEIMEtaRYSSETSVQDkDLISEQQTVLRQLEAILHIYRLARAGQTVDALRETIRLPF 794
O22224       712 --------ldgesRTSGLILAGNDILEtyKYYPEVSLQErERVMEQETILRELEAILSIHKLGRLGNHLDALREIAKLPF 783 thale cress
XP_003543674 712 --------ldgesRTAGLIHSGNEILEtySYYPDVRLQErEHVFDQQTVLRQLESILSIHKLARLGHYLDALREVAKLPF 783
EEC18450     652 -----------AW--ERLHSLAVELAE--RYRSH-GT---NASADATSALYLLLDLGLFFLQARQGQAVLALETMRKLQI 712
XP_005814359 659 ----------SNK--ERLKNTAVVIAE--RYRSQ-GT---AAEKSISSTFYLLLDLMTFFDEYHAGHVDRAYDVMERLKL 720
XP_001633614 653 ----------SPR--DRLHNMAVEIAD--RYRAQ-GH---NASQSRMSTFFLLLDLMQFFDLYHGNQTDTALDVIQKLKL 714
XP_002108984 662 ----------NTR--SRLQDLAVSIAQ--RFKSL-GH---FASRVRLKALYILLDVMLFFDLFHGHNYEQALDVVKKIGI 723
XP_019849727 654 ----------SDR--HRLQQLSVSIAE--RYRNH-GY---TTSMQISHTFFLLLDLMQFFDAYHAKRLDQAFDIIKKLHL 715 Amphimedon quee...
XP_002131359 666 ----------PDR--ARLKSMALAIAE--RYRNQ-SV---ETSRNVRSTFHLLLDLLVFFDLYHANRVEQALDVVNELQM 727 vase tunicate
5HB3_A       625 LPLtargDP-GTIRSYAARFPSLAQPVAINVPNLLMWTVLCCMRQRERL----------------AG--------GQFag 679 Thermochaetoide...
XP_004984390 795 LHL----DP-QSPNVTVDIFRNLSPHVQACIPDLLKVALNCIDNVRDTDg------------------------------ 839
O22224       784 LHL----DP-RMPDATADVFQSASPYFQTCVPDLLKVALTCLDNVPDTDg------------------------------ 828 thale cress
XP_003543674 784 LPL----DP-RGPDIAVDVLENLSPHVQACIPDLLKTALTCLDNVTDSDg------------------------------ 828
EEC18450     713 IPF----DP-SEVEASARALPQRSEEVRRILADVLLAVMNLLYSRYKEL----------------KG------------- 758
XP_005814359 721 LPL----SQ-DSVEERVAAFRNFSDEVRHNLSEVLLATMNILFTQYKRL----------------KGapagtpgrSPR-- 777
XP_001633614 715 VPL----SS-ETVEERVAAFRQYNDEIRRVLPDVLLATMNILYTKYRGT----------------KSsgq--splLDR-- 769
XP_002108984 724 LPL----EIdDTVEQKVASFKQIADEIKRNIPQVLLATMNILYAQYESI----------------RPgsiq-nplLTS-- 780
XP_019849727 716 LPL----TPgEKVEQRVQGFRTMSDYVRQCFPDLLLAVMTIICTQYRKArxeimriehallpfvfSSt------pVKG-- 783 Amphimedon quee...
XP_002131359 728 LPS----TM-EQVQSKVSMFKTYTDEIRQSISDILLATMTLLTKRCKLQ----------------QN--------LNK-- 776 vase tunicate
5HB3_A       680 N-ESTARLM-MDELKQMTVDLMAYTSQLRYRLPPHLHEA 716 Thermochaetoides thermophila DSM 1495
XP_004984390 840 --------T-LRAVKSKIANLV--ANNMSRNWPQDLYQK 867
O22224       829 --------S-IRAMRSKIAGFL--ASNTHRNWPRDLYEK 856 thale cress
XP_003543674 829 --------S-LRALRAKIASFI--ANNLRRNWPRDLYER 856
EEC18450     759 ----GERDeeRKRLKLQAQAILEYAGMIPYRMPGDTNAR 793
XP_005814359 778 StEDRGTQ-----LRLQARALITFAGTIPYNMAGDTNAR 811
XP_001633614 770 RrDDGGMEqlRMILRRQARSLLTFAGLIPYRMPGDTNAR 808
XP_002108984 781 RaNDGGRDmhVKEIRRQARTLITFAGMISYRIPGDTNSR 819
XP_019849727 784 KeQNDGIQmlMSRLRTNAQSLITFAGMIPYQMPGDINAR 822 Amphimedon queenslandica
XP_002131359 777 SvTTKSGDsvCTNARRYARSLITFAGMLPYHLPGDATAR 815 vase tunicate
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