6VKL


Conserved Protein Domain Family
Sec15_C

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pfam04091: Sec15_C (This model is not part of the current CDD release)
Exocyst complex subunit Sec15 C-terminal
Sec15 is a component of the exocyst complex involved in the tethering of post-Golgi Golgi secretory vesicles to the plasma membrane during exocytosis and plays a role in several cellular functions such as cell polarisation, cytokinesis, ciliogenesis and tumour invasion. The exocyst is one of the members of the complexes associated with tethering containing helical rods (CATCHR), together with COG, GARP, and Dsl1 complexes, which share a fold consisting of alpha-helical bundles forming a rod structure. This is the C-terminal domain of Sec15 which mediates Rab GTPases binding in a GTP-dependent manner.
Statistics
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PSSM-Id: 516028
Aligned: 96 rows
Threshold Bit Score: 314.094
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6VKL_F        477 PLYKILVSIFEKFCSVSLRAFDDEFQILLNDDDFMPLSINDKTLYEKVLKICWMkegehlslpDPTNGEPFAVTLPFSPL 556 Saccharomyces ...
XP_002427599  391 QLYDLLHEMRDHYNEVLMQRWVMIFREILDEETFSPIQISNQVEYDKIMESFPFq-------dDTANNLKFPRKLPFSQM 463
11_pfamImport   1 QIFEVLHEIRDHYNEVLMQRWVGVFREILDEESFLPIEVETQKEFDQVLSTFPFq-------dDALEAALFPKKFPFSPF 73 
XP_968337     389 PLWELVRELRDHYTEVLMQRWVQVFREILSKEDFQPIQVYDLEEYEHILSSFPWd-------eDLPNDVVFPHKFPFSGM 461
XP_002102631  384 ILWELLHNMRDHYNEVLLQRWVHVFREILDKEQFLPMVVQNTEEYECIIERFPFh-------sEQLENTPFPKKFPFSRM 456
XP_032523601  375 PLPLLLQEMAEHYTEVLMQRWVVVFRDILDNASFAPIEVSNQEEYDAVMDTFPYd-------gDELETQPFPRRFPFTSL 447
2_pfamImport    1 NYMELLHEIQEHYNEILMQKWVQVFRDILYRETFCHLEVDNQDQYDNVVRTFPYq-------dDQLESSTFPRKFPFSSM 73 
XP_002174992  392 KLHGLCIKLIDAFGGALIYKHAGMFAETLDNDNYAPLEIKDEQMYCELIQPYWY----------DKKVDSFPVTMPFSKM 461
XP_013025248  392 RLHSLSVELIDAFGGALILKHSVSFEEAFDTDLYAPMVINNEKEYDELIAPYWT-----------LPPAPFPRMVEFSKM 460
Q18286        433 PLYELLQNFRDQYNEILVKEYCAQFERDLEKDNYTPITVNSEEEFRTIIRKFPFy-------kRSMEQEPFPRRFPFSPF 505 Caenorhabditis...
6VKL_F        557 YPMTCTLAKKTYSKITAFLSIF--YRhelHTLNNILVKTMDDIFNDIVNKKIRSKLESTs----REEIAQILVNLDYFII 630 Saccharomyces ...
XP_002427599  464 VPNVYNQVKKYINACLKFSEDLhiSQ---ATNNDMVIKSTTLLLTRTFSGSLLSLFRKPgl--gLLQVVQIIIDIGYLEK 538
11_pfamImport  74 VPNIYQQVKEYIYACLKFSEDLnlSQ---GEVDDMIRKSTNLLLTRTFTGCLSSVFRKPgl--gLMQVIQIIIDTRYLED 148
XP_968337     462 VPKVYQQVKEFIYACLKFSEDLnlSQ---VEVDEMIRKSMNLLLTRTFSGCLSSTFRSPhi--nLQEIIQIIIDTGYLEE 536
XP_002102631  457 VPEVYHQAKEFMYACMKFAEELtlSP---NEVAAMVRKAANLLLTRSFSGCLSVVFRQPsi--tLTQLIQIIIDTQYLEK 531
XP_032523601  448 VPAVYVQVKEFIYAWLKYSAGLglGG---GRRAAAARHSASLLLSRSFTGCLSALFRRPl---pLTQLVQIIVDTQYLED 521
2_pfamImport   74 VPSVYDQVKQFIFACLKFSNDLnfSE---GEVDEMVQKSTKLLLSRTFSGCLSSAFHQPrl--gLLQVIQIIVDTGYLEK 148
XP_002174992  462 CYECCQNADSFIRRFFMFLNDS-------ITLAVEVNERAPRLFRRFIKFGFVNQLTDRlprlgISQVAQVVQNFDAFEE 534
XP_013025248  461 CSLCCITLSKFARHFFMFSNDS-------ITLALDVQEKIPRFYRRFILHSLLDRLKHLypklnLSQMAQLVKNFYAFEE 533
Q18286        506 VTDAYTQAKNYLIGCLKFMDNLqlNT---SAVDDTVRRCANVLLGR-WAGVLKSFVHKRl---sMIQLVQITINLGYLEK 578 Caenorhabditis...
6VKL_F        631 AAKEFSNFMTRENIlqNP----------DMEIRLSSIKYLAESRKLAETKLIELIDSKISDILETIEIDWQITEVRQDPD 700 Saccharomyces ...
XP_002427599  539 AAIFLDEFICTLTGcq-----------rEENIAVRKQAMFHVAKNDAEKQISLKLKEKIDEFLELENYNWSLVEPQGYAS 607
11_pfamImport 149 ATVYLEEFVSNITGt-------------NESCSRGQGHLFGVARDDAEKQICDKLKQKLDEFIELESYDWLLVEPQGHAS 215
XP_968337     537 ATVYLDQFISNITGe-ESrg-------vSTGVVQGQPAMFRVAREDAVRQICEKLRQKLNEFYELESYDWLLGEPSGHAS 608
XP_002102631  532 AGPFLDEFVCHMTNt-------------ERSVSQTPSAMFHVARQDAEKQVGLRICSKIDEFFELSAYDWLLVEPPGIAS 598
XP_032523601  522 ATSFLYEFISNITGs-------------ELVTTQTAGSMFQAARDDAEKQICEKLEKKVDEFLDLENYDWLLVEPSGQAS 588
2_pfamImport  149 SSKSIQQFVSEATGs------------tGGTVGDDAGITLGVARNDAEHHMYDKMKLKLNEFLDLEDYDWMLVEPTGQAS 216
XP_002174992  535 PLLRMERILSSNKSitPMaqmlpenaqpSSHKATEMLEEISHGRKQALHQIFICINHKIDDFVDLAEYDWITTTPRTTVS 614
XP_013025248  534 PLLQMEKTLVISKStsHAgne----itnVNIKSSELLEGLANARKSALHEIFVKINHKIDDFIGLAEYDWSTTVPRTAPS 609
Q18286        579 SCESLGAFITSKTSgeEAig-------tTSHQVVLSEKVFRDVRSEVEQQIDECMRSKVDEIIDLANYDWELPAAAGQAS 651 Caenorhabditis...
6VKL_F        701 ISIIDLAQFLEMMFASTLQNLPYSVQTLLIFREFDSLTRQFMGLLLHDTPSTITHESIMNFEVDVNYLESI-----IPRi 775 Saccharomyces ...
XP_002427599  608 NFITDLIAFLQSIFSS-FTNVPVHVAQESCKAACEHIAKSLMGFILSDNVKQLTMGALQQINLDTIQCEQFaasdpVPG- 685
11_pfamImport 216 TFVSDLIAFLNSTFTS-FTNLPSEVAQVACKSACEHIAKSLMGMITNNDVKQISMGAIHQLNLDTLQCEQFaasepVEG- 293
XP_968337     609 SYISDLIAFLQTTFQS-FTNLPPEVAQVACKSACEHIANSMFQLLMNDEIKQISMGALNQINLDLLQCEQFaasepVKG- 686
XP_002102631  599 AFITDMISYLKSTFDS-FAFKLPHIAQAACRRTFEHIAEKIYSIMYDEDVKQISTGALTQINLDLMQCEFFaasepVPG- 676
XP_032523601  589 SFVTDMLSYLSGVLTS-LEQLPQFARVAAVRAATNRIATRLRNLLLEPGVRQISSGALYQLDLDVIQCEQFaaaepVPG- 666
2_pfamImport  217 SFVTDLINFLRVVFNA-LRNLTEEVSVHVCQVAFEHISKSILNLLLSDDIKQLSMGALNQLNLDVIQCELFaasepVGK- 294
XP_002174992  615 GYLQEMLAYLQTMYMEILGGIDNSDKSYIYLETLDHLSTAIMKLITHPSVRRISSTAAAGFKLDIEFLESF-----AAK- 688
XP_013025248  610 GFLQEMVPYLQTIYLDSLAGLPNHDKSYVYLETLDHLCTAMIDLLSNPAIRKISTAAAEGFKVDVEYLESF-----ASQ- 683
Q18286        652 EFISDLINFLQTTFTS-FTNLPSGLAKHVCTQTCKHISQSMSDFLLSPETKCISTGALDQFSLDVMQCEMFttrcpVAG- 729 Caenorhabditis...
6VKL_F        776 fpstpgtidsngyqspmtpstptfpnangvdaptLfennIKSleATFMELKQCIELLKT-QGKDY-NEPEIRLRKYSRIR 853 Saccharomyces ...
XP_002427599  686 ----------------------------------Lee---gVllKYFAELRQLLDLLMAwDWSAYfHDYGQENSKYSHIN 728
11_pfamImport 294 ----------------------------------Lee---gVllQYFTDLRQLLDLFLSwDWSTYfHDYGQDNSKYQQVS 336
XP_968337     687 ----------------------------------Lqe---dVllSYFTKLRETLDLFTSwDWPTYfHDYGQETSKYKQVN 729
XP_002102631  677 ----------------------------------Lke---gElsKYFLRNRQLLDLLILeEWSTYfHDYGKQENRYHLVQ 719
XP_032523601  667 ----------------------------------Lre---gEllEHFASLRQLLDLITGwDWSSYlHDVGIEGGKYALVT 709
2_pfamImport  295 ----------------------------------Tde---pDfsQHFAPLRQLLDLLLSwDWSTYfHDYGQETSKYSHVK 337
XP_002174992  689 ----------------------------------Lpg-qSIVnaDSFIELRQSAKLLQAeNVEEY-MDADKFVRDFSRLD 732
XP_013025248  684 ----------------------------------Vpd-qSIVnaDSFIELRQCANLLLGdNIEDY-LDTDKFTRDFNRLH 727
Q18286        730 ----------------------------------Vdp---qTlsMTFADLRQLLDLVMSsDWTTFnAEYGKDHAKYLRVK 772 Caenorhabditis...
6VKL_F        854 QEDAALLLSK 863 Saccharomyces cerevisiae S288C
XP_002427599  729 PNTAIIILEK 738
11_pfamImport 337 PNTAIILLEK 346
XP_968337     730 PDDAIVLLEK 739
XP_002102631  720 PQSIIVILEK 729
XP_032523601  710 PRDAATLLEK 719
2_pfamImport  338 PTTAIIVLEK 347
XP_002174992  733 TSTAIKLLEK 742
XP_013025248  728 PSTSVKLLER 737
Q18286        773 ASTAIVVLEK 782 Caenorhabditis elegans
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