8RNU


Conserved Protein Domain Family
BRICHOS
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pfam04089: BRICHOS (This model is not part of the current CDD release)
BRICHOS domain
The BRICHOS domain is about 100 amino acids long. It is found in a variety of proteins implicated in dementia, respiratory distress and cancer. Its exact function is unknown; roles that have been proposed for it include (a) in targeting of the protein to the secretory pathway, (b) intramolecular chaperone-like function, and (c) assisting the specialised intracellular protease processing system. This C-terminal domain is embedded in the endoplasmic reticulum lumen, and binds to the N-terminal, transmembrane, SP_C, pfam08999, provided that it is in non-helical conformation. Thus the Brichos domain of proSP-C is a chaperone that induces alpha-helix formation of an aggregation-prone TM region.
Links
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Statistics
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PSSM-Id: 516026
Aligned: 107 rows
Threshold Bit Score: 48.4225
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8RNU_A         27 DSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIK-----AGTYLPQ---SYLiHeHMVITDRIE 98  human
XP_009019807  151 KVLPSVTIYDFSANYSTVEDEVNRLCYIMPMDKSAIQQPRNFLDTIDM-----------------Tl--K-VFRMMEMVD 210
13_pfamImport   1 GSEEVLEVHDFKNGITGIRFAEHQRCYIKTQTRQ-LPAEVE--EEEAEEAeqlvdETEATDMk-vEDSqV-WVPAEEAIV 75 
28_pfamImport   1 GSKEIVEVHDFKNGITGIRFTEHQRCFIRTQTRS-LPTAT--------EAvaepdQGESVDTk-vDDSqV-WVPAEEPIV 69 
XP_015207016   96 GTDEVLEVHDFKNGIAAVLFARHQRCYIRAQTKE-FPEITAVQREDMDVE------GTEIADtqfEDSqV-WVPAEEPIE 167
XP_001513037   96 GSKEILEIHDFKNGFTGILLVGLQKCFIKTQSKM-IPEPAE--AEVEELE-----DGAITTTy-fEQSvV-WVPGEKPIE 165
XP_003774964   98 GSDETLEIHDFKNGYTGIFFAELQKCFLKTQIKV-IPDFD--------ETemedaENDEITTtyfEQSmV-WIPGEKPIE 167
EGV94157       95 GTDETLEVHDFKNGYTGIYFVGLQKCFIKTQIKV-IPEFS--------EPeeeidENEEITTtffEQSvI-WVPAEKPIE 164
XP_023193296   98 EAGEAVEIHDFQIGITGIRFFGGDKCYIKSHIKANLSLLGAHNKDTLMFDl----TDEIMPVrfdEEFlI-WVAAKQPLK 172
XP_040058136  101 GADEAVEIHDFQIGITGIRFLGGEKCYIKSQIKSHLPHMGAHNKESQMFDm----TDEVIPVssgEQFlV-WVSAEQPLK 175

8RNU_A         99 -------------NIDHL-GFFIYRLCHDKETYK 118 human
XP_009019807  211 tkyevqvpqlteeELKKY-GERAFKACKNYRSFL 243
13_pfamImport  76 -------------NPAFLfDSKIWEICQELPIHW 96 
28_pfamImport  70 -------------NLAFLfDSKIWEVCQELPIHW 90 
XP_015207016  168 -------------NRAVLlSSRISEMCEHLPVHW 188
XP_001513037  166 -------------NKEFLkNSKISEVCKNVSIHW 186
XP_003774964  168 -------------NKDFLkGSKIFEVCQNVSIHW 188
EGV94157      165 -------------NRDFLkNSKILEICDNVTMYW 185
XP_023193296  173 -------------NTTFL-SNRILDLCGELPIFW 192
XP_040058136  176 -------------DTSFL-SNKILGLCTNLPIYW 195
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