Conserved Protein Domain Family
BRICHOS

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pfam04089: BRICHOS 
BRICHOS domain
The BRICHOS domain is about 100 amino acids long. It is found in a variety of proteins implicated in dementia, respiratory distress and cancer. Its exact function is unknown; roles that have been proposed for it include (a) in targeting of the protein to the secretory pathway, (b) intramolecular chaperone-like function, and (c) assisting the specialized intracellular protease processing system. This C-terminal domain is embedded in the endoplasmic reticulum lumen, and binds to the N-terminal, transmembrane, SP_C, pfam08999, provided that it is in non-helical conformation. Thus the Brichos domain of proSP-C is a chaperone that induces alpha-helix formation of an aggregation-prone TM region.
Statistics
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PSSM-Id: 397971
Aligned: 142 rows
Threshold Bit Score: 48.4485
Threshold Setting Gi: 156228868
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002610562   89 HVTALMDAKRGVAVYKDMTQEVCMVSRLDDSILPSNAQQARHFKVKVlteeeeeAYLSAAKdagQQPvLMTSTGAPVENL 168  Florida lancelet
OCA25059       38 EAIEIHDFKHGITGIYFAGLQKCFIKTQIKD-IPEIA--------ETefv--elEGSEITTtiyEQSmLWIPGEKPIEDK 106  tropical claw...
XP_003774964  101 ETLEIHDFKNGYTGIFFAELQKCFLKTQIKV-IPDFD--------ETeme--daENDEITTtyfEQSmVWIPGEKPIENK 169  Tasmanian devil
XP_002605924  109 TSFVIRDMKTSLSAYRFDGDEKCYILYESLEEVEDTAKMAEDMEQME-------EGELDAAerrPETfLTVDKDRGVVER 181  Florida lancelet
XP_002605926  792 TSFVIRDMSNSLSAYRFNGDEKCYVLYESLEEAEDTAELLEDLEQME-------EGEVDAAerrSEIfLSVDEERGHVER 864  Florida lancelet
XP_002605916 2615 AAAVMFDHNKDLKAYKFSGRDICYIVPEDEGEDEKAKEAAKELENKE-------EGSTQASkkgGRRkMSLDESRT--DT 2685 Florida lancelet
EEN45029       35 MAAVMFDHNKGLKAFKFSGRNICYIVPEDEREDWQVKETARDLEYIE-------ESSIQEVkngGRRkISIDEFRT--DA 105  Florida lancelet
XP_002605925  108 VAAVMFDHNKGLKAYKFSGRGMCFIVPEDKEEDKIVKEAARELENKE-------EGSTQPSksgGRRkMTLDESRT--DA 178  Florida lancelet
EEN46212      116 ETVVMYDTKNDLAAYKFSGLHICFIVEDSTYSEEAADMLANEVENEDe------RETVEEAeasEGLnLTLDESRGRVDR 189  Florida lancelet
XP_002605926  399 tSFVFRDMQKSLSAYRFDGDEKCYILDESLEESKDTTELLEDLEKME-------EGEVDVAerqPETfLSVDEELGHTER 471  Florida lancelet
XP_002610562  169 AEVaGQAAADLCGEYPVYE 187  Florida lancelet
OCA25059      107 DFMkNSKIFEVCKNVSVHW 125  tropical clawed frog
XP_003774964  170 DFLkGSKIFEVCQNVSIHW 188  Tasmanian devil
XP_002605924  182 SEL-SEGIVEFCEGLRTHW 199  Florida lancelet
XP_002605926  865 SVL-SESMAEFCEGLRTHW 882  Florida lancelet
XP_002605916 2686 LEL-SEAMRLFCGDLKPRW 2703 Florida lancelet
EEN45029      106 PEL-SEAMGSFCGDLQPRW 123  Florida lancelet
XP_002605925  179 PEL-SEAMGFFCGDLEPRW 196  Florida lancelet
EEN46212      190 SIL-SDNMLDFCKSHEVYW 207  Florida lancelet
XP_002605926  472 SVL-SESMLEFCKGLKTHW 489  Florida lancelet
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