5L3Q


Conserved Protein Domain Family
SRP-alpha_N

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pfam04086: SRP-alpha_N (This model is not part of the current CDD release)
Signal recognition particle, alpha subunit, N-terminal
SRP is a complex of six distinct polypeptides and a 7S RNA that is essential for transferring nascent polypeptide chains that are destined for export from the cell to the translocation apparatus of the endoplasmic reticulum (ER) membrane. SRP binds hydrophobic signal sequences as they emerge from the ribosome, and arrests translation.
Statistics
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PSSM-Id: 516023
Aligned: 96 rows
Threshold Bit Score: 120.209
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5L3Q_B         27 GPVNALIRSVLLQERG-GNNSFTHE----ALTLKYKLDNQFELVFVVGFQKILTLTYVDKLIDDVHRLFRD--------- 92  human
EPB83665       26 SPVEDLIRNVLIEERA-GtDSYFKE----NYALKWTFANELDLVFVVAYQKILQLNYIDELLETVKRMFLEtnkdliaqg 100
XP_004365719   28 TVINALISSAFIEKRavsDKQFVHD----HFALKWAIVNELDLVFVVVHQKALQLNYVDELLSSMATSFVNtngddvraf 103
XP_003549540   28 SPIDTLIRSCLLEERS-GaASFNYDapgaAYSLKWTFHNDLGLVFVAVYQRVLHLLYVDDLLAAVKREFSR--------- 97 
17_pfamImport   1 SPIDTLIRSCLLEERS-GeVSFNYG----AYTLKWTFHNDLGLVFVAVYQKILQLLYVDDLLSIVKQSFSE--------- 66 
XP_011387176   32 NPVNSLIKQAFLEQRT-AdQKFEKD----GYTLRWTFANELDLTFVVVYQRILQLSYIDELLDTIRTLFTD--------- 97 
GAC72537       32 NPVNALIKQAFLEQRT-AdHKFDKD----GYTLRWTFANELDLTFVVVYQRILQLSYIEELLDNVRSLFTD--------- 97 
CCA67186       33 SPVNNLIREALIEGRS-SeDRYEKD----GYAVRWTLANDLELIFVVAYQRILQLSYVEDLLTAIKTLFIK--------- 98 
EMD38485       33 SPVNSLIREALIEGRT-AeDKYEKD----GYAVKWSFVNDLELIFVVAYQRILQLTYVDELLAALKTLFVK--------- 98 
XP_007395939   33 SPVSSLIRDALIEGRS-AeSQFEKD----GYALKWTFVNDLELIFVVAYQRILQLTYVDDLLAALKTLFVK--------- 98 
5L3Q_B         93 -----KYRT---EIQ--------QQSALSLLngtFD----------------FQNDFL----RLLREAEESSKI------ 130 human
EPB83665      101 qlvdgDFAS-------------------------------------------FGPIFD----QLLQQIEDKYSSqnrqra 133
XP_004365719  104 aaglpLFKPsgkHVVd------------------------------------FDARFDtiweGVMQRYEESl-------- 139
XP_003549540   98 -----LYHP---QKTay---------------------------------rdFDEIFQ----QLQIEAESRSENfkkpnp 132
17_pfamImport  67 -----MYDP---KRMry---------------------------------ddFDETFR----QLRVEAEARAEEmkrtkq 101
XP_011387176   98 -----LFAPfvrKLTlss---ksAISSGASR---VItlsesarlefaaalkeWDDIFT----RTLRNLEKAAAQskrkgv 162
GAC72537       98 -----LFASfvrKLAlss---ksAVASGTSK---AAtlpesarlefsaalkeWDDIFS----KTLRSLEKAAAQskrkgv 162
CCA67186       99 -----LYAPfltKFVaslhaqanAAPTEVAD---ASpswdfa-----safkdWDKVFD----KVLRELEQKANQerrlrt 161
EMD38485       99 -----LFEPflaTFVaslhavngAKSVAAAG---TAaaswnf----aqafhnWDNVFD----KLLRGLEDKASQsrrnrl 162
XP_007395939   99 -----VFQPflaTFVaslhaassSTTLLGAS---GSgsetafawdftstfekWDTVFD----NLLKTFETKAAQerksrl 166
5L3Q_B        131 -RAPTTmkkfedsekakkpvrsmietrgeKpkekaknskkkgakkeGSdGPLATSKPVPA----E-------KSGLPVGP 198 human
EPB83665      134 prkfentk-------kfenslkgsqaqnmG-------------------------------------------------- 156
XP_004365719  140 -RIPKAmksfeeskk----------------------------aqksgiasPEPKSPSASivtsP-------TTSQPVSP 183
XP_003549540  133 vpalapnrkqng---------------------twqgqglgqnagsekksdGDGKKGRKLendnFsvansnsNANVNHSG 191
17_pfamImport 102 vAkplngvkkqgqvsk----------------------eetkksngekkddGDKVSVL---------------SNGNHKM 144
XP_011387176  163 lGERKGatnqaqttassd-------------------------------------------------------------- 180
GAC72537      163 lGEKKGitnqaqaadasdk------------------------------------------------------------- 181
CCA67186      162 rQLTGStalgasmsgn-----------------------------------------------esfneehpeRGSGATTP 194
EMD38485      163 sHPTPR----------------------------------------I---VEGPSPPSDDlstiP-------TESVAV-- 190
XP_007395939  167 kHIDPA----------------------------------------VH-TPVESTPPSDDqstfP-------SQSNPT-- 196
5L3Q_B        199 ----------E-NGVE----LskEELIRRKR------------EEFIqk-------hGRG------MEKSN--KStKSDA 236 human
EPB83665      157 ------------ALPVantnTvdEDEITKNI------------KALKlqasprvggrPRKgkssksTSAAAspSMnDDTT 212
XP_004365719  184 ------------TAASsgnsAfaPDSDTADRlk----------------------klGIQsrsagsASKSKpsPSaSTES 229
XP_003549540  192 gkssvnnnigKeNESSn---VgaFDVNRLQKlkgkk--gngngKKKDalvva---------------------------- 238
17_pfamImport 145 eddv---angKeNSADnnnnSvgVDVSKLAKlrskgvrgrgglRKADslgsn----------------------kgssKV 199
XP_011387176  181 kesgqntpiskeVKDSadisKsvEALKSRLKl-----------EASPggrrvvrgkkSASgisasnGGSAPgtPGnASGT 249
GAC72537      182 dsgldtpksikeGKDSadiaKsvEALKSRLKl-----------EASPggrrvvrgkkSTPgisasnGGSAPgtPGhASGT 250
CCA67186      195 akd-----atS-PLDGqeiaKniAHLKTRMKg------------------------rNSTsgkkgkGGGAGsgSDsDVSK 244
EMD38485      191 ------------VVDEeqiaRnvHSLKNRLRgrggr-----------------agrrGSGradpgsGDSL---PGsDTDT 238
XP_007395939  197 ------------TVDEeqiaRnvQALKNRLK------------PKGPggaagrkgrrGVGga--gsGLESVpgSDsDTPS 250
5L3Q_B        237 P-----KEKGKKapRVWELG--G---CA-N--KEVLDYSTPTTNgTPE---AAl---SEDINLI-------RGTGSG-GQ 289 human
EPB83665      213 Tq---kKKKSQKqaRVWDGQiaK---GEmE----ALDFSNNKSSnNNEgddEEadadAIAAQFVdes-klgQKNEKGiYE 281
XP_004365719  230 Ka---pPKKKKa--TAWDPIsgG---MMtNahSGPLDFSSDKPGtAAA-----------AAPDMsty-tagLERDSLkGD 289
XP_003549540  239 -aakgePKKVDKpnRVWDQPapQt----------KLDFTDHVDGdGDR-----------SADFLake-qgeSMMDKEeIL 295
17_pfamImport 200 Ve---pPKKATKknRVWDDAaaApkqEEe-----KLDFTDENGDnG-------------HVDVVaaadqgeSMMDKEeVF 258
XP_011387176  250 EspsgkKAKATKemRKWDGSrsV---SAqQ--VAALDFSGATEKsGDNga--------dLDSWIdek-smgKKRSDGvYE 315
GAC72537      251 EspcgkKTKAAKemRKWDGSrsV---SAqQ--VAALDFSGATEKdADDaa--------gLDSWIdek-smgTKRSDGvYE 316
CCA67186      245 Rq---sSLRGAKskRTWGDV------VPtEddMSALDFSTDKPSdLPSag--------vLDTLVdek-srgVKK-DGvYE 305
EMD38485      239 Qs---kRKAKAKvqRKWGDE------APsEsdMASLDYSYEKVDsARPgtsH------DVSALVdks-slgVRNEEGlYE 302
XP_007395939  251 Ka---kKSKTKAr-RKWGDE------APsEsdMASLDFSYIQVDsPSTkqtT-----MSLSALVdqa-smgTRTNEGmYE 314
5L3Q_B        290 LQDLDCS 296 human
EPB83665      282 VQDVMQE 288
XP_004365719  290 LPDIEYT 296
XP_003549540  296 SSDSEVE 302
17_pfamImport 259 SSDSESE 265
XP_011387176  316 IADVLEE 322
GAC72537      317 IADVLED 323
CCA67186      306 IRDWEFS 312
EMD38485      303 VKDWEFS 309
XP_007395939  315 VKDWDFD 321
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