6WGC,7JPO,7JGR


Conserved Protein Domain Family
RecA-like_ORC2

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pfam04084: RecA-like_ORC2 (This model is not part of the current CDD release)
Origin recognition complex subunit 2 RecA-like domain
All DNA replication initiation is driven by a single conserved eukaryotic initiator complex termed he origin recognition complex (ORC). The ORC is a six protein complex. This entry represents the RecA-like domain of ORC2 with no predicted ATPase activity.
Statistics
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PSSM-Id: 516021
Aligned: 121 rows
Threshold Bit Score: 158.075
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6WGC_B        259 SRHTMSMA--PDVTREEFSLVSNFfneNFQKR--PRQKLFEI--------QKKMFPQYWFELTQ-GFSLLFYGVGSKRNF 325  brewer's yeast
Q8IC17        507 IQENLDNL--DHIQKLQY--LIKNl-pYTHIK--EKRSLYHY--------NIKQFIKWKVYLLN-NINICLYGIGSKFHL 570  Plasmodium fa...
XP_001025157   30 KKQAADEV--IEFNNKNLISYLED---KYQVE--DTEKVKED--------KAKAIVKSCFMIQS-GFNVCLHGYGSKRQI 93  
EPS98601       91 SAAVFSQLv-PALDAPAYARALAG----SRALr-SPHVLESTrlwtderaRAALFAQWADELRE-GFSLLFYGFGSKRTV 163 
GAC71923      473 TSGTLISSklRALDARRLEGVVEA---QTREG--SLADIASRm-------YRHLLPVYFAQLLA-GYAIIFHGVGSKTRL 539 
XP_011388953  439 TSSSLISSklPALDARNLERVITE---NTRSGa-SISDVATSm-------YCHLFPVYLAQLLA-GYSIIFHGVGSKTKL 506 
XP_015788471   20 TKPSKYEDtlPDFDPDESDGCKNKy--ENHVK--EKLQLLNLy-------KENLCPKIHALLIN-NYNVILYGVGSKRGI 87  
XP_009269763   65 ARPSNSLFpyPPLTAKETRTALEN------AP--QKPCVPRQs-------HKRRYLQWKAELFLlHRPLIFTGFGSKRGA 129 
XP_012187658  915 TSTSLISSklPALDARNLERVVAE---HTRSGe-SISDVATCm-------YRHLLPVYLAQLLA-GYSIIFHGVGSKTAL 982 
XP_002366987  500 DSEDDTAAavPLLTRRVHQRMSQL----PCSNakAKNNLLHYl-------LAAHSLEWKAALLS-GYSVLVEGFGSKKLL 567  Toxoplasma go...
6WGC_B        326 LEEFAIDylspkiaysqlayenelqqnkpvnSIPCLILNGYNPSCNYRDVFKEIT-D--LLVPAeltr------------ 390  brewer's yeast
Q8IC17        571 LNLFTNIcl---------------------nDGNKCIILGFEDEINFEEILVRIL-Eyh--------------------- 607  Plasmodium fa...
XP_001025157   94 IQEISDQf----------------------iNYPKLIIQGYSAATQIQQILQKLKyIvvKITGQn--------------- 136 
EPS98601      164 LNAFARAltkrrrv-----------pggserGGHVVIANGYLPGFALKDLLNSIE-AipALQEAsda------------- 218 
GAC71923      540 LTELVRRrie------------------aegDAMGVVAQGAIKGFKVEDLLAEIE-SalSLGPLtlatqaa--------- 591 
XP_011388953  507 LAELVDKrid------------------segDAVGVVAQGAMKGFKVEDMLTEIE-RaaGLGSMtlsadaatr------- 560 
XP_015788471   88 IDEFITSyl---------------------nQNIVIVFYGYKEDVNPRKILSAFR-Ealn-------------------- 125 
XP_009269763  130 IDDFVREls---------------------gEYDVITIDAFNPSITFRGVLEGLL----AVHQKs--------------- 169 
XP_012187658  983 LVELVGKrie------------------aegDAVGVVAQGAMKGFKVEDMLAEIE-RavGLGSLtltanaagra------ 1037
XP_002366987  568 LDRFAHQal---------------------rDGVCCVVEGYRREVRLQHCLSDLLvFltNSSSKalasphtrqasaaasq 626  Toxoplasma go...
6WGC_B        391 ----------------setKYWGNHVILQIQKMIDFY---KNQPLDi--------kLILVVHNLDGPSIRK--NTFQTM- 440  brewer's yeast
Q8IC17        608 ------------------yKYKSSKTLKSFDLLYELI------QRVnds----nvpLYFIIHNLDNTKLYPyyEY----- 654  Plasmodium fa...
XP_001025157  137 ------------------------SGQKRIEGILEYL---KQQEENmgkissqvpfILILFHNIDSKQFIE----QDSVk 185 
EPS98601      219 -----------------qqGTAGTGLEAQVQRIYGYF---SGADDKagg----gerLYLVIHNIDGPGLRG--SKAQVV- 271 
GAC71923      592 -------------egdegvVVVSTLTAARAERIVRRF---NGTAAGgp------srLFLILETFDAPGMQS--IRFKSV- 646 
XP_011388953  561 ----------lgedhgqagLVVSTLTAARAERIVRRF---SRDDLVgp------skLFLILETFDAPGMQS--LRFKSV- 618 
XP_015788471  126 -----------------cdKMDEDVIMKKIDKLKEPI--------------------FLVIHSFDRLCIKH--NKIKPL- 165 
XP_009269763  170 -------------------SIPSSTPTDELMRSVQLQ---YSRASTp--------rIVAVLHSMDALTLHA--RKNVDVd 217 
XP_012187658 1038 ----------seedgkagtTVVSTLTAARAERIVRRF---SRDDIVgp------tkLFLILETVDAPGMQS--LRFKSM- 1095
XP_002366987  627 ggvalvspaaaaskgegeaASKRSSPFLSLEKLVKEVkalAKQls---------vpLYFVVHNIDAPPLRG-----EACr 692  Toxoplasma go...
6WGC_B        441 -LSFLSVI-RQIAIVASTDHIYAPLLWDNMKA-Q-------------------------------NYNFVFHDISNFEPS 486  brewer's yeast
Q8IC17        655 -FSFLSQY-ENIYFVCSIDDVSFELNMNFKNI-S-------------------------------SINFFYIKCHTWLDY 700  Plasmodium fa...
XP_001025157  186 iLSAVLNL-PYIKAVCSIDHVKYPIILTSKVL-E-------------------------------SFNFSFIEVHTHQCY 232 
EPS98601      272 -ISRLATA-PRIHVVASIDNVQAMGRWSLSEMfTrkrtqps-----------------sydvprrGYAWLWHDLTTLAPY 332 
GAC71923      647 -LEILARS-SHIHIMATTEHINSGFVASSAQQaAagdrte--------------------edrtaRLRWIWQNMSTFIPS 704 
XP_011388953  619 -LETLAKS-NNIHIMATTEHVNSGFIASTTGQqVsspptaskrsvv-------drdreatkrtsgRLRWIWQNMSTFTPS 689 
XP_015788471  166 -VNKILNRsSQIHLLTSVDHLNSPLLFTCSET-V-------------------------------TLNLVWLNCPTFQDY 212 
XP_009269763  218 kLKRVLGS-ERISVVASVDHLNAPLLFPAHDAaV-------------------------------GLPWLWHDLSTLEPH 265 
XP_012187658 1096 -LETLAKS-SNIHIMATTEHVNSGFIASSTGQqAstasrslddsampdvqedsdvdaagssrrsgRLRWIWQNMSTFTPS 1173
XP_002366987  693 aFASLAAC-SNIYLIGSADHHMHGLLFDGAEL-R-------------------------------SLSCLYYRCHTYMDY 739  Toxoplasma go...
6WGC_B        487 TVES---------------------------TFQD-VMKMGKsdt---------------------------ssGAEGA- 510  brewer's yeast
Q8IC17        701 RHEIlrqwnkflpew-------------------------------------------------vfnkkceeidIKKNI- 730  Plasmodium fa...
XP_001025157  233 LHEF---------------------------KVSQnTFNLKKe------------------------------kEGESL- 254 
EPS98601      333 DAEL---------------------------ASADpSSISGAstsgrranlat-----------gtaaggprivSETAA- 373 
GAC71923      705 LDEMlmmrsnpafatwmpvlppaldligssaSFAaatsatgtgaqegtgt---------ayfnglqvseafrtvSEASA- 774 
XP_011388953  690 LDEMlimrsnpafaswmpilppcldlmgsaaSLTSrHMQPVGtsssgsalngadgsgnvafynglqvsdtfrtvSETSA- 768 
XP_015788471  213 NIEK---------------------------SFAQlSTSRTSgsskhr----------------------saaatiMAV- 242 
XP_009269763  266 LMEM-----------------------------AQrATSLLHssqaasst--------------------givptvsGA- 295 
XP_012187658 1174 LDEMlimrsnpafaswmpalpacldligsaaSLNSrHTQPAGassssalngtdapsni-affnglqvsdtfrtvSETSA- 1251
XP_002366987  740 REEVlghwgstglfm-----plwlrncagagGFASsd------------------------------------gGAGGVw 778  Toxoplasma go...
6WGC_B        511 ------KYVLQSLTVNSKKMYKLLIET---QMQ 534  brewer's yeast
Q8IC17        731 ------ETILNALSINHKRLFKIIASI---QLE 754  Plasmodium falciparum 3D7
XP_001025157  255 ------KYIFRSLTKVQKEIIQFVAKYiqdKLD 281 
EPS98601      374 ------RHVLASVTQKARRLFVLLGSK---QLE 397 
GAC71923      775 ------ISILKSVTTKARALFNLLAKQ---CLS 798 
XP_011388953  769 ------ISILKSVTTKARALFNMLAKQ---SLV 792 
XP_015788471  243 ------SNVYDNLPDNSRKIFLLILNYystQLS 269 
XP_009269763  296 ------RHVIASVPDRARRLFVAIAQL---QLE 319 
XP_012187658 1252 ------ISILKSVTTKARALFNLLAKQ---SLA 1275
XP_002366987  779 gsgvnfAAVVAALTTNHKRLLKCVAER---QLE 808  Toxoplasma gondii ME49
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