5AP8


Conserved Protein Domain Family
RLI

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pfam04068: RLI 
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Possible Fer4-like domain in RNase L inhibitor, RLI
Possible metal-binding domain in endoribonuclease RNase L inhibitor. Found at the N-terminal end of RNase L inhibitor proteins, adjacent to the 4Fe-4S binding domain, fer4, pfam00037. Also often found adjacent to the DUF367 domain pfam04034 in uncharacterized proteins. The RNase L system plays a major role in the anti-viral and anti-proliferative activities of interferons, and could possibly play a more general role in the regulation of RNA stability in mammalian cells. Inhibitory activity requires concentration-dependent association of RLI with RNase L.
Statistics
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PSSM-Id: 397953
Aligned: 68 rows
Threshold Bit Score: 40.1866
Threshold Setting Gi: 74672717
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5AP8_B         1 MKVYIIDYHKDDPKRCTGKKLVKLKIAefTRVGK 34  Saccharolobus solfataricus
Q7S5I3        62 FKAACWDLGHCDPKRCSGKKLMKLGLMreLHLGQ 95  Neurospora crassa
Q0U8F9        49 YKAACWDLGHCDAKRCSGKRLMRLGMMreLHVGQ 82  Parastagonospora nodorum SN15
Q9VFA0        67 faVAMWDLNHCDPKKCSGRKLARLGLIsnLRLGQ 100 fruit fly
Q10409        27 LPLAMWDFGHCNPNACSGKRLERLGCVrnLRIGQ 60  Schizosaccharomyces pombe 972h-
Q4CZ40        37 VPLAMWDFEQCDPDACSGRRLYRQNALrlLKLRE 70  Trypanosoma cruzi
XP_001581978  35 VRLAMWDFGQCDPKRCSGIKLKRLGYVrvLNLRD 68  Trichomonas vaginalis G3
Q55G49        63 IKLSMWDFGQCDSKKCTGRKLERLGYVksINLTH 96  Dictyostelium discoideum AX4
A0CKJ4        68 VKLFMIDYGQCDVKKCTGRKMERFKLLtaIKPKV 101 Paramecium tetraurelia
Q4UEB4        73 VRMYLWYFNQCDNKRCTGKKLVRSGLVkeLPMTQ 106 Theileria annulata
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