7YJK


Conserved Protein Domain Family
ORMDL
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pfam04061: ORMDL (This model is not part of the current CDD release)
ORMDL family
Evidence form suggests that ORMDLs are involved in protein folding in the ER. Orm proteins have been identified as negative regulators of sphingolipid synthesis that form a conserved complex with serine palmitoyltransferase, the first and rate-limiting enzyme in sphingolipid production. This novel and conserved protein complex, has been termed the SPOTS complex (serine palmitoyltransferase, Orm1/2, Tsc3, and Sac1).
Links
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Statistics
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PSSM-Id: 516003
Aligned: 72 rows
Threshold Bit Score: 126.129
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7YJK_D         15 NRNTEWFMYPGVWTTYMLILFFGWLVVLSVSGCSPGMAWTVVNLAHFVVTYHSFHWMKGTPFAD-DQGIYNGLTWWEQMD 93  thale cress
XP_001984276   12 NPNSSWLSARGFWLAYFLGLLFVHLLLLSVPFVTIPVAWTVTNLLHNAVHLYFLHIIKGAPWLSiENDASRQWTHWEQID 91 
11_pfamImport   1 NPNKTYLSAKGIWVTYTLVVVSVHILLLAVPLVSISFAWTITNILHNLAQIYFLHTIKGHPWIStENSSDIRQTHWEQID 80 
XP_009023498   11 NPNSTYFSSRGMWVTYILVVAFIHYVFLSLPFLSVAMAWTLTNVIHNMLMFIILHIEKGTPFETaDQGKFRYRTVWEQLD 90 
Q5ZIU0         11 NPNTRVMSSRGIWLAYVISVAALHVILLSIPFFSIPVVWTLTNVIHNLVMYLLLHTVKGTPFETpDQGKDRLLTHWEQID 90  chicken
NP_001096387   11 NPNTRVMNSRGMWLTYALGVGMLHIVLLSIPFFSVPVAWTLTNVIHNLGMYVFLHAVKGTPFETpDQGKARLLTHWEQLD 90 
XP_788585      25 H---SWLHSRGVWFSYIVGVYGMHLFLLSLPFFSVSTVWTLTTVVHSVVTYFFFHHVKGSIWAD-SQGSERYQTQWEQID 100
XP_001635718   11 NPNESWLDSKGTWLTYIIMIILGHLVILSVPFFATSTAWTLTNTMHNLCMFLLLHYVKGTPFETsDQGKARRLTHWEQIN 90 
XP_002123459   11 NPNTVVWNSPGIWITYSILTAFMHLVLLSMPWFSTSVAWTLTNVVHGVGMYFFLHTIKGTPFETsDQGKYRYSTHWEQMD 90  vase tunicate
XP_002111281   11 NPNVEWLNSRGIWITYVLFILLEHFFFLSIPVLTVPQAWTLTFTFHNVFTFFLFHVMKGTPFDTfDQGKSRQLTHWEQID 90  Trichoplax adh...

7YJK_D         94 NGQQLTRNRKFLTLVPVVLYLIASHTTDYRHPWLFLNTLAVMVL-VVAKFPNMHKVR 149 thale cress
XP_001984276   92 DGVQMTPTRKFLTAVPIVLFLLTCLYTRNSTEHFIANFISLVVV-TLPKLPQFHGVR 147
11_pfamImport  81 DGEQFTATRKFLTAFPIVLFLLTCLYTRNDLDHFIVNFIALVAV-ILPKLPYFHGKR 136
XP_009023498   91 YGIQFSPSRKFLTIVPIILFFLASFYTKYDYYHFVFNSGSLLLV-LIPKLPQLDGVR 146
Q5ZIU0         91 YGMQCTSSRKFLSISPVVLYLLTSFYIKYDPAHFMINTASLLSV-LLPKLPQFHGVR 146 chicken
NP_001096387   91 YGVQFTSSRKFLTISPIILYFLTSFYTKYDPTHFFINTASLLSV-LIPKLPQLHGVR 146
XP_788585     101 NGEQFTSTRKLLTLVPVLLFFLASFYTKYGYYHFLINCAALLLG-VVPKLPMFHGFR 156
XP_001635718   91 QGVQFTQTRKFFTLIPIFLFMITSFYTKYDGIHFIINAVSLLLLsLVPKFPQMYKVR 147
XP_002123459   91 SGTQFTAARKFFMTTPIVLYILASFYSKYEFTHFVINTSILLLS-LLPKLPQLHGVR 146 vase tunicate
XP_002111281   91 SGEQFTRTRKFLIMVPIAMFMLTSFYTRYEVQHFLFNATTLCSV-IIPKLPALHTVR 146 Trichoplax adhaerens
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